Professor Donald Grosset
- Senior Research Fellow (Centre for Cognitive Neuroimaging)
- Honorary Professor (School of Psychology & Neuroscience)
telephone:
0141 9430913
email:
Donald.Grosset@glasgow.ac.uk
https://orcid.org/0000-0002-2757-8203Research interests
Donald Grosset is a consultant neurologist at the Institute of Neurological Sciences at the Queen Elizabeth University Hospital specialising in Parkinson’s disease and movement disorders. He has held an honorary post at Glasgow since 1995.
His current research focuses on population studies in Parkinson’s and he is the Chief Investigator of Tracking Parkinson’s (the PRoBaND Study), a 9-year, £3.4m project funded by Parkinson’s UK. Tracking Parkinson’s is the largest ever prospective, multi-centre study of Parkinson’s disease and collects clinical data and biosamples from more than 2,500 patients at 70 sites across the UK.
Since 2017, Donald has been the Clinical Director for the UK Parkinson’s Excellence Network. He is also a member of the Movement Disorder Advisory Group with the Association of British Neurologists, a member of the Parkinson’s Clinical Studies Group within DeNDRoN and a contributor to the Parkinson’s Academy.
Current Memberships
- Clinical Director, UK Parkinsons Excellence Network
- Member, Project Grants College of Experts for Parkinson’s UK
- Member, ABN Advisory group on movement disorders
- Chair, Steering Committee, Parkinson’s trial of UDCA
- Chair, Data Safety Committee, Parkinson’s trial of Statins (PDSTAT)
- Member, Excellence Network, Parkinson’s UK
- Representative, Advisory Panel, Parkinson’s UK
- Member, Parkinson’s Clinical Studies Group, DeNDRoN
- Clinical Experts Panel member, Scottish Medicines Consortium
- Trustee, Neurosciences Foundation, Glasgow
Previous Memberships
- Chair, ABN Advisory Group on Movement Disorders
- Treasurer, British & Irish Neurology Movement Disorder Group
- Editorial Board, Practical Neurology
- Chair (Parkinson’s disease), Scottish Intercollegiate Guidelines Network
- Programme Lead, Clinical & Cognitive Neuroscience Research, South Glasgow
- Medical chairman, R&D Committee, South Glasgow Hospitals
- Representative, Medical/Research Advisory Panel, Parkinson’s Disease Society of the United Kingdom
- Secretary & Treasurer, Scottish Association of Neurological Sciences
- New drugs sub-committee, Greater Glasgow Health Board
- Core Scientific Committee, International Cerebral Haemodynamics Society
- Clinical Effectiveness Committee, South Glasgow Hospitals
- Contributor, Scottish Intercollegiate Guidelines Network
- Contributor, Kings Fund Organisational Audit
- Scientific Committee, Neurosonology Research Group of the World Federation of Neurology
- Founder member, British Transcranial Doppler Group
- International Education Committee, Movement Disorders Society
- Editorial Board, Movement Disorders
Recent Grants
| £35k | Nuerosciences Foundation | 2016 | with Callum Smith |
| £1.5m | Parkinson's UK | 2016 | with the PRoBaND consortium |
| £1.4k | Michael's Movers | 2016 | with Katherine Grosset |
| £5k | Michael's Movers | 2015 | with Diane Swallow |
| £103k | Parkinson's UK | 2015 | with the PRoBaND consortium |
| £157k | Parkinson's UK | 2014 | with the PRoBaND consortium |
| £16k | Parkinson's UK | 2013 | with Monty Silverdale's Parkinson's Pain Study |
| £600k | Parkinson's UK | 2013 | with Dorothee Auer's PaMIR study |
| £750k | Parkinson's UK | 2013 | Simon Lovestone's Protemics as a biomarker for Parkinson's disease study |
| £1.6m | Parkinson's UK | 2011 | with the PRoBaND consortium |
| £27k | Distonia Society | 2007 | with Carl Counsell |
| £50k | RS Macdonald Trust | 2007 | with Carl Counsell |
| £31k | Sir Halley Stewart Trust | 2007 |
Publications
2024
Gandhi, S. E. et al. (2024) Motor complications in Parkinson's disease: results from 3343 patients followed for up to 12 years. Movement Disorders Clinical Practice, 11(6), pp. 686-697. (doi: 10.1002/mdc3.14044) (PMID:38587023)
Menon, P. J. et al. (2024) Genotype-phenotype correlation in PRKN-associated Parkinson's disease. npj Parkinson's Disease, 10(1), 72. (doi: 10.1038/s41531-024-00677-3) (PMID:38553467) (PMCID:PMC10980707)
Lawton, M., Ben-Shlomo, Y., Gkatzionis, A., Hu, M. T., Grosset, D. and Tilling, K. (2024) Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression. European Journal of Epidemiology, (doi: 10.1007/s10654-023-01093-2) (PMID:38281297) (Early Online Publication)
2023
Venuto, C. S., Smith, G., Herbst, K., Zielinski, R., Yung, N. C.W., Grosset, D. G. , Dorsey, E. R. and Kieburtz, K. (2023) Predicting ambulatory capacity in Parkinson's disease to analyze progression, biomarkers, and trial design. Movement Disorders, 38(10), pp. 1774-1785. (doi: 10.1002/mds.29519) (PMID:37363815)
Lawton, M., Ben-Shlomo, Y., Athauda, D., Malek, N. and Grosset, D. (2023) Commentary: “Association between diabetes mellitus, prediabetes and risk, disease progression of Parkinson’s disease: a systematic review and meta-analysis”. Frontiers in Aging Neuroscience, 15, 1223636. (doi: 10.3389/fnagi.2023.1223636) (PMID:37396660) (PMCID:PMC10309552)
Real, R. et al. (2023) Association between the LRP1B and APOE loci and the development of Parkinson’s disease dementia. Brain, 146(5), pp. 1873-1887. (doi: 10.1093/brain/awac414) (PMID:36348503) (PMCID:PMC10151192)
Heng, N., Malek, N., Lawton, M. A., Nodehi, A., Pitz, V. , Grosset, K. A., Ben-Shlomo, Y. and Grosset, D. G. (2023) Striatal dopamine loss in early Parkinson’s disease: systematic review and novel analysis of dopamine transporter imaging. Movement Disorders Clinical Practice, 10(4), pp. 539-546. (doi: 10.1002/mdc3.13687) (PMID:37070042) (PMCID:PMC10105104)
Winchester, L. et al. (2023) Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and CSF. Brain Communications, 5(1), fcac343. (doi: 10.1093/braincomms/fcac343) (PMID:36694577) (PMCID:PMC9856276)
2022
Lawton, M. et al. (2022) Genetics of validated Parkinson's Disease subtypes in the Oxford Discovery and Tracking Parkinson's cohorts. Journal of Neurology, Neurosurgery and Psychiatry, 93(9), pp. 952-959. (doi: 10.1136/jnnp-2021-327376) (PMID:35732412)
Morris, H., Grosset, D. , Heslegrave, A. and Zetterberg, H. (2022) Sample Collection and Measurement of Serum Neurofilament Light (NfL). (doi: 10.17504/protocols.io.bzbep2je)
Morris, H., Tan, M. M.X., Grosset, D. G. and Williams, N. M. (2022) SNP Genotyping and ApoE Genotyping V.1. [Protocols]
Vijiaratnam, N. et al. (2022) Diabetes and neuroaxonal damage in Parkinson's disease. Movement Disorders, 37(7), pp. 1568-1569. (doi: 10.1002/mds.29067) (PMID:35856732)
Vijiaratnam, N. et al. (2022) Combining biomarkers for prognostic modelling of Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 93(7), pp. 707-715. (doi: 10.1136/jnnp-2021-328365) (PMID:35577512) (PMCID:PMC9279845)
2021
Kanavou, S., Pitz, V. , Lawton, M. A., Malek, N., Grosset, K. A., Morris, H. R., Ben-Shlomo, Y. and Grosset, D. G. (2021) Comparison between four published definitions of hyposmia in Parkinson's disease. Brain and Behavior, 11(8), e2258. (doi: 10.1002/brb3.2258) (PMID:34190430) (PMCID:PMC8413742)
2020
Smith, C. R., Cullen, B. , Sheridan, M. P., Cavanagh, J. , Grosset, K. and Grosset, D. G. (2020) Cognitive impairment in Parkinson’s disease is multifactorial: a neuropsychological study. Acta Neurologica Scandinavica, 141(6), pp. 500-508. (doi: 10.1111/ane.13226) (PMID:32002988)
Grosset, D. G. , Dhall, R., Gurevich, T., Kassubek, J., Poewe, W. H., Rascol, O., Rudzinska, M., Cormier, J., Sedkov, A. and Oh, C. (2020) Inhaled levodopa in Parkinson's disease patients with OFF periods: A randomized 12-month pulmonary safety study. Parkinsonism and Related Disorders, 71, pp. 4-10. (doi: 10.1016/j.parkreldis.2019.12.012) (PMID:31927343)
Pitz, V. , Malek, N., Tobias, E. S. , Grosset, K. A., Gentleman, S. and Grosset, D. G. (2020) The levodopa response varies in pathologically confirmed Parkinson's disease: a systematic review. Movement Disorders Clinical Practice, 7(2), pp. 218-222. (doi: 10.1002/mdc3.12885) (PMID:32071945)
Smith, C., Cavanagh, J. , Sheridan, M., Grosset, K., Cullen, B. and Grosset, D. (2020) Factor structure of the Montreal Cognitive Assessment in Parkinson’s disease. International Journal of Geriatric Psychiatry, 35(2), pp. 188-194. (doi: 10.1002/gps.5234) (PMID:31736141)
2019
Jabbari, E. et al. (2019) The genetic and clinico-pathological profile of early-onset progressive supranuclear palsy. Movement Disorders, 34(9), pp. 1307-1314. (doi: 10.1002/mds.27786) (PMID:31299107) (PMCID:PMC6790973)
Eva-Juliane, V., Kasten, M., Klein, C. and MJFF Global Genetic Parkinson’s Disease Study Group, (2019) Using global team science to identify genetic Parkinson's disease worldwide. Annals of Neurology, 86(2), pp. 153-157. (doi: 10.1002/ana.25514) (PMID:31155756)
Malek, N. et al. (2019) L-dopa responsiveness in early Parkinson's disease is associated with the rate of motor progression. Parkinsonism and Related Disorders, 65, pp. 55-61. (doi: 10.1016/j.parkreldis.2019.05.022) (PMID:31105012)
Carroll, C. B., Wyse, R. K.H. and Grosset, D. G. (2019) Statins and Parkinson's: a complex interaction. Movement Disorders, 34(7), pp. 934-935. (doi: 10.1002/mds.27721) (PMID:31322771)
Blauwendraat, C. et al. (2019) Parkinson's disease age at onset genome‐wide association study: defining heritability, genetic loci, and α‐synuclein mechanisms. Movement Disorders, 34(6), pp. 866-875. (doi: 10.1002/mds.27659) (PMID:30957308)
Smith, C. R., Malek, N. M., Grosset, K. A., Cullen, B. , Gentleman, S. M. and Grosset, D. G. (2019) Neuropathology of dementia in patients with Parkinson’s disease: a systematic review of autopsy studies. Journal of Neurology, Neurosurgery and Psychiatry, 90(11), pp. 1234-1243. (doi: 10.1136/jnnp-2019-321111) (PMID:31444276)
Stephenson, D. et al. (2019) The qualification of an enrichment biomarker for clinical trials targeting early stages of Parkinson’s disease. Journal of Parkinson's Disease, 9(3), pp. 553-563. (doi: 10.3233/jpd-191648) (PMID:31306141)
2018
Lawton, M. et al. (2018) Developing and validating Parkinson’s disease subtypes and their motor and cognitive progression. Journal of Neurology, Neurosurgery and Psychiatry, 89(12), pp. 1279-1287. (doi: 10.1136/jnnp-2018-318337) (PMID:30464029) (PMCID:PMC6288789)
