Dr Jean Rodgers
- Lecturer (Host-Parasite Interactions & Pathogenesis)
telephone:
01413303797
email:
Jean.Rodgers@glasgow.ac.uk
R203 a, Ibahcm, Urquhart Building, Garscube Estate, Glasgow G61 1QH
Research interests
Google Scholar - Publications Profile
Investigating the pathogenesis and chemotherapy of human African trypanosomiasis and animal trypanosomiasis with particular interest in parasite migration into the CNS, the development of neuroinflammation and blood-brain barrier dysfunction.
Research groups
Publications
2023
Paterson, S., Vallatos, A. , Rodgers, J. and Holmes, W. M. (2023) Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis. Scientific Reports, 13, 8684. (doi: 10.1038/s41598-023-34665-z) (PMID:37248398) (PMCID:PMC10227057)
2022
Paterson, S., Holmes, W. and Rodgers, J. (2022) Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse. PLoS Neglected Tropical Diseases, 16(12), e0010962. (doi: 10.1371/journal.pntd.0010962) (PMID:36477669) (PMCID:PMC9728833)
2021
Montague, P., Bradley, B., Rodgers, J. and Kennedy, P. G.E. (2021) Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma.b.brucei infected CD1 mouse brains. PLoS Neglected Tropical Diseases, 15(11), e0009892. (doi: 10.1371/journal.pntd.0009892) (PMID:34762691) (PMCID:PMC8584711)
2020
Gummery, L., Jallow, S., Raftery, A. G. , Bennet, E. , Rodgers, J. and Sutton, D. G.M. (2020) Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia. PLoS ONE, 15(8), e0237187. (doi: 10.1371/journal.pone.0237187) (PMID:32833981) (PMCID:PMC7444819)
Raftery, A. , Jallow, S., Coultous, R. M. , Rodgers, J. and Sutton, D. G.M. (2020) Variation in disease phenotype is marked in equine trypanosomiasis. Parasites and Vectors, 13, 148. (doi: 10.1186/s13071-020-04020-6) (PMID:32199454) (PMCID:PMC7085162)
2019
Rodgers, J. , Steiner, I. and Kennedy, P. G.E. (2019) Generation of neuroinflammation in human African trypanosomiasis. Neurology: Neuroimmunology and Neuroinflammation, 6(6), e610. (doi: 10.1212/NXI.0000000000000610) (PMID:31467039) (PMCID:PMC6745723)
Raftery, A. G. , Jallow, S., Rodgers, J. and Sutton, D. G.M. (2019) Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. PLoS Neglected Tropical Diseases, 13(3), e0007175. (doi: 10.1371/journal.pntd.0007175) (PMID:30901321) (PMCID:PMC6447232)
Kennedy, P. G.E. and Rodgers, J. (2019) Clinical and neuropathogenetic aspects of human African trypanosomiasis. Frontiers in Immunology, 10, 39. (doi: 10.3389/fimmu.2019.00039)
2017
Laperchia, C., Tesoriero, C., La Verde, V., Seke-Etet, P. F., Colavito, V., Grassi-Zucconi, G., Rodgers, J. , Montague, P., Kennedy, P. G.E. and Bentivoglio, M. (2017) Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis. PLoS Neglected Tropical Diseases, 11(8), e0005854. (doi: 10.1371/journal.pntd.0005854) (PMID:28821016) (PMCID:PMC5576758)
Rodgers, J. , Bradley, B. and Kennedy, P. G.E. (2017) Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis. Methods, 127, pp. 79-87. (doi: 10.1016/j.ymeth.2017.06.015) (PMID:28636879) (PMCID:PMC5595161)
Sternberg, J. M., Forrest, C. M., Dalton, R. N., Turner, C., Rodgers, J. , Stone, T. W. and Kennedy, P. G.E. (2017) Kynurenine pathway activation in Human African trypanosomiasis. Journal of Infectious Diseases, 215(5), pp. 806-812. (doi: 10.1093/infdis/jiw623) (PMID:28013248) (PMCID:PMC5388295)
2016
Laperchia, C., Palomba, M., Etet, P. F. S., Rodgers, J. , Bradley, B., Montague, P., Grassi-Zucconi, G., Kennedy, P. G.E. and Bentivoglio, M. (2016) Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes. PLoS Neglected Tropical Diseases, 10(12), e0005242. (doi: 10.1371/journal.pntd.0005242) (PMID:28002454) (PMCID:PMC5217973)
Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi: 10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)
2015
Rodgers, J. , Bradley, B., Kennedy, P. G.E. and Sternberg, J. M. (2015) Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice. PLoS Neglected Tropical Diseases, 9(10), e0004201. (doi: 10.1371/journal.pntd.0004201) (PMID:26505761) (PMCID:PMC4624684)
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
Burrell-Saward, H., Rodgers, J. , Bradley, B., Croft, S. L. and Ward, T. H. (2015) A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis. Journal of Antimicrobial Chemotherapy, 70(2), pp. 510-517. (doi: 10.1093/jac/dku393) (PMID:25298516)
2013
MacLean, L., Myburgh, E. , Rodgers, J. and Price, H.P. (2013) Imaging African trypanosomes. Parasite Immunology, 35(9-10), pp. 283-294. (doi: 10.1111/pim.12046)
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
2012
Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)
2011
Rodgers, J. , McCabe, C. , Gettinby, G., Bradley, B., Condon, B. and Kennedy, P. G.E. (2011) Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84(2), pp. 344-350. (doi: 10.4269/ajtmh.2011.10-0487)
Jeganathan, S., Sanderson, L., Dogruel, M., Rodgers, J. , Croft, S. and Thomas, S.A. (2011) The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-CSF barriers. Journal of Pharmacology and Experimental Therapeutics, 336(2), pp. 506-515. (doi: 10.1124/jpet.110.172981)
Rodgers, J. , Jones, A., Gibaud, S., Bradley, B., McCabe, C. , Barrett, M. P. , Gettinby, G. and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi: 10.1371/journal.pntd.0001308)
2010
Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi: 10.1017/S0031182009991806)
Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi: 10.1017/S0031182009991806)
Carvalho, J.A., Rodgers, J. , Atouguia, J., Prazeres, D.M.F. and Monteiro, G.A. (2010) DNA vaccines: a rational design against parasitic diseases. Expert Review of Vaccines, 9(2), pp. 175-191. (doi: 10.1586/ERV.09.158)
2009
Rodgers, J. (2009) Human African trypanosomiasis, chemotherapy and CNS disease. Journal of Neuroimmunology, 211(1-2), pp. 16-22. (doi: 10.1016/j.jneuroim.2009.02.007)
Sanderson, L., Dogruel, M., Rodgers, J. , De Koning, H.P. and Thomas, S.A. (2009) Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein. Journal of Pharmacology and Experimental Therapeutics, 329(3), pp. 967-977. (doi: 10.1124/jpet.108.149872)
Rodgers, J. , Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi: 10.1093/brain/awp074)
2008
Rodgers, J. (2008) The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain. Journal of Neurochemistry, 107(4), pp. 1136-1146. (doi: 10.1111/j.1471-4159.2008.05706.x)
2005
Sternberg, J.M., Rodgers, J. , Bradley, B., MacLean, L., Murray, M. and Kennedy, P.G.E. (2005) Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. Journal of Neuroimmunology, 167(1-2), pp. 81-89. (doi: 10.1016/j.jneuroim.2005.06.017)
2003
Kennedy, P.G.E., Rodgers, J. , Bradley, B., Hunt, S.P., Gettinby, G., Leeman, S.E., De Felipe, C. and Murray, M. (2003) Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain, 126(7), pp. 1683-1690. (doi: 10.1093/brain/awg160)
2002
Kennedy, P. G. E., Murray, M., Jennings, F. and Rodgers, J. (2002) Response to: 'Uses of error: knowledge gaps' by David Spence. Lancet (North American Edition), 359(9318), pp. 1695-1696.
