Professor Owen Sansom
- Director, Institute of Cancer Sciences (CRUK Scotland Institute)
telephone:
01413307125
email:
Owen.Sansom@glasgow.ac.uk
Beatson Institute, Glasgow G61 1BD
https://orcid.org/0000-0001-9540-3010Research interests
Colorectal Cancer is the third most common cancer in the western world. The focus of the colorectal cancer and Wnt signalling group is to try to understand the early changes associated with intestinal neoplasia to identify novel markers of disease and new targets for therapy. The key intestinal tumour suppressor is the Apc gene which is mutated in approximately 80% of sporadic cancer. Germline heterozygosity of Apc leads to Familial Adenomatous Polyposis. Central to our work is the use of novel inducible models of intestinal tumourigenesis which allow us to study the functions of specific tumour suppressor genes.
Link to Colorectal Cancer and Wnt Signalling website
Publications
2025
Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z) (PMID:39972137) (Early Online Publication)
2024
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (Early Online Publication)
Dannhorn, A. et al. (2024) Morphological and molecular preservation through universal preparation of fresh-frozen tissue samples for multimodal imaging workflows. Nature Protocols, 19(9), pp. 2685-2716. (doi: 10.1038/s41596-024-00987-z) (PMID:38806741)
Lu, Y. et al. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports, 43(7), 114406. (doi: 10.1016/j.celrep.2024.114406) (PMID:38963759) (PMCID:PMC11290356)
Pereira, B. A. et al. (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10(27), eadl1197. (doi: 10.1126/sciadv.adl1197) (PMID:38959305) (PMCID:PMC11221519)
Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(6), 1321. (doi: 10.1038/s41588-024-01809-4) (PMID:38831011)
Malviya, G. et al. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30(8), pp. 1518-1529. (doi: 10.1158/1078-0432.ccr-23-1063) (PMID:38493804) (PMCID:PMC11016897)
Nair, R., Lannagan, T. R.M., Jackstadt, R., Andrusaite, A., Cole, J., Boyne, C., Nibbs, R. J.B. , Sansom, O. J. and Milling, S. (2024) Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance. OncoImmunology, 13(1), 2330194. (doi: 10.1080/2162402X.2024.2330194)
Domingo, E. et al. (2024) Prognostic and predictive value of Immunoscore in stage III colorectal cancer: pooled analysis of 2,608 cases from the SCOT and IDEA-HORG studies. Journal of Clinical Oncology, (doi: 10.1200/JCO.23.01648) (PMID:38484206) (Early Online Publication)
Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J. , Sansom, O. J., O'Neill, E., Jones, K. and Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17(3), dmm050463. (doi: 10.1242/dmm.050463) (PMID:38421046) (PMCID:PMC10958199)
Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)
Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(3), pp. 458-472. (doi: 10.1038/s41588-024-01654-5) (PMID:38351382)
Fetit, R. et al. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4(2), pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319) (PMID:38358352) (PMCID:PMC10903300)
Frei, A. L. et al. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25(2), pp. 198-211. (doi: 10.1016/S1470-2045(23)00560-0) (PMID:38301689)
2023
Malik, N. , Hay, J. , Almuhanna, H. N.B., Dunn, K. M., Lees, J., Cassels, J., Li, J., Nakagawa, R., Sansom, O. J. and Michie, A. M. (2023) mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia. Leukemia, 37, pp. 2414-2425. (doi: 10.1038/s41375-023-02043-3) (PMID:37775560) (PMCID:PMC10681897)
Frei, A. L. et al. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9(6), pp. 449-463. (doi: 10.1002/cjp2.342) (PMID:37697694) (PMCID:PMC10556275)
Holt, A. K. et al. (2023) Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition. Cancer and Metabolism, 11(1), 18. (doi: 10.1186/s40170-023-00318-y) (PMID:37858256) (PMCID:PMC10588174)
Bailey, P. et al. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, 5211. (doi: 10.1038/s41467-023-40822-9) (PMID:37626054) (PMCID:PMC10457401)
Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11(8), pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644) (PMID:37309673) (PMCID:PMC10398359)
Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)
May, S. et al. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78(5), pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009) (PMID:36702176)
Conway, J. R. W. et al. (2023) Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse. Science Advances, 9(17), eadf9063. (doi: 10.1126/sciadv.adf9063) (PMID:37126544) (PMCID:PMC10132756)
Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)
Barry, S. T., Gabrilovich, D. I., Sansom, O. J. , Campbell, A. D. and Morton, J. P. (2023) Therapeutic targeting of tumour myeloid cells. Nature Reviews Cancer, 23(4), pp. 216-237. (doi: 10.1038/s41568-022-00546-2) (PMID:36747021)
Amirkhah, R. et al. (2023) MmCMS: mouse models' consensus molecular subtypes of colorectal cancer. British Journal of Cancer, 128(7), pp. 1333-1343. (doi: 10.1038/s41416-023-02157-6) (PMID:36717674) (PMCID:PMC10050155)
Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)
Chen, F. et al. (2023) RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene, 42(9), pp. 679-692. (doi: 10.1038/s41388-022-02574-6) (PMID:36599922) (PMCID:PMC9957727)
2022
Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, 7551. (doi: 10.1038/s41467-022-35134-3) (PMID:36477656) (PMCID:PMC9729215)
Ali, A. et al. (2022) Prognostic implications of microRNA-21 overexpression in pancreatic ductal adenocarcinoma: an international multicenter study of 686 patients. American Journal of Cancer Research, 12(12), pp. 5668-5683. (PMID:36628279) (PMCID:PMC9827095)
Corry, S. M. et al. (2022) Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71(12), pp. 2502-2517. (doi: 10.1136/gutjnl-2021-326183) (PMID:35477539) (PMCID:PMC9664095)
Knight, J. R.P., Proud, C. G., Mallucci, G., von der Haar, T., Smales, C. M., Willis, A. E. and Sansom, O. J. (2022) Eukaryotic elongation factor 2 kinase activity is required for the phenotypes of the Rpl24Bst mouse. Journal of Investigative Dermatology, 142(12), 3346-3348.e1. (doi: 10.1016/j.jid.2022.06.019) (PMID:35850210)
Ramadan, R. et al. (2022) The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biology Open, 11(12), bio059544. (doi: 10.1242/bio.059544) (PMID:36350252) (PMCID:PMC9713296)
Hedayioglu, F., Mead, E. J., O‘Connor, P. B.F., Skiotys, M., Sansom, O. J. , Mallucci, G. R., Willis, A. E., Baranov, P. V., Smales, C. M. and von der Haar, T. (2022) Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles. Nucleic Acids Research, 50(19), e112. (doi: 10.1093/nar/gkac705) (PMID:35979952) (PMCID:PMC9638929)
Flanagan, D. J., Woodcock, S. A., Phillips, C., Eagle, C. and Sansom, O. J. (2022) Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition. Pharmacology and Therapeutics, 238, 108179. (doi: 10.1016/j.pharmthera.2022.108179) (PMID:35358569)
Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71(10), pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259) (PMID:35477863) (PMCID:PMC9484388)
May, S. et al. (2022) Modification of diet to reduce the stemness and tumorigenicity of murine and human intestinal cells. Molecular Nutrition and Food Research, 66(19), 2200234. (doi: 10.1002/mnfr.202200234) (PMID:36045438) (PMCID:PMC9539894)
Fisher, N. C. et al. (2022) Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data. Clinical Cancer Research, 28(18), pp. 4056-4069. (doi: 10.1158/1078-0432.CCR-22-1102) (PMID:35792866) (PMCID:PMC9475248)
Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)
Azkanaz, M. et al. (2022) Retrograde movements determine effective stem cell numbers in the intestine. Nature, 607(7919), pp. 548-554. (doi: 10.1038/s41586-022-04962-0) (PMID:35831497)
Patel, R. et al. (2022) Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression. Cancer Research, 82(14), pp. 2565-2575. (doi: 10.1158/0008-5472.CAN-21-1301) (PMID:35675421) (PMCID:PMC9381098)
Kidger, A. M. et al. (2022) Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene, 41(20), pp. 2811-2823. (doi: 10.1038/s41388-022-02302-0) (PMID:35418690) (PMCID:PMC9106580)
Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)
Walter, R. J. et al. (2022) Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop. Cell Death and Disease, 13(2), 168. (doi: 10.1038/s41419-022-04607-0) (PMID:35190527) (PMCID:PMC8861016)
Strittmatter, N. et al. (2022) Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging. Analytical Chemistry, 94(3), pp. 1795-1803. (doi: 10.1021/acs.analchem.1c04579) (PMID:35005896)