Silverdale, M. A. et al. (2018) A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease. Parkinsonism and Related Disorders, 56, pp. 27-32. (doi: 10.1016/j.parkreldis.2018.06.001) (PMID:29903584) (PMCID:PMC6302227)
Fackrell, R., Carroll, C. B., Grosset, D. G. , Mohamed, B., Reddy, P., Parry, M., Chaudhuri, K. R. and Foltynie, T. (2018) Noninvasive options for 'wearing-off' in Parkinson's disease: a clinical consensus from a panel of UK Parkinson's disease specialists. Neurodegenerative Disease Management, 8(5), pp. 349-360. (doi: 10.2217/nmt-2018-0020) (PMID:29975112)
Watson-Fargie, T., Grosset, D.G. , White, J. and Cowie, F. (2018) Possible modulation of concurrent Parkinson’s disease in the management of metastatic GIST: a review of two cases. Journal of the Royal College of Physicians of Edinburgh, 48(3), pp. 242-245. (doi: 10.4997/JRCPE.2018.309) (PMID:30191913)
Sackley, C. M. et al. (2018) Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and Feasibility Studies, 4(1), 30. (doi: 10.1186/s40814-017-0222-z) (PMID:29344405) (PMCID:PMC5763537)
Malek, N. et al. (2018) Features of GBA-associated Parkinson’s disease at presentation in the UK Tracking Parkinson’s study. Journal of Neurology, Neurosurgery and Psychiatry, 89(7), pp. 702-709. (doi: 10.1136/jnnp-2017-317348) (PMID:29378790) (PMCID:PMC6031283)
2017
Malek, N., Jampana, R. and Grosset, D. G. (2017) Rare case of atypical parkinsonism: Why family history is important. Scottish Medical Journal, 62(4), pp. 159-162. (doi: 10.1177/0036933017727966) (PMID:29192564)
Cheng, K. K.W., Swallow, D. M.A., Grosset, K. A. and Grosset, D. G. (2017) Statin usage, vascular diagnosis and vascular risk factors in Parkinson's disease. Scottish Medical Journal, 62(3), pp. 104-109. (doi: 10.1177/0036933017727432) (PMID:28836927)
Malek, N. et al. (2017) Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases. Parkinsonism and Related Disorders, 40, pp. 40-46. (doi: 10.1016/j.parkreldis.2017.04.006) (PMID:28431829)
Malek, N. et al. (2017) Autonomic dysfunction in early Parkinson's disease: results from the United Kingdom Tracking Parkinson's study. Movement Disorders Clinical Practice, 4(4), pp. 509-516. (doi: 10.1002/mdc3.12454) (PMID:30363477) (PMCID:PMC6174464)
2016
Lawton, M. et al. (2016) Equating scores of the University of Pennsylvania Smell Identification Test and Sniffin' Sticks test in patients with Parkinson's disease. Parkinsonism and Related Disorders, 33, pp. 96-101. (doi: 10.1016/j.parkreldis.2016.09.023) (PMID:27729202) (PMCID:PMC5159993)
Lubbe, S.J. et al. (2016) Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease. Neurobiology of Aging, 48, 222.e1-222.e7. (doi: 10.1016/j.neurobiolaging.2016.07.013) (PMID:27640074) (PMCID:PMC5096891)
Malek, N. et al. (2016) Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients. Acta Neurologica Scandinavica, 134(4), pp. 271-276. (doi: 10.1111/ane.12538) (PMID:26626018)
Malek, N. et al. (2016) Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Movement Disorders, 31(10), pp. 1518-1526. (doi: 10.1002/mds.26698) (PMID:27324570) (PMCID:PMC5082556)
LeWitt, P.A. et al. (2016) A randomized trial of inhaled levodopa (CVT-301) for motor fluctuations in Parkinson's disease. Movement Disorders, 31(9), pp. 1356-1365. (doi: 10.1002/mds.26611) (PMID:27090868)
Heinzel, S. et al. (2016) Prodromal markers in Parkinson's disease: Limitations in longitudinal studies and lessons learned. Frontiers in Aging Neuroscience, 8, 147. (doi: 10.3389/fnagi.2016.00147) (PMID:27445791) (PMCID:PMC4916171)
Lerche, S. et al. (2016) Aiming for study comparability in Parkinson's disease: Proposal for a modular set of biomarker assessments to be used in longitudinal studies. Frontiers in Aging Neuroscience, 8, 121. (doi: 10.3389/fnagi.2016.00121) (PMID:27303289) (PMCID:PMC4882324)
Swallow, D. M.A. et al. (2016) Variation in recent onset Parkinson's disease: Implications for prodromal detection. Journal of Parkinson's Disease, 6(2), pp. 289-300. (doi: 10.3233/JPD-150741) (PMID:27003780) (PMCID:PMC4927926)
Swallow, D. M.A., Grosset, K. A. and Grosset, D. G. (2016) Nonmotor symptoms in patients without evidence of dopaminergic deficit. Movement Disorders, 31(3), pp. 429-430. (doi: 10.1002/mds.26541) (PMID:26891715)
Counsell, C., Sinclair, H., Fowlie, J., Tyrrell, E., Derry, N., Meager, P., Norrie, J. and Grosset, D. (2016) A randomized trial of specialized versus standard neck physiotherapy in cervical dystonia. Parkinsonism and Related Disorders, 23, pp. 72-79. (doi: 10.1016/j.parkreldis.2015.12.010) (PMID:26723272)
Swallow, D. M.A. et al. (2016) Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts. Journal of Neurology, Neurosurgery and Psychiatry, 87(11), pp. 1183-1190. (doi: 10.1136/jnnp-2016-313642) (PMID:27671901) (PMCID:PMC5116532)
2015
Lerche, S. et al. (2015) Methods in neuroepidemiology characterization of European Longitudinal Cohort Studies in Parkinson's disease-Report of the JPND Working Group BioLoC-PD. Neuroepidemiology, 45(4), pp. 282-297. (doi: 10.1159/000439221) (PMID:26523894)
Malek, N. et al. (2015) Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease, 5(4), pp. 947-959. (doi: 10.3233/JPD-150662) (PMID:26485428) (PMCID:PMC4927877)
Malek, N. and Grosset, D. G. (2015) Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias. Current Geriatrics Reports, 4(2), pp. 124-130. (doi: 10.1007/s13670-015-0126-9)
Malek, N. and Grosset, D. G. (2015) Medication adherence in patients with Parkinson's disease. CNS Drugs, 29(19), pp. 47-53. (doi: 10.1007/s40263-014-0220-0) (PMID:25503824)
Grosset, D. G. , Tyrrell, E. G. and Grosset, K. A. (2015) Switch from abobotulinumtoxinA (Dysport®) to incobotulinumtoxinA (Xeomin®) botulinum toxin formulation: A review of 257 cases. Journal of Rehabilitation Medicine, 47, pp. 183-186. (doi: 10.2340/16501977-1895) (PMID:25325305)
Stephenson, D. et al. (2015) Precompetitive data sharing as a catalyst to address unmet needs in Parkinson’s disease. Journal of Parkinson's Disease, 5(3), pp. 581-594. (doi: 10.3233/jpd-150570) (PMID:26406139) (PMCID:PMC4887129)
2014
Grosset, D.G. et al. (2014) Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan). Journal of Nuclear Medicine, 55(8), pp. 1281-1287. (doi: 10.2967/jnumed.114.138032) (PMID:24947061)
Malek, N., Swallow, D., Grosset, K.A., Anichtchik, O., Spillantini, M. and Grosset, D.G. (2014) Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review. Acta Neurologica Scandinavica, 130(2), pp. 59-72. (doi: 10.1111/ane.12247) (PMID:24702516)
Seibyl, J.P. et al. (2014) Individual-reader diagnostic performance and between-reader agreement in assessment of subjects with Parkinsonian syndrome or dementia using 123I-Ioflupane injection (DaTscan) imaging. Journal of Nuclear Medicine, 55(8), pp. 1288-1296. (doi: 10.2967/jnumed.114.140228) (PMID:24925885)
O'Brien, J. T., Oertel, W. H., McKeith, I. G., Grosset, D. G. , Walker, Z., Tatsch, K., Tolosa, E., Sherwin, P. F. and Grachev, I. D. (2014) Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials. BMJ Open, 4(7), e005122. (doi: 10.1136/bmjopen-2014-005122) (PMID:24993764) (PMCID:PMC4091455)
Stewart, D., Morgan, B., Burn, D., Grosset, D. , Chaudhuri, K.R., MacMahon, D., Needleman, F., MacPhee, G. and Heywood, P. (2014) Dopamine agonist switching in Parkinson's disease. Hospital Medicine, 65(4), pp. 215-219. (doi: 10.12968/hosp.2004.65.4.12734) (PMID:15127675)
Nissen, T., Malek, N., Grosset, K.A., Newman, E.J., Patterson, J., Hadley, D. and Grosset, D.G. (2014) Baseline [123I]FP-CIT SPECT (DaTSCAN) severity correlates with medication use at 3 years in Parkinson's disease. Acta Neurologica Scandinavica, 129(3), pp. 204-208. (doi: 10.1111/ane.12178)
2013
Grosset, K.A., Malek, N., Morgan, F. and Grosset, D.G. (2013) Phase IIa randomized double-blind, placebo-controlled study of inhaled apomorphine as acute challenge for rescuing 'off' periods in patients with established Parkinson's disease. European Journal of Neurology, 20(11), pp. 1445-1450. (doi: 10.1111/ene.12091) (PMID:23350812)
Grosset, K.A., Malek, N., Morgan, F. and Grosset, D.G. (2013) Inhaled dry powder apomorphine (VR040) for 'off ' periods in Parkinson's disease: an in-clinic double-blind dose ranging study. Acta Neurologica Scandinavica, 128(3), pp. 166-171. (doi: 10.1111/ane.12107) (PMID:23527823)
Grosset, K. A., Malek, N., Morgan, F. and Grosset, D. (2013) Inhaled apomorphine in patients with 'on-off' fluctuations: a randomized, double-blind, placebo-controlled, clinic and home based, parallel-group study. Journal of Parkinson's Disease, 3(1), pp. 31-37. (doi: 10.3233/JPD-120142) (PMID:23938309)
2012
Bajaj, N.P.S., Wang, L., Gontu, V., Grosset, D.G. and Bain, P.G. (2012) Accuracy of subjective and objective handwriting assessment for differentiating Parkinson’s disease from tremulous subjects without evidence of dopaminergic deficits (SWEDDs): an FP-CIT-validated study. Journal of Neurology, 259(11), pp. 2335-2340. (doi: 10.1007/s00415-012-6495-5)
Nissen, T., Newman, E.J., Grosset, K.A., Daghem, M., Pal, G., Stewart, M., Odin, P., Macphee, G. and Grosset, D.G. (2012) Duration of L-dopa and dopamine agonist monotherapy in Parkinson's disease. Scottish Medical Journal, 57(4), pp. 217-220. (doi: 10.1258/smj.2012.012121)
Hauser, R. A. and Grosset, D. G. (2012) [123I]FP-CIT (DaTscan) SPECT brain imaging in patients with suspected parkinsonian syndromes. Journal of Neuroimaging, 22(3), pp. 225-230. (doi: 10.1111/j.1552-6569.2011.00583.x) (PMID:21410815)
Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J. , Pimlott, S. , Grosset, K.A. and Grosset, D.G. (2012) Serotonergic Function in Early Parkinson's Disease With and Without Depression: A Pilot Study. Association of British Neurologists Annual Meeting 2011, Newcastle, UK, 2011. (doi: 10.1136/jnnp-2011-301993.158)
2011
Grosset, D. G. , Cardoso, F. and Lees, A. (2011) Dopamine agonists vs levodopa in impulse control disorders. Archives of Neurology, 68(4), pp. 544-546. (doi: 10.1001/archneurol.2011.41) (PMID:21482941)
Djamshidian, A., Cardoso, F., Grosset, D. , Bowden-Jones, H. and Lees, A.J. (2011) Pathological gambling in Parkinson's disease - a review of the literature. Movement Disorders, 26(11), pp. 1976-1984. (doi: 10.1002/mds.23821)
Nissen, T. and Grosset, D.G. (2011) Benefits of L-dopa in the treatment of early Parkinson's disease. Focus on Parkinson's Disease, 22(1), 12-15-12-15.
