Dr Theo Pepler

  • Independent Biostatistician (Robertson Centre for Biostatistics)

email: Theo.Pepler@glasgow.ac.uk

Robertson Centre for Biostatistics, Clarice Pears Building, 90 Byres Road, University of Glasgow, Glasgow, G12 8TB

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-2961-6573

Biography

EPIC Scotland logo

I work as an applied statistician, and am a member of the Scottish Government's Centre of Expertise on Animal Disease Outbreaks (EPIC).

My personal webpage has information on a number of my R software packages, as well as links to various statistical and computing resources.

Research interests

Most of my scientific research work is applied in nature, using statistical and simulation methods to investigate biological questions.

Within the EPIC research programme, I study how animal movements contribute to infectious disease spread. By combining epidemiological simulation models with observed animal movement data, we can identify the agricultural premises potentially playing key roles in future epidemic outbreaks. Knowledge of these key premises is helpful in planning surveillance and control strategies for infectious animal disease in Scotland.

I also work on a number of projects about the diagnosis of clinical and subclinical mastitis in dairy cows. We are evaluating different diagnostic measures, including on-farm bacterial culture, and machine learning models based on biomarker data. More accurate diagnosis of subclinical mastitis helps to identify animals that will benefit from treatment; treating only this subset of animals reduces antimicrobial usage without compromising animal welfare.

On the methodological side, I am most interested in multivariate statistical analysis (spectral decomposition, in particular) and nonparametric techniques.

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2012
Number of items: 27.

2024

Cook, J.G., Pepler, P.T. , Viora, L. and Hill, D.L. (2024) Assessing transition cow management in dairy cows for improved health, milk production, pregnancy and culling outcomes. Journal of Dairy Science, (doi: 10.3168/jds.2024-25047) (PMID:39098491) (In Press)

Eckersall, P. D. , Brady, N., O'Reilly, E.L., Viora, L. and Pepler, P. T. (2024) An Elisa for Cathelicidin for Diagnosis of Bovine Mastitis. XXI International Society for Animal Clinical Pathology Congress, Crete, Greece, 14-18 May 2024.

O'Reilly, E. L. et al. (2024) Biomarker and proteome analysis of milk from dairy cows with clinical mastitis: determining the effect of different bacterial pathogens on the response to infection. Research in Veterinary Science, 172, 105240. (doi: 10.1016/j.rvsc.2024.105240) (PMID:38608347)

Berteau, M., Pepler, P. T. , Broadhurst, A., Hammond, G. , Zadoks, R. N. and Viora, L. (2024) Assessing teat canal morphology in the dry period and during lactation by high-resolution ultrasound. Journal of Dairy Research, 91(1), pp. 57-64. (doi: 10.1017/S0022029924000098) (PMID:38494752)

Viora, L. , Pepler, P. T. , O’Reilly, E. L., Brady, N., Zadoks, R. and Eckersall, D. (2024) Biomarker Analysis of Milk from Dairy Cows with Clinical Mastitis. 32nd World Buiatrics Congress, Cancún, México, 20-24 May 2024. (Accepted for Publication)

2023

Vazquez Belandria, R. , Denholm, K. , Pepler, P. T. , Cook, J. G., Pinho, P., Randi, F. and Viora, L. (2023) Comparison of three reproductive management strategies for lactating dairy cows using combination of estrus detection or ovulation synchronization and Fixed-Timed Artificial Insemination. Animal Reproduction Science, 257, 107331. (doi: 10.1016/j.anireprosci.2023.107331) (PMID:37717491)

Viora, L. , Pepler, T. , O'Reilly, E. L., Brady, N., Eckersall, D. and Zadoks, R. (2023) Exploring the Potential of a Novel Biomarker Panel in Selective Dry Cow Therapy. European Buiatrics Congress and ECBHM Jubilee Symposium 2023, Berlin, Germany, 24-26 Aug 2023.

Akhmetova, A. et al. (2023) Genomic epidemiology of Mycobacterium bovis infection in sympatric badger and cattle populations in Northern Ireland. Microbial Genomics, 9(5), 001023. (doi: 10.1099/mgen.0.001023) (PMID:37227264) (PMCID:PMC10272874)

2022

Simões, P. B. A., Viora, L. , Pepler, P. T. , Geraghty, T., McCafferty, D. J. and Zadoks, R. N. (2022) Evaluation of a novel infrared thermography projection to assess udder health in primigravid dairy heifers. Animals, 12(23), 3410. (doi: 10.3390/ani12233410) (PMID:36496931) (PMCID:PMC9738602)

Viora, L. , Pepler, T. , O'Reilly, E. L., Brady, N., Zadoks, R. N. and Eckersall, P. D. (2022) Selective dry cow therapy: the potential role of a novel biomarker panel. In: 31st World Buiatrics Congress, Madrid, Spain, 04-08 Sep 2022,

Cook, J. G., Pepler, P. T. and Viora, L. (2022) Use of Principal Components Analysis to Explore the Association Between Days in the Pre-partum Pen with Early Lactation Disease. Total Dairy 2022, Stratford-upon-Avon, UK, 23-24 Nov 2022.

