Dr Michael Ormsby

  • Lecturer in One Health Microbiology/Antimicrobial Resistance (Veterinary Science & Education )
  • Honorary Research Fellow (School of Biodiversity, One Health & Veterinary Medicine)

telephone: 01413308213
email: Michael.Ormsby@glasgow.ac.uk
pronouns: He/him/his

Rm 329, Jarrett Building, University of Glasgow, 464 Bearsden Rd., G61 1QH

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-3991-2336

Biography

Education:

  • BSc Hons Biological Sciences, Heriot-Watt University, 2011
  • PhD Bacteriology, University of Glasgow, 2015

I completed my BSc (Hons) in Biological Sciences at Heriot-Watt University in 2011 before commencing a BBSRC industrial CASE PhD studentship at the University of Glasgow, later that year.

My PhD research was carried out in Dr Robert Davies' laboratory.  The primary focus of this research was to use comparative phenotypic, proteomic and genomic approaches to characterise the fish pathogen, Yersinia ruckeri, in support of improved vaccine development.

Career History:

  • Lecturer in One Health Microbiology/AMR, University of Glasgow, 2024 – present
  • Postdoctoral Research Fellow, University of Stirling, 2021 – 2024
  • Postdoctoral Research Associate, University of Glasgow, 2020 – 2021
  • Postdoctoral Research Associate, University of Glasgow, 2015 – 2020

Following my PhD, I moved to the laboratory of Dr Donal Wall, also at the University of Glasgow, where I worked as a Postdoctoral Research Associate. This BBSRC-funded post involved examining the effect of the short chain fatty acid (SCFA) preservative propionic acid, on Adherent-invasive E. coli (AIEC) - a pathogen associated with Crohn’s disease. Adopting a multidisciplinary approach, we aimed to uncover any selective advantages that this common food additive may provide AIEC.

In 2020, I began working with Dr. Gill Douce. This Wellcome trust funded collaborative project (in conjunction with Dr. Robert Fagan [University of Sheffield] and Dr. Paula Salgado [Newcastle University]) involves examining the role of the S-layer in Clostridium difficile pathogenesis.

In 2021, I moved to the University of Stirling, where I worked with Professor Richard Quilliam. This NERC-GCRF funded SPACES project involved studying environmental microbiology and the ecology of plastic pollution. Specifically, we were interested in examining how dangerous enteric bacterial pathogens including E. coli, Salmonella spp., and Vibrio cholerae can attach to and persist on different materials, under environmental conditions. This project involved extensive collaboration with the Universities of Malawi and Dar es Salaam (Tanzania), including real-world studies in each country.

In 2024, I moved back to the University of Glasgow, to undertake a Lectureship position in the School of Biodiversity, One Health and Veterinary Medicine (sBOHVM) within the One Health Research into Bacterial Infectious Diseases (OHRBID) group.

Research interests

My research interests lie at the interface of veterinary, environmental, and clinical microbiology and focus on several development, sustainability, public health, and disease-related topics. I have a strong research background in bacterial pathogen ecology, antimicrobial resistance (AMR), and in the survival and cycling of enteric pathogens through different environmental matrices. My research focuses on understanding the relationship between pathogen evolution in the environment, and disease emergence in the clinic, creating a novel, cross-disciplinary research niche that firmly fits within the One Health philosophy. Additionally, I have a keen interest in the emergence of novel zoonotic pathogens. With increased urbanisation (primarily driven by climate change) bringing people and animals closer together, there is substantial risk of pathogen spread between groups. Concurrent with this, climate change is bringing more frequent rains (which increases run-off from agriculture, and sewer overflow events) and warmer temperatures (which widens the geographic area for pathogens to survive). I want to understand how the interaction between pathogens from different sources can lead to the emergence of more virulent bacterial pathotypes, and novel zoonotic diseases.

My research group uses a combination of culture-based and molecular approaches to answer fundamental questions regarding bacterial survival, persistence and evolution in the environment. We are particularly interested in how the increasing pressures of climate change can drive this.