2010
Bajaj, N. P.S., Gontu, V., Birchall, J., Patterson, J., Grosset, D. G. and Lees, A. J. (2010) Accuracy of clinical diagnosis in tremulous parkinsonian patients: a blinded video study. Journal of Neurology, Neurosurgery and Psychiatry, 81(11), pp. 1223-1228. (doi: 10.1136/jnnp.2009.193391) (PMID:20547625)
Grosset, D. and Grosset, A. (2010) The movement disorder society - 14th international congress of Parkinson's disease and movement disorders. IDrugs, 13(8), 539--542. (PMID:20721824)
Grosset, D. (2010) Therapy adherence issues in Parkinson's disease. Journal of the Neurological Sciences, 289(1-2), pp. 115-118. (doi: 10.1016/j.jns.2009.08.053) (PMID:19793590)
Grosset, D. (2010) Parkinson's Disease and Related Disorders - XVIII WFN World Congress. IDrugs, 13(2), pp. 82-84. (PMID:20127558)
Kalra, S., Grosset, D. G. and Benamer, H. T. (2010) Differentiating vascular parkinsonism from idiopathic Parkinson's disease: A systematic review. Movement Disorders, 25(25-26), pp. 149-156. (doi: 10.1002/mds.22937) (PMID:20077476)
Grosset, D.G. , Macphee, G.J.A. and Nairn, M. (2010) Diagnosis and pharmacological management of Parkinson's disease: Summary of SIGN guidelines. British Medical Journal, 340(7739), b5614. (doi: 10.1136/bmj.b5614) (PMID:20068048)
2009
Macphee, G. J.A., Copeland, C., Stewart, D., Grosset, K. and Grosset, D. (2009) Clinical follow up of pathological gambling in Parkinson's disease in the West Scotland study. Movement Disorders, 24(16), pp. 2430-2431. (doi: 10.1002/mds.22824) (PMID:19908308)
Newman, E. J., Breen, K., Patterson, J., Hadley, D. M., Grosset, K. and Grosset, D. (2009) Accuracy of Parkinson's disease diagnosis in 610 general practice patients in the West of Scotland. Movement Disorders, 24(1251), pp. 2379-2385. (doi: 10.1002/mds.22829) (PMID:19890985) (PMCID:19890985)
Benamer, H. T.S., Deleu, D. and Grosset, D. (2009) Epidemiology of headache in Arab countries. Journal of Headache and Pain, 11(1), pp. 1-3. (doi: 10.1007/s10194-009-0173-8) (PMID:19949829) (PMCID:PMC3452181)
Clarke, C.E., Worth, P., Grosset, D. and Stewart, D. (2009) Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease. Parkinsonism and Related Disorders, 15(10), pp. 728-741. (doi: 10.1016/j.parkreldis.2009.09.005) (PMID:19805000)
Benamer, H. T.S. and Grosset, D. G. (2009) A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia, 50(10), pp. 2301-2304. (doi: 10.1111/j.1528-1167.2009.02058.x) (PMID:19389149)
Grosset, D. et al. (2009) Adherence to antiparkinson medication in a multicenter European study. Movement Disorders, 24(6), pp. 826-832. (doi: 10.1002/mds.22112) (PMID:19191340)
Benamer, H. T.S., Ahmed, E. S.M., Al-Din, A. S. and Grosset, D. G. (2009) Frequency and clinical patterns of multiple sclerosis in Arab countries: A systematic review. Journal of the Neurological Sciences, 278(1-2), pp. 1-4. (doi: 10.1016/j.jns.2008.12.001) (PMID:19135686)
Marshall, V. L. et al. (2009) Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3-year European multicenter study with repeat [123I]FP-CIT SPECT. Movement Disorders, 24(4), pp. 500-508. (doi: 10.1002/mds.22108) (PMID:19117369)
Newman, E. J., Grosset, K. and Grosset, D. (2009) Geographical difference in Parkinson's disease prevalence within West Scotland. Movement Disorders, 24(3), pp. 401-406. (doi: 10.1002/mds.22359) (PMID:19021227)
Newman, E.J., Grosset, D. and Kennedy, P.G. (2009) The parkinsonism-hyperpyrexia syndrome. Neurocritical Care, 10(1), pp. 136-140. (doi: 10.1007/s12028-008-9125-4)
Benamer, H.T. and Grosset, D. (2009) Stroke in Arab countries: A systematic literature review. Journal of the Neurological Sciences, 284(1-2), pp. 18-23. (doi: 10.1016/j.jns.2009.04.029) (PMID:19428027)
Grosset, D. , Fernandez, H., Grosset, K. and Okun, M. (2009) Parkinson’s Disease. Series: Clinican’s desk reference. CRC Press. ISBN 9781840761016
Silveira-Moriyama, L. et al. (2009) Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs). Journal of Neurology, Neurosurgery and Psychiatry, 80(7), pp. 744-748. (doi: 10.1136/jnnp.2009.172825) (PMID:19276101)
2008
Benamer, H.T. and Grosset, D.G. (2008) Vascular Parkinsonism: A clinical review. European Neurology, 61(1), pp. 11-15. (doi: 10.1159/000165343) (PMID:18948694)
Grosset, D. (2008) Dopamine agonists and therapy compliance. Neurological Sciences, S5, 375-S3756. (doi: 10.1007/s10072-008-1050-y) (PMID:19381766)
Stocchi, F., Hersh, B.P., Scott, B.L., Nausieda, P.A., Giorgi, L. and , (2008) Ropinirole 24-hour prolonged release and ropinirole immediate release in early Parkinson's disease: A randomized, double-blind, non-inferiority crossover study. Current Medical Research and Opinion, 24(10), pp. 2883-2895. (doi: 10.1185/03007990802387130) (PMID:18768106)
Benamer, H.T., de Silva, R., Siddiqui, K.A. and Grosset, D.G. (2008) Parkinson's disease in Arabs: A systematic review. Movement Disorders, 23(9), pp. 1205-1210. (doi: 10.1002/mds.22041) (PMID:18442138)
Grosset, D. G. and Schapira, A.H. (2008) Timing the initiation of treatment in Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 79(6), p. 615. (doi: 10.1136/jnnp.2008.144741) (PMID:18487552)
Newman, E. and Grosset, D. (2008) Parkinson's Disease and Related Disorders - XVIIth WFN World Congress. IDrugs, 11(3), pp. 173-178. (PMID:18311651)
2007
Grosset, K. and Grosset, D. (2007) Pill counts, self reports, and electronic monitoring - Which is most informative in the study of therapy adherence in Parkinson's disease? Movement Disorders, 22(15), p. 2294. (doi: 10.1002/mds.21705) (PMID:17724748)
Grosset, K.A. and Grosset, D.G. (2007) Effect of educational intervention on medication timing in Parkinson's disease: A randomized controlled trial. BMC Neurology, 7, 20. (doi: 10.1186/1471-2377-7-20) (PMID:17634109) (PMCID:PMC1931606)
Scherfler, C., Schwarz, J., Antonini, A., Grosset, D. , Vallderiola, F., Marek, K., Oertel, W., Tolosoa, E., Lees, A. and Poewe, W. (2007) Role of DAT-SPECT in the diagnostic work up of Parkinsonism. Movement Disorders, 22(9), pp. 1229-1238. (doi: 10.1002/mds.21505) (PMID:17486648)
Davidson, D.F., Grosset, K. and Grosset, D. (2007) Parkinson's disease: the effect of L-dopa therapy on urinary free catecholamines and metabolites. Annals of Clinical Biochemistry, 44(4), pp. 364-368. (doi: 10.1258/000456307780945705) (PMID:17594783)
Grosset, D. et al. (2007) A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis. Journal of Neurology, Neurosurgery and Psychiatry, 78(5), pp. 465-469. (doi: 10.1136/jnnp.2006.098327) (PMID:17098846) (PMCID:PMC2117846)
2006
Grosset, K., MacPhee, G., Pal, G., Stewart, D., Watt, A., Davie, J. and Grosset, D.G. (2006) Problematic gambling on dopamine agonists: not such a rarity. Movement Disorders, 21(12), pp. 2206-2208. (doi: 10.1002/mds.21110)
Marshall, V. L., Patterson, J., Hadley, D. M., Grosset, K. A. and Grosset, D. G. (2006) Successful Antiparkinsonian medication withdrawal in patients with Parkinsonism and normal FP-CIT SPECT. Movement Disorders, 21(12), pp. 2247-2250. (doi: 10.1002/mds.21159) (PMID:17078059)
Marshall, V. L., Patterson, J., Hadley, D. M., Grosset, K. A. and Grosset, D. G. (2006) Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging. Nuclear Medicine Communications, 27(12), pp. 933-937. (doi: 10.1097/01.mnm.0000243374.11260.5b)
Grosset, K. A. and Grosset, D. (2006) Letter to the editor. Clinical Therapeutics, 28(7), pp. 1063-1064. (doi: 10.1016/j.clinthera.2006.06.016) (PMID:16990085)
Oertel, W. H. et al. (2006) Pergolide versus levodopa monotherapy in early Parkinson's disease patients: The PELMOPET study. Movement Disorders, 21(3), pp. 343-353. (doi: 10.1002/mds.20724) (PMID:16211594)
Grosset, D. , Schachter, M., Soar, K. and Turner, J. (2006) Ethical and managerial issues: A discussion. Round Table Series - Royal Society of Medicine(83), pp. 38-43.
Grosset, D. , Schachter, M., Soar, K. and Turner, J. (2006) Literature review: A discussion. Round Table Series - Royal Society of Medicine(83), pp. 20-24.
Grosset, D. , Soar, K., Schachter, M. and Blower, P. (2006) Discussion. Round Table Series - Royal Society of Medicine(83), pp. 29-30.
Grosset, D. (2006) Experience of patients with Parkinson's disease in clinical practice. Round Table Series - Royal Society of Medicine(83), pp. 25-29.
Schachter, M., Soar, K., Turner, J., Grosset, D. and Blower, P. (2006) Discussion. Round Table Series - Royal Society of Medicine(83), pp. 36-37.
2005
Grosset, K. A., Bone, I. and Grosset, D. G. (2005) Suboptimal medication adherence in Parkinson's disease. Movement Disorders, 20(11), pp. 1502-1507. (doi: 10.1002/mds.20602) (PMID:16037924)
Grosset, K. A., Reid, J. L. and Grosset, D. G. (2005) Medicine-taking behavior: implications of suboptimal compliance in Parkinson's disease. Movement Disorders, 20(11), pp. 1397-1404. (doi: 10.1002/mds.20525) (PMID:16092116)
Marshall, V.L. and Grosset, D. G. (2005) The role of radiotracer imaging in Parkinson disease. Neurology, 65(7), pp. 1144-1145. (doi: 10.1212/WNL.65.7.1144) (PMID:16217084)
Grosset, K. and Grosset, D. (2005) Hedonistic homeostatic dysregulation in Parkinson's disease and excess dopamine replacement therapy. Movement Disorders, 20(9), pp. 1230-1231. (doi: 10.1002/mds.20616) (PMID:16037920)
Grosset, D. and Grosset, K. (2005) Spheramine Titan/Schering. Current Opinion in Investigational Drugs, 6(7), pp. 722-728. (PMID:16044669)
Grosset, K. A. and Grosset, D. G. (2005) Patient-perceived involvement and satisfaction in Parkinson's disease: Effect on therapy decisions and quality of life. Movement Disorders, 20(5), pp. 616-619. (doi: 10.1002/mds.20393) (PMID:15719417)
Grosset, K., Grosset, D. and Lees, A. (2005) Trial of subtherapeutic pergolide in de novo Parkinson's disease. Movement Disorders, 20(3), pp. 363-366. (doi: 10.1002/mds.20361) (PMID:15580607)
Grosset, D.G. and Lees, A.J. (2005) Long duration asymmetric postural tremor in the development of Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 76(1), p. 9. (doi: 10.1136/jnnp.2004.053116) (PMID:15607986) (PMCID:PMC1739302)
Marshall, V. and Grosset, D. (2005) Reply: the meaning of negative DAT and F‐Dopa PET scans in a patient with clinical Parkinson's disease. Movement Disorders, p. 118. (doi: 10.1002/mds.20313)
2004
Grosset, K., Needleman, F., Macphee, G. and Grosset, D. (2004) Switching from ergot to nonergot dopamine agonists in Parkinson's disease: a clinical series and five-drug dose conversion table. Movement Disorders, 19(11), pp. 1370-1374. (doi: 10.1002/mds.20210) (PMID:15389984)
Morrish, P., Marshall, V. and Grosset, D.G. (2004) The meaning of negative DAT SPECT and F-Dopa PET scans in patients with clinical Parkinson's disease. Movement Disorders, 20(1), p. 117. (doi: 10.1002/mds.20304) (PMID:15468100)
Grosset, K.A. and Grosset, D.G. (2004) Prescribed drugs and neurological complications. Journal of Neurology, Neurosurgery and Psychiatry, 75(S3), iii2-iii8. (doi: 10.1136/jnnp.2004.045757) (PMID:15316038) (PMCID:PMC1765662)
Grosset, K. and Grosset, D. G. (2004) Pergolide in Parkinson's disease: time for a change? Lancet, 363(9424), pp. 1907-1908. (doi: 10.1016/S0140-6736(04)16369-1) (PMID:15183636)
Marshall, V.L. and Grosset, D.G. (2004) GPI-1485 Guilford. Current Opinion in Investigational Drugs, 5(1), pp. 107-112. (PMID:14983983)
Chaudhuri, K. R., Forbes, A., Grosset, D. , Lees, A., Shneerson, J., Schapira, A., Stillman, P. and Williams, A. (2004) Diagnosing restless legs syndrome (RLS) in primary care. Current Medical Research and Opinion, 20(11), pp. 1785-1795. (doi: 10.1185/030079904X5472) (PMID:15537479)
2003
Marshall, V. and Grosset, D. (2003) Role of dopamine transporter imaging in routine clinical practice. Movement Disorders, 18(12), pp. 1415-1423. (doi: 10.1002/mds.10592) (PMID:14673877)
Lees, A. J. and Grosset, D. G. (2003) Dopamine transporter imaging. Movement Disorders, 18(S7), S1-S2. (doi: 10.1002/mds.10570) (PMID:14531038)
Marshall, V. and Grosset, D. G. (2003) Role of dopamine transporter imaging in the diagnosis of atypical tremor disorders. Movement Disorders, 18(S7), S22-S27. (doi: 10.1002/mds.10574) (PMID:14531042)
Marshall, V.L. and Grosset, D.G. (2003) Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes. Neurology, 61(6), p. 871. (doi: 10.1212/WNL.61.6.871) (PMID:14504352)
Benamer, H. T.S., Oertel, W. H., Patterson, J., Hadley, D. M., Pogarell, O., Höffken, H., Gerstner, A. and Grosset, D. G. (2003) Prospective study of persynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: Part 1. baseline and 3-month observations. Movement Disorders, 18(9), pp. 977-984. (doi: 10.1002/mds.10482) (PMID:14502664)
2002
Yang, Y., Grosset, D. G. , Li, Q., Shuaib, A. and Lees, K. R. (2002) Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model. American Journal of Neuroradiology, 23(7), pp. 1229-1236. (PMID:12169484)
2001
Bhatia, K., Brooks, D.J., Burn, D.J., Clarke, C.E., Grosset, D.G. , MacMahon, D.G., Playfer, J., Schapira, A., Stewart, D. and Williams, A.C. (2001) Updated guidelines for the management of Parkinson's disease. Hospital Medicine, 62(8), pp. 456-470. (doi: 10.12968/hosp.2001.62.8.1621) (PMID:11530583)
Yang, Y., Grosset, D. G. , Yang, T. and Lees, K. R. (2001) Characterization of ultrasound-detected cerebral microemboli in patients undergoing cardiac catheterization using an in vitro middle cerebral artery model. Catheterization and Cardiovascular Interventions, 53(3), pp. 323-330. (doi: 10.1002/ccd.1175) (PMID:11458408)
Barber, M., Stewart, D., Grosset, D. and MacPhee, G. (2001) Patient and carer perception of the management of Parkinson's disease after surgery. Age and Ageing, 30(2), pp. 171-172. (doi: 10.1093/ageing/30.2.171) (PMID:11395349)
Lees, K. R., Dyker, A. G., Sharma, A., Ford, G. A., Ardron, M. E. and Grosset, D. G. (2001) Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients: a dose-ranging study. Stroke, 32(2), pp. 466-472. (doi: 10.1161/01.STR.32.2.466) (PMID:11157184)
2000
Benamer, H. T.S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G.J.A. and Grosset, D. G. (2000) Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake. Movement Disorders, 15(4), pp. 692-698. (doi: 10.1002/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V) (PMID:10928580)
Muir, K.W. , Watt, A., Baxter, G., Grosset, D.G. and Lees, K.R. (2000) Randomized trial of graded compression stockings for prevention of deep-vein thrombosis after acute stroke. QJM: An International Journal of Medicine, 93(6), pp. 359-364. (doi: 10.1093/qjmed/93.6.359) (PMID:10873185)
Benamer, H. T. S. et al. (2000) Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: The [123I]-FP-CIT study group. Movement Disorders, 15(3), pp. 503-510. (doi: 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V) (PMID:10830416)
Yang, Y., Grosset, D. G. , Li, Q. and Lees, K. R. (2000) Identification of echocardiographic 'smoke' in a bench model with transcranial Doppler ultrasound. Stroke, 31(4), pp. 907-914. (doi: 10.1161/01.STR.31.4.907) (PMID:10753997)
Benamer, H. T.S., Russell, A. J.C., Hadley, D. M. and Grosset, D. G. (2000) Unilateral arm tremor as the sole feature of ischemic stroke: a 5-year follow up. Movement Disorders, 15(2), pp. 346-347. (doi: 10.1002/1531-8257(200003)15:2<346::AID-MDS1027>3.0.CO;2-C) (PMID:10752593)
Grosset, D. (2000) Good clinical practice in idiopathic Parkinson's disease: a review of clinical trial issues. Good Clinical Practice Journal, 7(5), pp. 26-31.