2021
Knight, J. R.P. et al. (2021) Rpl24 Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K. eLife, 10, e69729. (doi: 10.7554/elife.69729) (PMID:34895463) (PMCID:PMC8668188)
Falcomata, C. et al. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. Cancer Discovery, 11(12), pp. 3158-3177. (doi: 10.1158/2159-8290.CD-21-0209) (PMID:34282029) (PMCID:PMC7612573)
Heino, S. et al. (2021) Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science Advances, 7(47), eabj0512. (doi: 10.1126/sciadv.abj0512) (PMID:34788095) (PMCID:PMC8598008)
O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)
Lampis, A. et al. (2021) MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer. Cell Death and Differentiation, 28, pp. 2970-2982. (doi: 10.1038/s41418-021-00820-0) (PMID:34226680) (PMCID:PMC8481293)
Murphy, K. J. et al. (2021) Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Science Advances, 7(40), eabh0363. (doi: 10.1126/sciadv.abh0363) (PMID:34586840) (PMCID:PMC8480933)
Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, 4920. (doi: 10.1038/s41467-021-25173-7) (PMID:34389715) (PMCID:PMC8363647)
Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)
Flanagan, D. J. et al. (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature, 594, pp. 430-435. (doi: 10.1038/s41586-021-03525-z) (PMID:34079124)
Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, 3464. (doi: 10.1038/s41467-021-23717-5) (PMID:34103493) (PMCID:PMC8187652)
Nielsen, S. R. et al. (2021) Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature Communications, 12, 3414. (doi: 10.1038/s41467-021-23731-7) (PMID:34099731) (PMCID:PMC8184753)
Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)
Gudiño, V. et al. (2021) RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nature Communications, 12, 2335. (doi: 10.1038/s41467-021-22531-3) (PMID:33879799) (PMCID:PMC8058071)
Galbraith, L. C.A., Mui, E., Nixon, C., Hedley, A., Strachan, D., MacKay, G., Sumpton, D., Sansom, O. J. , Leung, H. Y. and Ahmad, I. (2021) PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene, 40(13), pp. 2355-2366. (doi: 10.1038/s41388-021-01707-7) (PMID:33654198) (PMCID:PMC8016665)
Rosenfeldt, M. T., O’Prey, J., Lindsay, C. R., Nixon, C., Roth, S., Sansom, O. J. and Ryan, K. (2021) Loss of autophagy affects melanoma development in a manner dependent on PTEN status. Cell Death and Differentiation, 28(4), pp. 1437-1439. (doi: 10.1038/s41418-021-00746-7) (PMID:33664481) (PMCID:PMC8027884)
van der Weyden, L. et al. (2021) CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Communications Biology, 4, 395. (doi: 10.1038/s42003-021-01912-w) (PMID:33758365) (PMCID:PMC7987976)
Sphyris, N., Hodder, M. C. and Sansom, O. J. (2021) Subversion of niche-signalling pathways in colorectal cancer: what makes and breaks the intestinal stem cell. Cancers, 13(5), 1000. (doi: 10.3390/cancers13051000) (PMID:33673710) (PMCID:PMC7957493)
Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F. , Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J. and Machesky, L. M. (2021) The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice. Journal of Investigative Dermatology, 141(3), 628-637.e15. (doi: 10.1016/j.jid.2020.06.029) (PMID:32777214)
Alexander, P.G. et al. (2021) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)
Race, A. M. et al. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93(6), pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726) (PMID:33534548)
Murta, T. et al. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93(4), pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179) (PMID:33395266)
Tajan, M. et al. (2021) Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12, 366. (doi: 10.1038/s41467-020-20223-y) (PMID:33446657) (PMCID:PMC7809039)
Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)
Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, 56. (doi: 10.1038/s41467-020-20255-4) (PMID:33397922) (PMCID:PMC7782582)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
Lähde, M. et al. (2021) Expression of R-spondin 1 in ApcMin/+ mice suppresses growth of intestinal adenomas by altering Wnt and transforming growth factor beta signaling. Gastroenterology, 160(1), pp. 245-259. (doi: 10.1053/j.gastro.2020.09.011) (PMID:32941878)
2020
Roseweir, A. K. et al. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6(4), pp. 283-296. (doi: 10.1002/cjp2.171) (PMID:32401426) (PMCID:PMC7578335)
Muthalagu, N. et al. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10(6), pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620) (PMID:32200350) (PMCID:PMC7611248)
Rooney, N. et al. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80(11), pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870) (PMID:32156779)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
Michalopoulou, E., Auciello, F. R., Bulusu, V., Strachan, D., Campbell, A. D., Tait-Mulder, J., Karim, S. A., Morton, J. P. , Sansom, O. J. and Kamphorst, J. J. (2020) Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition. Cell Reports, 30(8), 2729-2742.e4. (doi: 10.1016/j.celrep.2020.01.080) (PMID:32101748) (PMCID:PMC7043007)
Patel, R. et al. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80(3), pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684) (PMID:31719098)
Kennedy, S. A. et al. (2020) Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nature Communications, 11, 499. (doi: 10.1038/s41467-019-14224-9) (PMID:31980649) (PMCID:PMC6981206)
Wilson, D. H. et al. (2020) Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nature Communications, 11, 445. (doi: 10.1038/s41467-020-14283-3) (PMID:31974352) (PMCID:PMC6978415)
Maniati, E. et al. (2020) Mouse ovarian cancer models recapitulate the human tumor microenvironment and patient response to treatment. Cell Reports, 30(2), 525-540.e7. (doi: 10.1016/j.celrep.2019.12.034) (PMID:31940494) (PMCID:PMC6963791)
Dreyer, S.B., Jamieson, N.B. , Morton, J.P. , Sansom, O.J. , Biankin, A.V. and Chang, D.K. (2020) Pancreatic cancer: from genome discovery to PRECISION-Panc. Clinical Oncology, 32(1), pp. 5-8. (doi: 10.1016/j.clon.2019.08.007) (PMID:31522943)
McGregor, G. H. et al. (2020) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, 80(2), pp. 175-188. (doi: 10.1158/0008-5472.CAN-19-0644) (PMID:31562248)
2019
Liko, D. et al. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26(12), pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7) (PMID:30858608) (PMCID:PMC6861133)
Malik, N. , Dunn, K. M., Cassels, J., Hay, J. , Estell, C., Sansom, O. J. and Michie, A. M. (2019) mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Scientific Reports, 9, 16917. (doi: 10.1038/s41598-019-53141-1) (PMID:31729420) (PMCID:PMC6858379)
Schmidt, S. et al. (2019) A MYC/GCN2/eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature Cell Biology, 21, pp. 1413-1424. (doi: 10.1038/s41556-019-0408-0) (PMID:31685988) (PMCID:PMC6927814)
Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)
Vennin, C. et al. (2019) CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, 3637. (doi: 10.1038/s41467-019-10968-6) (PMID:31406163) (PMCID:PMC6691013)
Reader, C. S. et al. (2019) The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology, 249(3), pp. 332-342. (doi: 10.1002/path.5320) (PMID:31259422) (PMCID:PMC6852434)
Leach, J., Morton, J. P. and Sansom, O. J. (2019) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, 110, pp. 69-76. (doi: 10.1016/j.molimm.2017.12.013) (PMID:29269005) (PMCID:PMC6544568)
Johansson, J. et al. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, 24(4), 592-607.E7. (doi: 10.1016/j.stem.2019.02.002) (PMID:30853556) (PMCID:PMC6459002)
Cosimo, E. et al. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25(5), pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036) (PMID:30559170) (PMCID:PMC6398589)
Gay, D. M. et al. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, 723. (doi: 10.1038/s41467-019-08586-3) (PMID:30760720) (PMCID:PMC6374445)
Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)
Spender, L. C. et al. (2019) Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor β superfamily type 1 receptors. Molecular Pharmacology, 95(2), pp. 222-234. (doi: 10.1124/mol.118.112946) (PMID:30459156)
Allen-Petersen, B. L. et al. (2019) Activation of PP2A and Inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma. Cancer Research, 79(1), pp. 209-219. (doi: 10.1158/0008-5472.CAN-18-0717) (PMID:30389701) (PMCID:PMC6318036)
Menon, M. et al. (2019) A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific Reports, 9, 201. (doi: 10.1038/s41598-018-36447-4) (PMID:30655555) (PMCID:PMC6336890)