2021

Cook, J.G., Pepler, P.T. and Viora, L. (2021) Association of days in close up, gestation length and rumination around time of calving with disease and pregnancy outcomes in dairy cows. Journal of Dairy Science, 104(8), pp. 9093-9105. (doi: 10.3168/jds.2020-19768) (PMID:33934871)

Malcata, F. B., Pepler, P. T. , Zadoks, R. N. and Viora, L. (2021) Laboratory-based evaluation of a simplified point-of-care test intended to support treatment decisions in non-severe bovine clinical mastitis. Journal of Dairy Research, 88(2), pp. 170-175. (doi: 10.1017/S0022029921000303) (PMID:33958019)

Ruget, A.-S., Rossi, G., Pepler, P. T. , Beaunée, G., Banks, C. J., Enright, J. and Kao, R. R. (2021) Multi-species temporal network of livestock movements for disease spread. Applied Network Science, 6, 15. (doi: 10.1007/s41109-021-00354-x)

2020

Malcata, F. B., Pepler, P. T. , O'Reilly, E. L., Brady, N., Eckersall, P. D. , Zadoks, R. N. and Viora, L. (2020) Point-of-care tests for bovine clinical mastitis: what do we have and what do we need? Journal of Dairy Research, 87(S1), pp. 60-66. (doi: 10.1017/S002202992000062X) (PMID:33213589)

2019

Malcata, F.B., Viora, L. , Pepler, P.T. and Zadoks, R.N. (2019) Comparison of two point-of-care tests to support treatment decision in non-severe bovine clinical mastitis. In: 2019 British Mastitis Conference, Worcester, UK, 6th November 2019,

Malcata, F.B., Viora, L. , Pepler, P.T. and Zadoks, R. N. (2019) Do point of care tests for bovine mastitis can reduce antimicrobial use without animal welfare loss? European Bovine Congress 2019, ‘s-Hertogenbosch, The Netherlands, 11-13 Sept 2019.

Viora, L. , O'Reilly, E. L., Brady, N., Pepler, T. , Zadoks, R. N. and Eckersall, P. D. (2019) New biomarkers for selective dry cow therapy. European Bovine Congress 2019, ‘s-Hertogenbosch, The Netherlands, 11-13 Sept 2019.

O'Reilly, E., Viora, L. , Brady, N., Pepler, T. , Zadoks, R. N. and Eckersall, D. P. (2019) Haptoglobin and α-Lactalbumin Biomarkers for Selective Dry Cow Therapy? 8th Edinburgh Infectious Diseases Annual Symposium, Edinburgh, UK, 5 Jun 2019.

O'Reilly, E., Viora, L. , Brady, N., Pepler, T. , Zadoks, R. N. and Eckersall, D. P. (2019) Haptoglobin and α-Lactalbumin Biomarkers for Selective Dry Cow Therapy? International Dairy Federation Mastitis Conference, Copenhagen, Denmark, 15-16 May 2019.

2018

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2018) Regularised covariance matrix estimation under the common principal components model. Communications in Statistics: Simulation and Computation, 47(3), pp. 631-643. (doi: 10.1080/03610918.2015.1040499)

2017

Bester, R., Pepler, P. T. , Aldrich, D. J. and Maree, H. J. (2017) Harbin: a quantitation PCR analysis tool. Biotechnology Letters, 39(1), pp. 171-178. (doi: 10.1007/s10529-016-2221-1) (PMID:27695982)

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2017) Discriminant analysis under the common principal components model. Communications in Statistics: Simulation and Computation, 46(6), pp. 4812-4827. (doi: 10.1080/03610918.2015.1134568)

2016

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2016) A comparison of some methods for the selection of a common eigenvector model for the covariance matrices of two groups. Communications in Statistics: Simulation and Computation, 45(8), pp. 2917-2936. (doi: 10.1080/03610918.2014.932801)

2014

Bester, R., Pepler, P.T. , Burger, J.T. and Maree, H.J. (2014) Relative quantitation goes viral: an RT-qPCR assay for a grapevine virus. Journal of Virological Methods, 210, pp. 67-75. (doi: 10.1016/j.jviromet.2014.09.022) (PMID:25286180)

Hauser, N.D., Dyer, R.A., Pepler, P.T. and Rolfe, D.A. (2014) An observational audit of pain scores post-orthopaedic surgery at a level two state hospital in Cape Town. Southern African Journal of Anaesthesia and Analgesia, 20(2), pp. 110-116.

