Publications - Host-Pathogen Interactions
Bakker, D., Buckley, A.M., de Jong, A., van Winden, V.J., Verhoeks, J.P., Kuipers, O.P., Douce, G.R., Kuijper, E.J., Smits, W.K., Corver, J. (2014) The HtrA-like protease CD3284 modulates virulence of Clostridium difficile. Infect Immun. 82:4222-32.
Bayes, H. K., Bicknell, S., MacGregor, G., and Evans, T. J. (2014) T helper cell subsets specific for pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis. PLoS ONE, 9(2), e90263.(doi:10.1371/journal.pone.0090263)
Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi:10.1111/mmi.12651)
Buckley, A.M., Spencer, J., MacLellan, L.M., Candlish, D., Irvine, J.J., and Douce, G.R. (2013) Susceptibility of hamsters to Clostridium difficile isolates of differing toxinotype. PLoS ONE, 8(5), e64121. (doi:10.1371/journal.pone.0064121)
Carter, G, Douce, G.R., et.al. (2011). The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile. PLoS Pathogens 7: e1002317
Chen, J., Carpena, N., Quiles-Puchalt, N., Ram, G., Novick, R. P., and Penadés, J. R. (2015) Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages. ISME Journal, 9(5), pp. 1260-1263. (doi:10.1038/ismej.2014.187) (PMID:25314321)
Connolly, J. P. R. , Goldstone, R. J., Burgess, K., Cogdell, R. J.,Beatson, S. A., Vollmer, W., Smith, D. G. E., and Roe, A. (2015) The host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9, pp. 1039-1051.(doi:10.1038/ismej.2014.242) (PMID:25526369)
de Greeff, A., Zadoks, R., Ruuls, L., Toussaint, M., Nguyen, T.K.A., Downing, A., Rebel, J., Stockhofe-Zurwieden, N., and Smith, H. (2013) Early host response in the mammary gland after experimental Streptococcus uberis challenge in heifers. Journal of Dairy Science, 96(6), pp. 3723-3736. (doi:10.3168/jds.2012-6320)
Delannoy, C. M. J., Zadoks, R. N., Crumlish, M., Rodgers, D., Lainson, F. A., Ferguson, H. W., Turnbull, J., and Fontaine, M. C. (2015) Genomic comparison of virulent and non-virulent Streptococcus agalactiae in fish; . Journal of Fish Diseases, (doi:10.1111/jfd.12319)
Dolieslager, S. M. J., Lappin, D. F., Bennett, D., Graham, L., Johnston, N., and Riggio, M. P. (2013) The influence of oral bacteria on tissue levels of Toll-like receptor and cytokine mRNAs in feline chronic gingivostomatitis and oral health. Veterinary Immunology and Immunopathology, 151(3-4), pp. 263-274. (doi:10.1016/j.vetimm.2012.11.016)
Dunne, K.A. et al. (2013) Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive escherichia coli (AIEC) in immune cells. PLoS ONE, 8(7), e68386. (doi:10.1371/journal.pone.0068386)
E-komon, T., Burchmore, R., Herzyk, P., and Davies, R. (2012) Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation. BMC Bioinformatics, 13(1), p. 63. (doi:10.1186/1471-2105-13-63)
English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R., and Coulthurst, S. J. (2014) Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex. Biochemical Journal, 461(2), pp. 291-304. (doi:10.1042/BJ20131426)
Elmi, A. et al. (2012) Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells. Infection and Immunity, 80(12), pp. 4089-4098. (doi:10.1128/IAI.00161-12)
Faulds-Pain, A., Twine, S.M., Vinogradov, E., Stron, P.C.R., Dell, A., Buckley, A.M., Douce, G.R., Valiente, E., Logan, S.M., Wren, B.W. 2014. A novel post-translational modification of the Clostridium difficile flagellin affects motility, cell surface properties and virulence. Mol Microbiol Aug 18. doi: 10.1111/mmi.12755
Haig, S.J., Davies, R.L., Welch, T.J., Reese, R.A., and Verner-Jeffreys, D.W. (2011) Comparative susceptibility of Atlantic salmon and rainbow trout to Yersinia ruckeri: relationship to O antigen serotype and resistance to serum killing. Veterinary Microbiology, 147(1-2), pp. 155-161. (doi:10.1016/j.vetmic.2010.06.022)
Hounsome, J. D.A., Baillie, S., Noofeli, M., Riboldi-Tunnicliffe, A.,Burchmore, R. J.S., Isaacs, N. W., and Davies, R. L. (2011) Outer membrane protein A of bovine and ovine isolates of mannheimia haemolytica is surface exposed and contains host species-specific epitopes. Infection and Immunity, 79(11), pp. 4332-4341.(doi:10.1128/IAI.05469-11 )
Humphrey, S., MacVicar, T., Stevenson, A., Roberts, M., Humphrey, T.J., and Jepson, M.A. (2011) SulA-induced filamentation in Salmonella enterica serovar Typhimurium: effects on SPI-1 expression and epithelial infection. Journal of Applied Microbiology, 111(1), pp. 185-196. (doi:10.1111/j.1365-2672.2011.05022.x)
Jabir, M. et al. (2015) Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy, 11(1), pp. 166-182
Josts, I., Grinter, R., Kelly, S. M., Mosbahi, K., Roszak, A., Cogdell, R., Smith, B. O., Byron, O., and Walker, D. (2014) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490963–1138 domain of TamB from Escherichia coli. Acta Crystallographica. Section F: Structural Biology Communications, 70(9), pp. 1272-1275. (doi:10.1107/S2053230X14017403)
McCaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898.