Rohwer, N. et al. (2019) Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene, 38(28), pp. 5670-5685. (doi: 10.1038/s41388-019-0816-4) (PMID:31043706)
2018
Chou, A. et al. (2018) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut, 67(12), pp. 2142-2155. (doi: 10.1136/gutjnl-2017-315144) (PMID:29080858) (PMCID:PMC6241608)
Greenhough, A. et al. (2018) Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis. EMBO Molecular Medicine, 10(11), e8699. (doi: 10.15252/emmm.201708699) (PMID:30143543) (PMCID:PMC6220329)
Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J. and Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, 246(3), pp. 331-343. (doi: 10.1002/path.5143) (PMID:30043421) (PMCID:PMC6334176)
Malik, N. , Sansom, O. J. and Michie, A. M. (2018) The role of mTOR-mediated signals during haemopoiesis and lineage commitment. Biochemical Society Transactions, 46(5), pp. 1313-1324. (doi: 10.1042/BST20180141) (PMID:30154096) (PMCID:PMC6195642)
Flanagan, D.J., Hodder, M.C. and Sansom, O.J. (2018) Microenvironmental cues in cancer stemness. Nature Cell Biology, 20(10), pp. 1102-1104. (doi: 10.1038/s41556-018-0210-4) (PMID:30258126)
Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)
May, S. et al. (2018) Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology, 245(3), pp. 270-282. (doi: 10.1002/path.5074) (PMID:29603746) (PMCID:PMC6032908)
Morris, H. T. , Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H. , Snapper, S. B., Carey, F. A., Sansom, O. J. and Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, 245(3), pp. 337-348. (doi: 10.1002/path.5086) (PMID:29672847) (PMCID:PMC6033012)
Conway, J. R.W. et al. (2018) Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer. Cell Reports, 23(11), pp. 3312-3326. (doi: 10.1016/j.celrep.2018.05.038) (PMID:29898401) (PMCID:PMC6019737)
Hodder, M. C., Flanagan, D. J. and Sansom, O. J. (2018) Intestinal stem cell dynamics: a story of mice and humans. Cell Stem Cell, 22(6), pp. 785-787. (doi: 10.1016/j.stem.2018.05.005) (PMID:29859166)
Godfrey, J. D., Morton, J. P. , Wilczynska, A., Sansom, O. J. and Bushell, M. D. (2018) MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. Cell Death and Disease, 9(6), 644. (doi: 10.1038/s41419-018-0628-4) (PMID:29844410) (PMCID:PMC5973943)
Pearson, H. B. et al. (2018) Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery, 8(6), pp. 764-779. (doi: 10.1158/2159-8290.CD-17-0867) (PMID:29581176)
Woroniuk, A. et al. (2018) STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature Communications, 9, 2124. (doi: 10.1038/s41467-018-04404-4) (PMID:29844364) (PMCID:PMC5974301)
Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131) (PMID:29719257) (PMCID:PMC5946718)
Ahmad, I. and Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi: 10.1002/path.5029) (PMID:29314004)
Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)
Patel, R. et al. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10(4), e8347. (doi: 10.15252/emmm.201708347) (PMID:29540470) (PMCID:PMC5887544)
Huels, D.J. et al. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, 1132. (doi: 10.1038/s41467-018-03426-2) (PMID:29556067) (PMCID:PMC5859272)
Vlachogiannis, G. et al. (2018) Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science, 359(6378), pp. 920-926. (doi: 10.1126/science.aao2774) (PMID:29472484) (PMCID:PMC6112415)
Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J. and Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi: 10.1038/onc.2017.394) (PMID:29106388)
Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J. and Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13(1), e0183585. (doi: 10.1371/journal.pone.0183585) (PMID:29293509) (PMCID:PMC5749721)
Burke, Z. D., Reed, K. R., Yeh, S.-W., Meniel, V., Sansom, O. J. , Clarke, A. R. and Tosh, D. (2018) Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway. Scientific Reports, 8, 2735. (doi: 10.1038/s41598-018-20888-y) (PMID:29426940) (PMCID:PMC5807466)
Ferro, R. et al. (2018) GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine. Oncogene, 37, pp. 6368-6382. (doi: 10.1038/s41388-018-0390-1) (PMID:30061636)
Sierra Gonzalez, P. et al. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi: 10.1038/s41586-018-0729-3) (PMID:30464341)
Unal, E. B., Kiel, C., Benisty, H., Campbell, A., Pickering, K., Blüthgen, N., Sansom, O. J. and Serrano, L. (2018) Systems level expression correlation of Ras GTPase regulators. Cell Communication and Signaling, 16, 46. (doi: 10.1186/s12964-018-0256-8) (PMID:30111366) (PMCID:PMC6094892)
2017
Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, 1728. (doi: 10.1038/s41467-017-01967-6) (PMID:29170413) (PMCID:PMC5701042)
D'Costa, Z. et al. (2017) Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Research, 77(21), pp. 5952-5962. (doi: 10.1158/0008-5472.CAN-16-2833) (PMID:28765154)
Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi: 10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)
Nobis, M. et al. (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21, pp. 274-288. (doi: 10.1016/j.celrep.2017.09.022) (PMID:28978480)
Cammareri, P. et al. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24(10), pp. 1681-1693. (doi: 10.1038/cdd.2017.92) (PMID:28622298)
Phesse, T. J., Durban, V. M. and Sansom, O. J. (2017) Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models. Carcinogenesis, 38(10), pp. 953-965. (doi: 10.1093/carcin/bgx080) (PMID:28981588) (PMCID:PMC5862284)
Chuvin, N. et al. (2017) Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS(G12D)-driven pancreatic tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 4(2), pp. 263-282. (doi: 10.1016/j.jcmgh.2017.05.005) (PMID:28752115) (PMCID:PMC5524227)
Tian, A. et al. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13(7), e1006870. (doi: 10.1371/journal.pgen.1006870) (PMID:28708826) (PMCID:PMC5510812)
Phesse, T. J. and Sansom, O. J. (2017) Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology, 19(7), pp. 752-754. (doi: 10.1038/ncb3567) (PMID:28659641)
Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi: 10.1038/cdd.2016.120) (PMID:28106883)
Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565) (PMID:28515147)
Diamantopoulou, Z. et al. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31(5), pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007) (PMID:28416184) (PMCID:PMC5425402)
Zhang, Q. et al. (2017) An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse. PLoS ONE, 12(4), e0176693. (doi: 10.1371/journal.pone.0176693) (PMID:28453537) (PMCID:PMC5409175)
Maddocks, O. D.K. et al. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544(7650), pp. 372-376. (doi: 10.1038/nature22056) (PMID:28425994)
Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504. (doi: 10.1126/scitranslmed.aai8504) (PMID:28381539) (PMCID:PMC5777504)
Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi: 10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)
Fumagalli, A. et al. (2017) Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357-E2364. (doi: 10.1073/pnas.1701219114) (PMID:28270604) (PMCID:PMC5410814)
Azad, A. et al. (2017) PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Molecular Medicine, 9(2), pp. 167-180. (doi: 10.15252/emmm.201606674) (PMID:27932443) (PMCID:PMC5286375)
Myant, K. B. et al. (2017) HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. EMBO Molecular Medicine, 9(2), pp. 181-197. (doi: 10.15252/emmm.201606684) (PMID:28003334) (PMCID:PMC5286368)
van der Weyden, L. et al. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541(7636), pp. 233-236. (doi: 10.1038/nature20792) (PMID:28052056)
Jackstadt, R. and Sansom, O. J. (2017) The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. EMBO Journal, 36(1), pp. 3-4. (doi: 10.15252/embj.201695973) (PMID:27932445) (PMCID:PMC5210127)
Humphris, J. L. et al. (2017) Hypermutation in pancreatic cancer. Gastroenterology, 152(1), 68-74.e2. (doi: 10.1053/j.gastro.2016.09.060) (PMID:27856273)
Morton, J. P. and Sansom, O. J. (2017) CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy? Immunotherapy, 9(1), pp. 9-12. (doi: 10.2217/imt-2016-0115) (PMID:28000523)
Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P. , Sansom, O. J. , Zender, L. and Keyes, W. M. (2017) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes and Development, 31(2), pp. 172-183. (doi: 10.1101/gad.290635.116) (PMID:28143833)
Rose, A. M., Sansom, O. J. and Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16(5), pp. 386-387. (doi: 10.1080/15384101.2016.1259892) (PMID:27860538) (PMCID:PMC5351926)