Kennedy, P.G.E., Murray, M., Jennings, F. and Rodgers, J. (2002) Sleeping sickness: new drugs from old? [corrected]. Lancet, 359(9318), pp. 1695-1696. (doi: 10.1016/S0140-6736(02)08569-0)
Jennings, F.W., Rodgers, J. , Bradley, B., Gettinby, G., Kennedy, P.G.E. and Murray, M. (2002) Human African trypanosomiasis: Potential therapeutic benefits of an alternative suramin and melarsoprol regimen. Parasitology International, 51(4), pp. 381-388. (doi: 10.1016/S1383-5769(02)00044-2)
1997
Jennings, F. W., Gichuki, C. W., Kennedy, P. G. E., Rodgers, J. , Hunter, C. A., Murray, M. and Burke, J. M. (1997) The role of the polyamine inhibitor ef lornithine in the neuropathogenesis of experimental murine African trypanosomiasis. Neuropathology and Applied Neurobiology, 23(3), pp. 225-234. (doi: 10.1111/j.1365-2990.1997.tb01206.x)
Kennedy, P. G. E., Rodgers, J. , Jennings, F. W., Murray, M., Leeman, S. E. and Burke, J. M. (1997) A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proceedings of the National Academy of Sciences of the United States of America, 94(8), pp. 4167-4170.
1993
Gichuki, C., Burke, J., N'gure, R., Jennings, F., Hunter, C., Rodgers, J. , Ndung'u, J., Omuse, J., Kennedy, P. and Murray, M. (1993) Do astrocytes have a role in the neuropathogenesis of African trypanosomiasis? In: 22nd Meeting of The International Scientific Council for Trypanosomiasis Research and Control, Kampala, Uganda, 1993, pp. 113-118.
Articles
Paterson, S., Vallatos, A. , Rodgers, J. and Holmes, W. M. (2023) Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis. Scientific Reports, 13, 8684. (doi: 10.1038/s41598-023-34665-z) (PMID:37248398) (PMCID:PMC10227057)
Paterson, S., Holmes, W. and Rodgers, J. (2022) Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse. PLoS Neglected Tropical Diseases, 16(12), e0010962. (doi: 10.1371/journal.pntd.0010962) (PMID:36477669) (PMCID:PMC9728833)
Montague, P., Bradley, B., Rodgers, J. and Kennedy, P. G.E. (2021) Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma.b.brucei infected CD1 mouse brains. PLoS Neglected Tropical Diseases, 15(11), e0009892. (doi: 10.1371/journal.pntd.0009892) (PMID:34762691) (PMCID:PMC8584711)
Gummery, L., Jallow, S., Raftery, A. G. , Bennet, E. , Rodgers, J. and Sutton, D. G.M. (2020) Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia. PLoS ONE, 15(8), e0237187. (doi: 10.1371/journal.pone.0237187) (PMID:32833981) (PMCID:PMC7444819)
Raftery, A. , Jallow, S., Coultous, R. M. , Rodgers, J. and Sutton, D. G.M. (2020) Variation in disease phenotype is marked in equine trypanosomiasis. Parasites and Vectors, 13, 148. (doi: 10.1186/s13071-020-04020-6) (PMID:32199454) (PMCID:PMC7085162)
Rodgers, J. , Steiner, I. and Kennedy, P. G.E. (2019) Generation of neuroinflammation in human African trypanosomiasis. Neurology: Neuroimmunology and Neuroinflammation, 6(6), e610. (doi: 10.1212/NXI.0000000000000610) (PMID:31467039) (PMCID:PMC6745723)
Raftery, A. G. , Jallow, S., Rodgers, J. and Sutton, D. G.M. (2019) Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. PLoS Neglected Tropical Diseases, 13(3), e0007175. (doi: 10.1371/journal.pntd.0007175) (PMID:30901321) (PMCID:PMC6447232)
Kennedy, P. G.E. and Rodgers, J. (2019) Clinical and neuropathogenetic aspects of human African trypanosomiasis. Frontiers in Immunology, 10, 39. (doi: 10.3389/fimmu.2019.00039)
Laperchia, C., Tesoriero, C., La Verde, V., Seke-Etet, P. F., Colavito, V., Grassi-Zucconi, G., Rodgers, J. , Montague, P., Kennedy, P. G.E. and Bentivoglio, M. (2017) Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis. PLoS Neglected Tropical Diseases, 11(8), e0005854. (doi: 10.1371/journal.pntd.0005854) (PMID:28821016) (PMCID:PMC5576758)
Rodgers, J. , Bradley, B. and Kennedy, P. G.E. (2017) Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis. Methods, 127, pp. 79-87. (doi: 10.1016/j.ymeth.2017.06.015) (PMID:28636879) (PMCID:PMC5595161)