1999
Muir, K. W. and Grosset, D. G. (1999) Using pathophysiology in acute stroke trials: Authors' response. Stroke, 30(6), p. 1293. (doi: 10.1161/01.STR.30.6.1293)
Muir, K. W. and Grosset, D. G. (1999) Neuroprotection for acute stroke: making clinical trials work. Stroke, 30(1), pp. 180-182. (doi: 10.1161/01.STR.30.1.180) (PMID:9880407)
1998
Grosset, D. (1998) Cerebrovascular reactivity measurement using near-infrared spectroscopy. Clinical Science, 95(4), p. 395. (doi: 10.1042/cs0950395) (PMID:9748414)
Ringelstein, E. B., Droste, D. W., Babikian, V. L., Evans, D. H., Grosset, D. G. , Kaps, M., Markus, H. S., Russell, D. and Siebler, M. (1998) Consensus on microembolus detection by TCD: International consensus group on microembolus detection. Stroke, 29(3), pp. 725-729. (doi: 10.1161/01.STR.29.3.725) (PMID:9506619)
1997
Bath, P., Lees, K., Dennis, M., Smithard, D., Bone, I., Grosset, D. , Macdonald, J. and Pollock, S. (1997) Should stroke medicine be a separate subspecialty? British Medical Journal, 315(7116), p. 1167. (doi: 10.1136/bmj.315.7116.1167a)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1997) Effects of prolonged infusions of the NMDA antagonist aptiganel hydrochloride (CNS 1102) in normal volunteers. Clinical Neuropharmacology, 20(4), pp. 311-321. (doi: 10.1097/00002826-199708000-00003) (PMID:9260729)
Markus, H. S., Ackerstaff, R., Babikian, V., Bladin, C., Droste, D., Grosset, D. , Levi, C., Russell, D., Siebler, M. and Tegeler, C. (1997) Intercenter agreement in reading Doppler embolic signals: a multicenter international study. Stroke, 28(7), pp. 1307-1310. (doi: 10.1161/01.STR.28.7.1307) (PMID:9227673)
Dyker, A. G., Grosset, D. G. and Lees, K. (1997) Perindopril reduces blood pressure but not cerebral blood flow in patients with recent cerebral ischemic stroke. Stroke, 28(3), pp. 580-583. (doi: 10.1161/01.STR.28.3.580) (PMID:9056614)
1996
Muir, K.W. , McNeish, I. , Grosset, D.G. and Metcalfe, M. (1996) Visualization of cardiac emboli from mitral valve papillary fibroelastoma. Stroke, 27(6), pp. 1133-1134. (PMID:8650729)
Grosset, D. G. et al. (1996) Detection of microemboli by transcranial Doppler ultrasound. Texas Heart Institute Journal, 23(4), pp. 289-292. (PMID:8969029) (PMCID:PMC325373)
1995
Glen, S. K., Wilson, E. S. and Grosset, D. G. (1995) Transesophageal echocardiography microbubbles with prosthetic valves. American Heart Journal, 130(6), p. 1312. (doi: 10.1016/0002-8703(95)90169-8) (PMID:7484796)
Morris, A.D., Ritchie, C., Grosset, D.G. , Adams, F.G. and Lees, K.R. (1995) A pilot study of streptokinase for acute cerebral infarction. QJM: An International Journal of Medicine, 88(10), pp. 727-731. (doi: 10.1093/oxfordjournals.qjmed.a068997) (PMID:7493170)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in man. Annals of the New York Academy of Sciences, 765(1), pp. 336-337. (doi: 10.1111/j.1749-6632.1995.tb16609.x) (PMID:7486638)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in volunteers. Annals of the New York Academy of Sciences, 765(1), pp. 279-289. (doi: 10.1111/j.1749-6632.1995.tb16585.x) (PMID:7486614)
Glen, S.K. and Grosset, D.G. (1995) Duplex versus angiography. Journal of the Royal Society of Medicine, 88(7), pp. 423-424. (PMID:7562817) (PMCID:PMC1295284)
Mackay, T.G., Georgiadis, D., Grosset, D.G. , Kelman, A.W., Lees, K.R. and Wheatley, D.J. (1995) Transcranial Doppler ultrasound signals associated with prosthetic heart valves: an in vitro study. Journal of Heart Valve Disease, 4(4), pp. 414-419. (PMID:7582153)
Wilson, E.S. and Grosset, D.G. (1995) High intensity transcranial Doppler signals (HITS) after prosthetic valve implantation. Journal of Heart Valve Disease, 4(4), pp. 420-421. (PMID:7582154)
Glen, S.K., Georgiadis, D., Grosset, D.G. , Douglas, J.D. and Lees, K.R. (1995) Transcranial Doppler ultrasound in commercial air divers: a field study including cases with right-to-left shunting. Undersea and Hyperbaric Medicine, 22(2), pp. 129-135. (PMID:7633274)
Houston, J.G., Morris, A.D., Grosset, D.G. , Lees, K.R., McMillan, N. and Bone, I. (1995) Ultrasonic evaluation of movement of the diaphragm after acute cerebral infarction. Journal of Neurology, Neurosurgery and Psychiatry, 58(6), pp. 738-741. (doi: 10.1136/jnnp.58.6.738) (PMID:7608679) (PMCID:PMC1073558)
Grosset, D. , Muir, K. and Lees, K. (1995) Systemic and cerebral hemodynamic responses to the noncompetitive N-methyl-D-aspartate (NMDA) antagonist CNS 1102. Journal of Cardiovascular Pharmacology, 25(5), pp. 705-709. (doi: 10.1097/00005344-199505000-00004) (PMID:7630148)
Grosset, D. G. , Ebrahim, S., Bone, I. and Warlow, C. (1995) Stroke in pregnancy and the puerperium: What magnitude of risk? Journal of Neurology, Neurosurgery and Psychiatry, 58(2), pp. 129-131. (doi: 10.1136/jnnp.58.2.129) (PMID:7876840) (PMCID:PMC1073306)
Glen, S., Grosset, D. and Lees, K. (1995) Anticoagulant monitoring with transcranial doppler. Lancet, 345(8941), pp. 579-58. (doi: 10.1016/S0140-6736(95)91180-4) (PMID:7799717)
Mackay, T. G., Georgiadis, D., Grosset, D. G. , Lees, K. R. and Wheatley, D. J. (1995) On the origin of cerebrovascular microemboli associated with prosthetic heart valves. Neurological Research, 17(5), pp. 349-352. (doi: 10.1080/01616412.1995.11740341) (PMID:8584125)
1994
Weir, C.J., Lees, K.R., Muir, K.W. , Grosset, D.G. and Murray, G.D. (1994) Stroke scoring systems: Author's reply. Lancet, 344(8939-4), p. 1781. (doi: 10.1016/S0140-6736(94)92923-8)
Weir, C.J., Murray, G.D., Adams, F.G., Muir, K.W. , Grosset, D.G. and Lees, K.R. (1994) Poor accuracy of stroke scoring systems for differential clinical diagnosis of intracranial haemorrhage and infarction. Lancet, 344(8928), pp. 999-1002. (doi: 10.1016/S0140-6736(94)91648-9) (PMID:7934437)
Grosset, D. G. , Georgiadis, D., Cowburn, P. and Lees, K. R. (1994) Transcranial doppler for emboli. Neurology, 44(10), pp. 1980-1981. (doi: 10.1212/WNL.44.10.1980-c) (PMID:7818671)
Georgiadis, D., Mackay, T.G., Kelman, A.W., Grosset, D.G. , Wheatley, D.J. and Lees, K.R. (1994) Differentiation between gaseous and formed embolic materials in vivo: application in prosthetic heart valve patients. Stroke, 25(8), pp. 1559-1563. (doi: 10.1161/01.STR.25.8.1559) (PMID:7913774)
Grosset, D.G. , McDonald, I., Cockburn, M., Straiton, J. and Bullock, R.R. (1994) Prediction of delayed neurological deficit after subarachnoid haemorrhage: a CT blood load and Doppler velocity approach. Neuroradiology, 36(6), pp. 418-421. (doi: 10.1007/BF00593673) (PMID:7991081)
Muir, K.W. , Grosset, D.G. , Gamzu, E. and Lees, K.R. (1994) Pharmacological effects of the non‐competitive NMDA antagonist CNS 1102 in normal volunteers. British Journal of Clinical Pharmacology, 38(1), pp. 33-38. (doi: 10.1111/j.1365-2125.1994.tb04318.x) (PMID:7946934) (PMCID:PMC1364834)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1994) Interconversion of stroke scales: implications for therapeutic trials. Stroke, 25(7), pp. 1366-1370. (doi: 10.1161/01.STR.25.7.1366) (PMID:8023351)
Georgiadis, D., Mallinson, A., Grosset, D. G. and Lees, K. R. (1994) Coagulation activity and emboli counts in patients with prosthetic cardiac valves. Stroke, 25(6), pp. 1211-1214. (doi: 10.1161/01.STR.25.6.1211) (PMID:8202982)
Georgiadis, D., Grosset, D. G. , Quin, R. O., Nichol, J. A.R., Bone, I. and Lees, K. R. (1994) Detection of intracranial emboli in patients with carotid disease. European Journal of Vascular Surgery, 8(3), pp. 309-314. (doi: 10.1016/S0950-821X(05)80147-1) (PMID:8013681)
Georgiadis, D., Grosset, D. G. , Kelman, A., Faichney, A. and Lees, K. R. (1994) Prevalence and characteristics of intracranial microemboli signals in patients with different types of prosthetic cardiac valves. Stroke, 25(3), pp. 587-592. (doi: 10.1161/01.STR.25.3.587) (PMID:8128512)
Georgiadis, D., Grosset, D. G. and Lees, K. R. (1994) Bilateral cerebral embolization in patients with carotid stenosis. Stroke, 25(3), p. 717. (doi: 10.1161/01.STR.25.3.717) (PMID:8128535)
Grosset, D.G. , Cowburn, P., Georgiadis, D., Dargie, H.J., Faichney, A. and Lees, K.R. (1994) Ultrasound detection of cerebral emboli in patients with prosthetic heart valves. Journal of Heart Valve Disease, 3(2), pp. 128-132. (PMID:7912147)
Grosset, D.G. , Georgiadis, S., Stirling, S., Cowburn, P., Kehnan, A.W., Lees, K.R. and Faichney, A. (1994) Subclinical embolism in patients undergoing cardiac valve implantation and coronary artery bypass surgery. European Journal of Cardio-Thoracic Surgery, 8(2), pp. 63-66. (doi: 10.1016/1010-7940(94)90092-2) (PMID:7909671)
Grosset, D. G. , Georgiadis, D., Abdullah, I., Bone, I. and Lees, K. R. (1994) Doppler emboli signals vary according to stroke subtype. Stroke, 25(2), pp. 382-384. (doi: 10.1161/01.STR.25.2.382) (PMID:7905679)
1993
Grosset, D. G. , Squire, I. B., Georgiadis, D. and Lees, K. R. (1993) Repeatability testing for transcranial Doppler sonography. Clinical Science, 85(6), p. 761. (doi: 10.1042/cs0850761) (PMID:7904549)
Grosset, D. G. , Georgiadis, D., Kelman, A. W. and Lees, K. R. (1993) Quantification of ultrasound emboli signals in patients with cardiac and carotid disease. Stroke, 24(12), pp. 1922-1924. (doi: 10.1161/01.STR.24.12.1922) (PMID:7902622)
Georgiadis, D., Grosset, D. G. and Lees, K. R. (1993) Transhemispheric passage of microemboli in patients with unilateral internal carotid artery occlusion. Stroke, 24(11), pp. 1664-1666. (doi: 10.1161/01.STR.24.11.1664) (PMID:8236339)
Grosset, D. G. , Georgiadis, D., Hillis, W. S. and Lees, K. R. (1993) Clinical significance of cerebral emboli signals. Lancet, 342(8870), p. 559. (doi: 10.1016/0140-6736(93)91690-N) (PMID:8102700)
Morris, A.D., Grosset, D.G. , Squire, I.B., Lees, K.R., Bone, I. and Reid, J.L. (1993) The experiences of an acute stroke unit-implications for multicentre acute stroke trials. Journal of Neurology, Neurosurgery and Psychiatry, 56(4), pp. 352-355. (doi: 10.1136/jnnp.56.4.352) (PMID:8482954) (PMCID:PMC1014949)
Grosset, D. G. , Straiton, J., McDonald, I., Cockburn, M. and Bullock, R. (1993) Use of transcranial Doppler sonography to predict development of a delayed ischemic deficit after subarachnoid hemorrhage. Journal of Neurosurgery, 78(2), pp. 183-187. (doi: 10.3171/jns.1993.78.2.0183) (PMID:8421200)
Squire, I. B., Grosset, D. G. and Lees, K. R. (1993) Immunosuppressive treatment in stroke and renal failure. Annals of the Rheumatic Diseases, 52(2), pp. 165-166. (doi: 10.1136/ard.52.2.165-b) (PMID:8095385) (PMCID:PMC1005001)
Grosset, D. G. , Straiton, J., McDonald, I. and Bullock, R. (1993) Angiographic and Doppler diagnosis of cerebral artery vasospasm following subarachnoid haemorrhage. British Journal of Neurosurgery, 7(3), pp. 291-298. (doi: 10.3109/02688699309023812) (PMID:8338650)
1992
Grosset, D.G. (1992) Clinical, radiological, and functional evaluation following acute stroke. British Journal of Clinical Pharmacology, 34(6), pp. 477-485. (doi: 10.1111/j.1365-2125.1992.tb05654.x) (PMID:1493079) (PMCID:PMC1381448)
Grosset, D. and Lees, K. (1992) Applications of transcranial doppler sonography in acute ischemic stroke. Stroke, 23(12), pp. 1840-1841. (doi: 10.1161/str.23.12.1840b) (PMID:1448837)
Grosset, D.G. (1992) What have drugs to offer the patient with acute stroke? British Journal of Clinical Pharmacology, 33(5), pp. 467-472. (doi: 10.1111/j.1365-2125.1992.tb04072.x) (PMID:1524958) (PMCID:PMC1381431)
Grosset, D.G. , Straiton, J., du Trevou, M. and Bullock, R. (1992) Prediction of symptomatic vasospasm after subarachnoid hemorrhage by rapidly increasing transcranial Doppler velocity and cerebral blood flow changes. Stroke, 23(5), pp. 674-679. (doi: 10.1161/01.STR.23.5.674) (PMID:1579965)
Grosset, D.G. , Patterson, J. and Bone, I. (1992) Intracranial haemodynamics in Takayasu's arteritis. Acta Neurochirurgica, 119(1-4), pp. 161-165. (doi: 10.1007/BF01541802) (PMID:1362319)
1990
Grosset, D.G. (1990) Pulmonary arteriovenous fistulas are at high neurologic risk. Stroke, 21(11), p. 1641. (doi: 10.1161/str.21.11.1641b) (PMID:2237963)
Grosset, D. (1990) Aneurysm re-rupture: Doppler evidence of first phase vasospasm? Journal of Neurology, Neurosurgery and Psychiatry, 53(4), p. 361. (doi: 10.1136/jnnp.53.4.361-b) (PMID:2187951) (PMCID:PMC1014188)
