Professor Stephen Tait

Professor (Therapeutic Science Research)

telephone: 01413308703
email: Stephen.Tait@glasgow.ac.uk

Ri Cancer Sciences, Beatson Institute Cancer Researc, Bearsden Rd, Garscube

Research interests

Mitochondria and Cell Death

‌Cell death is a key tumour suppressor mechanism that must be inhibited in order for cancer to develop. Sensitivity to cell death also governs therapeutic efficacy because anti-cancer therapies often act by killing cells. The major form of programmed cell death is apoptosis, a process in which mitochondria play an essential role. Our research focuses upon understanding how mitochondria control cell death and addressing how this is deregulated in cancer. Clinical translation of our findings should lead to improvements of existing therapies and development of new approaches to enable tumour selective killing.

Visualising the distinct steps of apoptosis. HeLa cells expressing YFP-Bax and Smac 1–60 mCherry were induced to undergo apoptosis (Trail plus ABT-737). Images of the same cells are shown, progressing in time, left to right. Following activation, YFP-Bax translocates to the mitochondria and MOMP occurs, detected by redistribution of Smac 1–60 mCherry throughout the cell. Caspase activity now ensues leading to typical apoptotic characteristics: cell shrinkage, nuclear condensation (blue) and phosphatidylserine relocalisation to the outer leaflet of the plasma membrane (detected by Annexin V APC binding, violet).

Link to research page in the Beatson Institute

Publications

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Number of items: 96.

2024

Glover, H. L. , Schreiner, A., Dewson, G. and Tait, S. W.G. (2024) Mitochondria and cell death. Nature Cell Biology, (doi: 10.1038/s41556-024-01429-4) (Early Online Publication)

Ahmed Hassan Elshiekh, A. and Tait, S. W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18(5), pp. 1054-1057. (doi: 10.1002/1878-0261.13627) (PMID:38520041) (PMCID:PMC11077003)

Vringer, E. et al. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43(6), pp. 904-930. (doi: 10.1038/s44318-024-00044-1) (PMID:38337057) (PMCID:PMC10943237)

2023

Victorelli, S. et al. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622(7983), pp. 627-636. (doi: 10.1038/s41586-023-06621-4) (PMID:37821702) (PMCID:PMC10584674)

Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w) (PMID:37100955) (PMCID:PMC10130819)

Marchi, S., Guilbaud, E., Tait, S. W.G. , Yamazaki, T. and Galluzzi, L. (2023) Mitochondrial control of inflammation. Nature Reviews Immunology, 23(3), pp. 159-173. (doi: 10.1038/s41577-022-00760-x) (PMID:35879417) (PMCID:PMC9310369)

Heilig, R., Lee, J. and Tait, S. W.G. (2023) Mitochondrial DNA in cell death and inflammation. Biochemical Society Transactions, 51(1), pp. 457-472. (doi: 10.1042/BST20221525) (PMID:36815695) (PMCID:PMC9988000)

Vringer, E. and Tait, S. W.G. (2023) Mitochondria and cell death-associated inflammation. Cell Death and Differentiation, 30(2), pp. 304-312. (doi: 10.1038/s41418-022-01094-w) (PMID:36447047) (PMCID:PMC9950460)

Koessinger, D. et al. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5(1), vdad067. (doi: 10.1093/noajnl/vdad067) (PMID:37334166) (PMCID:PMC10276538)

2022

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29(10), pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3) (PMID:35473984) (PMCID:PMC9525582)

Kalkavan, H., Chen, M. J., Crawford, J. C., Quarato, G., Fitzgerald, P., Tait, S. W.G. , Goding, C. R. and Green, D. R. (2022) Sublethal cytochrome c release generates drug-tolerant persister cells. Cell, 185(18), 3356-3374.e22. (doi: 10.1016/j.cell.2022.07.025) (PMID:36055199)