Noofeli, M., Bokhari, H., Blackburn, P., Roberts, M., Coote, J.G., and Parton, R.G. (2011) BapC autotransporter protein is a virulence determinant of Bordetella pertussis. Microbial Pathogenesis, 51(3), pp. 169-177. (doi:10.1016/j.micpath.2011.04.004)
Othman, S., Roe, A.J., Parton, R., and Coote, J.G. (2013) Use of a dual reporter plasmid to demonstrate bactofection with an attenuated aroa- derivative of Pasteurella multocida b:2. PLoS ONE, 8(8), e71524. (doi:10.1371/journal.pone.0071524)
Penadés, J. R., Chen, J., Quiles-Puchalt, N., Carpena, N., and Novick, R. P. (2015) Bacteriophage-mediated spread of bacterial virulence genes. Current Opinion in Microbiology, 23, pp. 171-178. (doi:10.1016/j.mib.2014.11.019)
Rezuchova, B., Homerova, D., Sevcikova, B., Novakova, R., Feckova, L., Roberts, M., and Kormanec, J. (2013) Phenotypic analysis of Salmonella enterica serovar typhimurium rpoE mutants encoding RNA polymerase extracytoplasmic stress response sigma factors σE with altered promoter specificity. Archives of Microbiology, 195(1), pp. 27-36. (doi:10.1007/s00203-012-0843-9)
Selkrig, J. et al. (2012) Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural and Molecular Biology, 19(5), pp. 506-510. (doi:10.1038/nsmb.2261)
Sherry, A.E., Inglis, N.F., Stevenson, A., Fraser-Pitt, D.G.E., Everest, P., Smith, D., and Roberts, M. (2011) Characterisation of proteins extracted from the surface of Salmonella typhimurium grown under SPI-2-inducing conditions by LC-ESI/MS/MS sequencing. Proteomics, 11(3), pp. 361-370. (doi:10.1002/pmic.200900802)
Srikanth, C.V., Wall, D.M., Maldonado-Contreras, A., Shi, H.N., Zhou, D.G., Demma, Z., Mumy, K.L., and Mccormick, B.A. (2010) Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3. Science, 330(6002), pp. 390-393.
Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G., and Walker, D. (2012) Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 56(3), pp. 1599-1601.
Tassi R, McNeilly TN, Fitzpatrick JL, Fontaine MC, Reddick D, Ramage C, Lutton M, Schukken YH, Zadoks RN. Strain-specific pathogenicity of putative host-adapted and nonadapted strains of Streptococcus uberis in dairy cattle. J Dairy Sci. 2013 Aug;96(8):5129-45. doi: 10.3168/jds.2013-6741. Epub 2013 Jun 13. PubMed PMID: 23769372
Tormo-Más, M.Á., Mir, I., Shrestha, A., Tallent, S.M., Campoy, S., Lasa, I., et al. (2010) Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature 465: 779–782.
Viana, D. et al. (2015) A single natural nucleotide mutation alters bacterial pathogen host tropism. Nature Genetics, 47, pp. 361-366.(doi:10.1038/ng.3219) (PMID:25685890)
Wall, D. M., and McCormick, B. A. (2014) Bacterial secreted effectors and caspase-3 interactions. Cellular Microbiology, 16(12), pp. 1746-1756.
Watson, E., Alberdi, M. P., Inglis, N. F., Lainson, A., Porter, M. E., Manson, E., Imrie, L., Mclean, K., and Smith, D. G.E. (2014) Proteomic analysis of Lawsonia intracellularis reveals expression of outer membrane proteins during infection. Veterinary Microbiology, 174(3-4), pp. 448-455. (doi:10.1016/j.vetmic.2014.10.002)
Wheelhouse, N., Sait, M., Wilson, K., Aitchison, K., McLean, K., Smith, D.G.E., and Longbottom, D. (2012) Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle. Veterinary Microbiology, 160(3-4), pp. 525-529. (doi:10.1016/j.vetmic.2012.06.017)
White, B., Seaton, A., and Evans, T.J. (2013) Management of suspected Lyme borreliosis: experience from an outpatient parenteral antibiotic therapy service. Quarterly Journal of Medicine, 106(2), pp. 133-138. (doi:10.1093/qjmed/hcs189)