Sternberg, J. M., Forrest, C. M., Dalton, R. N., Turner, C., Rodgers, J. , Stone, T. W. and Kennedy, P. G.E. (2017) Kynurenine pathway activation in Human African trypanosomiasis. Journal of Infectious Diseases, 215(5), pp. 806-812. (doi: 10.1093/infdis/jiw623) (PMID:28013248) (PMCID:PMC5388295)
Laperchia, C., Palomba, M., Etet, P. F. S., Rodgers, J. , Bradley, B., Montague, P., Grassi-Zucconi, G., Kennedy, P. G.E. and Bentivoglio, M. (2016) Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes. PLoS Neglected Tropical Diseases, 10(12), e0005242. (doi: 10.1371/journal.pntd.0005242) (PMID:28002454) (PMCID:PMC5217973)
Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi: 10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)
Rodgers, J. , Bradley, B., Kennedy, P. G.E. and Sternberg, J. M. (2015) Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice. PLoS Neglected Tropical Diseases, 9(10), e0004201. (doi: 10.1371/journal.pntd.0004201) (PMID:26505761) (PMCID:PMC4624684)
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
Burrell-Saward, H., Rodgers, J. , Bradley, B., Croft, S. L. and Ward, T. H. (2015) A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis. Journal of Antimicrobial Chemotherapy, 70(2), pp. 510-517. (doi: 10.1093/jac/dku393) (PMID:25298516)
MacLean, L., Myburgh, E. , Rodgers, J. and Price, H.P. (2013) Imaging African trypanosomes. Parasite Immunology, 35(9-10), pp. 283-294. (doi: 10.1111/pim.12046)
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)
Rodgers, J. , McCabe, C. , Gettinby, G., Bradley, B., Condon, B. and Kennedy, P. G.E. (2011) Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84(2), pp. 344-350. (doi: 10.4269/ajtmh.2011.10-0487)
Jeganathan, S., Sanderson, L., Dogruel, M., Rodgers, J. , Croft, S. and Thomas, S.A. (2011) The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-CSF barriers. Journal of Pharmacology and Experimental Therapeutics, 336(2), pp. 506-515. (doi: 10.1124/jpet.110.172981)
Rodgers, J. , Jones, A., Gibaud, S., Bradley, B., McCabe, C. , Barrett, M. P. , Gettinby, G. and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi: 10.1371/journal.pntd.0001308)
Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi: 10.1017/S0031182009991806)
Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi: 10.1017/S0031182009991806)
Carvalho, J.A., Rodgers, J. , Atouguia, J., Prazeres, D.M.F. and Monteiro, G.A. (2010) DNA vaccines: a rational design against parasitic diseases. Expert Review of Vaccines, 9(2), pp. 175-191. (doi: 10.1586/ERV.09.158)
Rodgers, J. (2009) Human African trypanosomiasis, chemotherapy and CNS disease. Journal of Neuroimmunology, 211(1-2), pp. 16-22. (doi: 10.1016/j.jneuroim.2009.02.007)
Sanderson, L., Dogruel, M., Rodgers, J. , De Koning, H.P. and Thomas, S.A. (2009) Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein. Journal of Pharmacology and Experimental Therapeutics, 329(3), pp. 967-977. (doi: 10.1124/jpet.108.149872)
Rodgers, J. , Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi: 10.1093/brain/awp074)
Rodgers, J. (2008) The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain. Journal of Neurochemistry, 107(4), pp. 1136-1146. (doi: 10.1111/j.1471-4159.2008.05706.x)
Sternberg, J.M., Rodgers, J. , Bradley, B., MacLean, L., Murray, M. and Kennedy, P.G.E. (2005) Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. Journal of Neuroimmunology, 167(1-2), pp. 81-89. (doi: 10.1016/j.jneuroim.2005.06.017)
Kennedy, P.G.E., Rodgers, J. , Bradley, B., Hunt, S.P., Gettinby, G., Leeman, S.E., De Felipe, C. and Murray, M. (2003) Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain, 126(7), pp. 1683-1690. (doi: 10.1093/brain/awg160)
Kennedy, P. G. E., Murray, M., Jennings, F. and Rodgers, J. (2002) Response to: 'Uses of error: knowledge gaps' by David Spence. Lancet (North American Edition), 359(9318), pp. 1695-1696.