1989
Grosset, D.G. , Hadley, D.M. and Bone, I. (1989) Single central nervous system lesions can simulate multiple sclerosis. Postgraduate Medical Journal, 65(767), pp. 656-659. (doi: 10.1136/pgmj.65.767.656) (PMID:2608598) (PMCID:PMC2429200)
Articles
Gandhi, S. E. et al. (2024) Motor complications in Parkinson's disease: results from 3343 patients followed for up to 12 years. Movement Disorders Clinical Practice, 11(6), pp. 686-697. (doi: 10.1002/mdc3.14044) (PMID:38587023)
Menon, P. J. et al. (2024) Genotype-phenotype correlation in PRKN-associated Parkinson's disease. npj Parkinson's Disease, 10(1), 72. (doi: 10.1038/s41531-024-00677-3) (PMID:38553467) (PMCID:PMC10980707)
Lawton, M., Ben-Shlomo, Y., Gkatzionis, A., Hu, M. T., Grosset, D. and Tilling, K. (2024) Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression. European Journal of Epidemiology, (doi: 10.1007/s10654-023-01093-2) (PMID:38281297) (Early Online Publication)
Venuto, C. S., Smith, G., Herbst, K., Zielinski, R., Yung, N. C.W., Grosset, D. G. , Dorsey, E. R. and Kieburtz, K. (2023) Predicting ambulatory capacity in Parkinson's disease to analyze progression, biomarkers, and trial design. Movement Disorders, 38(10), pp. 1774-1785. (doi: 10.1002/mds.29519) (PMID:37363815)
Lawton, M., Ben-Shlomo, Y., Athauda, D., Malek, N. and Grosset, D. (2023) Commentary: “Association between diabetes mellitus, prediabetes and risk, disease progression of Parkinson’s disease: a systematic review and meta-analysis”. Frontiers in Aging Neuroscience, 15, 1223636. (doi: 10.3389/fnagi.2023.1223636) (PMID:37396660) (PMCID:PMC10309552)
Real, R. et al. (2023) Association between the LRP1B and APOE loci and the development of Parkinson’s disease dementia. Brain, 146(5), pp. 1873-1887. (doi: 10.1093/brain/awac414) (PMID:36348503) (PMCID:PMC10151192)
Heng, N., Malek, N., Lawton, M. A., Nodehi, A., Pitz, V. , Grosset, K. A., Ben-Shlomo, Y. and Grosset, D. G. (2023) Striatal dopamine loss in early Parkinson’s disease: systematic review and novel analysis of dopamine transporter imaging. Movement Disorders Clinical Practice, 10(4), pp. 539-546. (doi: 10.1002/mdc3.13687) (PMID:37070042) (PMCID:PMC10105104)
Winchester, L. et al. (2023) Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and CSF. Brain Communications, 5(1), fcac343. (doi: 10.1093/braincomms/fcac343) (PMID:36694577) (PMCID:PMC9856276)
Lawton, M. et al. (2022) Genetics of validated Parkinson's Disease subtypes in the Oxford Discovery and Tracking Parkinson's cohorts. Journal of Neurology, Neurosurgery and Psychiatry, 93(9), pp. 952-959. (doi: 10.1136/jnnp-2021-327376) (PMID:35732412)
Morris, H., Grosset, D. , Heslegrave, A. and Zetterberg, H. (2022) Sample Collection and Measurement of Serum Neurofilament Light (NfL). (doi: 10.17504/protocols.io.bzbep2je)
Vijiaratnam, N. et al. (2022) Diabetes and neuroaxonal damage in Parkinson's disease. Movement Disorders, 37(7), pp. 1568-1569. (doi: 10.1002/mds.29067) (PMID:35856732)
Vijiaratnam, N. et al. (2022) Combining biomarkers for prognostic modelling of Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 93(7), pp. 707-715. (doi: 10.1136/jnnp-2021-328365) (PMID:35577512) (PMCID:PMC9279845)
Kanavou, S., Pitz, V. , Lawton, M. A., Malek, N., Grosset, K. A., Morris, H. R., Ben-Shlomo, Y. and Grosset, D. G. (2021) Comparison between four published definitions of hyposmia in Parkinson's disease. Brain and Behavior, 11(8), e2258. (doi: 10.1002/brb3.2258) (PMID:34190430) (PMCID:PMC8413742)
Smith, C. R., Cullen, B. , Sheridan, M. P., Cavanagh, J. , Grosset, K. and Grosset, D. G. (2020) Cognitive impairment in Parkinson’s disease is multifactorial: a neuropsychological study. Acta Neurologica Scandinavica, 141(6), pp. 500-508. (doi: 10.1111/ane.13226) (PMID:32002988)
Grosset, D. G. , Dhall, R., Gurevich, T., Kassubek, J., Poewe, W. H., Rascol, O., Rudzinska, M., Cormier, J., Sedkov, A. and Oh, C. (2020) Inhaled levodopa in Parkinson's disease patients with OFF periods: A randomized 12-month pulmonary safety study. Parkinsonism and Related Disorders, 71, pp. 4-10. (doi: 10.1016/j.parkreldis.2019.12.012) (PMID:31927343)
Pitz, V. , Malek, N., Tobias, E. S. , Grosset, K. A., Gentleman, S. and Grosset, D. G. (2020) The levodopa response varies in pathologically confirmed Parkinson's disease: a systematic review. Movement Disorders Clinical Practice, 7(2), pp. 218-222. (doi: 10.1002/mdc3.12885) (PMID:32071945)
Smith, C., Cavanagh, J. , Sheridan, M., Grosset, K., Cullen, B. and Grosset, D. (2020) Factor structure of the Montreal Cognitive Assessment in Parkinson’s disease. International Journal of Geriatric Psychiatry, 35(2), pp. 188-194. (doi: 10.1002/gps.5234) (PMID:31736141)
Jabbari, E. et al. (2019) The genetic and clinico-pathological profile of early-onset progressive supranuclear palsy. Movement Disorders, 34(9), pp. 1307-1314. (doi: 10.1002/mds.27786) (PMID:31299107) (PMCID:PMC6790973)
Eva-Juliane, V., Kasten, M., Klein, C. and MJFF Global Genetic Parkinson’s Disease Study Group, (2019) Using global team science to identify genetic Parkinson's disease worldwide. Annals of Neurology, 86(2), pp. 153-157. (doi: 10.1002/ana.25514) (PMID:31155756)
Malek, N. et al. (2019) L-dopa responsiveness in early Parkinson's disease is associated with the rate of motor progression. Parkinsonism and Related Disorders, 65, pp. 55-61. (doi: 10.1016/j.parkreldis.2019.05.022) (PMID:31105012)
Carroll, C. B., Wyse, R. K.H. and Grosset, D. G. (2019) Statins and Parkinson's: a complex interaction. Movement Disorders, 34(7), pp. 934-935. (doi: 10.1002/mds.27721) (PMID:31322771)
Blauwendraat, C. et al. (2019) Parkinson's disease age at onset genome‐wide association study: defining heritability, genetic loci, and α‐synuclein mechanisms. Movement Disorders, 34(6), pp. 866-875. (doi: 10.1002/mds.27659) (PMID:30957308)
Smith, C. R., Malek, N. M., Grosset, K. A., Cullen, B. , Gentleman, S. M. and Grosset, D. G. (2019) Neuropathology of dementia in patients with Parkinson’s disease: a systematic review of autopsy studies. Journal of Neurology, Neurosurgery and Psychiatry, 90(11), pp. 1234-1243. (doi: 10.1136/jnnp-2019-321111) (PMID:31444276)
Stephenson, D. et al. (2019) The qualification of an enrichment biomarker for clinical trials targeting early stages of Parkinson’s disease. Journal of Parkinson's Disease, 9(3), pp. 553-563. (doi: 10.3233/jpd-191648) (PMID:31306141)
Lawton, M. et al. (2018) Developing and validating Parkinson’s disease subtypes and their motor and cognitive progression. Journal of Neurology, Neurosurgery and Psychiatry, 89(12), pp. 1279-1287. (doi: 10.1136/jnnp-2018-318337) (PMID:30464029) (PMCID:PMC6288789)
Silverdale, M. A. et al. (2018) A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease. Parkinsonism and Related Disorders, 56, pp. 27-32. (doi: 10.1016/j.parkreldis.2018.06.001) (PMID:29903584) (PMCID:PMC6302227)
Fackrell, R., Carroll, C. B., Grosset, D. G. , Mohamed, B., Reddy, P., Parry, M., Chaudhuri, K. R. and Foltynie, T. (2018) Noninvasive options for 'wearing-off' in Parkinson's disease: a clinical consensus from a panel of UK Parkinson's disease specialists. Neurodegenerative Disease Management, 8(5), pp. 349-360. (doi: 10.2217/nmt-2018-0020) (PMID:29975112)
Watson-Fargie, T., Grosset, D.G. , White, J. and Cowie, F. (2018) Possible modulation of concurrent Parkinson’s disease in the management of metastatic GIST: a review of two cases. Journal of the Royal College of Physicians of Edinburgh, 48(3), pp. 242-245. (doi: 10.4997/JRCPE.2018.309) (PMID:30191913)
Sackley, C. M. et al. (2018) Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and Feasibility Studies, 4(1), 30. (doi: 10.1186/s40814-017-0222-z) (PMID:29344405) (PMCID:PMC5763537)
Malek, N. et al. (2018) Features of GBA-associated Parkinson’s disease at presentation in the UK Tracking Parkinson’s study. Journal of Neurology, Neurosurgery and Psychiatry, 89(7), pp. 702-709. (doi: 10.1136/jnnp-2017-317348) (PMID:29378790) (PMCID:PMC6031283)
Malek, N., Jampana, R. and Grosset, D. G. (2017) Rare case of atypical parkinsonism: Why family history is important. Scottish Medical Journal, 62(4), pp. 159-162. (doi: 10.1177/0036933017727966) (PMID:29192564)
Cheng, K. K.W., Swallow, D. M.A., Grosset, K. A. and Grosset, D. G. (2017) Statin usage, vascular diagnosis and vascular risk factors in Parkinson's disease. Scottish Medical Journal, 62(3), pp. 104-109. (doi: 10.1177/0036933017727432) (PMID:28836927)
Malek, N. et al. (2017) Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases. Parkinsonism and Related Disorders, 40, pp. 40-46. (doi: 10.1016/j.parkreldis.2017.04.006) (PMID:28431829)
Malek, N. et al. (2017) Autonomic dysfunction in early Parkinson's disease: results from the United Kingdom Tracking Parkinson's study. Movement Disorders Clinical Practice, 4(4), pp. 509-516. (doi: 10.1002/mdc3.12454) (PMID:30363477) (PMCID:PMC6174464)
Lawton, M. et al. (2016) Equating scores of the University of Pennsylvania Smell Identification Test and Sniffin' Sticks test in patients with Parkinson's disease. Parkinsonism and Related Disorders, 33, pp. 96-101. (doi: 10.1016/j.parkreldis.2016.09.023) (PMID:27729202) (PMCID:PMC5159993)
Lubbe, S.J. et al. (2016) Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease. Neurobiology of Aging, 48, 222.e1-222.e7. (doi: 10.1016/j.neurobiolaging.2016.07.013) (PMID:27640074) (PMCID:PMC5096891)
Malek, N. et al. (2016) Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients. Acta Neurologica Scandinavica, 134(4), pp. 271-276. (doi: 10.1111/ane.12538) (PMID:26626018)
Malek, N. et al. (2016) Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Movement Disorders, 31(10), pp. 1518-1526. (doi: 10.1002/mds.26698) (PMID:27324570) (PMCID:PMC5082556)
LeWitt, P.A. et al. (2016) A randomized trial of inhaled levodopa (CVT-301) for motor fluctuations in Parkinson's disease. Movement Disorders, 31(9), pp. 1356-1365. (doi: 10.1002/mds.26611) (PMID:27090868)
Heinzel, S. et al. (2016) Prodromal markers in Parkinson's disease: Limitations in longitudinal studies and lessons learned. Frontiers in Aging Neuroscience, 8, 147. (doi: 10.3389/fnagi.2016.00147) (PMID:27445791) (PMCID:PMC4916171)
Lerche, S. et al. (2016) Aiming for study comparability in Parkinson's disease: Proposal for a modular set of biomarker assessments to be used in longitudinal studies. Frontiers in Aging Neuroscience, 8, 121. (doi: 10.3389/fnagi.2016.00121) (PMID:27303289) (PMCID:PMC4882324)
Swallow, D. M.A. et al. (2016) Variation in recent onset Parkinson's disease: Implications for prodromal detection. Journal of Parkinson's Disease, 6(2), pp. 289-300. (doi: 10.3233/JPD-150741) (PMID:27003780) (PMCID:PMC4927926)
Swallow, D. M.A., Grosset, K. A. and Grosset, D. G. (2016) Nonmotor symptoms in patients without evidence of dopaminergic deficit. Movement Disorders, 31(3), pp. 429-430. (doi: 10.1002/mds.26541) (PMID:26891715)
Counsell, C., Sinclair, H., Fowlie, J., Tyrrell, E., Derry, N., Meager, P., Norrie, J. and Grosset, D. (2016) A randomized trial of specialized versus standard neck physiotherapy in cervical dystonia. Parkinsonism and Related Disorders, 23, pp. 72-79. (doi: 10.1016/j.parkreldis.2015.12.010) (PMID:26723272)
Swallow, D. M.A. et al. (2016) Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts. Journal of Neurology, Neurosurgery and Psychiatry, 87(11), pp. 1183-1190. (doi: 10.1136/jnnp-2016-313642) (PMID:27671901) (PMCID:PMC5116532)
Lerche, S. et al. (2015) Methods in neuroepidemiology characterization of European Longitudinal Cohort Studies in Parkinson's disease-Report of the JPND Working Group BioLoC-PD. Neuroepidemiology, 45(4), pp. 282-297. (doi: 10.1159/000439221) (PMID:26523894)
Malek, N. et al. (2015) Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease, 5(4), pp. 947-959. (doi: 10.3233/JPD-150662) (PMID:26485428) (PMCID:PMC4927877)
Malek, N. and Grosset, D. G. (2015) Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias. Current Geriatrics Reports, 4(2), pp. 124-130. (doi: 10.1007/s13670-015-0126-9)
Malek, N. and Grosset, D. G. (2015) Medication adherence in patients with Parkinson's disease. CNS Drugs, 29(19), pp. 47-53. (doi: 10.1007/s40263-014-0220-0) (PMID:25503824)
