2024

Shek, N. et al. (2024) Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), 15. (doi: 10.1038/s41514-024-00143-7) (PMID:38413600) (PMCID:PMC10899634)

2022

Thomson, N. C., Polosa, R. and Sin, D. D. (2022) Cigarette smoking and asthma. Journal of Allergy and Clinical Immunology: In Practice, 10(11), pp. 2783-2797. (doi: 10.1016/j.jaip.2022.04.034) (PMID:35533997)

Thomson, N. C. (2022) Frequent exacerbators in severe asthma: focus on clinical and transcriptional factors. Clinical and Translational Medicine, 12(5), e860. (doi: 10.1002/ctm2.860) (PMID:35538891) (PMCID:PMC9091991)

2021

Thomson, N. C. (2021) Asthma with a smoking history and pre–chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 204(1), pp. 109-110. (doi: 10.1164/rccm.202102-0440le) (PMID:33831325) (PMCID:PMC8437125)

2020

Portelli, M. A. et al. (2020) Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI Insight, 5(8), e132446. (doi: 10.1172/jci.insight.132446) (PMID:32324168) (PMCID:PMC7205441)

2018

Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)

Thomson, N. C. (2018) Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities. Current Opinion in Pharmacology, 40, pp. 1-8. (doi: 10.1016/j.coph.2017.11.013) (PMID:29223018)

Thomson, N. C. (2018) Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD. Respirology, 23(5), pp. 446-447. (doi: 10.1111/resp.13246) (PMID:29316060)

Thomson, N. C. (2018) Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties. Expert Review of Respiratory Medicine, 12(4), pp. 269-282. (doi: 10.1080/17476348.2018.1444991) (PMID:29471685)

2017

Thomson, N. C. and Chanez, P. (2017) How effective is bronchial thermoplasty for severe asthma in clinical practice? European Respiratory Journal, 50(2), 1701140. (doi: 10.1183/13993003.01140-2017) (PMID:28860271) (PMCID:PMC5593391)

Thomson, N. C. (2017) Asthma and smoking-induced airway disease without spirometric COPD. European Respiratory Journal, 49(5), 1602061. (doi: 10.1183/13993003.02061-2016) (PMID:28461294)

Thomson, N. C. (2017) New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma. Expert Opinion on Pharmacotherapy, 18(3), pp. 283-293. (doi: 10.1080/14656566.2017.1284794) (PMID:28099820)

2016

Johnston, S. L. et al. (2016) Azithromycin for acute exacerbations of asthma : The AZALEA randomized clinical trial. JAMA Internal Medicine, 176(11), pp. 1630-1637. (doi: 10.1001/jamainternmed.2016.5664)

Huang, J. T.J., Bolton, C. E., Miller, B. E., Tal-Singer, R., Rabinovich, R. A., Palmer, C. N.A., Thomson, N. C. and MacNee, W. (2016) Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease. European Respiratory Journal, 48(4), pp. 1215-1218. (doi: 10.1183/13993003.01125-2016) (PMID:27587547)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Thomson, N. C. (2016) Does age of onset of asthma influence the effect of cigarette smoking on lung function? American Journal of Respiratory and Critical Care Medicine, 194(3), pp. 249-250. (doi: 10.1164/rccm.201602-0389ED) (PMID:27479055)

Marsden, P. A., Satia, I., Ibrahim, B., Woodcock, A., Yates, L., Donnelly, I., Jolly, L., Thomson, N., Fowler, S. J. and Smith, J. A. (2016) Objective cough frequency, airway inflammation, and disease control in asthma. Chest, 149(6), pp. 1460-1466. (doi: 10.1016/j.chest.2016.02.676) (PMID:26973014)

Thomson, N. C. (2016) Novel approaches to the management of noneosinophilic asthma. Therapeutic Advances in Respiratory Disease, 10(3), pp. 211-234. (doi: 10.1177/1753465816632638) (PMID:26929306)

Morrison, D. , Wyke, S. , Saunderson, K., McConnachie, A. , Agur, K., Chaudhuri, R. , Thomas, M., Thomson, N.C., Yardley, L. and Mair, F.S. (2016) Findings from a pilot randomised trial of an asthma internet self-management intervention (RAISIN). BMJ Open, 6(5), e009254. (doi: 10.1136/bmjopen-2015-009254) (PMID:27173807) (PMCID:PMC4874112)

Thomson, N. C. (2016) Addressing corticosteroid insensitivity in adults with asthma. Expert Review of Respiratory Medicine, 10(2), pp. 137-156. (doi: 10.1586/17476348.2016.1133304) (PMID:26678267)

2015

Artigas, M. S. et al. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, 8658. (doi: 10.1038/ncomms9658) (PMID:26635082) (PMCID:PMC4686825)

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Thomson, N. C. (2015) Reliever inhaler overuse, asthma symptoms, and depression. Journal of Allergy and Clinical Immunology: In Practice, 3(6), pp. 963-964. (doi: 10.1016/j.jaip.2015.07.002) (PMID:26553619)

Gaga, M., Brand, P. and Thomson, N. (2015) The quest for the grail: multidimensional efforts for understanding and targeting severe asthma. European Respiratory Journal, 46(5), pp. 1227-1231. (doi: 10.1183/13993003.01414-2015) (PMID:26521270)

Wain, L. V. et al. (2015) Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respiratory Medicine, 3(10), pp. 769-781. (doi: 10.1016/s2213-2600(15)00283-0) (PMID:26423011) (PMCID:PMC4593935)

Morrison, D. , Mair, F. S. , Chaudhuri, R. , McGee-Lennon, M., Thomas, M., Thomson, N. C., Yardley, L. and Wyke, S. (2015) Details of development of the resource for adults with asthma in the RAISIN (randomized trial of an asthma internet self-management intervention) study. BMC Medical Informatics and Decision Making, 15, 57. (doi: 10.1186/s12911-015-0177-z)

Thomson, N. C., McSharry, C. and Chaudhuri, R. (2015) Response. CHEST Journal, 148(1), e33-e34. (doi: 10.1378/chest.15-0890) (PMID:26149566)

Thomson, N. C., Chaudhuri, R. , Spears, M., Haughney, J. and McSharry, C. (2015) Serum periostin in smokers and never smokers with asthma. Respiratory Medicine, 109(6), pp. 708-715. (doi: 10.1016/j.rmed.2015.03.009) (PMID:PMID:25869)