Wildenberg, M.E. et al. (2017) The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunology, 10(2), pp. 352-360. (doi: 10.1038/mi.2016.65)
2016
Spender, L. C. et al. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget, 7(50), pp. 81995-82012. (doi: 10.18632/oncotarget.13226) (PMID:27835901) (PMCID:PMC5347669)
Driscoll, D. R. et al. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76(23), pp. 6911-6923. (doi: 10.1158/0008-5472.CAN-16-0810) (PMID:27758884) (PMCID:PMC5135633)
Bangi, E., Murgia, C., Teague, A. G.S., Sansom, O. J. and Cagan, R. L. (2016) Functional exploration of colorectal cancer genomes using Drosophila. Nature Communications, 7, 13615. (doi: 10.1038/ncomms13615) (PMID:27897178) (PMCID:PMC5141297)
Guest, R. V. et al. (2016) Notch3 drives development and progression of cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 113(43), pp. 12250-12255. (doi: 10.1073/pnas.1600067113) (PMID:27791012) (PMCID:PMC5086988)
Koppens, M. A.J., Bounova, G., Cornelissen-Steijger, P., de Vries, N., Sansom, O. J. , Wessels, L. F.A. and van Lohuizen, M. (2016) Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget, 7(43), pp. 69816-69828. (doi: 10.18632/oncotarget.12002) (PMID:27634879) (PMCID:PMC5342517)
Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)
Kumar, N. et al. (2016) A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development, 143(20), pp. 3711-3722. (doi: 10.1242/dev.137992) (PMID:27802136)
Cammareri, P. et al. (2016) Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications, 7, 12493. (doi: 10.1038/ncomms12493) (PMID:27558455) (PMCID:PMC5007296)
Lesina, M. et al. (2016) RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. Journal of Clinical Investigation, 126(8), pp. 2919-2932. (doi: 10.1172/jci86477) (PMID:27454298)
Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi: 10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)
Ahmad, I. et al. (2016) Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 113(29), pp. 8290-8295. (doi: 10.1073/pnas.1601571113) (PMID:27357679) (PMCID:PMC4961202)
Gao, Y., Vincent, D., Davis, A. J., Sansom, O. , Bartholin, L. and Li, Q. (2016) Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. Oncotarget, 7(27), pp. 40904-40918. (doi: 10.18632/oncotarget.10149) (PMID:27344183)
Wörmann, S. M. et al. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151(1), 180-193.e12. (doi: 10.1053/j.gastro.2016.03.010) (PMID:27003603)
Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)
Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)
Bailey, P. et al. (2016) Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 531(7592), pp. 47-52. (doi: 10.1038/nature16965) (PMID:26909576)
Marusiak, A. A. et al. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76(3), pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t) (PMID:26637668) (PMCID:PMC4740929)
Matzke-Ogi, A. et al. (2016) Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling. Gastroenterology, 150(2), 513-525.e10. (doi: 10.1053/j.gastro.2015.10.020) (PMID:26597578)
Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020) (PMID:26725115)
Cheung, E., Lee, P., Ceteci, F., Nixon, C., Blyth, K. , Sansom, O. and Vousden, K. (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes and Development, 30(1), pp. 52-63. (doi: 10.1101/gad.271130.115) (PMID:26679840) (PMCID:PMC4701978)
Jackstadt, R. and Sansom, O. (2016) Mouse models of intestinal cancer. Journal of Pathology, 238(2), pp. 141-151. (doi: 10.1002/path.4645) (PMID:26414675) (PMCID:PMC4832380)
Carotenuto, P. et al. (2016) Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut, 66(7), pp. 1268-1277. (doi: 10.1136/gutjnl-2016-312278) (PMID:27618837) (PMCID:PMC5530482)
Elbediwy, A. et al. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. (doi: 10.1242/dev.133728) (PMID:26989177) (PMCID:PMC4874484)
2015
Fordham, R. P. and Sansom, O. (2015) Colon contradictions: NF-κB signaling in intestinal tumorigenesis. Journal of Experimental Medicine, 212(13), pp. 2184-2188. (doi: 10.1084/jem.21213insight2) (PMID:26666752)
Kanellos, G. et al. (2015) ADF and Cofilin1 control actin stress fibers, nuclear integrity, and cell survival. Cell Reports, 13(9), pp. 1949-1964. (doi: 10.1016/j.celrep.2015.10.056) (PMID:26655907) (PMCID:PMC4678118)
Ladang, A. et al. (2015) Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212(12), pp. 2057-2075. (doi: 10.1084/jem.20142288) (PMID:26527802)
Gopinathan, A., Morton, J. P. , Jodrell, D. I. and Sansom, O. J. (2015) GEMMs as preclinical models for testing pancreatic cancer therapies. Disease Models and Mechanisms, 8(10), pp. 1185-1200. (doi: 10.1242/dmm.021055) (PMID:26438692) (PMCID:PMC4610236)
Huels, D. J. et al. (2015) E‐cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal, 34(18), pp. 2321-2333. (doi: 10.15252/embj.201591739) (PMID:26240067) (PMCID:PMC4570519)
Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi: 10.1002/path.4555) (PMID:25950520)
Myant, K. et al. (2015) Serine 62-phosphorylated MYC associates with nuclear lamins and its regulation by CIP2A is essential for regenerative proliferation. Cell Reports, 12(6), pp. 1019-1031. (doi: 10.1016/j.celrep.2015.07.003) (PMID:26235622)
Topham, C. et al. (2015) MYC is a major determinant of mitotic cell fate. Cancer Cell, 28(1), pp. 129-140. (doi: 10.1016/j.ccell.2015.06.001) (PMID:26175417) (PMCID:PMC4518499)
Méniel, V., Megges, M., Young, M.A., Cole, A., Sansom, O.J. and Clarke, A.R. (2015) Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene, 34(31), pp. 4118-4129. (doi: 10.1038/onc.2014.342) (PMID:25347740)
Wiegering, A. et al. (2015) Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer. Cancer Discovery, 5(7), pp. 768-781. (doi: 10.1158/2159-8290.CD-14-1040) (PMID:25934076) (PMCID:PMC5166973)
Flanagan, D. J. et al. (2015) Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells. Stem Cell Reports, 4(5), pp. 759-767. (doi: 10.1016/j.stemcr.2015.03.003) (PMID:25892522) (PMCID:PMC4437483)
von Karstedt, S. et al. (2015) Cancer cell-autonomous trail-r signaling promotes kras-driven cancer progression, invasion, and metastasis. Cancer Cell, 27(4), pp. 561-573. (doi: 10.1016/j.ccell.2015.02.014) (PMID:25843002) (PMCID:PMC6591140)
Kundu, P. et al. (2015) An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine, 7(281), 281ra44. (doi: 10.1126/scitranslmed.3010567) (PMID:25834110)
Loveridge, C., Mui, E., Ahmad, I. , Welsh, M., Tan, E., Fleming, J., Sansom, O. and Leung, H. (2015) The Role of Erk5 in Prostate Carcinogenesis. In: 11th World Congress on Urological Research, Nijmegen, The Nertherlands, September 2015, (Unpublished)
Boulter, L. et al. (2015) WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Journal of Clinical Investigation, 125(3), pp. 1269-1285. (doi: 10.1172/JCI76452) (PMID:25689248) (PMCID:PMC4362247)
Lindström, N. O. et al. (2015) Integrated β-catenin, BMP, PTEN, and notch signalling patterns the nephron. eLife, 4, e04000. (doi: 10.7554/eLife.04000) (PMID:25647637) (PMCID:4337611)
Ueberham, E. et al. (2015) Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors. Molecular Cancer Research, 13(2), pp. 239-249. (doi: 10.1158/1541-7786.MCR-14-0278-T) (PMID:25270420)
Faller, W. et al. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature, 517(7535), pp. 497-500. (doi: 10.1038/nature13896) (PMID:25383520) (PMCID:PMC4304784)
Davis, H. et al. (2015) Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nature Medicine, 21(1), pp. 62-70. (doi: 10.1038/nm.3750) (PMID:25419707) (PMCID:PMC4594755)
Conde-Perez, A. et al. (2015) A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nature Communications, 6, 8093. (doi: 10.1038/ncomms9093) (PMID:26307673) (PMCID:PMC4560817)
Ferrari, N. et al. (2015) Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports, 5, 15658. (doi: 10.1038/srep15658) (PMID:26489514) (PMCID:PMC4614940)
Huels, D.J. and Sansom, O.J. (2015) Stem vs non-stem cell origin of colorectal cancer. British Journal of Cancer, 113(1), pp. 1-5. (doi: 10.1038/bjc.2015.214) (PMID:26110974)
Lindsay, C. R., Li, A., Faller, W., Ozanne, B., Welch, H., Machesky, L. M. and Sansom, O. (2015) A Rac1-independent role for P-Rex1 in melanoblasts. Journal of Investigative Dermatology, 135(1), pp. 314-318. (doi: 10.1038/jid.2014.323)
Lu, W.-Y. et al. (2015) Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nature Cell Biology, 17(8), pp. 971-983. (doi: 10.1038/ncb3203) (PMID:26192438) (PMCID:PMC4612439)
Ma, Y., Faller, W., Sansom, O. , Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi: 10.1097/CMR.0000000000000135) (PMID:25535872)
Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)