Publications

List by: Type | Date

Jump to: 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016
Number of items: 15.

2023

Li, X., Ormsby, M. J. , Fallata, G., Meikle, L. M., Walker, D. , Xu, D. and Wall, D. M. (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

Ormsby, M. J. et al. (2023) An intact S-layer is advantageous to Clostridioides difficile within the host. PLoS Pathogens, 19(6), e1011015. (doi: 10.1371/journal.ppat.1011015) (PMID:37384772) (PMCID:PMC10310040)

2021

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Ormsby, M. J. and Davies, R. L. (2021) Diversification of OmpA and OmpF of Yersinia ruckeri is independent of the underlying species phylogeny and evidence of virulence-related selection. Scientific Reports, 11, 3493. (doi: 10.1038/s41598-021-82925-7) (PMID:33568758) (PMCID:PMC7876001)

2020

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

Johnson, S. A., Ormsby, M. J. , McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Ormsby, M. J. , Grahame, E., Burchmore, R. and Davies, R. L. (2019) Comparative bioinformatic and proteomic approaches to evaluate the outer membrane proteome of the fish pathogen Yersinia ruckeri. Journal of Proteomics, 199, pp. 135-147. (doi: 10.1016/j.jprot.2019.02.014) (PMID:30831250) (PMCID:PMC6447952)

Ormsby, M. J. et al. (2019) Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli. EBioMedicine, 43, pp. 325-332. (doi: 10.1016/j.ebiom.2019.03.071) (PMID:31036531) (PMCID:PMC6557746)

2018

Gulla, S. et al. (2018) Multilocus variable-number tandem-repeat analysis of Yersinia ruckeri confirms the existence of host specificity, geographic endemism, and anthropogenic dissemination of virulent clones. Applied and Environmental Microbiology, 84(16), e00730-18. (doi: 10.1128/AEM.00730-18) (PMID:29884756) (PMCID:PMC6070765)

2017

McIntosh, A., Meikle, L. M., Ormsby, M. J. , McCormick, B. A., Christie, J. M. , Brewer, J. M. , Roberts, M. and Wall, D. M. (2017) SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar typhimurium Infection. Infection and Immunity, 85(9), e00393-17. (doi: 10.1128/IAI.00393-17) (PMID:28630067) (PMCID:PMC5563584)

Johnson, S. A., Ormsby, M. J. and Wall, D. (2017) Draft genome sequence of the tumor-targeting salmonella enterica serovar typhimurium strain SL7207. Genome Announcements, 5(5), e01591-16. (doi: 10.1128/genomeA.01591-16) (PMID:28153911) (PMCID:PMC5289697)

Ormsby, M. and Davies, R. (2017) Yersinia ruckeri. In: Woo, P. T. K. and Cipriano, R. C. (eds.) Fish Viruses and Bacteria: Pathobiology and Protection. CABI, p. 339. ISBN 9781780647784 (doi: 10.1079/9781780647784.0339)

2016

Ormsby, M. J. , Johnson, S. A. and Wall, D. M. (2016) Draft genome sequence of the commensal Escherichia coli strain F-18. Genome Announcements, 4(6), e01416-16. (doi: 10.1128/genomeA.01416-16) (PMID:28007857) (PMCID:PMC5180385)

Ormsby, M. J. , Caws, T., Burchmore, R. , Wallis, T., Verner-Jeffreys, D. W. and Davies, R. L. (2016) Yersinia ruckeri isolates recovered from diseased Atlantic Salmon (Salmo salar) in Scotland are more diverse than those from Rainbow Trout (Oncorhynchus mykiss) and represent distinct subpopulations. Applied and Environmental Microbiology, 82(19), pp. 5785-5794. (doi: 10.1128/aem.01173-16) (PMID:27451448) (PMCID:PMC5038039)

This list was generated on Thu Oct 31 01:02:58 2024 GMT.
Number of items: 15.

