Dr Lauren Carruthers

  • Affiliate Researcher (School of Biodiversity, One Health & Veterinary Medicine)
  • Affiliate (School of Chemistry)
  • Affiliate (School of Infection & Immunity)

Biography

Research Overview

I graduated with a BSc (Hons) in Parasitology before undertaking two short-term research technician positions on diminazene resistance in Trypanosoma congolense parasites and the role of lipids in trypanosome cytokinesis. I then undertook a PhD exploring interactions between Schistosoma mansoni infection, gut bacteria and anti-helminthic treatment. I compared the bacterial composition of stool from individuals from a rural Ugandan community, with high and low schistosome infection intensities and explored how these bacterial structures change post-treatment with combined praziquantel and albendazole treatment. During my PhD, I also received funding to undertake an internship at the Texas Biomedical Research Centre, where I learnt about schistosome maintenance in the lab and explored the microbiota of Biomphalaria snails. I am currently characterising the role of a new family of zinc finger proteins in Plasmodium parasites in the laboratory of Dr Katarzyna Modrzynska.

 

Research Experience

  • 2021 – Present: BBSRC Research Assistant, University of Glasgow.

Researching zinc finger proteins in Plasmodium berghei.

  • 2017 - 2021: PhD researcher.

"The impact of Schistosoma mansoni infection and treatment on the gut microbiota of school-aged children in Uganda.”

  • 2019: Summer Internship, Texas Biomedical Research Institute.

Researching the microbiome of Biomphalaria snails and learning schistosome parasite life cycle maintenance.

  • 2017: Microbiome Techniques, Quadram Institute, University of East Anglia.
  • 2016 –2017: Research Technician, University of Glasgow

(1) The role of lipids in Trypanosoma brucei cytokinesis.

(2) Diminazine drug resistance in Trypanosoma congolense.

  • 2015: Undergraduate Honours Project

“Drug induced changes in the trypanosome metabolome.”

  • 2015: Wellcome Trust Vacation Scholarship

“Cloning and sequencing of phosphodiesterase genes A and D from Trypanosoma cruzi strains.”

 

International Conferences

  • BioMalPar XIX: Biology and Pathology of the Malaria Parasite 2023.

Poster Presenter: “Characterisation of the Apicomplexa-specific zinc-finger protein (ZINGER) family in Plasmodium.”

  • British Society for Parasitology Spring Meeting 2022.

Virtual Oral Presenter: “Characterisation of a member of the Apicomplexa-specific zinc-finger protein family in Plasmodium.”

  • Molecular Parasitology Meeting 2021.

Virtual Oral Presenter: “Characterisation of the Apicomplexa-specific zinc-finger protein family in Plasmodium.”

  • Virtual Women in Malaria Conference 2021.

Virtual Attendee.

  • Molecular Helminthology; An Integrated Approach 2019.

Poster Presenter: “The microbiota profiles: are schistosomes and anti-helminthic drugs influential agents?”

  • International Society for Neglected Tropical Diseases Festival 2019.

Workshop: “Poop Pondering.” 

  • American Society for Tropical Medicine and Hygiene Annual Meeting 2018.

Poster Presenter 1320: “Unravelling interactions between schistosomes, the microbiome and anti-helminthic drugs in a Ugandan field setting.”

  • British Society for Parasitology Spring Meeting 2018.

Oral Presenter: “Unravelling interactions between schistosomes, the microbiome and anti-helminthic drugs in a Ugandan field setting.”

  • International Society for Neglected Tropical Diseases Festival 2018.

Attendee.

  • British Society for Parasitology Spring Meeting 2017.

Oral Presenter: “A decrease in mitochondrial membrane potential may be associated with diminazene resistance in Trypanosoma congolense.”

 

Public Engagement

I am passionate about public engagement and have volunteered at a variety of events, created activites, and written blogs. I have created a booklet of science cross stitch patterns and run the 'Parasites in Stitches,' (@ParasiteXStitch) twitter and instagram accounts. 

Public Engagement Awards

  • 2023: Medical, Veterinary and Life Sciences Public Engagement Award Small Grant (University of Glasgow).
  • 2019: International Society for Neglected Tropical Diseases Art award.