Mills, J.C. and Sansom, O.J. (2015) Reserve stem cells: differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Science Signaling, 8(385), re8. (doi: 10.1126/scisignal.aaa7540) (PMID:26175494)
2014
Peter, S. et al. (2014) Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE 1 ubiquitin ligase. EMBO Molecular Medicine, 6(12), pp. 1525-1541. (doi: 10.15252/emmm.201403927) (PMID:25253726) (PMCID:PMC4287973)
Lunardi, S. et al. (2014) IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget, 5(22), pp. 11064-11080. (doi: 10.18632/oncotarget.2519) (PMID:25415223) (PMCID:PMC4294325)
Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (doi: 10.1371/journal.pbio.1001966) (PMID:25313567) (PMCID:PMC4196730)
Morran, D. C. et al. (2014) Targeting mTOR dependency in pancreatic cancer. Gut, 63(9), pp. 1481-1489. (doi: 10.1136/gutjnl-2013-306202) (PMID:24717934) (PMCID:PMC4145424)
Walz, S. et al. (2014) Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature, 511(7510), pp. 483-487. (doi: 10.1038/nature13473) (PMID:25043018) (PMCID:PMC6879323)
Hamilton, G. et al. (2014) AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Oncotarget, 5(15), pp. 6142-6167. (doi: 10.18632/oncotarget.2178) (PMID:25071014) (PMCID:PMC4171619)
Rajan, P. et al. (2014) Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy. European Urology, 66(1), pp. 32-39. (doi: 10.1016/j.eururo.2013.08.011) (PMID:24054872) (PMCID:PMC4062940)
Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J. and Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Current Biology, 24(11), pp. 1199-1211. (doi: 10.1016/j.cub.2014.04.007)
Foth, M. et al. (2014) Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. Journal of Pathology, 233(2), pp. 148-158. (doi: 10.1002/path.4334)
Cheung, E., Lee, P., Berkers, C., Blyth, K. , Sansom, O. and Vousden, K. (2014) The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism. Cancer and Metabolism, 2, P15. (doi: 10.1186/2049-3002-2-S1-P15) (PMCID:PMC4072993)
Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi: 10.1053/j.gastro.2014.01.046) (PMID:24462734) (PMCID:PMC4000441)
Valeri, N. et al. (2014) MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell, 25(4), pp. 469-483. (doi: 10.1016/j.ccr.2014.03.006) (PMID:24735923) (PMCID:PMC3995091)
Song, J.-H., Huels, D. J., Ridgway, R. A., Sansom, O. J. , Kholodenko, B. N., Kolch, W. and Cho, K.-H. (2014) The APC network regulates the removal of mutated cells from colonic crypts. Cell Reports, 7(1), pp. 94-103. (doi: 10.1016/j.celrep.2014.02.043)
Johnsson, A.-K. E. et al. (2014) The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Reports, 6(6), pp. 1153-1164. (doi: 10.1016/j.celrep.2014.02.024)
Arjonen, A. et al. (2014) Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis. Journal of Clinical Investigation, 124(3), pp. 1069-1082. (doi: 10.1172/JCI67280) (PMID:24487586) (PMCID:PMC3934176)
Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi: 10.1136/gutjnl-2012-303883)
Guest, R. V., Boulter, L., Kendall, T. J., Minnis-Lyons, S. E., Walker, R., Wigmore, S. J., Sansom, O. and Forbes, S. J. (2014) Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Research, 74(4), pp. 1005-1010. (doi: 10.1158/0008-5472.CAN-13-1911)
Ali, A. et al. (2014) Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel. BMC Clinical Pathology, 14, p. 35. (doi: 10.1186/1472-6890-14-35)
Belmont, P. J. et al. (2014) Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease. Disease Models and Mechanisms, 7(6), pp. 613-623. (doi: 10.1242/dmm.013904)
Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M., Muller, W. J., Vidal, M. and Sansom, O. J. (2014) c-Src drives intestinal regeneration and transformation. EMBO Journal, 33(3), pp. 1474-1491. (doi: 10.1002/embj.201387454)
Dhillon, A. and Sansom, O. (2014) Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom. Disease Models and Mechanisms, 7(8), pp. 937-940. (doi: 10.1242/dmm.017350)
Myant, K. and Sansom, O. J. (2014) Wnt signaling and colorectal cancer. In: Hoppler, Stefan and Moon, Randall (eds.) Wnt Signaling in Development and Disease. John Wiley & Sons, pp. 357-367. ISBN 9781118444122 (doi: 10.1002/9781118444122.ch27)
Phesse, T.J. et al. (2014) Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation, 21(6), pp. 956-966. (doi: 10.1038/cdd.2014.15) (PMID:24583641) (PMCID:PMC4013513)
Ragusa, S. et al. (2014) PROX1 promotes metabolic adaptation and fuels outgrowth of Wnt high metastatic colon cancer cells. Cell Reports, 8(6), pp. 1957-1973. (doi: 10.1016/j.celrep.2014.08.041) (PMID:25242332)
Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi: 10.1101/gad.247528.114) (PMID:25512559) (PMCID:PMC4265675)
Tan, E.H., Morton, J.P. , Timpson, P., Tucci, P., Melino, G., Flores, E.R., Sansom, O.J. , Vousden, K.H. and Muller, P.A.J. (2014) Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene, 33, pp. 3325-3333. (doi: 10.1038/onc.2013.287) (PMID:23873029) (PMCID:PMC4181588)
2013
Phesse, T. J. and Sansom, O. J. (2013) Responding to R-Spondin: Slit2 potentiates intestinal regeneration. Cell Stem Cell, 13(5), pp. 512-514. (doi: 10.1016/j.stem.2013.10.006)
Nobis, M., Carragher, N.O., McGhee, E.J., Morton, J.P. , Sansom, O.J. , Anderson, K.I. and Timpson, P. (2013) Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS Journal, 280(21), pp. 5177-5197. (doi: 10.1111/febs.12348)
Cheung, E.C., Athineos, D., Lee, P., Ridgway, R.A., Lambie, W., Nixon, C., Strathdee, D., Blyth, K. , Sansom, O.J. and Vousden, K.H. (2013) TIGAR is required for efficient intestinal regeneration and tumorigenesis. Developmental Cell, 25(5), pp. 463-477. (doi: 10.1016/j.devcel.2013.05.001)
Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi: 10.1016/j.stem.2013.04.006)
Ma, Y., Li, A., Faller, W.J., Libertini, S., Fiorito, F., Gillespie, D.A., Sansom, O.J. , Yamashiro, S. and Machesky, L.M. (2013) Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development, 140(10), pp. 2203-2211. (doi: 10.1242/dev.089789)
Bird, T.G. et al. (2013) Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proceedings of the National Academy of Sciences of the United States of America, 110(16), pp. 6542-6547. (doi: 10.1073/pnas.1302168110)
Morton, J. and Sansom, O.J. (2013) MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC. Molecular Oncology, 7(2), pp. 248-258. (doi: 10.1016/j.molonc.2013.02.015)
Radulescu, S. et al. (2013) Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene, 32(16), pp. 2048-2057. (doi: 10.1038/onc.2012.224)
Steele, C.W., Jamieson, N.B. , Evans, T.R.J. , McKay, C.J., Sansom, O.J. , Morton, J. and Carter, C.R. (2013) Exploiting inflammation for therapeutic gain in pancreatic cancer. British Journal of Cancer, 108(5), pp. 997-1003. (doi: 10.1038/bjc.2013.24)
Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi: 10.1038/onc.2012.148)
Patel, R. et al. (2013) Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Journal of Clinical Investigation, 123(3), pp. 1157-1175. (doi: 10.1172/JCI63672)
Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi: 10.1158/2159-8290.CD-12-0292)
Schwitalla, S. et al. (2013) Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell, 152(1-2), pp. 25-38. (doi: 10.1016/j.cell.2012.12.012)
Acosta, J.C. et al. (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature Cell Biology, 15, pp. 978-990. (doi: 10.1038/ncb2784)
Huels, D.J., Cammareri, P., Ridgway, R.A., Medema, J.P. and Sansom, O.J. (2013) Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis. Methods in Molecular Biology, 1012, pp. 237-248. (doi: 10.1007/978-1-62703-429-6_16)
Karim, S.A., Creedon, H., Patel, H., Carragher, N.O., Morton, J.P. , Muller, W.J., Evans, T.R.J. , Gusterson, B., Sansom, O.J. and Brunton, V.G. (2013) Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. Journal of Pathology, 230(4), pp. 430-440. (doi: 10.1002/path.4202)
Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J. and Cordero, J.B. (2013) Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle, 12(18), pp. 2973-2977. (doi: 10.4161/cc.26031)
Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)
Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi: 10.1038/nature12865)
Wiese, K. E., Walz, S., von Eyss, B., Wolf, E., Athineos, D., Sansom, O. and Eilers, M. (2013) The role of MIZ-1 in MYC-dependent tumorigenesis. Cold Spring Harbor Perspectives in Medicine, 3(12), a014290. (doi: 10.1101/cshperspect.a014290)
2012
Cordero, J. B., Stefanatos, R. K. , Myant, K., Vidal, M. and Sansom, O. J. (2012) Non-autonomous crosstalk between the Jak/Stat and EGFR pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development, 139(24), pp. 4524-4535. (doi: 10.1242/dev.078261)