Zacharioudakis, E. et al. (2022) Modulating mitofusins to control mitochondrial function and signaling. Nature Communications, 13, 3775. (doi: 10.1038/s41467-022-31324-1) (PMID:35798717) (PMCID:PMC9262907)

Cao, K. et al. (2022) Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Developmental Cell, 57(10), 1211-1225.e6. (doi: 10.1016/j.devcel.2022.03.019) (PMID:35447090) (PMCID:PMC9616799)

Tait, S. W.G. (2022) Killing cells using light (activated) sabers. Journal of Cell Biology, 221(6), e202205018. (doi: 10.1083/jcb.202205018) (PMID:35575773)

Fanfone, D. et al. (2022) Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. eLife, 11, e73150. (doi: 10.7554/eLife.73150) (PMID:35256052) (PMCID:PMC8903834)

2021

Rabas, N. et al. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220(12), e202006049. (doi: 10.1083/jcb.202006049) (PMID:34623384) (PMCID:PMC8641410)

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Bock, F. J. et al. (2021) Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death. Nature Communications, 12, 6572. (doi: 10.1038/s41467-021-26613-0) (PMID:34772930) (PMCID:PMC8590049)

Campbell, K. J. et al. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28(9), pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4) (PMID:33785871) (PMCID:PMC8408186)

Koessinger, A. L. et al. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)

Roca-Portoles, A. and Tait, S. W.G. (2021) Mitochondrial quality control: from molecule to organelle. Cellular and Molecular Life Sciences, 78(8), pp. 3853-3866. (doi: 10.1007/s00018-021-03775-0) (PMID:33782711) (PMCID:PMC8106605)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1-382. (doi: 10.1080/15548627.2020.1797280) (PMID:33634751) (PMCID:PMC7996087)

2020

Ahmed, A. and Tait, S. W.G. (2020) Targeting immunogenic cell death in cancer. Molecular Oncology, 14(12), pp. 2994-3006. (doi: 10.1002/1878-0261.12851) (PMID:33179413) (PMCID:PMC7718954)

Stöhr, D. et al. (2020) Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death and Differentiation, 27(11), pp. 3037-3052. (doi: 10.1038/s41418-020-0559-3) (PMID:32433558) (PMCID:PMC7560834)

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N. , Chalmers, A. J. , Norman, J. C. and Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, 15361. (doi: 10.1038/s41598-020-72322-x) (PMID:32958777) (PMCID:PMC7506024)

Roca Portoles, A., Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O'Neill, K., Lemgruber Soares, L. , Luo, X. and Tait, S. W.G. (2020) Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell Death and Disease, 11, 616. (doi: 10.1038/s41419-020-02867-2) (PMID:32792521) (PMCID:PMC7426836)

Riley, J. S. and Tait, S. W.G. (2020) Mitochondrial DNA in inflammation and immunity. EMBO Reports, 21(4), e49799. (doi: 10.15252/embr.201949799) (PMID:32202065) (PMCID:PMC7132203)

Bock, F. J. and Tait, S. W.G. (2020) Mitochondria as multifaceted regulators of cell death. Nature Reviews Molecular Cell Biology, 21, pp. 85-100. (doi: 10.1038/s41580-019-0173-8) (PMID:31636403)

2019

Orozco, S. L. et al. (2019) RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity. Cell Reports, 28(9), 2275-2287.e5. (doi: 10.1016/j.celrep.2019.07.077) (PMID:31461645) (PMCID:PMC6857709)

Johnson, S. A., Ormsby, M. J. , McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Vringer, E. and Tait, S. W.G. (2019) Mitochondria and inflammation: cell death heats up. Frontiers in Cell and Developmental Biology, 7, 100. (doi: 10.3389/fcell.2019.00100) (PMID:31316979) (PMCID:PMC6610339)

Beaumatin, F. et al. (2019) DRAM-1 is required for mTORC1 activation by facilitating lysosomal amino acid efflux. Molecular Cell, 76(1), 163-176.E8. (doi: 10.1016/j.molcel.2019.07.021) (PMID:31492633) (PMCID:PMC6892261)