Blog Posts and Magazine Articles

  • The World of Cross Stitching Issue: March 2020: "Science in Stitches."
  • I’m Not Ubi-quitin Yet: Translating “Ubiquitination” Into Simple Language. (Read more)
  • Public Engagement: A Penguin’s Perspective. (Read more)
  • Engaging Communities About Research Through Community Led Performance: Schistosomiasis and Acting for Health. (Read more)
  • Parasitologists flock to Aberystwyth for Annual BSP Conference. (Read more)
  • The Story of Storing Stool: An insight into the Lamberton Lab. (Read more)
  • Norfolk – Broadening My Knowledge: Adventure with the Hall Lab. (Read more)
  • Schisto Gist: Worming Our Way in the Field to Fight Neglected Tropical Diseases. (Read more)
  • The Antibiotic Resistance are Fighting Bac - teria. (Read more)

 

Research interests

My current research focuses on characterising the role of a new family of zinc finger proteins in Plasmodium parasites in the laboratory of Dr Katarzyna Modrzynska. I have also received an ECR Futurescope grant from the Wellcome Centre for Integrative Parasitology to explore the RNA interactome in the Plasmodium berghei ookinete.

Publications

List by: Type | Date

Jump to: 2022 | 2021 | 2019 | 2018
Number of items: 5.

2022

Clark, J. et al. (2022) Reconciling egg- and antigen-based estimates of Schistosoma mansoni clearance and reinfection: a modelling study. Clinical Infectious Diseases, 74(9), pp. 1557-1563. (doi: 10.1093/cid/ciab679) (PMID:34358299)

Clark, J. et al. (2022) Translating from egg-to antigen-based indicators for Schistosoma mansoni elimination targets: a Bayesian latent class analysis study. Frontiers in Tropical Diseases, 3, 825721. (doi: 10.3389/fitd.2022.825721) (PMID:35784267) (PMCID:PMC7612949)

2021

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

2019

Carruthers, L. V. , Moses, A., Adriko, M., Faust, C. L. , Tukahebwa, E. M., Hall, L. J., Ranford-Cartwright, L. C. and Lamberton, P. H.L. (2019) The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity. PeerJ, 7, e8133. (doi: 10.7717/peerj.8133) (PMID:31824766) (PMCID:PMC6894433)

2018

Adriko, M., Faust, C. L. , Carruthers, L. V. , Moses, A., Tukahebwa, E. M. and Lamberton, P. H.L. (2018) Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to the absence of treatment opportunities, rather than systematic non-compliance. Tropical Medicine and Infectious Disease, 3(4), 111. (doi: 10.3390/tropicalmed3040111) (PMID:30297642) (PMCID:PMC6306755)

This list was generated on Sat Oct 5 15:15:03 2024 BST.
Jump to: Articles
Number of items: 5.

Articles

Clark, J. et al. (2022) Reconciling egg- and antigen-based estimates of Schistosoma mansoni clearance and reinfection: a modelling study. Clinical Infectious Diseases, 74(9), pp. 1557-1563. (doi: 10.1093/cid/ciab679) (PMID:34358299)

Clark, J. et al. (2022) Translating from egg-to antigen-based indicators for Schistosoma mansoni elimination targets: a Bayesian latent class analysis study. Frontiers in Tropical Diseases, 3, 825721. (doi: 10.3389/fitd.2022.825721) (PMID:35784267) (PMCID:PMC7612949)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Carruthers, L. V. , Moses, A., Adriko, M., Faust, C. L. , Tukahebwa, E. M., Hall, L. J., Ranford-Cartwright, L. C. and Lamberton, P. H.L. (2019) The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity. PeerJ, 7, e8133. (doi: 10.7717/peerj.8133) (PMID:31824766) (PMCID:PMC6894433)

Adriko, M., Faust, C. L. , Carruthers, L. V. , Moses, A., Tukahebwa, E. M. and Lamberton, P. H.L. (2018) Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to the absence of treatment opportunities, rather than systematic non-compliance. Tropical Medicine and Infectious Disease, 3(4), 111. (doi: 10.3390/tropicalmed3040111) (PMID:30297642) (PMCID:PMC6306755)

This list was generated on Sat Oct 5 15:15:03 2024 BST.

Supervision

I have supervised the following Masters projects in the laboratory of Dr Katarzyna Modrzynska:

  • Exploring expression of a Plasmodium berghei 3xCCCH Zinc Finger Protein throughout the parasite life cycle (May - August 2022).
  • Expression analysis of an RNA-binding protein through the malaria parasite life cycle (May - August 2022).

Teaching

  • 2022: Diploma in Tropical Hygiene and Medicine (DTMH) lab demonstrator.
  • 2022: Masters lab rotation supervision.
  • 2020 – 2021: Graduate Teaching Assistant (University of Glasgow).
  • 2019: DTMH Schistosomiasis lecture.
  • 2017 - 2019: DTMH lab demonstrator.
  • 2017 - 2019: Undergraduate and Masters lab rotation supervision.