Mohammed Mansour has secured a Newton International Fellowship from the Royal Society/British Academy and will be joining Dave Bryant’s lab from Tanta University, Egypt in March 2017 for 2 years. His project will explore the function of ubiquitination of Podocalyxin (Podxl), a protein involved in prostate cancer metastasis. This project builds on work from Dave’s lab showing that cell surface expression of Podxl is essential for invasion of metastatic prostate cancer cells and that this is regulated by ubiquitination of Podxl. Mohammed will use 3D spheroid cultures of a metastatic prostate cancer cell line to determine which Podxl residues are ubiquitinated and how this affects Podxl localisation and function. He will also use biotinylation assays to investigate endocytosis, recycling, and degradation of Podxl. Finally Mohammed will investigate which E3 Ub ligase regulates the ubiquitination of Podxl during invasion.

 

http://www.beatson.gla.ac.uk/Invasion-and-Metastasis/dave-bryant-molecular-control-of-epithelial-polarity.html

 

 

First published: 8 November 2016

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