Lopez, J. and Tait, S. W.G. (2019) Application of mito-priming to generate BCL-2 addicted cells. In: Gavathiotis, E. (ed.) BCL-2 Family Proteins. Series: Methods in molecular biology (1877). Humana Press: New York, pp. 45-60. ISBN 9781493988600 (doi: 10.1007/978-1-4939-8861-7_3)

2018

Chauhan, D. et al. (2018) BAX/BAK induced apoptosis results in caspase-8 dependent IL-1β maturation in macrophages. Cell Reports, 25(9), 2354-2368.e5. (doi: 10.1016/j.celrep.2018.10.087) (PMID:30485805)

Riley, J. S. et al. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37(17), e99238. (doi: 10.15252/embj.201899238) (PMID:30049712) (PMCID:PMC6120664)

Campbell, K. J. and Tait, S. W.J. (2018) Targeting BCL-2 regulated apoptosis in cancer. Open Biology, 8(5), 180002. (doi: 10.1098/rsob.180002) (PMID:29769323) (PMCID:PMC5990650)

Galluzzi, L. et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25(3), pp. 486-541. (doi: 10.1038/s41418-017-0012-4) (PMID:29362479) (PMCID:PMC5864239)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi: 10.1038/s41419-017-0035-2) (PMID:29339815) (PMCID:PMC5833338)

Cao, K. and Tait, S. W.G. (2018) Apoptosis and cancer: force awakens, phantom menace, or both? In: Galluzzi, L. (ed.) International Review of Cell and Molecular Biology. Elsevier, pp. 135-152. ISBN 9780128151952 (doi: 10.1016/bs.ircmb.2017.12.003)

Giampazolias, E. and Tait, S. W.G. (2018) Caspase-independent cell death: an anti-cancer double-whammy. Cell Cycle, 17(3), pp. 269-270. (doi: 10.1080/15384101.2017.1408229) (PMID:29169278)

2017

Villa, E. et al. (2017) Parkin-independent mitophagy controls chemotherapeutic response in cancer cells. Cell Reports, 20(12), pp. 2846-2859. (doi: 10.1016/j.celrep.2017.08.087) (PMID:28930681)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)

Daniels, B. P., Snyder, A. G., Olsen, T. M., Orozco, S., Oguin III, T. H., Tait, S. W.G. , Martinez, J., Gale, M., Loo, Y.-M. and Oberst, A. (2017) RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation. Cell, 169(2), 301-313.e11. (doi: 10.1016/j.cell.2017.03.011) (PMID:28366204) (PMCID:PMC5405738)

Ichim, G. and Tait, S. W.G. (2017) Cancer therapy-induced PAFR ligand expression: any role for caspase activity? Nature Reviews Cancer, 17(4), p. 253. (doi: 10.1038/nrc.2017.16) (PMID:28280269)

Woodham, E. F. et al. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27(5), pp. 624-637. (doi: 10.1016/j.cub.2017.01.033) (PMID:28238662) (PMCID:PMC5344686)

Gutierrez, K. D., Davis, M. A., Daniels, B. P., Olsen, T. M., Ralli-Jain, P., Tait, S. W.G. , Gale, Jr., M. and Oberst, A. (2017) MLKL activation triggers NLRP3-mediated processing and release of IL-1β independently of gasdermin-D. Journal of Immunology, 198(5), pp. 2156-2164. (doi: 10.4049/jimmunol.1601757) (PMID:28130493) (PMCID:PMC5321867)

Simon, H.-U., Friis, R., Tait, S. W.G. and Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10(468), eaag2791. (doi: 10.1126/scisignal.aag2791) (PMID:28246201)

Correia-Melo, C., Ichim, G., Tait, S. and Passos, J. F. (2017) Depletion of mitochondria in mammalian cells through enforced mitophagy. Nature Protocols, 12(1), pp. 183-194. (doi: 10.1038/nprot.2016.159) (PMID:28005069)