Articles

Li, X., Ormsby, M. J. , Fallata, G., Meikle, L. M., Walker, D. , Xu, D. and Wall, D. M. (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

Ormsby, M. J. et al. (2023) An intact S-layer is advantageous to Clostridioides difficile within the host. PLoS Pathogens, 19(6), e1011015. (doi: 10.1371/journal.ppat.1011015) (PMID:37384772) (PMCID:PMC10310040)

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Ormsby, M. J. and Davies, R. L. (2021) Diversification of OmpA and OmpF of Yersinia ruckeri is independent of the underlying species phylogeny and evidence of virulence-related selection. Scientific Reports, 11, 3493. (doi: 10.1038/s41598-021-82925-7) (PMID:33568758) (PMCID:PMC7876001)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

Johnson, S. A., Ormsby, M. J. , McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Ormsby, M. J. , Grahame, E., Burchmore, R. and Davies, R. L. (2019) Comparative bioinformatic and proteomic approaches to evaluate the outer membrane proteome of the fish pathogen Yersinia ruckeri. Journal of Proteomics, 199, pp. 135-147. (doi: 10.1016/j.jprot.2019.02.014) (PMID:30831250) (PMCID:PMC6447952)

Ormsby, M. J. et al. (2019) Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli. EBioMedicine, 43, pp. 325-332. (doi: 10.1016/j.ebiom.2019.03.071) (PMID:31036531) (PMCID:PMC6557746)

Gulla, S. et al. (2018) Multilocus variable-number tandem-repeat analysis of Yersinia ruckeri confirms the existence of host specificity, geographic endemism, and anthropogenic dissemination of virulent clones. Applied and Environmental Microbiology, 84(16), e00730-18. (doi: 10.1128/AEM.00730-18) (PMID:29884756) (PMCID:PMC6070765)

McIntosh, A., Meikle, L. M., Ormsby, M. J. , McCormick, B. A., Christie, J. M. , Brewer, J. M. , Roberts, M. and Wall, D. M. (2017) SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar typhimurium Infection. Infection and Immunity, 85(9), e00393-17. (doi: 10.1128/IAI.00393-17) (PMID:28630067) (PMCID:PMC5563584)

Johnson, S. A., Ormsby, M. J. and Wall, D. (2017) Draft genome sequence of the tumor-targeting salmonella enterica serovar typhimurium strain SL7207. Genome Announcements, 5(5), e01591-16. (doi: 10.1128/genomeA.01591-16) (PMID:28153911) (PMCID:PMC5289697)

Ormsby, M. J. , Johnson, S. A. and Wall, D. M. (2016) Draft genome sequence of the commensal Escherichia coli strain F-18. Genome Announcements, 4(6), e01416-16. (doi: 10.1128/genomeA.01416-16) (PMID:28007857) (PMCID:PMC5180385)

Ormsby, M. J. , Caws, T., Burchmore, R. , Wallis, T., Verner-Jeffreys, D. W. and Davies, R. L. (2016) Yersinia ruckeri isolates recovered from diseased Atlantic Salmon (Salmo salar) in Scotland are more diverse than those from Rainbow Trout (Oncorhynchus mykiss) and represent distinct subpopulations. Applied and Environmental Microbiology, 82(19), pp. 5785-5794. (doi: 10.1128/aem.01173-16) (PMID:27451448) (PMCID:PMC5038039)

Book Sections

Ormsby, M. and Davies, R. (2017) Yersinia ruckeri. In: Woo, P. T. K. and Cipriano, R. C. (eds.) Fish Viruses and Bacteria: Pathobiology and Protection. CABI, p. 339. ISBN 9781780647784 (doi: 10.1079/9781780647784.0339)

This list was generated on Thu Oct 31 01:02:58 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Elucidating the role of bacterial microcompartments in the pathogenesis of Crohns disease associated adherent-invasive Escherichia coli
    Tenovus Scotland
    2018 - 2019
     

Supervision

I am open to Undergraduate Students who wish to apply for the Microbiology Society Vacation Studentship to spend a summer gaining research experience

Microbiology Society Summer Studentship Grants