Machesky, L.M. and Sansom, O.J. (2012) Rac1 in the driver’s seat for melanoma. Pigment Cell and Melanoma Research, 25(6), pp. 762-764. (doi: 10.1111/pcmr.12004)
Radulescu, S. et al. (2012) Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Reports, 2(2), pp. 270-282. (doi: 10.1016/j.celrep.2012.07.003)
Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)
Gao, M. et al. (2012) SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis. EMBO Molecular Medicine, 4(8), pp. 776-790. (doi: 10.1002/emmm.201100944)
Cheung, E. C., Athineos, D., Ridgway, R., Blyth, K. , Strathdee, D., Sansom, O. and Vousden, K. H. (2012) The in vivo function of the p53 target gene TIGAR. BMC Proceedings, 6, P12. (doi: 10.1186/1753-6561-6-S3-P12) (PMCID:PMC3395062)
Ahmad, I., Sansom, O.J. and Leung, H.Y. (2012) Exploring molecular genetics of bladder cancer: lessons learned from mouse models. Disease Models and Mechanisms, 5(3), pp. 323-332. (doi: 10.1242/dmm.008888)
Stevenson, R. P., Myant, K., Jamieson, T., Ma, Y., Li, A., Tan, E. H., Yamashiro, S., Pignatelli, M., Sansom, O. and Machesky, L. M. (2012) Targeting the Actin Cytoskeletal Protein Fascin as a Novel Modulator of Intestinal Epithelial Cell Proliferation and Colon Cancer. Gastroenterology, 142(5 Sup1), S-44. (doi: 10.1016/S0016-5085(12)60167-X)
Boulter, L. et al. (2012) Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nature Medicine, 18(4), pp. 572-579. (doi: 10.1038/nm.2667)
Blyth, K. , Morton, J.P. and Sansom, O.J. (2012) The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? Current Opinion in Genetics and Development, 22(1), pp. 28-35. (doi: 10.1016/j.gde.2012.02.009)
Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi: 10.1016/j.devcel.2011.11.008)
Jamieson, N. B. , Morran, D. C., Morton, J. P., Ali, A., Dickson, E. J., Carter, C. R., Sansom, O. J. , Evans, T. R. J. , McKay, C. J. and Oien, K. A. (2012) MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clinical Cancer Research, 18(2), pp. 534-545. (doi: 10.1158/1078-0432.CCR-11-0679)
Cordero, J.B. and Sansom, O.J. (2012) Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiologica, 204(1), pp. 137-143. (doi: 10.1111/j.1748-1716.2011.02288.x)
Sandilands, E. et al. (2012) Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nature Cell Biology, 14(1), pp. 51-60. (doi: 10.1038/ncb2386)
Cordero, J. B., Stefanatos, R. K. , Scopelliti, A., Vidal, M. and Sansom, O. J. (2012) Inducible progenitor-derived wingless regulates adult midgut regeneration in drosophila. EMBO Journal, 31(19), pp. 3901-3917. (doi: 10.1038/emboj.2012.248)
Klotz, D.M., Nelson, S.A., Kroboth, K., Newton, I.P., Radulescu, S., Ridgway, R.A., Sansom, O.J. , Appleton, P.L. and Nathke, I.S. (2012) The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. Journal of Cell Science, 125(4), pp. 887-895. (doi: 10.1242/jcs.091843)
Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K. , Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi: 10.1038/jid.2012.186)
McCall, P. et al. (2012) NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression. British Journal of Cancer, 107(9), pp. 1554-1563. (doi: 10.1038/bjc.2012.372)
Tho, L.M., Libertini, S., Rampling, R., Sansom, O. and Gillespie, D.A. (2012) Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene, 31(11), pp. 1366-1375. (doi: 10.1038/onc.2011.326)
2011
Myant, K. and Sansom, O.J. (2011) Wnt/Myc interactions in intestinal cancer: partners in crime. Experimental Cell Research, 317(19), pp. 2725-2731. (doi: 10.1016/j.yexcr.2011.08.001)
Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi: 10.1016/j.devcel.2011.07.008)
Ahmad, I. , Singh, L.B., Foth, M., Morris, C.-A., Taketo, M.M., Wu, X.-R., Leung, H.Y. , Sansom, O.J. and Iwata, T. (2011) K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Disease Models and Mechanisms, 4(4), pp. 548-555. (doi: 10.1242/dmm.006874)
Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi: 10.1038/cr.2010.154)
Kennedy, A.l. et al. (2011) Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Molecular Cell, 42(1), pp. 36-49. (doi: 10.1016/j.molcel.2011.02.020)
Ahmad, I. , Patel, R., Liu, Y., Singh, L.B., Taketo, M.M., Wu, X.-R., Leung, H.Y. and Sansom, O.J. (2011) Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death and Disease, 2, e124. (doi: 10.1038/cddis.2011.7)
Subauste, M.C., Ventura-Holman, T., Lu, D., Du, L., Sansom, O.J. and Maher, J.F. (2011) Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia. Cancer Epidemiology, 35(1), pp. 97-100. (doi: 10.1016/j.canep.2010.09.007)
Ahmad, I. et al. (2011) β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene, 30(2), pp. 178-189. (doi: 10.1038/onc.2010.399)
Ahmad, I. et al. (2011) HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 108(39), pp. 16392-16397. (doi: 10.1073/pnas.1101263108)
Graham, K., Moran-Jones, K., Sansom, O.J. , Brunton, V.G. and Frame, M.C. (2011) FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. PLoS ONE, 6(12), e27806. (doi: 10.1371/journal.pone.0027806) (PMID:22194793) (PMCID:PMC3237418)
Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2, pp. 1-9. (doi: 10.1038/ncomms1560)
Matallanas, D. et al. (2011) Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Molecular Cell, 44(6), pp. 893-906. (doi: 10.1016/j.molcel.2011.10.016)
Matthews, J.R., Sansom, O.J. and Clarke, A.R. (2011) Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell Death and Differentiation, 18(12), pp. 1934-1943. (doi: 10.1038/cdd.2011.77)
McGhee, E. J., Morton, J. P. , Von Kriegsheim, A., Schwarz, J. P., Karim, S. A., Carragher, N. O., Sansom, O. , Anderson, K. I. and Timpson, P. (2011) FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion. Small GTPases, 2(4), pp. 239-244. (doi: 10.4161/sgtp.2.4.17275) (PMID:22145098) (PMCID:PMC3225915)
Morton, J.P., Myant, K.B. and Sansom, O.J. (2011) A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis. Cell Cycle, 10(2), pp. 173-175. (doi: 10.4161/cc.10.2.14350)
Morton, J.P. , Steele, C.W. and Sansom, O.J. (2011) Timing Is Everything: Brca2 and p53 Mutations in Pancreatic Cancer. Gastroenterology, 140(4), pp. 1143-1146. (doi: 10.1053/j.gastro.2011.02.026)
Myant, K. and Sansom, O. (2011) Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex. Cell Division, 6(3), pp. 1-4. (doi: 10.1186/1747-1028-6-3)
Myant, K. and Sansom, O.J. (2011) More, More, More: Downregulation of a MK5-FoxO3a-mir34b/c Pathway Further Increases c-Myc Levels in Colorectal Cancer. Molecular Cell, 41(4), pp. 369-370. (doi: 10.1016/j.molcel.2011.01.028)
Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi: 10.1016/j.ccr.2011.05.008)
Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi: 10.1158/0008-5472.CAN-10-2267)
2010
Calaminus, S. D., Inman, G. , Ghaevert, C., Sansom, O. , Watson, S. P., Holyoake, T. L. and Machesky, L. (2010) Alterations In Wnt Signalling In the Megakaryocytic Lineage Leads to Bone Marrow Failure and Myelofibrosis. Blood, 116(21), 628. (doi: 10.1182/blood.V116.21.628.628)
Doyle, B., Morton, J. P. , Delaney, D. W., Ridgway, R. A., Wilkins, J. A. and Sansom, O. J. (2010) p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. Journal of Pathology, 222(2), pp. 129-137. (doi: 10.1002/path.2748) (PMID:20662002)
Morton, J.P. et al. (2010) Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 107(1), pp. 246-251. (doi: 10.1073/pnas.0908428107)
Ashton, G.H. et al. (2010) Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling. Developmental Cell, 19(2), pp. 259-269. (doi: 10.1016/j.devcel.2010.07.015)
Athineos, D. and Sansom, O. (2010) Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine. Oncogene, 29(17), pp. 2585-2590. (doi: 10.1038/onc.2010.5)
Cole, A.M., Ridgway, R.A., Derkits, S.E., Parry, L., Barker, N., Clevers, H., Clarke, A.R. and Sansom, O.J. (2010) p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine, 2(11), pp. 472-486. (doi: 10.1002/emmm.201000101)
Morton, J. et al. (2010) LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology, 139(2), 586-597.e6. (doi: 10.1053/j.gastro.2010.04.055)
Morton, J.P. et al. (2010) Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma. Gastroenterology, 139(1), pp. 292-303. (doi: 10.1053/j.gastro.2010.03.034)
Nusse, R. et al. (2010) Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo. PLoS Genetics, 6(1), e1000816. (doi: 10.1371/journal.pgen.1000816)
Quyn, A., Appleton, P., Carey, F., Steele, R., Barker, N., Clevers, H., Ridgway, R., Sansom, O. and Näthke, I. (2010) Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue. Cell Stem Cell, 6(2), p. 175. (doi: 10.1016/j.stem.2009.12.007)