2012

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2012) Predicting mortality and length-of-stay for neonatal admissions to private hospital neonatal intensive care units: a Southern African retrospective study. African Health Sciences, 12(2), pp. 166-173. (doi: 10.4314/ahs.v12i2.14) (PMID:23056023) (PMCID:PMC3462546)

This list was generated on Thu Nov 21 04:43:14 2024 GMT.
Jump to: Articles | Conference or Workshop Item | Conference Proceedings
Number of items: 27.

Articles

Cook, J.G., Pepler, P.T. , Viora, L. and Hill, D.L. (2024) Assessing transition cow management in dairy cows for improved health, milk production, pregnancy and culling outcomes. Journal of Dairy Science, (doi: 10.3168/jds.2024-25047) (PMID:39098491) (In Press)

O'Reilly, E. L. et al. (2024) Biomarker and proteome analysis of milk from dairy cows with clinical mastitis: determining the effect of different bacterial pathogens on the response to infection. Research in Veterinary Science, 172, 105240. (doi: 10.1016/j.rvsc.2024.105240) (PMID:38608347)

Berteau, M., Pepler, P. T. , Broadhurst, A., Hammond, G. , Zadoks, R. N. and Viora, L. (2024) Assessing teat canal morphology in the dry period and during lactation by high-resolution ultrasound. Journal of Dairy Research, 91(1), pp. 57-64. (doi: 10.1017/S0022029924000098) (PMID:38494752)

Vazquez Belandria, R. , Denholm, K. , Pepler, P. T. , Cook, J. G., Pinho, P., Randi, F. and Viora, L. (2023) Comparison of three reproductive management strategies for lactating dairy cows using combination of estrus detection or ovulation synchronization and Fixed-Timed Artificial Insemination. Animal Reproduction Science, 257, 107331. (doi: 10.1016/j.anireprosci.2023.107331) (PMID:37717491)

Akhmetova, A. et al. (2023) Genomic epidemiology of Mycobacterium bovis infection in sympatric badger and cattle populations in Northern Ireland. Microbial Genomics, 9(5), 001023. (doi: 10.1099/mgen.0.001023) (PMID:37227264) (PMCID:PMC10272874)

Simões, P. B. A., Viora, L. , Pepler, P. T. , Geraghty, T., McCafferty, D. J. and Zadoks, R. N. (2022) Evaluation of a novel infrared thermography projection to assess udder health in primigravid dairy heifers. Animals, 12(23), 3410. (doi: 10.3390/ani12233410) (PMID:36496931) (PMCID:PMC9738602)

Cook, J.G., Pepler, P.T. and Viora, L. (2021) Association of days in close up, gestation length and rumination around time of calving with disease and pregnancy outcomes in dairy cows. Journal of Dairy Science, 104(8), pp. 9093-9105. (doi: 10.3168/jds.2020-19768) (PMID:33934871)

Malcata, F. B., Pepler, P. T. , Zadoks, R. N. and Viora, L. (2021) Laboratory-based evaluation of a simplified point-of-care test intended to support treatment decisions in non-severe bovine clinical mastitis. Journal of Dairy Research, 88(2), pp. 170-175. (doi: 10.1017/S0022029921000303) (PMID:33958019)

Ruget, A.-S., Rossi, G., Pepler, P. T. , Beaunée, G., Banks, C. J., Enright, J. and Kao, R. R. (2021) Multi-species temporal network of livestock movements for disease spread. Applied Network Science, 6, 15. (doi: 10.1007/s41109-021-00354-x)

Malcata, F. B., Pepler, P. T. , O'Reilly, E. L., Brady, N., Eckersall, P. D. , Zadoks, R. N. and Viora, L. (2020) Point-of-care tests for bovine clinical mastitis: what do we have and what do we need? Journal of Dairy Research, 87(S1), pp. 60-66. (doi: 10.1017/S002202992000062X) (PMID:33213589)

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2018) Regularised covariance matrix estimation under the common principal components model. Communications in Statistics: Simulation and Computation, 47(3), pp. 631-643. (doi: 10.1080/03610918.2015.1040499)

Bester, R., Pepler, P. T. , Aldrich, D. J. and Maree, H. J. (2017) Harbin: a quantitation PCR analysis tool. Biotechnology Letters, 39(1), pp. 171-178. (doi: 10.1007/s10529-016-2221-1) (PMID:27695982)

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2017) Discriminant analysis under the common principal components model. Communications in Statistics: Simulation and Computation, 46(6), pp. 4812-4827. (doi: 10.1080/03610918.2015.1134568)

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2016) A comparison of some methods for the selection of a common eigenvector model for the covariance matrices of two groups. Communications in Statistics: Simulation and Computation, 45(8), pp. 2917-2936. (doi: 10.1080/03610918.2014.932801)

Bester, R., Pepler, P.T. , Burger, J.T. and Maree, H.J. (2014) Relative quantitation goes viral: an RT-qPCR assay for a grapevine virus. Journal of Virological Methods, 210, pp. 67-75. (doi: 10.1016/j.jviromet.2014.09.022) (PMID:25286180)

Hauser, N.D., Dyer, R.A., Pepler, P.T. and Rolfe, D.A. (2014) An observational audit of pain scores post-orthopaedic surgery at a level two state hospital in Cape Town. Southern African Journal of Anaesthesia and Analgesia, 20(2), pp. 110-116.