Weigert, M. et al. (2017) RIPK3 promotes adenovirus type 5 activity. Cell Death and Disease, 8, 3206. (doi: 10.1038/s41419-017-0110-8) (PMID:29238045) (PMCID:PMC5870599)

2016

Pécot, J. et al. (2016) Tight sequestration of BH3 proteins by BCL-xL at subcellular membranes contributes to apoptotic resistance. Cell Reports, 17(12), pp. 3347-3358. (doi: 10.1016/j.celrep.2016.11.064) (PMID:28009301)

Ichim, G. and Tait, S. W.G. (2016) A fate worse than death: apoptosis as an oncogenic process. Nature Reviews Cancer, 16, pp. 539-548. (doi: 10.1038/nrc.2016.58) (PMID:27364482)

Riley, J. S. and Tait, S. W.G. (2016) Mechanisms of mitophagy: putting the powerhouse into the doghouse. Biological Chemistry, 397(7), pp. 617-635. (doi: 10.1515/hsz-2016-0137) (PMID:27071149)

Correia-Melo, C. et al. (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal, 35, pp. 724-742. (doi: 10.15252/embj.201592862) (PMID:26848154) (PMCID:PMC4818766)

Giampazolias, E. and Tait, S. W.G. (2016) Mitochondria and the hallmarks of cancer. FEBS Journal, 283(5), pp. 803-814. (doi: 10.1111/febs.13603) (PMID:26607558)

Lopez, J. et al. (2016) Mito-priming as a method of engineered Bcl-2 addiction. Nature Communications, 7, 10538. (doi: 10.1038/ncomms10538) (PMID:26833356) (PMCID:PMC4740867)

Klionsky, D. J. et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. (doi: 10.1080/15548627.2015.1100356) (PMID:26799652) (PMCID:PMC4835977)

Oberst, A., Ichim, G. and Tait, S. W.G. (2016) Mitochondrial permeabilization: from lethality to vitality. In: Hockenbery, D. M. (ed.) Mitochondria and Cell Death. Series: Cell death in biology and diseases. Springer: New York, pp. 213-226. ISBN 9781493936106 (doi: 10.1007/978-1-4939-3612-0_11)

2015

Ichim, G. et al. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Molecular Cell, 57(5), pp. 860-872. (doi: 10.1016/j.molcel.2015.01.018) (PMID:25702873) (PMCID:PMC4352766)

Baudot, A., Haller, M., Mrschtik, M., Tait, S. and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi: 10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Lopez, J. and Tait, S. (2015) Mitochondrial apoptosis: killing cancer using the enemy within. British Journal of Cancer, 112(6), pp. 957-962. (doi: 10.1038/bjc.2015.85) (PMID:25742467) (PMCID:PMC4366906)

Todt, F. et al. (2015) Differential retrotranslocation of mitochondrial Bax and Bak. EMBO Journal, 34(1), pp. 67-80. (doi: 10.15252/embj.201488806) (PMID:25378477) (PMCID:PMC4291481)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi: 10.1016/j.celrep.2015.07.055) (PMID:26299965) (PMCID:PMC4562906)

Galluzzi, L. et al. (2015) Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation, 22(1), pp. 58-73. (doi: 10.1038/cdd.2014.137)

2014

Lopez, J. and Tait, S. W.G. (2014) Killing the killer: PARC/CUL9 promotes cell survival by destroying Cytochrome c. Science Signaling, 7(334), pe17-pe17. (doi: 10.1126/scisignal.2005619)

Tait, S. W. G. , Ichim, G. and Green, D. R. (2014) Die another way - non-apoptotic mechanisms of cell death. Journal of Cell Science, 127(10), pp. 2135-2144. (doi: 10.1242/jcs.093575)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M. , Vousden, K. H. and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi: 10.4161/15548627.2014.981914) (PMID:25629932) (PMCID:PMC4502749)