McSharry, C., Vesper, S., Wymer, L., Howieson, S., Chaudhuri, R. , Wright, G. R. and Thomson, N.C. (2015) Decreased FEV1% in asthmatic adults in Scottish homes with high environmental relative moldiness index values. Clinical and Experimental Allergy, 45(5), pp. 902-907. (doi: 10.1111/cea.12482) (PMID:25580663)

Thomson, N. C., Charron, C. E., Chaudhuri, R. , Spears, M., Ito, K. and McSharry, C. (2015) Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma. Pulmonary Pharmacology and Therapeutics, 31, pp. 1-8. (doi: 10.1016/j.pupt.2015.01.001) (PMID:25595138)

Thomson, N. C., Chaudhuri, R. , Spears, M., Messow, C.-M. , MacNee, W., Connell, M., Murchison, J. T., Sproule, M. and McSharry, C. (2015) Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma. Chest, 147(3), p. 735. (doi: 10.1378/chest.14-1119) (PMID:25356950)

2014

McSharry, C., Spears, M., Chaudhuri, R. , Cameron, E. J., Husi, H. and Thomson, N. C. (2014) Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. Journal of Allergy and Clinical Immunology, 134(5), pp. 1068-1075. (doi: 10.1016/j.jaci.2014.08.022) (PMID:25262463)

Chaudhuri, R. et al. (2014) Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma. European Respiratory Journal, 44(4), pp. 895-904. (doi: 10.1183/09031936.00047014)

Djukanović, R. et al. (2014) The effect of Inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. American Journal of Respiratory and Critical Care Medicine, 190(2), pp. 145-154. (doi: 10.1164/rccm.201312-2235OC)

Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)

Thomson, N.C. (2014) Novel therapies targeting eosinophilic inflammation in asthma. Clinical and Experimental Allergy, 44(4), pp. 462-468. (doi: 10.1111/cea.12268)

Arron, J.R. et al. (2014) Disconnect between sputum neutrophils and other measures of airway inflammation in asthma. European Respiratory Journal, 43(2), pp. 627-629. (doi: 10.1183/09031936.00117013)

Chaudhuri, R. , Norris, V., Kelly, K., Zhu, C.-Q., Ambery, C., Lafferty, J., Cameron, E. and Thomson, N.C. (2014) Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils. Pulmonary Pharmacology and Therapeutics, 27(1), pp. 62-69. (doi: 10.1016/j.pupt.2013.11.007)

Cowan, D. , Smith, A. and Thomson, N. (2014) Drugs that act on the respiratory tract. In: Aronson, J. K. (ed.) Side Effects of Drugs Annual 35. Series: Side Effects of Drugs Annual, 35. Elsevier, pp. 309-326. ISBN 9780444626356 (doi: 10.1016/b978-0-444-62635-6.00016-4)

Morrison, D. , Wyke, S. , Agur, K., Cameron, E., Docking, R., MacKenzie, A., McConnachie, A. , Raghuvir, V., Thomson, N. and Mair, F. (2014) Digital Asthma Self-Management Interventions: A Systematic Review. Journal of Medical Internet Research, 16(2), e51. (doi: 10.2196/jmir.2814)

Morrison, D. , Wyke, S. , Thomson, N. C., McConnachie, A. , Agur, K., Saunderson, K., Chaudhuri, R. and Mair, F. S. (2014) A randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial. Trials, 15, p. 185. (doi: 10.1186/1745-6215-15-185) (PMID:24884722)

2013

Wechsler, M.E. et al. (2013) Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma. Journal of Allergy and Clinical Immunology, 132(6), 1295-1302.e3. (doi: 10.1016/j.jaci.2013.08.009)

Cameron, E.J. et al. (2013) Randomised controlled trial of azithromycin in smokers with asthma. European Respiratory Journal, 42(5), pp. 1412-1415. (doi: 10.1183/09031936.00093913)

Pavord, I.D., Thomson, N.C., Niven, R.M., Corris, P.A., Chung, K.F., Cox, G., Armstrong, B., Shargill, N.S. and Laviolette, M. (2013) Safety of bronchial thermoplasty in patients with severe refractory asthma. Annals of Allergy, Asthma and Immunology, 111(5), pp. 402-407. (doi: 10.1016/j.anai.2013.05.002)

Thomson, N.C., Chaudhuri, R. , Messow, C.M. , Spears, M., MacNee, W., Connell, M., Murchison, J.T., Sproule, M. and McSharry, C. (2013) Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Respiratory Medicine, 107(10), pp. 1501-1508. (doi: 10.1016/j.rmed.2013.07.017)

Thomson, N.C., Chaudhuri, R. , Heaney, L., Bucknall, C., Niven, R.M., Brightling, C.E., Menzies-Gow, A., Mansur, A.H. and McSharry, C. (2013) Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. Journal of Allergy and Clinical Immunology, 131(4), pp. 1008-1016. (doi: 10.1016/j.jaci.2012.12.1574)

Polosa, R. and Thomson, N.C. (2013) Smoking and asthma: dangerous liaisons. European Respiratory Journal, 41(3), pp. 716-726. (doi: 10.1183/09031936.00073312)

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R. , Thomson, N. C., Palmer, C. N.A., Devereux, G. and Huang, J. T.-J. (2013) Characterization and validation of an isotope-dilution LC–MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis, 5(16), pp. 1991-2001. (doi: 10.4155/BIO.13.164)

Spears, M., McSharry, C., Chaudhuri, R. , Weir, C.J., de Wet, C. and Thomson, N.C. (2013) Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study. PLoS ONE, 8(8), e71460. (doi: 10.1371/journal.pone.0071460) (PMID:23951170) (PMCID:PMC3739804)

2012

Salmond, R.J., Mirchandani, A.S., Besnard, A.-G., Bain, C.C., Thomson, N.C. and Liew, F.Y. (2012) IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of rapamycin. Journal of Allergy and Clinical Immunology, 130(5), pp. 1159-1166. (doi: 10.1016/j.jaci.2012.05.018)

Komai-Koma, M. et al. (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67(9), pp. 1118-1126. (doi: 10.1111/j.1398-9995.2012.02859.x) (PMID:22702477) (PMCID:PMC3660789)

Thomson, N.C. and Spears, M. (2012) Asthma guidelines and smokers: it's time to be inclusive. Chest, 141(2), pp. 286-288. (doi: 10.1378/chest.11-1424)

Huang, J.T.-J. et al. (2012) Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax, 67(6), pp. 502-508. (doi: 10.1136/thoraxjnl-2011-200279)

Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)