Kennedy, P.G.E., Murray, M., Jennings, F. and Rodgers, J. (2002) Sleeping sickness: new drugs from old? [corrected]. Lancet, 359(9318), pp. 1695-1696. (doi: 10.1016/S0140-6736(02)08569-0)
Jennings, F.W., Rodgers, J. , Bradley, B., Gettinby, G., Kennedy, P.G.E. and Murray, M. (2002) Human African trypanosomiasis: Potential therapeutic benefits of an alternative suramin and melarsoprol regimen. Parasitology International, 51(4), pp. 381-388. (doi: 10.1016/S1383-5769(02)00044-2)
Jennings, F. W., Gichuki, C. W., Kennedy, P. G. E., Rodgers, J. , Hunter, C. A., Murray, M. and Burke, J. M. (1997) The role of the polyamine inhibitor ef lornithine in the neuropathogenesis of experimental murine African trypanosomiasis. Neuropathology and Applied Neurobiology, 23(3), pp. 225-234. (doi: 10.1111/j.1365-2990.1997.tb01206.x)
Kennedy, P. G. E., Rodgers, J. , Jennings, F. W., Murray, M., Leeman, S. E. and Burke, J. M. (1997) A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proceedings of the National Academy of Sciences of the United States of America, 94(8), pp. 4167-4170.
Conference Proceedings
Gichuki, C., Burke, J., N'gure, R., Jennings, F., Hunter, C., Rodgers, J. , Ndung'u, J., Omuse, J., Kennedy, P. and Murray, M. (1993) Do astrocytes have a role in the neuropathogenesis of African trypanosomiasis? In: 22nd Meeting of The International Scientific Council for Trypanosomiasis Research and Control, Kampala, Uganda, 1993, pp. 113-118.
Key Findings
Nicolson, L., Rodgers, J. , Dowell, F., Nasir, L., Evans, N. , Robinson, J. and Hammond, J. Personal development plan case study. [Key Findings]
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- ISSF Catalyst: Comparative transcriptomic analysis of central nervous system and bloodstream -resident trypanosomes in a murine model of human African sleeping sickness.
Wellcome Trust
2015 - 2017
- Development of a sensitive Taqman PCR based assay for detection of low level trypanosome infections in cattle.
Department for International Development
2012 - 2013
- Defining the role of kynurenine pathway metabolites in the inflammatory response to trypanosome invasion of the CNS
Wellcome Trust
2012 - 2015
- Defining the role of the chemokine CXCL10 in determining traversal across the blood-brain barrier in experimental and human African trypanosomiasis
Wellcome Trust
2011 - 2014
- In vivo imaging models of African trypanosomiasis to support drug discovery programmes.
Bill and Melinda Gates Foundation
2010 - 2013
- Defining the therapeutic role of IL-10 in African trypanosomiasis.
Wellcome Trust
2008 - 2011
- Combination chemotherapy of human African trypanosomiasis - the potential of drug synergism and the blood-brain barrier
Medical Research Council
2007 - 2010
- Production of DNA vaccine prototypes and the study of the humoral and cellular response following immunisation with the candidate DNA vaccines.
Fundacao para a Cienca e Technologia
2007 - 2010
Research datasets
2020
Jallow, S., Raftery, A. , Bennet, E. , Rodgers, J. , Sutton, D. and Gummery, L. (2020) Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei spp. in equids in The Gambia. [Data Collection] (Unpublished)