Orozco, S., Yatim, N., Werner, M.R., Tran, H., Gunja, S.Y., Tait, S.W.G. , Albert, M.L., Green, D.R. and Oberst, A. (2014) RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death and Differentiation, 21(10), pp. 1511-1521. (doi: 10.1038/cdd.2014.76)

2013

Tait, S.W.G. et al. (2013) Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Reports, 5(4), pp. 878-885. (doi: 10.1016/j.celrep.2013.10.034) (PMID:24268776) (PMCID:PMC4005921)

Tait, S. (2013) DNA: leukemia's secret weapon of bone mass destruction. Oncogene, 32(44), pp. 5199-5200. (doi: 10.1038/onc.2012.639)

Tait, S.W.T. and Green, D.R. (2013) Mitochondrial regulation of cell death. Cold Spring Harbor Perspectives in Biology, 5(9), a008706. (doi: 10.1101/cshperspect.a008706)

2012

Bender, C.E., Fitzgerald, P., Tait, S.W.G. , Llambi, F., McStay, G.P., Tupper, D.O., Pellettieri, J., Alvarado, A.S., Salvesen, G.S. and Green, D.R. (2012) Mitochondrial pathway of apoptosis is ancestral in metazoans. Proceedings of the National Academy of Sciences of the United States of America, 109(13), pp. 4904-4909. (doi: 10.1073/pnas.1120680109)

Tait, S.W.G. and Green, D.R. (2012) Mitochondria and cell signalling. Journal of Cell Science, 125(4), pp. 807-815. (doi: 10.1242/jcs.099234)

2011

Anand, P.K., Tait, S.W.G. , Lamkanfi, M., Amer, A.O., Nunez, G., Pages, G., Pouyssegur, J., McGargill, M.A., Green, D.R. and Kanneganti, T.-D. (2011) TLR2 and RIP2 pathways mediate autophagy of listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. Journal of Biological Chemistry, 286(50), pp. 42981-42991. (doi: 10.1074/jbc.M111.310599)

Llambi, F., Moldoveanu, T., Tait, S.W.G. , Bouchier-Hayes, L., Temirov, J., McCormick, L.L., Dillon, C.P. and Green, D.R. (2011) A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Molecular Cell, 44(4), pp. 517-531. (doi: 10.1016/j.molcel.2011.10.001)

Maas, C., de Vries, E., Tait, S.W.G. and Borst, J. (2011) Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53. Oncogene, 30(33), pp. 3636-3647. (doi: 10.1038/onc.2011.75)

Niemi, N.M. et al. (2011) MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Molecular and Cellular Biology, 31(7), pp. 1357-1368. (doi: 10.1128/MCB.00788-10)

Taherbhoy, A.M. et al. (2011) Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Molecular Cell, 44(3), pp. 451-461. (doi: 10.1016/j.molcel.2011.08.034)

2010

Caro-Maldonado, A., Tait, S.W.G. , Ramírez-Peinado, S., Ricci, J.-E., Fabregat, I., Green, D.R. and Muñoz-Pinedo, C. (2010) Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death and Differentiation, 17(8), pp. 1335-1344. (doi: 10.1038/cdd.2010.21)

Maas, C., Verbrugge, I., de Vries, E., Savich, G., van de Kooij, L.W., Tait, S.W.G. and Borst, J. (2010) Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation. Cell Death and Differentiation, 17(10), pp. 1613-1623. (doi: 10.1038/cdd.2010.39)

Tait, S.W.G. and Green, D.R. (2010) Cell survival in tough times: the mitochondrial recovery plan. Cell Cycle, 9(21), pp. 4254-4255. (doi: 10.4161/cc.9.21.13962)

Tait, S.W.G. and Green, D.R. (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nature Reviews Molecular Cell Biology, 11(9), pp. 621-632. (doi: 10.1038/nrm2952)