Smith, A. and Thomson, N. (2012) Drugs that act on the respiratory tract. Side Effects of Drugs Annual, 34(2012), pp. 277-286. (doi: 10.1016/B978-0-444-59499-0.00016-7)

Thomson, N.C., Bicknell, S. and Chaudhuri, R. (2012) Bronchial thermoplasty for severe asthma. Current Opinion in Allergy and Clinical Immunology, 12(3), pp. 241-248. (doi: 10.1097/ACI.0b013e32835335ca)

Thomson, N.C. and Chaudhuri, R. (2012) Omalizumab: clinical use for the management of asthma. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 6, pp. 27-40. (doi: 10.4137/CCRPM.S7793)

Wan, Y.I. et al. (2012) Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 67(9), pp. 762-768. (doi: 10.1136/thoraxjnl-2011-201262)

2011

Braganza, G. et al. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial. BMC Pulmonary Medicine, 11(16), (doi: 10.1186/1471-2466-11-16)

Patel, M. and Thomson, N.C. (2011) (R)-salbutamol in the treatment of asthma and chronic obstructive airways disease. Expert Opinion on Pharmacotherapy, 12(7), pp. 1133-1141. (doi: 10.1517/14656566.2011.571210)

Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)

Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E. and Thomson, N.C. (2011) Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma. Respiratory Medicine, 105(12), pp. 1823-1830. (doi: 10.1016/j.rmed.2011.06.014)

Thomson, N.C., Chaudhuri, R. and Spears, M. (2011) Emerging therapies for severe asthma. BMC Medicine, 9(1), p. 102. (doi: 10.1186/1741-7015-9-102)

Thomson, N.C. et al. (2011) Long term (5 Year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulmonary Medicine, 11(8), (doi: 10.1186/1471-2466-11-8)

2010

Moffatt, M.F. et al. (2010) A large-scale, consortium-based genomewide association study of asthma. New England Journal of Medicine, 363, pp. 1211-1221.

Castro, M. et al. (2010) Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. American Journal of Respiratory and Critical Care Medicine, 181(2), pp. 116-124. (doi: 10.1164/rccm.200903-0354OC)

Spears, M., Cameron, E., Chaudhuri, R. and Thomson, N.C. (2010) Challenges of treating asthma in people who smoke. Expert Review of Clinical Immunology, 6(2), pp. 257-268. (doi: 10.1586/ECI.09.85)

2009

Wright, G.R. et al. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy, 64(11), pp. 1671-1680. (doi: 10.1111/j.1398-9995.2009.02098.x)

Murphy, C., Blyth, K., Chaudhuri, R., Lafferty, J., Hothersall, E., Steedman, T., McSharry, C., Dargie, H. and Thomson, N. (2009) Assessment of the Presence of Occult Myocardial Infarction in Chronic Obstructive Pulmonary Disease Using Contrast-Enhanced Cardiac Magnetic Resonance Imaging. Respiration, 78(3), pp. 263-269.

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

Spears, M. et al. (2009) Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. European Respiratory Journal, 33(5), pp. 1010-1017. (doi: 10.1183/09031936.00158208)

Spears, M. et al. (2009) Bronchodilatory Effect of the PPAR-gamma Agonist Rosiglitazone in Smokers With Asthma. Clinical Pharmacology and Therapeutics, 86(1), pp. 49-53. (doi: 10.1038/clpt.2009.41)

Thomson, N. and Chaudhuri, R. (2009) Asthma in smokers: challenges and opportunities. Current Opinion in Pulmonary Medicine, 15(1), pp. 39-45.

2008

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2008) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased local Th2 cytokine and chemokine production. In: Scottish Thoracic Society Meeting, Stirling, UK, 26 Oct 2007, p. 50. (doi: 10.1258/rsmsmj.53.2.48)

Chaudhuri, R., McSharry, C., McCoard, A., Livingston, E., Hothersall, E., Spears, M., Lafferty, J. and Thomson, N. (2008) Role of symptoms and lung function in determining asthma control in smokers with asthma. Allergy, 63(1), pp. 132-135.

Hothersall, E. et al. (2008) Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax, 63(12), pp. 1070-1075. (doi: 10.1136/thx.2008.100198)

2007

Pavord, I., Cox, G., Thomson, N., Rubin, A., Corris, P., Niven, R., Chung, K. and Laviolette, M. (2007) Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. American Journal of Respiratory and Critical Care Medicine, 176(12), pp. 1185-1191. (doi: 10.1164/rccm.200704-571OC)

Thomson, N. (2007) Smokers with asthma - What are the management options? American Journal of Respiratory and Critical Care Medicine, 175(8), pp. 749-750. (doi: 10.1164/rccm.200701-017ED)

Cox, G., Laviolette, M. and Thomson, N. (2007) Bronchial thermoplasty - Reply. New England Journal of Medicine, 356(26), p. 2745.

Cox, G. et al. (2007) Asthma control during the year after bronchial thermoplasty. New England Journal of Medicine, 356(13), pp. 1327-1337.

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2007) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased ST2 dependent local Th2 cytokine and chemokine production. In: Winter Meeting of the British-Thoracic-Society, London, UK, 05-07 Dec 2007, A1.

Livingston, E., Chaudhuri, R., McMahon, A. , Fraser, I., McSharry, C. and Thomson, N. (2007) Systemic sensitivity to corticosteroids in smokers with asthma. European Respiratory Journal, 29, pp. 64-70. (doi: 10.1183/09031936.06.00120505)

Thomson, N. (2007) The role of environmental tobacco smoke in the origins and progression of asthma. Current Allergy and Asthma Reports, 7, pp. 303-309.

2006

Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P. and Thomson, N. C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), pp. 127-133. (doi: 10.1164/rccm.200510-1589OC)

Barnes, N., Qiu, Y., Pavord, I., Parker, D., Davis, P., Zhu, L., Johnson, M., Thomson, N. and Jeffery, P. (2006) Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. American Journal of Respiratory and Critical Care Medicine, 173(7), pp. 736-743. (doi: 10.1164/rccm.200508-1321OC)

Hothersall, E., McSharry, C. and Thomson, N. (2006) Potential therapeutic role for statins in respiratory disease. Thorax, 61, pp. 729-734. (doi: 10.1136/thx.2005.057976)

McSharry, C., Fraser, I., Chaudhuri, R., Anderson, K., Bourke, S., Thomson, N. and Boyd, G. (2006) Nerve growth factor in serum and lymphocyte culture in pigeon fanciers' acute hypersensitivity pneumonitis. Chest, 130(1), pp. 37-42. (doi: 10.1378/chest.130.1.37)

Spears, M. and Thomson, N. (2006) Factors Influencing Individual Variability in the Therapeutic Response to Corticosteroids in Asthma. Current Respiratory Medicine Reviews, 2, pp. 197-209.