Grosset, D. G. , Tyrrell, E. G. and Grosset, K. A. (2015) Switch from abobotulinumtoxinA (Dysport®) to incobotulinumtoxinA (Xeomin®) botulinum toxin formulation: A review of 257 cases. Journal of Rehabilitation Medicine, 47, pp. 183-186. (doi: 10.2340/16501977-1895) (PMID:25325305)
Stephenson, D. et al. (2015) Precompetitive data sharing as a catalyst to address unmet needs in Parkinson’s disease. Journal of Parkinson's Disease, 5(3), pp. 581-594. (doi: 10.3233/jpd-150570) (PMID:26406139) (PMCID:PMC4887129)
Grosset, D.G. et al. (2014) Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan). Journal of Nuclear Medicine, 55(8), pp. 1281-1287. (doi: 10.2967/jnumed.114.138032) (PMID:24947061)
Malek, N., Swallow, D., Grosset, K.A., Anichtchik, O., Spillantini, M. and Grosset, D.G. (2014) Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review. Acta Neurologica Scandinavica, 130(2), pp. 59-72. (doi: 10.1111/ane.12247) (PMID:24702516)
Seibyl, J.P. et al. (2014) Individual-reader diagnostic performance and between-reader agreement in assessment of subjects with Parkinsonian syndrome or dementia using 123I-Ioflupane injection (DaTscan) imaging. Journal of Nuclear Medicine, 55(8), pp. 1288-1296. (doi: 10.2967/jnumed.114.140228) (PMID:24925885)
O'Brien, J. T., Oertel, W. H., McKeith, I. G., Grosset, D. G. , Walker, Z., Tatsch, K., Tolosa, E., Sherwin, P. F. and Grachev, I. D. (2014) Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials. BMJ Open, 4(7), e005122. (doi: 10.1136/bmjopen-2014-005122) (PMID:24993764) (PMCID:PMC4091455)
Stewart, D., Morgan, B., Burn, D., Grosset, D. , Chaudhuri, K.R., MacMahon, D., Needleman, F., MacPhee, G. and Heywood, P. (2014) Dopamine agonist switching in Parkinson's disease. Hospital Medicine, 65(4), pp. 215-219. (doi: 10.12968/hosp.2004.65.4.12734) (PMID:15127675)
Nissen, T., Malek, N., Grosset, K.A., Newman, E.J., Patterson, J., Hadley, D. and Grosset, D.G. (2014) Baseline [123I]FP-CIT SPECT (DaTSCAN) severity correlates with medication use at 3 years in Parkinson's disease. Acta Neurologica Scandinavica, 129(3), pp. 204-208. (doi: 10.1111/ane.12178)
Grosset, K.A., Malek, N., Morgan, F. and Grosset, D.G. (2013) Phase IIa randomized double-blind, placebo-controlled study of inhaled apomorphine as acute challenge for rescuing 'off' periods in patients with established Parkinson's disease. European Journal of Neurology, 20(11), pp. 1445-1450. (doi: 10.1111/ene.12091) (PMID:23350812)
Grosset, K.A., Malek, N., Morgan, F. and Grosset, D.G. (2013) Inhaled dry powder apomorphine (VR040) for 'off ' periods in Parkinson's disease: an in-clinic double-blind dose ranging study. Acta Neurologica Scandinavica, 128(3), pp. 166-171. (doi: 10.1111/ane.12107) (PMID:23527823)
Grosset, K. A., Malek, N., Morgan, F. and Grosset, D. (2013) Inhaled apomorphine in patients with 'on-off' fluctuations: a randomized, double-blind, placebo-controlled, clinic and home based, parallel-group study. Journal of Parkinson's Disease, 3(1), pp. 31-37. (doi: 10.3233/JPD-120142) (PMID:23938309)
Bajaj, N.P.S., Wang, L., Gontu, V., Grosset, D.G. and Bain, P.G. (2012) Accuracy of subjective and objective handwriting assessment for differentiating Parkinson’s disease from tremulous subjects without evidence of dopaminergic deficits (SWEDDs): an FP-CIT-validated study. Journal of Neurology, 259(11), pp. 2335-2340. (doi: 10.1007/s00415-012-6495-5)
Nissen, T., Newman, E.J., Grosset, K.A., Daghem, M., Pal, G., Stewart, M., Odin, P., Macphee, G. and Grosset, D.G. (2012) Duration of L-dopa and dopamine agonist monotherapy in Parkinson's disease. Scottish Medical Journal, 57(4), pp. 217-220. (doi: 10.1258/smj.2012.012121)
Hauser, R. A. and Grosset, D. G. (2012) [123I]FP-CIT (DaTscan) SPECT brain imaging in patients with suspected parkinsonian syndromes. Journal of Neuroimaging, 22(3), pp. 225-230. (doi: 10.1111/j.1552-6569.2011.00583.x) (PMID:21410815)
Grosset, D. G. , Cardoso, F. and Lees, A. (2011) Dopamine agonists vs levodopa in impulse control disorders. Archives of Neurology, 68(4), pp. 544-546. (doi: 10.1001/archneurol.2011.41) (PMID:21482941)
Djamshidian, A., Cardoso, F., Grosset, D. , Bowden-Jones, H. and Lees, A.J. (2011) Pathological gambling in Parkinson's disease - a review of the literature. Movement Disorders, 26(11), pp. 1976-1984. (doi: 10.1002/mds.23821)
Nissen, T. and Grosset, D.G. (2011) Benefits of L-dopa in the treatment of early Parkinson's disease. Focus on Parkinson's Disease, 22(1), 12-15-12-15.
Bajaj, N. P.S., Gontu, V., Birchall, J., Patterson, J., Grosset, D. G. and Lees, A. J. (2010) Accuracy of clinical diagnosis in tremulous parkinsonian patients: a blinded video study. Journal of Neurology, Neurosurgery and Psychiatry, 81(11), pp. 1223-1228. (doi: 10.1136/jnnp.2009.193391) (PMID:20547625)
Grosset, D. and Grosset, A. (2010) The movement disorder society - 14th international congress of Parkinson's disease and movement disorders. IDrugs, 13(8), 539--542. (PMID:20721824)
Grosset, D. (2010) Therapy adherence issues in Parkinson's disease. Journal of the Neurological Sciences, 289(1-2), pp. 115-118. (doi: 10.1016/j.jns.2009.08.053) (PMID:19793590)
Grosset, D. (2010) Parkinson's Disease and Related Disorders - XVIII WFN World Congress. IDrugs, 13(2), pp. 82-84. (PMID:20127558)
Kalra, S., Grosset, D. G. and Benamer, H. T. (2010) Differentiating vascular parkinsonism from idiopathic Parkinson's disease: A systematic review. Movement Disorders, 25(25-26), pp. 149-156. (doi: 10.1002/mds.22937) (PMID:20077476)
Grosset, D.G. , Macphee, G.J.A. and Nairn, M. (2010) Diagnosis and pharmacological management of Parkinson's disease: Summary of SIGN guidelines. British Medical Journal, 340(7739), b5614. (doi: 10.1136/bmj.b5614) (PMID:20068048)
Macphee, G. J.A., Copeland, C., Stewart, D., Grosset, K. and Grosset, D. (2009) Clinical follow up of pathological gambling in Parkinson's disease in the West Scotland study. Movement Disorders, 24(16), pp. 2430-2431. (doi: 10.1002/mds.22824) (PMID:19908308)
Newman, E. J., Breen, K., Patterson, J., Hadley, D. M., Grosset, K. and Grosset, D. (2009) Accuracy of Parkinson's disease diagnosis in 610 general practice patients in the West of Scotland. Movement Disorders, 24(1251), pp. 2379-2385. (doi: 10.1002/mds.22829) (PMID:19890985) (PMCID:19890985)
Benamer, H. T.S., Deleu, D. and Grosset, D. (2009) Epidemiology of headache in Arab countries. Journal of Headache and Pain, 11(1), pp. 1-3. (doi: 10.1007/s10194-009-0173-8) (PMID:19949829) (PMCID:PMC3452181)
Clarke, C.E., Worth, P., Grosset, D. and Stewart, D. (2009) Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease. Parkinsonism and Related Disorders, 15(10), pp. 728-741. (doi: 10.1016/j.parkreldis.2009.09.005) (PMID:19805000)
Benamer, H. T.S. and Grosset, D. G. (2009) A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia, 50(10), pp. 2301-2304. (doi: 10.1111/j.1528-1167.2009.02058.x) (PMID:19389149)
Grosset, D. et al. (2009) Adherence to antiparkinson medication in a multicenter European study. Movement Disorders, 24(6), pp. 826-832. (doi: 10.1002/mds.22112) (PMID:19191340)
Benamer, H. T.S., Ahmed, E. S.M., Al-Din, A. S. and Grosset, D. G. (2009) Frequency and clinical patterns of multiple sclerosis in Arab countries: A systematic review. Journal of the Neurological Sciences, 278(1-2), pp. 1-4. (doi: 10.1016/j.jns.2008.12.001) (PMID:19135686)
Marshall, V. L. et al. (2009) Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3-year European multicenter study with repeat [123I]FP-CIT SPECT. Movement Disorders, 24(4), pp. 500-508. (doi: 10.1002/mds.22108) (PMID:19117369)
Newman, E. J., Grosset, K. and Grosset, D. (2009) Geographical difference in Parkinson's disease prevalence within West Scotland. Movement Disorders, 24(3), pp. 401-406. (doi: 10.1002/mds.22359) (PMID:19021227)
Newman, E.J., Grosset, D. and Kennedy, P.G. (2009) The parkinsonism-hyperpyrexia syndrome. Neurocritical Care, 10(1), pp. 136-140. (doi: 10.1007/s12028-008-9125-4)
Benamer, H.T. and Grosset, D. (2009) Stroke in Arab countries: A systematic literature review. Journal of the Neurological Sciences, 284(1-2), pp. 18-23. (doi: 10.1016/j.jns.2009.04.029) (PMID:19428027)
Silveira-Moriyama, L. et al. (2009) Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs). Journal of Neurology, Neurosurgery and Psychiatry, 80(7), pp. 744-748. (doi: 10.1136/jnnp.2009.172825) (PMID:19276101)
Benamer, H.T. and Grosset, D.G. (2008) Vascular Parkinsonism: A clinical review. European Neurology, 61(1), pp. 11-15. (doi: 10.1159/000165343) (PMID:18948694)
Grosset, D. (2008) Dopamine agonists and therapy compliance. Neurological Sciences, S5, 375-S3756. (doi: 10.1007/s10072-008-1050-y) (PMID:19381766)
Stocchi, F., Hersh, B.P., Scott, B.L., Nausieda, P.A., Giorgi, L. and , (2008) Ropinirole 24-hour prolonged release and ropinirole immediate release in early Parkinson's disease: A randomized, double-blind, non-inferiority crossover study. Current Medical Research and Opinion, 24(10), pp. 2883-2895. (doi: 10.1185/03007990802387130) (PMID:18768106)
Benamer, H.T., de Silva, R., Siddiqui, K.A. and Grosset, D.G. (2008) Parkinson's disease in Arabs: A systematic review. Movement Disorders, 23(9), pp. 1205-1210. (doi: 10.1002/mds.22041) (PMID:18442138)
Grosset, D. G. and Schapira, A.H. (2008) Timing the initiation of treatment in Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 79(6), p. 615. (doi: 10.1136/jnnp.2008.144741) (PMID:18487552)
Newman, E. and Grosset, D. (2008) Parkinson's Disease and Related Disorders - XVIIth WFN World Congress. IDrugs, 11(3), pp. 173-178. (PMID:18311651)
Grosset, K. and Grosset, D. (2007) Pill counts, self reports, and electronic monitoring - Which is most informative in the study of therapy adherence in Parkinson's disease? Movement Disorders, 22(15), p. 2294. (doi: 10.1002/mds.21705) (PMID:17724748)
Grosset, K.A. and Grosset, D.G. (2007) Effect of educational intervention on medication timing in Parkinson's disease: A randomized controlled trial. BMC Neurology, 7, 20. (doi: 10.1186/1471-2377-7-20) (PMID:17634109) (PMCID:PMC1931606)
Scherfler, C., Schwarz, J., Antonini, A., Grosset, D. , Vallderiola, F., Marek, K., Oertel, W., Tolosoa, E., Lees, A. and Poewe, W. (2007) Role of DAT-SPECT in the diagnostic work up of Parkinsonism. Movement Disorders, 22(9), pp. 1229-1238. (doi: 10.1002/mds.21505) (PMID:17486648)
Davidson, D.F., Grosset, K. and Grosset, D. (2007) Parkinson's disease: the effect of L-dopa therapy on urinary free catecholamines and metabolites. Annals of Clinical Biochemistry, 44(4), pp. 364-368. (doi: 10.1258/000456307780945705) (PMID:17594783)
Grosset, D. et al. (2007) A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis. Journal of Neurology, Neurosurgery and Psychiatry, 78(5), pp. 465-469. (doi: 10.1136/jnnp.2006.098327) (PMID:17098846) (PMCID:PMC2117846)
Grosset, K., MacPhee, G., Pal, G., Stewart, D., Watt, A., Davie, J. and Grosset, D.G. (2006) Problematic gambling on dopamine agonists: not such a rarity. Movement Disorders, 21(12), pp. 2206-2208. (doi: 10.1002/mds.21110)
Marshall, V. L., Patterson, J., Hadley, D. M., Grosset, K. A. and Grosset, D. G. (2006) Successful Antiparkinsonian medication withdrawal in patients with Parkinsonism and normal FP-CIT SPECT. Movement Disorders, 21(12), pp. 2247-2250. (doi: 10.1002/mds.21159) (PMID:17078059)
Marshall, V. L., Patterson, J., Hadley, D. M., Grosset, K. A. and Grosset, D. G. (2006) Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging. Nuclear Medicine Communications, 27(12), pp. 933-937. (doi: 10.1097/01.mnm.0000243374.11260.5b)
Grosset, K. A. and Grosset, D. (2006) Letter to the editor. Clinical Therapeutics, 28(7), pp. 1063-1064. (doi: 10.1016/j.clinthera.2006.06.016) (PMID:16990085)
Oertel, W. H. et al. (2006) Pergolide versus levodopa monotherapy in early Parkinson's disease patients: The PELMOPET study. Movement Disorders, 21(3), pp. 343-353. (doi: 10.1002/mds.20724) (PMID:16211594)
Grosset, D. , Schachter, M., Soar, K. and Turner, J. (2006) Ethical and managerial issues: A discussion. Round Table Series - Royal Society of Medicine(83), pp. 38-43.