Tait, S.W.G. , Parsons, M.J., Llambi, F., Bouchier-Hayes, L., Connell, S., Muñoz-Pinedo, C. and Green, D.R. (2010) Resistance to caspase-independent cell death requires persistence of intact mitochondria. Developmental Cell, 18(5), pp. 802-813. (doi: 10.1016/j.devcel.2010.03.014)

2009

Tait, S.W.G. , Bouchier-Hayes, L., Oberst, A., Connell, S. and Green, D.R. (2009) Live to dead cell imaging. Methods in Molecular Biology, 559(1), pp. 33-48. (doi: 10.1007/978-1-60327-017-5_3)

2008

Tait, S.W.G. and Green, D.R. (2008) Caspase-independent cell death: leaving the set without the final cut. Oncogene, 27(50), pp. 6452-6461. (doi: 10.1038/onc.2008.311)

Verbrugge, I., de Vries, E., Tait, S.W.G. , Wissink, E.H.J., Walczak, H., Verheij, M. and Borst, J. (2008) Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene, 27(5), pp. 574-584. (doi: 10.1038/sj.onc.1210696)

2007

Colell, A. et al. (2007) GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell, 129(5), pp. 983-997. (doi: 10.1016/j.cell.2007.03.045)

Sanjuan, M.A. et al. (2007) Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature, 450(7173), pp. 1253-1257. (doi: 10.1038/nature06421)

Tait, S.W.G. , de Vries, E., Maas, C., Keller, A.M., D'Santos, C.S. and Borst, J. (2007) Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. Journal of Cell Biology, 179(7), pp. 1453-1466. (doi: 10.1083/jcb.200707063)

2006

Ortiz-Ferrón, G., Tait, S.W.G. , Robledo, G., de Vries, E., Borst, J. and López-Rivas, A. (2006) The mitogen-activated protein kinase pathway can inhibit TRAIL-induced apoptosis by prohibiting association of truncated Bid with mitochondria. Cell Death and Differentiation, 13(11), pp. 1857-1865. (doi: 10.1038/sj.cdd.4401875)

2004

Danen-van Oorschot, A.A.A.M., Voskamp, P., Seelen, M.C.M.J., van Miltenburg, M.H.A.M., Bolk, M.W., Tait, S.W.G. , Boesen-de Cock, J.G.R., Rohn, J.L., Borst, J. and Noteborn, M.H.M. (2004) Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. Cell Death and Differentiation, 11(5), pp. 564-573. (doi: 10.1038/sj.cdd.4401391)

Tait, S.W.G. , Werner, A.B., de Vries, E. and Borst, J. (2004) Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability. Cell Death and Differentiation, 11(8), pp. 800-811. (doi: 10.1038/sj.cdd.4401410)

Werner, A.B., Tait, S.W.G. , de Vries, E., Eldering, E. and Borst, J. (2004) Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens. Journal of Biological Chemistry, 279(27), pp. 28771-28780. (doi: 10.1074/jbc.M400268200)

2002

Werner, A.B., de Vries, E., Tait, S.W.G. , Bontjer, I. and Borst, J. (2002) Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic Bak or Bax. Journal of Biological Chemistry, 277(25), pp. 22781-22788. (doi: 10.1074/jbc.M201469200)

Werner, A.B., de Vries, E., Tait, S.W.G. , Bontjer, I. and Borst, J. (2002) TRAIL receptor and CD95 signal to mitochondria via FADD, Caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid. Journal of Biological Chemistry, 277(43), pp. 40760-40767. (doi: 10.1074/jbc.M204351200)

2000

Tait, S.W.G. (2000) Mechanism of inactivation of NF-κΒ by a viral homologue of ΙκΒα. Signal-induced release of ΙκΒα results in the binding of the viral homologue to NF-κΒ. Journal of Biological Chemistry, 275(44), pp. 34656-34664. (doi: 10.1074/jbc.M000320200)

This list was generated on Sat Dec 21 08:18:07 2024 GMT.

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