Spears, M., McSharry, C. and Thomson, N.C. (2006) Peroxisome proliferator-activated receptor-? agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clinical and Experimental Allergy, 36(12), pp. 1494-1504. (doi: 10.1111/j.1365-2222.2006.02604.x)

Spears, M., McSharry, C. and Thomson, N.C. (2006) Peroxisome proliferator-activated receptor-7 agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clinical and Experimental Allergy, 36, pp. 1494-1504.

Thomson, N.C., Shepherd, M., Spears, M. and Chaudhuri, R. (2006) Corticosteroid Insensitivity in Smokers with Asthma: Clinical Evidence, Mechanisms, and Management. Treatments in Respiratory Medicine, 5(6), pp. 467-481.

2005

Chaudhuri, R., McMahon, A. , McSharry, C., MacLeod, K., Fraser, I., Livingston, E. and Thomson, N. (2005) Serum and sputum neurotrophin levels in chronic persistent cough. Clinical and Experimental Allergy, 35, pp. 949-953. (doi: 10.1111/j.1365-2222.2005.02286.x)

Choo-Kang, B., Kewin, P., Liew, F., McSharry, C., Patel, M., Thomson, N. and Xu, D. (2005) Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. European Journal of Immunology, 35, pp. 3581-3590. (doi: 10.1002/eji.200535421)

Choo-Kang, B., Kewin, P., Liew, F., McSharry, C., Patel, M., Thomson, N. and Xu, D. (2005) TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. Journal of Immunology, 174, pp. 7558-7563.

Livingston, E., Thomson, N. and Chalmers, G. (2005) Impact of smoking on asthma therapy - A critical review of clinical evidence. Drugs, 65(11), pp. 1521-1536.

McSharry, C., Mckay, I., Chaudhuri, R., Livingston, E., Fraser, I. and Thomson, N. (2005) Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma. Journal of Allergy and Clinical Immunology, 116, pp. 88-93. (doi: 10.1016/j.jaci.2005.03.025)

Thomson, N.C. and Spears, M. (2005) The influence of smoking on the treatment response in patients with asthma. Current Opinion in Allergy and Clinical Immunology, 5, pp. 57-63.

Tomlinson, J., McMahon, A. , Chaudhuri, R., Thompson, J., Wood, S. and Thomson, N. (2005) Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax, 60, pp. 282-287. (doi: 10.1136/thx.2004.033688)

2004

Thomson, N. C. and Chaudhuri, R. (2004) Why is eosinophilic bronchitis not asthma? American Journal of Respiratory and Critical Care Medicine, 170(1), pp. 4-5. (doi: 10.1164/rccm.2404005)

Chaudhuri, R., Livingston, E., Thomson, N., Ricciardolo, F. L.M. and Stefano, A. D. (2004) Corticosteroid resistance in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 169(11), pp. 1252-1253. (doi: 10.1164/ajrccm.169.11.950)

McKay, A., Leung, B.P., McInnes, I.B. , Thomson, N.C. and Liew, F.Y. (2004) A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. Journal of Immunology, 172(5), pp. 2903-2908. (doi: 10.4049/jimmunol.172.5.2903) (PMID:14978092)

Chaudhuri, R., McMahon, A. , Thomson, L., MacLeod, K., McSharry, C., Livingston, E., Mckay, A. and Thomson, N. (2004) Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. Journal of Allergy and Clinical Immunology, 113, pp. 1063-1070. (doi: 10.1016/j.jaci.2004.03.019)

Chaudhuri, R., Gibson, P.G., Livingston, E., McMahon, A.D. and Thomson, N.C. (2004) Smokers and ex-smokers with chronic stable asthma did not respond to high dose oral corticosteroids. Evidence-Based Medicine, 9(4), p. 115.

Hawkins, G., McMahon, A.D., Peters, J.I., Thomson, N.C. and Twaddle, S. (2004) Inhaled corticosteroid were safely stepped down in chronic, stable asthma. Evidence-Based Medicine, 9(1), p. 16.

Livingston, E., Darroch, C., Chaudhuri, R., McPhee, I., McMahon, A., MacKenzie, S. and Thomson, N. (2004) Glucocorticoid receptor alpha :beta ratio in blood mononuclear cells is reduced in cigarette smokers. Journal of Allergy and Clinical Immunology, 114(6), pp. 1475-1478.

Mckay, A., Komai-Koma, M., Mcleod, K., Thomson, L., Chaudhari, R., McSharry, C., Liew, F. and Thomson, N. (2004) Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers. Clinical and Experimental Allergy, 34, pp. 904-910. (doi: 10.1111/j.1365-2222.2004.01973.x)

Thomson, N., Chaudhuri, R. and Livingston, E. (2004) Asthma and cigarette smoking. European Respiratory Journal, 24, pp. 822-833. (doi: 10.1183/09031936.04.00039004)

2003

Chaudhuri, R. , Livingston, E., McMahon, A. D., Thomson, L., Borland, W. and Thomson, N. C. (2003) Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. American Journal of Respiratory and Critical Care Medicine, 168(11), pp. 1308-1311. (doi: 10.1164/rccm.200304-503OC)

Ford, I., Hawkins, G., McMahon, A., Thomson, N., Twaddle, S. and Wood, S. (2003) Stepping down inhaled corticosteroids in asthma: randomised controlled trial.[see comment]. British Medical Journal, 326(7399), p. 1115.

Gracie, J., Komai-Koma, M., Liew, F., McInnes, I. , Thomson, N., Wei, X. and Xu, D. (2003) Chemoattraction of human T cells by IL-18. Journal of Immunology, 170, pp. 1084-1090. (doi: 10.4049/jimmunol.170.2.1084) (PMID:12517977)

Lalloo, U., Malolepszy, J., Kozma, D., Krofta, K., Ankerst, J., Johansen, B. and Thomson, N. (2003) Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma. Chest, 123, pp. 1480-1487.

Livingston, E. and Thomson, N. (2003) Managing chronic obstructive pulmonary disease. Practitioner, 247, pp. 289-304.

Thomson, N., Chaudhuri, R. and Livingston, E. (2003) Active cigarette smoking and asthma. Clinical and Experimental Allergy, 33(11), pp. 1471-1475.