Grosset, D. , Schachter, M., Soar, K. and Turner, J. (2006) Literature review: A discussion. Round Table Series - Royal Society of Medicine(83), pp. 20-24.
Grosset, D. , Soar, K., Schachter, M. and Blower, P. (2006) Discussion. Round Table Series - Royal Society of Medicine(83), pp. 29-30.
Grosset, D. (2006) Experience of patients with Parkinson's disease in clinical practice. Round Table Series - Royal Society of Medicine(83), pp. 25-29.
Schachter, M., Soar, K., Turner, J., Grosset, D. and Blower, P. (2006) Discussion. Round Table Series - Royal Society of Medicine(83), pp. 36-37.
Grosset, K. A., Bone, I. and Grosset, D. G. (2005) Suboptimal medication adherence in Parkinson's disease. Movement Disorders, 20(11), pp. 1502-1507. (doi: 10.1002/mds.20602) (PMID:16037924)
Grosset, K. A., Reid, J. L. and Grosset, D. G. (2005) Medicine-taking behavior: implications of suboptimal compliance in Parkinson's disease. Movement Disorders, 20(11), pp. 1397-1404. (doi: 10.1002/mds.20525) (PMID:16092116)
Marshall, V.L. and Grosset, D. G. (2005) The role of radiotracer imaging in Parkinson disease. Neurology, 65(7), pp. 1144-1145. (doi: 10.1212/WNL.65.7.1144) (PMID:16217084)
Grosset, K. and Grosset, D. (2005) Hedonistic homeostatic dysregulation in Parkinson's disease and excess dopamine replacement therapy. Movement Disorders, 20(9), pp. 1230-1231. (doi: 10.1002/mds.20616) (PMID:16037920)
Grosset, D. and Grosset, K. (2005) Spheramine Titan/Schering. Current Opinion in Investigational Drugs, 6(7), pp. 722-728. (PMID:16044669)
Grosset, K. A. and Grosset, D. G. (2005) Patient-perceived involvement and satisfaction in Parkinson's disease: Effect on therapy decisions and quality of life. Movement Disorders, 20(5), pp. 616-619. (doi: 10.1002/mds.20393) (PMID:15719417)
Grosset, K., Grosset, D. and Lees, A. (2005) Trial of subtherapeutic pergolide in de novo Parkinson's disease. Movement Disorders, 20(3), pp. 363-366. (doi: 10.1002/mds.20361) (PMID:15580607)
Grosset, D.G. and Lees, A.J. (2005) Long duration asymmetric postural tremor in the development of Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 76(1), p. 9. (doi: 10.1136/jnnp.2004.053116) (PMID:15607986) (PMCID:PMC1739302)
Marshall, V. and Grosset, D. (2005) Reply: the meaning of negative DAT and F‐Dopa PET scans in a patient with clinical Parkinson's disease. Movement Disorders, p. 118. (doi: 10.1002/mds.20313)
Grosset, K., Needleman, F., Macphee, G. and Grosset, D. (2004) Switching from ergot to nonergot dopamine agonists in Parkinson's disease: a clinical series and five-drug dose conversion table. Movement Disorders, 19(11), pp. 1370-1374. (doi: 10.1002/mds.20210) (PMID:15389984)
Morrish, P., Marshall, V. and Grosset, D.G. (2004) The meaning of negative DAT SPECT and F-Dopa PET scans in patients with clinical Parkinson's disease. Movement Disorders, 20(1), p. 117. (doi: 10.1002/mds.20304) (PMID:15468100)
Grosset, K.A. and Grosset, D.G. (2004) Prescribed drugs and neurological complications. Journal of Neurology, Neurosurgery and Psychiatry, 75(S3), iii2-iii8. (doi: 10.1136/jnnp.2004.045757) (PMID:15316038) (PMCID:PMC1765662)
Grosset, K. and Grosset, D. G. (2004) Pergolide in Parkinson's disease: time for a change? Lancet, 363(9424), pp. 1907-1908. (doi: 10.1016/S0140-6736(04)16369-1) (PMID:15183636)
Marshall, V.L. and Grosset, D.G. (2004) GPI-1485 Guilford. Current Opinion in Investigational Drugs, 5(1), pp. 107-112. (PMID:14983983)
Chaudhuri, K. R., Forbes, A., Grosset, D. , Lees, A., Shneerson, J., Schapira, A., Stillman, P. and Williams, A. (2004) Diagnosing restless legs syndrome (RLS) in primary care. Current Medical Research and Opinion, 20(11), pp. 1785-1795. (doi: 10.1185/030079904X5472) (PMID:15537479)
Marshall, V. and Grosset, D. (2003) Role of dopamine transporter imaging in routine clinical practice. Movement Disorders, 18(12), pp. 1415-1423. (doi: 10.1002/mds.10592) (PMID:14673877)
Lees, A. J. and Grosset, D. G. (2003) Dopamine transporter imaging. Movement Disorders, 18(S7), S1-S2. (doi: 10.1002/mds.10570) (PMID:14531038)
Marshall, V. and Grosset, D. G. (2003) Role of dopamine transporter imaging in the diagnosis of atypical tremor disorders. Movement Disorders, 18(S7), S22-S27. (doi: 10.1002/mds.10574) (PMID:14531042)
Marshall, V.L. and Grosset, D.G. (2003) Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes. Neurology, 61(6), p. 871. (doi: 10.1212/WNL.61.6.871) (PMID:14504352)
Benamer, H. T.S., Oertel, W. H., Patterson, J., Hadley, D. M., Pogarell, O., Höffken, H., Gerstner, A. and Grosset, D. G. (2003) Prospective study of persynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: Part 1. baseline and 3-month observations. Movement Disorders, 18(9), pp. 977-984. (doi: 10.1002/mds.10482) (PMID:14502664)
Yang, Y., Grosset, D. G. , Li, Q., Shuaib, A. and Lees, K. R. (2002) Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model. American Journal of Neuroradiology, 23(7), pp. 1229-1236. (PMID:12169484)
Bhatia, K., Brooks, D.J., Burn, D.J., Clarke, C.E., Grosset, D.G. , MacMahon, D.G., Playfer, J., Schapira, A., Stewart, D. and Williams, A.C. (2001) Updated guidelines for the management of Parkinson's disease. Hospital Medicine, 62(8), pp. 456-470. (doi: 10.12968/hosp.2001.62.8.1621) (PMID:11530583)
Yang, Y., Grosset, D. G. , Yang, T. and Lees, K. R. (2001) Characterization of ultrasound-detected cerebral microemboli in patients undergoing cardiac catheterization using an in vitro middle cerebral artery model. Catheterization and Cardiovascular Interventions, 53(3), pp. 323-330. (doi: 10.1002/ccd.1175) (PMID:11458408)
Barber, M., Stewart, D., Grosset, D. and MacPhee, G. (2001) Patient and carer perception of the management of Parkinson's disease after surgery. Age and Ageing, 30(2), pp. 171-172. (doi: 10.1093/ageing/30.2.171) (PMID:11395349)
Lees, K. R., Dyker, A. G., Sharma, A., Ford, G. A., Ardron, M. E. and Grosset, D. G. (2001) Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients: a dose-ranging study. Stroke, 32(2), pp. 466-472. (doi: 10.1161/01.STR.32.2.466) (PMID:11157184)
Benamer, H. T.S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G.J.A. and Grosset, D. G. (2000) Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake. Movement Disorders, 15(4), pp. 692-698. (doi: 10.1002/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V) (PMID:10928580)
Muir, K.W. , Watt, A., Baxter, G., Grosset, D.G. and Lees, K.R. (2000) Randomized trial of graded compression stockings for prevention of deep-vein thrombosis after acute stroke. QJM: An International Journal of Medicine, 93(6), pp. 359-364. (doi: 10.1093/qjmed/93.6.359) (PMID:10873185)
Benamer, H. T. S. et al. (2000) Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: The [123I]-FP-CIT study group. Movement Disorders, 15(3), pp. 503-510. (doi: 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V) (PMID:10830416)
Yang, Y., Grosset, D. G. , Li, Q. and Lees, K. R. (2000) Identification of echocardiographic 'smoke' in a bench model with transcranial Doppler ultrasound. Stroke, 31(4), pp. 907-914. (doi: 10.1161/01.STR.31.4.907) (PMID:10753997)
Benamer, H. T.S., Russell, A. J.C., Hadley, D. M. and Grosset, D. G. (2000) Unilateral arm tremor as the sole feature of ischemic stroke: a 5-year follow up. Movement Disorders, 15(2), pp. 346-347. (doi: 10.1002/1531-8257(200003)15:2<346::AID-MDS1027>3.0.CO;2-C) (PMID:10752593)
Grosset, D. (2000) Good clinical practice in idiopathic Parkinson's disease: a review of clinical trial issues. Good Clinical Practice Journal, 7(5), pp. 26-31.