Pepler, P.T. , Uys, D.W. and Nel, D.G. (2012) Predicting mortality and length-of-stay for neonatal admissions to private hospital neonatal intensive care units: a Southern African retrospective study. African Health Sciences, 12(2), pp. 166-173. (doi: 10.4314/ahs.v12i2.14) (PMID:23056023) (PMCID:PMC3462546)

Conference or Workshop Item

Eckersall, P. D. , Brady, N., O'Reilly, E.L., Viora, L. and Pepler, P. T. (2024) An Elisa for Cathelicidin for Diagnosis of Bovine Mastitis. XXI International Society for Animal Clinical Pathology Congress, Crete, Greece, 14-18 May 2024.

Viora, L. , Pepler, P. T. , O’Reilly, E. L., Brady, N., Zadoks, R. and Eckersall, D. (2024) Biomarker Analysis of Milk from Dairy Cows with Clinical Mastitis. 32nd World Buiatrics Congress, Cancún, México, 20-24 May 2024. (Accepted for Publication)

Viora, L. , Pepler, T. , O'Reilly, E. L., Brady, N., Eckersall, D. and Zadoks, R. (2023) Exploring the Potential of a Novel Biomarker Panel in Selective Dry Cow Therapy. European Buiatrics Congress and ECBHM Jubilee Symposium 2023, Berlin, Germany, 24-26 Aug 2023.

Cook, J. G., Pepler, P. T. and Viora, L. (2022) Use of Principal Components Analysis to Explore the Association Between Days in the Pre-partum Pen with Early Lactation Disease. Total Dairy 2022, Stratford-upon-Avon, UK, 23-24 Nov 2022.

Malcata, F.B., Viora, L. , Pepler, P.T. and Zadoks, R. N. (2019) Do point of care tests for bovine mastitis can reduce antimicrobial use without animal welfare loss? European Bovine Congress 2019, ‘s-Hertogenbosch, The Netherlands, 11-13 Sept 2019.

Viora, L. , O'Reilly, E. L., Brady, N., Pepler, T. , Zadoks, R. N. and Eckersall, P. D. (2019) New biomarkers for selective dry cow therapy. European Bovine Congress 2019, ‘s-Hertogenbosch, The Netherlands, 11-13 Sept 2019.

O'Reilly, E., Viora, L. , Brady, N., Pepler, T. , Zadoks, R. N. and Eckersall, D. P. (2019) Haptoglobin and α-Lactalbumin Biomarkers for Selective Dry Cow Therapy? 8th Edinburgh Infectious Diseases Annual Symposium, Edinburgh, UK, 5 Jun 2019.

O'Reilly, E., Viora, L. , Brady, N., Pepler, T. , Zadoks, R. N. and Eckersall, D. P. (2019) Haptoglobin and α-Lactalbumin Biomarkers for Selective Dry Cow Therapy? International Dairy Federation Mastitis Conference, Copenhagen, Denmark, 15-16 May 2019.

Conference Proceedings

Viora, L. , Pepler, T. , O'Reilly, E. L., Brady, N., Zadoks, R. N. and Eckersall, P. D. (2022) Selective dry cow therapy: the potential role of a novel biomarker panel. In: 31st World Buiatrics Congress, Madrid, Spain, 04-08 Sep 2022,

Malcata, F.B., Viora, L. , Pepler, P.T. and Zadoks, R.N. (2019) Comparison of two point-of-care tests to support treatment decision in non-severe bovine clinical mastitis. In: 2019 British Mastitis Conference, Worcester, UK, 6th November 2019,

This list was generated on Thu Nov 21 04:43:14 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Adapting the movenet toolkit for effective use of livestock movement data in Scottish and Danish veterinary public health practices.
    Engineering and Physical Sciences Research Council
    2024 - 2024
     
  • EPIC Centre of Expertise in Animal Disease Outbreaks 2022- 2025
    Scottish Government
    2022 - 2025
     
  • Rapid, accurate, on-farm diagnosis and monitoring of mastitis in dairy cows
    Innovate UK
    2018 - 2020
     

Supervision

  • Cook, John
    Management factors associated with transition success in dairy cows

Theo Pepler staff photo