Thomson, N. and Shepherd, M. (2003) Leukotriene receptor antagonists as add-on therapy tor adults with asthma. Thorax, 58(3), pp. 190-192.

2002

Little, S.A., Sproule, M.W., Cowan, M.D., Macleod, K.J., Robertson, M., Love, J.G., Chalmers, G.W., McSharry, C. and Thomson, N. (2002) High resolution computed tomography assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax, 57(3), pp. 247-253. (doi: 10.1136/thorax.57.3.247)

Chalmers, G., MacLeod, K., Little, S., Thomson, L., McSharry, C. and Thomson, N. (2002) Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax, 57, pp. 226-230.

Little, S., Sproule, M., Cowan, M., MacLeod, K., Robertson, M., Love, J., Chalmers, G., McSharry, C. and Thomson, N. (2002) High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax, 57, pp. 247-253.

2001

Chalmers, G., Clayton, R., Dagg, K., McGrath, J. , Thomson, L. and Thomson, N. (2001) The effect of acute alteration in oxygen tension on the bronchodilator response to salbutamol in vitro and in vivo in man. Pulmonary Pharmacology and Therapeutics, 14, pp. 99-105.

Chalmers, G., Komai-Koma, M., Liew, F., Mckay, A., McSharry, C., Thomson, L. and Thomson, N. (2001) Immuno-regulatory cytokines in asthma: IL-15 and IL-13 in induced sputum. Clinical and Experimental Allergy, 31, pp. 1441-1448.

Chalmers, G., MacLeod, K., Thomson, L., Little, S., McSharry, C. and Thomson, N. (2001) Smoking and airway inflammation in patients with mild asthma. Chest, 120(6), pp. 1917-1922.

2000

Tan, K. S. and Thomson, N. C. (2000) Asthma in pregnancy. American Journal of Medicine, 109(9), pp. 727-733. (doi: 10.1016/S0002-9343(00)00615-X)

Articles

Shek, N. et al. (2024) Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), 15. (doi: 10.1038/s41514-024-00143-7) (PMID:38413600) (PMCID:PMC10899634)

Thomson, N. C., Polosa, R. and Sin, D. D. (2022) Cigarette smoking and asthma. Journal of Allergy and Clinical Immunology: In Practice, 10(11), pp. 2783-2797. (doi: 10.1016/j.jaip.2022.04.034) (PMID:35533997)

Thomson, N. C. (2022) Frequent exacerbators in severe asthma: focus on clinical and transcriptional factors. Clinical and Translational Medicine, 12(5), e860. (doi: 10.1002/ctm2.860) (PMID:35538891) (PMCID:PMC9091991)

Thomson, N. C. (2021) Asthma with a smoking history and pre–chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 204(1), pp. 109-110. (doi: 10.1164/rccm.202102-0440le) (PMID:33831325) (PMCID:PMC8437125)

Portelli, M. A. et al. (2020) Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI Insight, 5(8), e132446. (doi: 10.1172/jci.insight.132446) (PMID:32324168) (PMCID:PMC7205441)

Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)

Thomson, N. C. (2018) Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities. Current Opinion in Pharmacology, 40, pp. 1-8. (doi: 10.1016/j.coph.2017.11.013) (PMID:29223018)

Thomson, N. C. (2018) Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD. Respirology, 23(5), pp. 446-447. (doi: 10.1111/resp.13246) (PMID:29316060)

Thomson, N. C. (2018) Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties. Expert Review of Respiratory Medicine, 12(4), pp. 269-282. (doi: 10.1080/17476348.2018.1444991) (PMID:29471685)

Thomson, N. C. and Chanez, P. (2017) How effective is bronchial thermoplasty for severe asthma in clinical practice? European Respiratory Journal, 50(2), 1701140. (doi: 10.1183/13993003.01140-2017) (PMID:28860271) (PMCID:PMC5593391)

Thomson, N. C. (2017) Asthma and smoking-induced airway disease without spirometric COPD. European Respiratory Journal, 49(5), 1602061. (doi: 10.1183/13993003.02061-2016) (PMID:28461294)

Thomson, N. C. (2017) New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma. Expert Opinion on Pharmacotherapy, 18(3), pp. 283-293. (doi: 10.1080/14656566.2017.1284794) (PMID:28099820)

Johnston, S. L. et al. (2016) Azithromycin for acute exacerbations of asthma : The AZALEA randomized clinical trial. JAMA Internal Medicine, 176(11), pp. 1630-1637. (doi: 10.1001/jamainternmed.2016.5664)

Huang, J. T.J., Bolton, C. E., Miller, B. E., Tal-Singer, R., Rabinovich, R. A., Palmer, C. N.A., Thomson, N. C. and MacNee, W. (2016) Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease. European Respiratory Journal, 48(4), pp. 1215-1218. (doi: 10.1183/13993003.01125-2016) (PMID:27587547)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Thomson, N. C. (2016) Does age of onset of asthma influence the effect of cigarette smoking on lung function? American Journal of Respiratory and Critical Care Medicine, 194(3), pp. 249-250. (doi: 10.1164/rccm.201602-0389ED) (PMID:27479055)

Marsden, P. A., Satia, I., Ibrahim, B., Woodcock, A., Yates, L., Donnelly, I., Jolly, L., Thomson, N., Fowler, S. J. and Smith, J. A. (2016) Objective cough frequency, airway inflammation, and disease control in asthma. Chest, 149(6), pp. 1460-1466. (doi: 10.1016/j.chest.2016.02.676) (PMID:26973014)

Thomson, N. C. (2016) Novel approaches to the management of noneosinophilic asthma. Therapeutic Advances in Respiratory Disease, 10(3), pp. 211-234. (doi: 10.1177/1753465816632638) (PMID:26929306)

Morrison, D. , Wyke, S. , Saunderson, K., McConnachie, A. , Agur, K., Chaudhuri, R. , Thomas, M., Thomson, N.C., Yardley, L. and Mair, F.S. (2016) Findings from a pilot randomised trial of an asthma internet self-management intervention (RAISIN). BMJ Open, 6(5), e009254. (doi: 10.1136/bmjopen-2015-009254) (PMID:27173807) (PMCID:PMC4874112)

Thomson, N. C. (2016) Addressing corticosteroid insensitivity in adults with asthma. Expert Review of Respiratory Medicine, 10(2), pp. 137-156. (doi: 10.1586/17476348.2016.1133304) (PMID:26678267)

Artigas, M. S. et al. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, 8658. (doi: 10.1038/ncomms9658) (PMID:26635082) (PMCID:PMC4686825)