Muir, K. W. and Grosset, D. G. (1999) Using pathophysiology in acute stroke trials: Authors' response. Stroke, 30(6), p. 1293. (doi: 10.1161/01.STR.30.6.1293)
Muir, K. W. and Grosset, D. G. (1999) Neuroprotection for acute stroke: making clinical trials work. Stroke, 30(1), pp. 180-182. (doi: 10.1161/01.STR.30.1.180) (PMID:9880407)
Grosset, D. (1998) Cerebrovascular reactivity measurement using near-infrared spectroscopy. Clinical Science, 95(4), p. 395. (doi: 10.1042/cs0950395) (PMID:9748414)
Ringelstein, E. B., Droste, D. W., Babikian, V. L., Evans, D. H., Grosset, D. G. , Kaps, M., Markus, H. S., Russell, D. and Siebler, M. (1998) Consensus on microembolus detection by TCD: International consensus group on microembolus detection. Stroke, 29(3), pp. 725-729. (doi: 10.1161/01.STR.29.3.725) (PMID:9506619)
Bath, P., Lees, K., Dennis, M., Smithard, D., Bone, I., Grosset, D. , Macdonald, J. and Pollock, S. (1997) Should stroke medicine be a separate subspecialty? British Medical Journal, 315(7116), p. 1167. (doi: 10.1136/bmj.315.7116.1167a)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1997) Effects of prolonged infusions of the NMDA antagonist aptiganel hydrochloride (CNS 1102) in normal volunteers. Clinical Neuropharmacology, 20(4), pp. 311-321. (doi: 10.1097/00002826-199708000-00003) (PMID:9260729)
Markus, H. S., Ackerstaff, R., Babikian, V., Bladin, C., Droste, D., Grosset, D. , Levi, C., Russell, D., Siebler, M. and Tegeler, C. (1997) Intercenter agreement in reading Doppler embolic signals: a multicenter international study. Stroke, 28(7), pp. 1307-1310. (doi: 10.1161/01.STR.28.7.1307) (PMID:9227673)
Dyker, A. G., Grosset, D. G. and Lees, K. (1997) Perindopril reduces blood pressure but not cerebral blood flow in patients with recent cerebral ischemic stroke. Stroke, 28(3), pp. 580-583. (doi: 10.1161/01.STR.28.3.580) (PMID:9056614)
Muir, K.W. , McNeish, I. , Grosset, D.G. and Metcalfe, M. (1996) Visualization of cardiac emboli from mitral valve papillary fibroelastoma. Stroke, 27(6), pp. 1133-1134. (PMID:8650729)
Grosset, D. G. et al. (1996) Detection of microemboli by transcranial Doppler ultrasound. Texas Heart Institute Journal, 23(4), pp. 289-292. (PMID:8969029) (PMCID:PMC325373)
Glen, S. K., Wilson, E. S. and Grosset, D. G. (1995) Transesophageal echocardiography microbubbles with prosthetic valves. American Heart Journal, 130(6), p. 1312. (doi: 10.1016/0002-8703(95)90169-8) (PMID:7484796)
Morris, A.D., Ritchie, C., Grosset, D.G. , Adams, F.G. and Lees, K.R. (1995) A pilot study of streptokinase for acute cerebral infarction. QJM: An International Journal of Medicine, 88(10), pp. 727-731. (doi: 10.1093/oxfordjournals.qjmed.a068997) (PMID:7493170)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in man. Annals of the New York Academy of Sciences, 765(1), pp. 336-337. (doi: 10.1111/j.1749-6632.1995.tb16609.x) (PMID:7486638)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1995) Clinical pharmacology of CNS 1102 in volunteers. Annals of the New York Academy of Sciences, 765(1), pp. 279-289. (doi: 10.1111/j.1749-6632.1995.tb16585.x) (PMID:7486614)
Glen, S.K. and Grosset, D.G. (1995) Duplex versus angiography. Journal of the Royal Society of Medicine, 88(7), pp. 423-424. (PMID:7562817) (PMCID:PMC1295284)
Mackay, T.G., Georgiadis, D., Grosset, D.G. , Kelman, A.W., Lees, K.R. and Wheatley, D.J. (1995) Transcranial Doppler ultrasound signals associated with prosthetic heart valves: an in vitro study. Journal of Heart Valve Disease, 4(4), pp. 414-419. (PMID:7582153)
Wilson, E.S. and Grosset, D.G. (1995) High intensity transcranial Doppler signals (HITS) after prosthetic valve implantation. Journal of Heart Valve Disease, 4(4), pp. 420-421. (PMID:7582154)
Glen, S.K., Georgiadis, D., Grosset, D.G. , Douglas, J.D. and Lees, K.R. (1995) Transcranial Doppler ultrasound in commercial air divers: a field study including cases with right-to-left shunting. Undersea and Hyperbaric Medicine, 22(2), pp. 129-135. (PMID:7633274)
Houston, J.G., Morris, A.D., Grosset, D.G. , Lees, K.R., McMillan, N. and Bone, I. (1995) Ultrasonic evaluation of movement of the diaphragm after acute cerebral infarction. Journal of Neurology, Neurosurgery and Psychiatry, 58(6), pp. 738-741. (doi: 10.1136/jnnp.58.6.738) (PMID:7608679) (PMCID:PMC1073558)
Grosset, D. , Muir, K. and Lees, K. (1995) Systemic and cerebral hemodynamic responses to the noncompetitive N-methyl-D-aspartate (NMDA) antagonist CNS 1102. Journal of Cardiovascular Pharmacology, 25(5), pp. 705-709. (doi: 10.1097/00005344-199505000-00004) (PMID:7630148)
Grosset, D. G. , Ebrahim, S., Bone, I. and Warlow, C. (1995) Stroke in pregnancy and the puerperium: What magnitude of risk? Journal of Neurology, Neurosurgery and Psychiatry, 58(2), pp. 129-131. (doi: 10.1136/jnnp.58.2.129) (PMID:7876840) (PMCID:PMC1073306)
Glen, S., Grosset, D. and Lees, K. (1995) Anticoagulant monitoring with transcranial doppler. Lancet, 345(8941), pp. 579-58. (doi: 10.1016/S0140-6736(95)91180-4) (PMID:7799717)
Mackay, T. G., Georgiadis, D., Grosset, D. G. , Lees, K. R. and Wheatley, D. J. (1995) On the origin of cerebrovascular microemboli associated with prosthetic heart valves. Neurological Research, 17(5), pp. 349-352. (doi: 10.1080/01616412.1995.11740341) (PMID:8584125)
Weir, C.J., Lees, K.R., Muir, K.W. , Grosset, D.G. and Murray, G.D. (1994) Stroke scoring systems: Author's reply. Lancet, 344(8939-4), p. 1781. (doi: 10.1016/S0140-6736(94)92923-8)
Weir, C.J., Murray, G.D., Adams, F.G., Muir, K.W. , Grosset, D.G. and Lees, K.R. (1994) Poor accuracy of stroke scoring systems for differential clinical diagnosis of intracranial haemorrhage and infarction. Lancet, 344(8928), pp. 999-1002. (doi: 10.1016/S0140-6736(94)91648-9) (PMID:7934437)
Grosset, D. G. , Georgiadis, D., Cowburn, P. and Lees, K. R. (1994) Transcranial doppler for emboli. Neurology, 44(10), pp. 1980-1981. (doi: 10.1212/WNL.44.10.1980-c) (PMID:7818671)
Georgiadis, D., Mackay, T.G., Kelman, A.W., Grosset, D.G. , Wheatley, D.J. and Lees, K.R. (1994) Differentiation between gaseous and formed embolic materials in vivo: application in prosthetic heart valve patients. Stroke, 25(8), pp. 1559-1563. (doi: 10.1161/01.STR.25.8.1559) (PMID:7913774)
Grosset, D.G. , McDonald, I., Cockburn, M., Straiton, J. and Bullock, R.R. (1994) Prediction of delayed neurological deficit after subarachnoid haemorrhage: a CT blood load and Doppler velocity approach. Neuroradiology, 36(6), pp. 418-421. (doi: 10.1007/BF00593673) (PMID:7991081)
Muir, K.W. , Grosset, D.G. , Gamzu, E. and Lees, K.R. (1994) Pharmacological effects of the non‐competitive NMDA antagonist CNS 1102 in normal volunteers. British Journal of Clinical Pharmacology, 38(1), pp. 33-38. (doi: 10.1111/j.1365-2125.1994.tb04318.x) (PMID:7946934) (PMCID:PMC1364834)
Muir, K. W. , Grosset, D. G. and Lees, K. R. (1994) Interconversion of stroke scales: implications for therapeutic trials. Stroke, 25(7), pp. 1366-1370. (doi: 10.1161/01.STR.25.7.1366) (PMID:8023351)
Georgiadis, D., Mallinson, A., Grosset, D. G. and Lees, K. R. (1994) Coagulation activity and emboli counts in patients with prosthetic cardiac valves. Stroke, 25(6), pp. 1211-1214. (doi: 10.1161/01.STR.25.6.1211) (PMID:8202982)
Georgiadis, D., Grosset, D. G. , Quin, R. O., Nichol, J. A.R., Bone, I. and Lees, K. R. (1994) Detection of intracranial emboli in patients with carotid disease. European Journal of Vascular Surgery, 8(3), pp. 309-314. (doi: 10.1016/S0950-821X(05)80147-1) (PMID:8013681)
Georgiadis, D., Grosset, D. G. , Kelman, A., Faichney, A. and Lees, K. R. (1994) Prevalence and characteristics of intracranial microemboli signals in patients with different types of prosthetic cardiac valves. Stroke, 25(3), pp. 587-592. (doi: 10.1161/01.STR.25.3.587) (PMID:8128512)
Georgiadis, D., Grosset, D. G. and Lees, K. R. (1994) Bilateral cerebral embolization in patients with carotid stenosis. Stroke, 25(3), p. 717. (doi: 10.1161/01.STR.25.3.717) (PMID:8128535)
Grosset, D.G. , Cowburn, P., Georgiadis, D., Dargie, H.J., Faichney, A. and Lees, K.R. (1994) Ultrasound detection of cerebral emboli in patients with prosthetic heart valves. Journal of Heart Valve Disease, 3(2), pp. 128-132. (PMID:7912147)
Grosset, D.G. , Georgiadis, S., Stirling, S., Cowburn, P., Kehnan, A.W., Lees, K.R. and Faichney, A. (1994) Subclinical embolism in patients undergoing cardiac valve implantation and coronary artery bypass surgery. European Journal of Cardio-Thoracic Surgery, 8(2), pp. 63-66. (doi: 10.1016/1010-7940(94)90092-2) (PMID:7909671)
Grosset, D. G. , Georgiadis, D., Abdullah, I., Bone, I. and Lees, K. R. (1994) Doppler emboli signals vary according to stroke subtype. Stroke, 25(2), pp. 382-384. (doi: 10.1161/01.STR.25.2.382) (PMID:7905679)
Grosset, D. G. , Squire, I. B., Georgiadis, D. and Lees, K. R. (1993) Repeatability testing for transcranial Doppler sonography. Clinical Science, 85(6), p. 761. (doi: 10.1042/cs0850761) (PMID:7904549)
Grosset, D. G. , Georgiadis, D., Kelman, A. W. and Lees, K. R. (1993) Quantification of ultrasound emboli signals in patients with cardiac and carotid disease. Stroke, 24(12), pp. 1922-1924. (doi: 10.1161/01.STR.24.12.1922) (PMID:7902622)
Georgiadis, D., Grosset, D. G. and Lees, K. R. (1993) Transhemispheric passage of microemboli in patients with unilateral internal carotid artery occlusion. Stroke, 24(11), pp. 1664-1666. (doi: 10.1161/01.STR.24.11.1664) (PMID:8236339)
Grosset, D. G. , Georgiadis, D., Hillis, W. S. and Lees, K. R. (1993) Clinical significance of cerebral emboli signals. Lancet, 342(8870), p. 559. (doi: 10.1016/0140-6736(93)91690-N) (PMID:8102700)
Morris, A.D., Grosset, D.G. , Squire, I.B., Lees, K.R., Bone, I. and Reid, J.L. (1993) The experiences of an acute stroke unit-implications for multicentre acute stroke trials. Journal of Neurology, Neurosurgery and Psychiatry, 56(4), pp. 352-355. (doi: 10.1136/jnnp.56.4.352) (PMID:8482954) (PMCID:PMC1014949)
Grosset, D. G. , Straiton, J., McDonald, I., Cockburn, M. and Bullock, R. (1993) Use of transcranial Doppler sonography to predict development of a delayed ischemic deficit after subarachnoid hemorrhage. Journal of Neurosurgery, 78(2), pp. 183-187. (doi: 10.3171/jns.1993.78.2.0183) (PMID:8421200)
Squire, I. B., Grosset, D. G. and Lees, K. R. (1993) Immunosuppressive treatment in stroke and renal failure. Annals of the Rheumatic Diseases, 52(2), pp. 165-166. (doi: 10.1136/ard.52.2.165-b) (PMID:8095385) (PMCID:PMC1005001)
Grosset, D. G. , Straiton, J., McDonald, I. and Bullock, R. (1993) Angiographic and Doppler diagnosis of cerebral artery vasospasm following subarachnoid haemorrhage. British Journal of Neurosurgery, 7(3), pp. 291-298. (doi: 10.3109/02688699309023812) (PMID:8338650)
Grosset, D.G. (1992) Clinical, radiological, and functional evaluation following acute stroke. British Journal of Clinical Pharmacology, 34(6), pp. 477-485. (doi: 10.1111/j.1365-2125.1992.tb05654.x) (PMID:1493079) (PMCID:PMC1381448)
Grosset, D. and Lees, K. (1992) Applications of transcranial doppler sonography in acute ischemic stroke. Stroke, 23(12), pp. 1840-1841. (doi: 10.1161/str.23.12.1840b) (PMID:1448837)
Grosset, D.G. (1992) What have drugs to offer the patient with acute stroke? British Journal of Clinical Pharmacology, 33(5), pp. 467-472. (doi: 10.1111/j.1365-2125.1992.tb04072.x) (PMID:1524958) (PMCID:PMC1381431)
Grosset, D.G. , Straiton, J., du Trevou, M. and Bullock, R. (1992) Prediction of symptomatic vasospasm after subarachnoid hemorrhage by rapidly increasing transcranial Doppler velocity and cerebral blood flow changes. Stroke, 23(5), pp. 674-679. (doi: 10.1161/01.STR.23.5.674) (PMID:1579965)
Grosset, D.G. , Patterson, J. and Bone, I. (1992) Intracranial haemodynamics in Takayasu's arteritis. Acta Neurochirurgica, 119(1-4), pp. 161-165. (doi: 10.1007/BF01541802) (PMID:1362319)
Grosset, D.G. (1990) Pulmonary arteriovenous fistulas are at high neurologic risk. Stroke, 21(11), p. 1641. (doi: 10.1161/str.21.11.1641b) (PMID:2237963)
Grosset, D. (1990) Aneurysm re-rupture: Doppler evidence of first phase vasospasm? Journal of Neurology, Neurosurgery and Psychiatry, 53(4), p. 361. (doi: 10.1136/jnnp.53.4.361-b) (PMID:2187951) (PMCID:PMC1014188)
Grosset, D.G. , Hadley, D.M. and Bone, I. (1989) Single central nervous system lesions can simulate multiple sclerosis. Postgraduate Medical Journal, 65(767), pp. 656-659. (doi: 10.1136/pgmj.65.767.656) (PMID:2608598) (PMCID:PMC2429200)
Books
Grosset, D. , Fernandez, H., Grosset, K. and Okun, M. (2009) Parkinson’s Disease. Series: Clinican’s desk reference. CRC Press. ISBN 9781840761016
Conference or Workshop Item
Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J. , Pimlott, S. , Grosset, K.A. and Grosset, D.G. (2012) Serotonergic Function in Early Parkinson's Disease With and Without Depression: A Pilot Study. Association of British Neurologists Annual Meeting 2011, Newcastle, UK, 2011. (doi: 10.1136/jnnp-2011-301993.158)
Protocols
Morris, H., Tan, M. M.X., Grosset, D. G. and Williams, N. M. (2022) SNP Genotyping and ApoE Genotyping V.1. [Protocols]
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Improving Healthcare Quality in Parkinson's: Preventive Approaches for Better Bone Health
Parkinson's Disease Society of the UK
2024 - 2025
- Genetic analysis in Parkinson's
Genuity Science (Ireland) Ltd
2024 - 2026
- Defining proteomic subtypes to understand the heterogeneity of Parkinson's pathophysiology
Michael J Fox Foundation for Parkinson's Research
2023 - 2025
- COmBining memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial (COBALT)
National Institute for Health Research
2021 - 2025
- From pathophysiology to precision medicine for Parkinson¿s disease
France Parkinson
2019 - 2024
- Tracking Parkinson's: The long term development and analysis of the Parkinson's repository of biomarkers and networked datasets (PROBAND phase 2)
Parkinson`s UK
2016 - 2020
- PaMIR: Parkinson MR Imaging Repository
Parkinson`s UK
2014 - 2018
- PROBAND: Parkinson's repository of biosamples and networked datasets
Parkinson`s UK
2011 - 2022
Supervision
Research Assistant
- Vicky Marshall (Affiliate)
Research datasets
2019
Grosset, D. (2019) Tracking Parkinson's (PRoBaND: Parkinson's Repository of Biosamples and Networked Datasets). [Data Collection]