Radulescu, S., Ridgway, R.A., Appleton, P., Kroboth, K., Patel, S., Woodgett, J., Taylor, S., Nathke, I.S. and Sansom, O.J. (2010) Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Oncogene, 29(49), pp. 6418-6427. (doi: 10.1038/onc.2010.373)
Woodcock, S., Rushton, H., Castañeda-Saucedo, E., Myant, K., White, G., Blyth, K. , Sansom, O. and Malliri, A. (2010) Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression. Current Biology, 20(7), pp. 669-675. (doi: 10.1016/j.cub.2010.02.033)
2009
Wellner, U. et al. (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biology, 11(12), 1487-U236. (doi: 10.1038/ncb1998) (PMID:19935649)
Cordero, J. B., Vidal, M. and Sansom, O. J. (2009) APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates. Cell Cycle, 8(18), pp. 2927-2931. (doi: 10.4161/cc.8.18.9472)
Serrels, B. et al. (2009) A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model. Carcinogenesis, 30(2), pp. 249-257. (doi: 10.1093/carcin/bgn278)
Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2009) The role of murine models of prostate cancer in drug target discovery and validation. Expert Opinion on Drug Discovery, 4(8), pp. 879-888. (doi: 10.1517/17460440903049308)
Barker, N., Ridgway, R., van Es, J., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A., Sansom, O. and Clevers, H. (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457(7229), pp. 608-611. (doi: 10.1038/nature07602)
Burke, Z., Reed, K., Phesse, T., Sansom, O. , Clarke, A. and Tosh, D. (2009) Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism. Gastroenterology, 136(7), pp. 2316-2324. (doi: 10.1053/j.gastro.2009.02.063)
Chong, J. et al. (2009) E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells. Nature, 462(7275), pp. 930-934. (doi: 10.1038/nature08677)
Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi: 10.1016/j.cell.2009.11.026)
Ritchie, K. J., Walsh, S., Sansom, O. J. , Henderson, C. J. and Wolf, C. R. (2009) Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi. Proceedings of the National Academy of Sciences of the United States of America, 106(49), pp. 20859-20864. (doi: 10.1073/pnas.0911351106)
Subauste, M., Sansom, O. , Porecha, N., Raich, N., Du, L. and Maher, J. (2009) Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. Molecular Carcinogenesis, 49(2), pp. 105-113. (doi: 10.1002/mc.20594)
2008
Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2008) Advances in mouse models of prostate cancer. Expert Reviews in Molecular Medicine, 10, e16. (doi: 10.1017/S1462399408000689)
Marsh, V., Winton, D., Williams, G., Dubois, N., Trumpp, A., Sansom, O. and Clarke, A. (2008) Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics, 40(12), pp. 1436-1444. (doi: 10.1038/ng.256)
Patek, C. et al. (2008) Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Experimental Cell Research, 314(5), pp. 1105-1114. (doi: 10.1016/j.yexcr.2007.11.004)
Patek, C. et al. (2008) The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterology, 8, p. 24. (doi: 10.1186/1471-230X-8-24)
Phesse, T. J., Parry, L., Reed, K. R., Ewan, K. B., Dale, T. C., Sansom, O. J. and Clarke, A. R. (2008) Deficiency of Mbd2 Attenuates Wnt Signaling. Molecular and Cellular Biology, 28(19), pp. 6094-6103. (doi: 10.1128/MCB.00539-08)
Reed, K. R., Athineos, D., Meniel, V. S., Wilkins, J. A., Ridgway, .A., Burke, Z. D., Muncan, V., Clarke, A. R. and Sansom, O.J. (2008) B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America, 105(48), pp. 18919-18923. (doi: 10.1073/pnas.0805778105)
Reed, K., Meniel, V., Marsh, V., Cole, A., Sansom, O. and Clarke, A. (2008) A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer, 8, p. 162. (doi: 10.1186/1471-2407-8-162)
Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A., Sansom, O. and Hupp, T. (2008) Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling. Journal of Biological Chemistry, 284(1), pp. 334-344. (doi: 10.1074/jbc.M805165200)
Wilkins, J. A. and Sansom, O. J. (2008) C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine. Cancer Research, 68(13), pp. 4963-4966. (doi: 10.1158/0008-5472.CAN-07-5558)
2007
Berger, J., Sansom, O., Clarke, A. and Bird, A. (2007) MBD2 is required for correct spatial gene expression in the gut. Molecular and Cellular Biology, 27(11), pp. 4049-4057. (doi: 10.1158/1535-7163.MCT-06-0382)
Clarke, A., Jones, N., Pryde, F., Adachi, Y. and Sansom, O. (2007) 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene, 26(43), pp. 6349-6355. (doi: 10.1038/sj.onc.1210457)
Clarke, A., Jones, N., Pryde, F., Adachi, Y. and Sansom, O. (2007) 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene, 26(43), pp. 6349-6355. (doi: 10.1038/sj.onc.1210457)
Dikovskaya, D., Schiffmann, D., Newton, I., Oakley, A., Kroboth, K., Sansom, O. , Jamieson, T., Meniel, V., Clarke, A. and Nathke, I. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of Cell Biology, 176(2), pp. 183-195. (doi: 10.1083/jcb.200610099)
Sansom, O. , Maddison, K. and Clarke, A. (2007) Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nature Clinical Practice Oncology, 4(5), pp. 305-315. (doi: 10.1038/ncponc0812)
Sansom, O. , Mansergh, F., Evans, M., Wilkins, J. and Clarke, A. (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APC(Min/+) mice. Gut, 56(10), pp. 1410-1414. (doi: 10.1136/gut.2006.116921)
Sansom, O. , Meniel, V., Muncan, V., Phesse, T., Wilkins, J., Reed, K., Vass, J., Athineos, D., Clevers, H. and Clarke, A. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature, 446(7136), pp. 676-679. (doi: 10.1038/nature05674)
Stark, L., Reid, K., Sansom, O. , Din, F., Guichard, S., Mayer, I., Jodrell, D., Clarke, A. and Dunlop, M. (2007) Aspirin activates the NF-kappa B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis, 28(5), pp. 968-976. (doi: 10.1093/carcin/bgl220)
2006
Serrels, A., MacPherson, I.R.J. , Evans, T.R.J. , Lee, F.Y., Clark, E.A., Sansom, O.J. , Ashton, G.H., Frame, M.C. and Brunton, V.G. (2006) Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Molecular Cancer Therapeutics, 5(12), pp. 3014-3022. (doi: 10.1158/1535-7163.MCT-06-0382)
Muncan, V. et al. (2006) Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and Cellular Biology, 26(22), pp. 8418-8426. (doi: 10.1125/MCB.00821-06)
Prokhortchouk, A. et al. (2006) Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology, 26(1), pp. 199-208.
Reed, K., Sansom, O. , Hayes, A., Gescher, A., Peters, J. and Clarke, A. (2006) PPAR delta status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer, 6, p. 113. (doi: 10.1186/1471-2407-6-113)
Sansom, O. et al. (2006) Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103(38), pp. 14122-14127. (doi: 10.1073/pnas.0604130103)
2005
Hay, T., Jenkins, H., Sansom, O. , Martin, N., Smith, G. and Clarke, A. (2005) Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Research, 65(22), pp. 10145-10148. (doi: 10.1158/0008-5472.CAN-05-1186)
Hay, T., Patrick, T., Winton, D., Sansom, O. and Clarke, A. (2005) Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene, 24(23), pp. 3842-3846. (doi: 10.1038/sj.onc.1208533)
Meniel, V., Hay, T., Douglas-Jones, A., Sansom, O. and Clarke, A. (2005) Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Research, 65(2), pp. 410-416.
Sansom, O. , Bishop, S., Bird, A. and Clarke, A. (2005) MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene, 24(14), pp. 2430-2432. (doi: 10.1038/sj.onc.1208166)
Sansom, O. , Reed, K., van de Wetering, M., Muncan, V., Winton, D., Clevers, H. and Clarke, A. (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. Journal of Biological Chemistry, 280(31), pp. 28463-28467. (doi: 10.1074/jbc.M500191200)
2004
Ireland, H., Kemp, R., Houghton, C., Howard, L., Clarke, A., Sansom, O. and Winton, D. (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of beta-catenin. Gastroenterology, 126(5), pp. 1236-1246. (doi: 10.1053/j.gastro.2004.03.020)
Marquez, N., Chappell, S., Sansom, O. , Clarke, A., Teesdale-Spittle, P., Errington, R. and Smith, P. (2004) Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle, 3(5), pp. 662-671.
Reed, K., Sansom, O. , Hayes, A., Gescher, A., Winton, D., Peters, J. and Clarke, A. (2004) PPAR delta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene, 23, pp. 8992-8996. (doi: 10.1038/sj.onc.1208143)
Sansom, O. , Bishop, S., Bird, A. and Clarke, A. (2004) MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene, 23(33), pp. 5693-5696. (doi: 10.1038/sj.onc.1207767)
2003
Clarke, A. and Sansom, O. (2003) Analyzing tumor suppressor activities in the murine small intestine. Oncology Research, 13(06-Oct), pp. 333-337.