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Thomson, N. C. (2015) Reliever inhaler overuse, asthma symptoms, and depression. Journal of Allergy and Clinical Immunology: In Practice, 3(6), pp. 963-964. (doi: 10.1016/j.jaip.2015.07.002) (PMID:26553619)

Gaga, M., Brand, P. and Thomson, N. (2015) The quest for the grail: multidimensional efforts for understanding and targeting severe asthma. European Respiratory Journal, 46(5), pp. 1227-1231. (doi: 10.1183/13993003.01414-2015) (PMID:26521270)

Wain, L. V. et al. (2015) Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respiratory Medicine, 3(10), pp. 769-781. (doi: 10.1016/s2213-2600(15)00283-0) (PMID:26423011) (PMCID:PMC4593935)

Morrison, D. , Mair, F. S. , Chaudhuri, R. , McGee-Lennon, M., Thomas, M., Thomson, N. C., Yardley, L. and Wyke, S. (2015) Details of development of the resource for adults with asthma in the RAISIN (randomized trial of an asthma internet self-management intervention) study. BMC Medical Informatics and Decision Making, 15, 57. (doi: 10.1186/s12911-015-0177-z)

Thomson, N. C., McSharry, C. and Chaudhuri, R. (2015) Response. CHEST Journal, 148(1), e33-e34. (doi: 10.1378/chest.15-0890) (PMID:26149566)

Thomson, N. C., Chaudhuri, R. , Spears, M., Haughney, J. and McSharry, C. (2015) Serum periostin in smokers and never smokers with asthma. Respiratory Medicine, 109(6), pp. 708-715. (doi: 10.1016/j.rmed.2015.03.009) (PMID:PMID:25869)

McSharry, C., Vesper, S., Wymer, L., Howieson, S., Chaudhuri, R. , Wright, G. R. and Thomson, N.C. (2015) Decreased FEV1% in asthmatic adults in Scottish homes with high environmental relative moldiness index values. Clinical and Experimental Allergy, 45(5), pp. 902-907. (doi: 10.1111/cea.12482) (PMID:25580663)

Thomson, N. C., Charron, C. E., Chaudhuri, R. , Spears, M., Ito, K. and McSharry, C. (2015) Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma. Pulmonary Pharmacology and Therapeutics, 31, pp. 1-8. (doi: 10.1016/j.pupt.2015.01.001) (PMID:25595138)

Thomson, N. C., Chaudhuri, R. , Spears, M., Messow, C.-M. , MacNee, W., Connell, M., Murchison, J. T., Sproule, M. and McSharry, C. (2015) Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma. Chest, 147(3), p. 735. (doi: 10.1378/chest.14-1119) (PMID:25356950)

McSharry, C., Spears, M., Chaudhuri, R. , Cameron, E. J., Husi, H. and Thomson, N. C. (2014) Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. Journal of Allergy and Clinical Immunology, 134(5), pp. 1068-1075. (doi: 10.1016/j.jaci.2014.08.022) (PMID:25262463)

Chaudhuri, R. et al. (2014) Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma. European Respiratory Journal, 44(4), pp. 895-904. (doi: 10.1183/09031936.00047014)

Djukanović, R. et al. (2014) The effect of Inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. American Journal of Respiratory and Critical Care Medicine, 190(2), pp. 145-154. (doi: 10.1164/rccm.201312-2235OC)

Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)

Thomson, N.C. (2014) Novel therapies targeting eosinophilic inflammation in asthma. Clinical and Experimental Allergy, 44(4), pp. 462-468. (doi: 10.1111/cea.12268)

Arron, J.R. et al. (2014) Disconnect between sputum neutrophils and other measures of airway inflammation in asthma. European Respiratory Journal, 43(2), pp. 627-629. (doi: 10.1183/09031936.00117013)

Chaudhuri, R. , Norris, V., Kelly, K., Zhu, C.-Q., Ambery, C., Lafferty, J., Cameron, E. and Thomson, N.C. (2014) Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils. Pulmonary Pharmacology and Therapeutics, 27(1), pp. 62-69. (doi: 10.1016/j.pupt.2013.11.007)

Morrison, D. , Wyke, S. , Agur, K., Cameron, E., Docking, R., MacKenzie, A., McConnachie, A. , Raghuvir, V., Thomson, N. and Mair, F. (2014) Digital Asthma Self-Management Interventions: A Systematic Review. Journal of Medical Internet Research, 16(2), e51. (doi: 10.2196/jmir.2814)

Morrison, D. , Wyke, S. , Thomson, N. C., McConnachie, A. , Agur, K., Saunderson, K., Chaudhuri, R. and Mair, F. S. (2014) A randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial. Trials, 15, p. 185. (doi: 10.1186/1745-6215-15-185) (PMID:24884722)

Wechsler, M.E. et al. (2013) Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma. Journal of Allergy and Clinical Immunology, 132(6), 1295-1302.e3. (doi: 10.1016/j.jaci.2013.08.009)

Cameron, E.J. et al. (2013) Randomised controlled trial of azithromycin in smokers with asthma. European Respiratory Journal, 42(5), pp. 1412-1415. (doi: 10.1183/09031936.00093913)

Pavord, I.D., Thomson, N.C., Niven, R.M., Corris, P.A., Chung, K.F., Cox, G., Armstrong, B., Shargill, N.S. and Laviolette, M. (2013) Safety of bronchial thermoplasty in patients with severe refractory asthma. Annals of Allergy, Asthma and Immunology, 111(5), pp. 402-407. (doi: 10.1016/j.anai.2013.05.002)

Thomson, N.C., Chaudhuri, R. , Messow, C.M. , Spears, M., MacNee, W., Connell, M., Murchison, J.T., Sproule, M. and McSharry, C. (2013) Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Respiratory Medicine, 107(10), pp. 1501-1508. (doi: 10.1016/j.rmed.2013.07.017)

Thomson, N.C., Chaudhuri, R. , Heaney, L., Bucknall, C., Niven, R.M., Brightling, C.E., Menzies-Gow, A., Mansur, A.H. and McSharry, C. (2013) Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. Journal of Allergy and Clinical Immunology, 131(4), pp. 1008-1016. (doi: 10.1016/j.jaci.2012.12.1574)

Polosa, R. and Thomson, N.C. (2013) Smoking and asthma: dangerous liaisons. European Respiratory Journal, 41(3), pp. 716-726. (doi: 10.1183/09031936.00073312)