Marquez, N., Chappell, S., Sansom, O. , Clarke, A., Court, J., Errington, R. and Smith, P. (2003) Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint. Oncogene, 22(48), pp. 7642-7648. (doi: 10.1038/sj.onc.1206876)
Sansom, O. , Berger, J., Bishop, S., Hendrich, B., Bird, A. and Clarke, A. (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics, 34(2), pp. 145-147. (doi: 10.1038/ng1155)
Sansom, O. , Bishop, S., Court, H., Dudley, S., Liskay, R. and Clarke, A. (2003) Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair, 2(9), pp. 1029-1039. (doi: 10.1016/S1568-7864(03)00111-3)
Sansom, O. , Zabkiewicz, J., Bishop, S., Guy, J., Bird, A. and Clarke, A. (2003) MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene, 22(46), pp. 7130-7136. (doi: 10.1038/sj.onc.1206850)
Screaton, R., Kiessling, S., Sansom, O. , Millar, C., Maddison, K., Bird, A., Clarke, A. and Frisch, S. (2003) Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 100(9), pp. 5211-5216. (doi: 10.1073/pnas.0431215100)
2002
Gallagher, R. et al. (2002) Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene, 21(42), pp. 6446-6457. (doi: 10.1038/sj.onc.1205892)
Millar, C., Guy, J., Sansom, O. , Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P., Bishop, S., Clarke, A. and Bird, A. (2002) Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science, 297(5580), pp. 403-405. (doi: 10.1126/science.1073354)
Sansom, O. and Clarke, A. (2002) The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice. Oncogene, 21(38), pp. 5934-5939. (doi: 10.1038/sj.onc.1205760)
Toft, N., Curtis, L., Sansom, O. , Leitch, A., Wyllie, A., Riele, H., Arends, M. and Clarke, A. (2002) Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. Oncogene, 21(15), pp. 6299-6306. (doi: 10.1038/sj.onc.1205727)
2001
Sansom, O. (2001) A role for mismatch repair in control of DNA ploidy following DNA damage. Oncogene, 20(15), pp. 1923-1927. (doi: 10.1038/sj.onc.1204276)
Sansom, O. , Stark, L., Dunlop, M. and Clarke, A. (2001) Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. Cancer Research, 61(19), pp. 7060-7064.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Unleashing the power of the circadian rhythm to tackle metastasis
Medical Research Council
2024 - 2028
- Investigating BRAF driven systemic neutrophilia and clinical utility of neutrophil blockade in colorectal cancer
Office of the Chief Scientific Adviser
2024 - 2026
- UKRI Engineering Biology
UK Research and Innovation
2024 - 2029
- National Mouse Genetics Network Business Engagement Fund
Medical Research Council
2024 - 2025
- Translating Cutting-Edge Discovery Science into Patient Benefit
Medical Research Council
2023 - 2030
- ECMC QQR 2023-2028
Cancer Research UK
2023 - 2024
- Validating an in vivo b-Catenin DamID-seq system and illuminating b-Catenin targets in steatosis and hepatocellular carcinoma
Medical Research Council
2023 - 2025
- In-situ transcriptomic and proteomic Subcellular molecular Imager
Medical Research Council
2022 - 2023
- Development and Characterisation of Transgenic Low Grade Serous Ovarian Carcinoma Mouse Models to Explore Novel Therapeutic Targets
Cancer Research UK
2022 - 2025
- Edinburgh and Glasgow Clinical Academic Training Programme (TRACC) / Year 4
Cancer Research UK
2022 - 2025
- Investigating the pro-tumor functions of gamma delta T cells in hepatocellular carcinoma.
Worldwide Cancer Research
2022 - 2025
- CRUK Centre Renewal 2021
Cancer Research UK
2022 - 2023
- The TRACC Programme: to Train and Retain Academic Cancer Clinicians / Year 4
Cancer Research UK
2022 - 2025
- MRC Mouse Genetics Network Director's Core Funding
Medical Research Council
2022 - 2027
- MGN Award
Medical Research Council
2022 - 2027
- MRC MGN Director's flexible funding award
Medical Research Council
2022 - 2027
- RadNet PPA
Cancer Research UK
2022 - 2022
- Combining Radiation with JAK inhibitors as a novel therapeutic strategy
Cancer Research UK
2022 - 2022
- The TRACC Programme: to Train and Retain Academic Cancer Clinicians / Year 3
Cancer Research UK
2021 - 2024
- Investigating tumour metabolic stress as a driver of radioresistance in preclinical models of Kras mutant rectal adenocarcinoma
Cancer Research UK
2021 - 2021
- National Mouse Genetics Network Grant award: Directorship Development Phase
Medical Research Council
2020 - 2022
- The TRACC Programme: to Train and Retain Academic Cancer Clinicians / Year 2
Cancer Research UK
2020 - 2023
- Cancer Research UK Glasgow Centre - Year 4
Cancer Research UK
2020 - 2021
- A Phase I/II study of the CXCR2 inhibitor, AZD5069, in combination with Durvalumab in patients with advanced Hepatocellular Carcinoma (HCC)
Cancer Research UK
2020 - 2021
- The TRACC Programme: to Train and Retain Academic Cancer Clinicians
Cancer Research UK
2019 - 2022
- Translational Scot Trial
University of Oxford
2019 - 2021
- SITING OF A SMALL ANIMAL RADIATION RESEARCH PLATFORM (SARRP)
Beatson Institute for Cancer Research
2019 - 2020
- PREDICT-Meso : PRE-malignant Drivers Combined with Target-Drug validation in Mesothelioma
Cancer Research UK
2019 - 2019
- Cancer Research UK Glasgow Centre Yr 3 C7932/A25142
Cancer Research UK
2019 - 2020
- ECMC supplement
Chief Scientist Office
2019 - 2020
- Pre-clinical in vivo evaluation of immuno-modulatory therapy in MPM
British Lung Foundation (BLF)
2019 - 2022
- HUNTER: Hepatocellular Carcinoma Expediter Network
Cancer Research UK
2019 - 2019
- Targeting the Wnt Receptor Frizzled-7 for the Treatment of Gastric Cancer
Medical Research Council
2018 - 2021
- Investigating the function of the BCL-3/Beta-catenin complex in promoting intestinal tumorigenesis and acquisition of therapeutic resistance
Medical Research Council (MRC)
2018 - 2021
- Are CXCR2 positive cells important in generating an immunosuppressive metastatic niche for colorectal metastatic disease in the liver?
Cancer Research UK
2018 - 2020
- Characterising CXCR2 expressing neutrophils in colorectal liver metastases.
Academy of Medical Sciences
2018 - 2020
- ACRClerate: Colorectal Cancer Stratified Medicine Network
Cancer Research UK
2017 - 2018
- Clinical Training Award Cycle 3 2017
Cancer Research UK
2017 - 2020
- Developing new clinically relevant positron emission tomography (PET) probes in Glasgow
Beatson Cancer Charity
2017 - 2022
- Glasgow ECMC
Cancer Research UK
2017 - 2019
- Glasgow ECMC
Chief Scientist Office
2017 - 2018
- Precision Medicine Laboratory sequencing of patient tumour samples
Beatson Cancer Charity
2017 - 2022
- Precision-Panc: a dynamic therapeutic development platform for pancreatic cancer
Cancer Research UK
2017 - 2018
- Examining the relationship between KRAS mutation and immunotherapy resistance in colorectal cancer
Medical Research Council
2016 - 2019
- Elucidating the role of individual mTor complexes in the development and progression of chronic lymphocytic leukaemia
Blood Cancer UK
2016 - 2019
- Optimising the use of chemotherapy in prostate cancer
Prostate Cancer Research Foundation
2015 - 2018
- CRUK Centre Renewal
Cancer Research UK
2014 - 2019
- In Vivo Optimization of Therapy in Pancreatic Ductal Adenocarcinoma.
Beatson West of Scotland Cancer Centre
2013 - 2014
- The relationship between genetic aberrations and CpG Island Methylator Phenotype in colorectal cancer
Cancer Research UK
2012 - 2013
- Investigating the role of CXCR2 in pancreatic inflammation and cancer.
Wellcome Trust
2011 - 2014
- In vivo Evaluation of Src Kinase Inhibition as Adjuvant Therapy following Pancreatic Cancer Resection
Pancreatic Cancer Research Fund
2011 - 2013
- Using the Drosophila fly intestine to investigate Wnt targets in vivo.
National Centre for the Replacement of Animals Research
2010 - 2013
- Investigating the use of an EUS core biopsy needle versus a traditional FNA cytology aspiration technique in obtaining tumour tissue for diagnostic, IHC and kinome-signature analysis
Cancer Research UK
2010 - 2012
- Investigating personalised therapy in mouse models of pancreatic cancer.
Medical Research Council
2010 - 2013
- An investigation of the pro-tumorigenic activity of the chemokine receptor CXCR2 using models of de novo tumorigenesis.
Medical Research Council
2010 - 2012
Research datasets
2021
Nászai, M., Bellec, K. , Yu, Y., Román-Fernández, Á., Sandilands, E., Johansson, J., Campbell, A., Norman, J. , Sansom, O. , Bryant, D. and Cordero, J. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis. [Data Collection]
2019
Johansson, J., Naszai, M. , Hodder, M., Pickering, K. A., Miller, B. W., Ridgway, R., Yu, Y., Peschard, P., Brachmann, S., Campbell, A., Cordero, J. and Sansom, O. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. [Data Collection]
2018
Maddocks, O. , Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J.F., Mackay, G., Labuschagne, C. F., Gay, D., Kruiswijk, F., Blagih, J., Vincent, D., Campbell, K., Ceteci, F., Sansom, O. , Blyth, K. and Vousden, K. (2018) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. [Data Collection]