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R. , Thomson, N. C., Palmer, C. N.A., Devereux, G. and Huang, J. T.-J. (2013) Characterization and validation of an isotope-dilution LC–MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis, 5(16), pp. 1991-2001. (doi: 10.4155/BIO.13.164)

Spears, M., McSharry, C., Chaudhuri, R. , Weir, C.J., de Wet, C. and Thomson, N.C. (2013) Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study. PLoS ONE, 8(8), e71460. (doi: 10.1371/journal.pone.0071460) (PMID:23951170) (PMCID:PMC3739804)

Salmond, R.J., Mirchandani, A.S., Besnard, A.-G., Bain, C.C., Thomson, N.C. and Liew, F.Y. (2012) IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of rapamycin. Journal of Allergy and Clinical Immunology, 130(5), pp. 1159-1166. (doi: 10.1016/j.jaci.2012.05.018)

Komai-Koma, M. et al. (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67(9), pp. 1118-1126. (doi: 10.1111/j.1398-9995.2012.02859.x) (PMID:22702477) (PMCID:PMC3660789)

Thomson, N.C. and Spears, M. (2012) Asthma guidelines and smokers: it's time to be inclusive. Chest, 141(2), pp. 286-288. (doi: 10.1378/chest.11-1424)

Huang, J.T.-J. et al. (2012) Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax, 67(6), pp. 502-508. (doi: 10.1136/thoraxjnl-2011-200279)

Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)

Smith, A. and Thomson, N. (2012) Drugs that act on the respiratory tract. Side Effects of Drugs Annual, 34(2012), pp. 277-286. (doi: 10.1016/B978-0-444-59499-0.00016-7)

Thomson, N.C., Bicknell, S. and Chaudhuri, R. (2012) Bronchial thermoplasty for severe asthma. Current Opinion in Allergy and Clinical Immunology, 12(3), pp. 241-248. (doi: 10.1097/ACI.0b013e32835335ca)

Thomson, N.C. and Chaudhuri, R. (2012) Omalizumab: clinical use for the management of asthma. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 6, pp. 27-40. (doi: 10.4137/CCRPM.S7793)

Wan, Y.I. et al. (2012) Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 67(9), pp. 762-768. (doi: 10.1136/thoraxjnl-2011-201262)

Braganza, G. et al. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial. BMC Pulmonary Medicine, 11(16), (doi: 10.1186/1471-2466-11-16)

Patel, M. and Thomson, N.C. (2011) (R)-salbutamol in the treatment of asthma and chronic obstructive airways disease. Expert Opinion on Pharmacotherapy, 12(7), pp. 1133-1141. (doi: 10.1517/14656566.2011.571210)

Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)

Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E. and Thomson, N.C. (2011) Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma. Respiratory Medicine, 105(12), pp. 1823-1830. (doi: 10.1016/j.rmed.2011.06.014)

Thomson, N.C., Chaudhuri, R. and Spears, M. (2011) Emerging therapies for severe asthma. BMC Medicine, 9(1), p. 102. (doi: 10.1186/1741-7015-9-102)

Thomson, N.C. et al. (2011) Long term (5 Year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulmonary Medicine, 11(8), (doi: 10.1186/1471-2466-11-8)

Moffatt, M.F. et al. (2010) A large-scale, consortium-based genomewide association study of asthma. New England Journal of Medicine, 363, pp. 1211-1221.

Castro, M. et al. (2010) Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. American Journal of Respiratory and Critical Care Medicine, 181(2), pp. 116-124. (doi: 10.1164/rccm.200903-0354OC)

Spears, M., Cameron, E., Chaudhuri, R. and Thomson, N.C. (2010) Challenges of treating asthma in people who smoke. Expert Review of Clinical Immunology, 6(2), pp. 257-268. (doi: 10.1586/ECI.09.85)

Wright, G.R. et al. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy, 64(11), pp. 1671-1680. (doi: 10.1111/j.1398-9995.2009.02098.x)

Murphy, C., Blyth, K., Chaudhuri, R., Lafferty, J., Hothersall, E., Steedman, T., McSharry, C., Dargie, H. and Thomson, N. (2009) Assessment of the Presence of Occult Myocardial Infarction in Chronic Obstructive Pulmonary Disease Using Contrast-Enhanced Cardiac Magnetic Resonance Imaging. Respiration, 78(3), pp. 263-269.

Spears, M. et al. (2009) Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. European Respiratory Journal, 33(5), pp. 1010-1017. (doi: 10.1183/09031936.00158208)

Spears, M. et al. (2009) Bronchodilatory Effect of the PPAR-gamma Agonist Rosiglitazone in Smokers With Asthma. Clinical Pharmacology and Therapeutics, 86(1), pp. 49-53. (doi: 10.1038/clpt.2009.41)

Thomson, N. and Chaudhuri, R. (2009) Asthma in smokers: challenges and opportunities. Current Opinion in Pulmonary Medicine, 15(1), pp. 39-45.

Chaudhuri, R., McSharry, C., McCoard, A., Livingston, E., Hothersall, E., Spears, M., Lafferty, J. and Thomson, N. (2008) Role of symptoms and lung function in determining asthma control in smokers with asthma. Allergy, 63(1), pp. 132-135.

Hothersall, E. et al. (2008) Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax, 63(12), pp. 1070-1075. (doi: 10.1136/thx.2008.100198)

Pavord, I., Cox, G., Thomson, N., Rubin, A., Corris, P., Niven, R., Chung, K. and Laviolette, M. (2007) Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. American Journal of Respiratory and Critical Care Medicine, 176(12), pp. 1185-1191. (doi: 10.1164/rccm.200704-571OC)

Thomson, N. (2007) Smokers with asthma - What are the management options? American Journal of Respiratory and Critical Care Medicine, 175(8), pp. 749-750. (doi: 10.1164/rccm.200701-017ED)

Cox, G., Laviolette, M. and Thomson, N. (2007) Bronchial thermoplasty - Reply. New England Journal of Medicine, 356(26), p. 2745.

Cox, G. et al. (2007) Asthma control during the year after bronchial thermoplasty. New England Journal of Medicine, 356(13), pp. 1327-1337.

Livingston, E., Chaudhuri, R., McMahon, A. , Fraser, I., McSharry, C. and Thomson, N. (2007) Systemic sensitivity to corticosteroids in smokers with asthma. European Respiratory Journal, 29, pp. 64-70. (doi: 10.1183/09031936.06.00120505)

Thomson, N. (2007) The role of environmental tobacco smoke in the origins and progression of asthma. Current Allergy and Asthma Reports, 7, pp. 303-309.

Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P. and Thomson, N. C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), pp. 127-133. (doi: 10.1164/rccm.200510-1589OC)

Barnes, N., Qiu, Y., Pavord, I., Parker, D., Davis, P., Zhu, L., Johnson, M., Thomson, N. and Jeffery, P. (2006) Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. American Journal of Respiratory and Critical Care Medicine, 173(7), pp. 736-743. (doi: 10.1164/rccm.200508-1321OC)

Hothersall, E., McSharry, C. and Thomson, N. (2006) Potential therapeutic role for statins in respiratory disease. Thorax, 61, pp. 729-734. (doi: 10.1136/thx.2005.057976)

McSharry, C., Fraser, I., Chaudhuri, R., Anderson, K., Bourke, S., Thomson, N. and Boyd, G. (2006) Nerve growth factor in serum and lymphocyte culture in pigeon fanciers' acute hypersensitivity pneumonitis. Chest, 130(1), pp. 37-42. (doi: 10.1378/chest.130.1.37)

Spears, M. and Thomson, N. (2006) Factors Influencing Individual Variability in the Therapeutic Response to Corticosteroids in Asthma. Current Respiratory Medicine Reviews, 2, pp. 197-209.

Spears, M., McSharry, C. and Thomson, N.C. (2006) Peroxisome proliferator-activated receptor-? agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clinical and Experimental Allergy, 36(12), pp. 1494-1504. (doi: 10.1111/j.1365-2222.2006.02604.x)

Spears, M., McSharry, C. and Thomson, N.C. (2006) Peroxisome proliferator-activated receptor-7 agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clinical and Experimental Allergy, 36, pp. 1494-1504.

Thomson, N.C., Shepherd, M., Spears, M. and Chaudhuri, R. (2006) Corticosteroid Insensitivity in Smokers with Asthma: Clinical Evidence, Mechanisms, and Management. Treatments in Respiratory Medicine, 5(6), pp. 467-481.

Chaudhuri, R., McMahon, A. , McSharry, C., MacLeod, K., Fraser, I., Livingston, E. and Thomson, N. (2005) Serum and sputum neurotrophin levels in chronic persistent cough. Clinical and Experimental Allergy, 35, pp. 949-953. (doi: 10.1111/j.1365-2222.2005.02286.x)

Choo-Kang, B., Kewin, P., Liew, F., McSharry, C., Patel, M., Thomson, N. and Xu, D. (2005) Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. European Journal of Immunology, 35, pp. 3581-3590. (doi: 10.1002/eji.200535421)

Choo-Kang, B., Kewin, P., Liew, F., McSharry, C., Patel, M., Thomson, N. and Xu, D. (2005) TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. Journal of Immunology, 174, pp. 7558-7563.

Livingston, E., Thomson, N. and Chalmers, G. (2005) Impact of smoking on asthma therapy - A critical review of clinical evidence. Drugs, 65(11), pp. 1521-1536.

McSharry, C., Mckay, I., Chaudhuri, R., Livingston, E., Fraser, I. and Thomson, N. (2005) Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma. Journal of Allergy and Clinical Immunology, 116, pp. 88-93. (doi: 10.1016/j.jaci.2005.03.025)

Thomson, N.C. and Spears, M. (2005) The influence of smoking on the treatment response in patients with asthma. Current Opinion in Allergy and Clinical Immunology, 5, pp. 57-63.

Tomlinson, J., McMahon, A. , Chaudhuri, R., Thompson, J., Wood, S. and Thomson, N. (2005) Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax, 60, pp. 282-287. (doi: 10.1136/thx.2004.033688)

Thomson, N. C. and Chaudhuri, R. (2004) Why is eosinophilic bronchitis not asthma? American Journal of Respiratory and Critical Care Medicine, 170(1), pp. 4-5. (doi: 10.1164/rccm.2404005)

Chaudhuri, R., Livingston, E., Thomson, N., Ricciardolo, F. L.M. and Stefano, A. D. (2004) Corticosteroid resistance in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 169(11), pp. 1252-1253. (doi: 10.1164/ajrccm.169.11.950)

McKay, A., Leung, B.P., McInnes, I.B. , Thomson, N.C. and Liew, F.Y. (2004) A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. Journal of Immunology, 172(5), pp. 2903-2908. (doi: 10.4049/jimmunol.172.5.2903) (PMID:14978092)

Chaudhuri, R., McMahon, A. , Thomson, L., MacLeod, K., McSharry, C., Livingston, E., Mckay, A. and Thomson, N. (2004) Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. Journal of Allergy and Clinical Immunology, 113, pp. 1063-1070. (doi: 10.1016/j.jaci.2004.03.019)

Chaudhuri, R., Gibson, P.G., Livingston, E., McMahon, A.D. and Thomson, N.C. (2004) Smokers and ex-smokers with chronic stable asthma did not respond to high dose oral corticosteroids. Evidence-Based Medicine, 9(4), p. 115.

Hawkins, G., McMahon, A.D., Peters, J.I., Thomson, N.C. and Twaddle, S. (2004) Inhaled corticosteroid were safely stepped down in chronic, stable asthma. Evidence-Based Medicine, 9(1), p. 16.

Livingston, E., Darroch, C., Chaudhuri, R., McPhee, I., McMahon, A., MacKenzie, S. and Thomson, N. (2004) Glucocorticoid receptor alpha :beta ratio in blood mononuclear cells is reduced in cigarette smokers. Journal of Allergy and Clinical Immunology, 114(6), pp. 1475-1478.

Mckay, A., Komai-Koma, M., Mcleod, K., Thomson, L., Chaudhari, R., McSharry, C., Liew, F. and Thomson, N. (2004) Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers. Clinical and Experimental Allergy, 34, pp. 904-910. (doi: 10.1111/j.1365-2222.2004.01973.x)

Thomson, N., Chaudhuri, R. and Livingston, E. (2004) Asthma and cigarette smoking. European Respiratory Journal, 24, pp. 822-833. (doi: 10.1183/09031936.04.00039004)

Chaudhuri, R. , Livingston, E., McMahon, A. D., Thomson, L., Borland, W. and Thomson, N. C. (2003) Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. American Journal of Respiratory and Critical Care Medicine, 168(11), pp. 1308-1311. (doi: 10.1164/rccm.200304-503OC)

Ford, I., Hawkins, G., McMahon, A., Thomson, N., Twaddle, S. and Wood, S. (2003) Stepping down inhaled corticosteroids in asthma: randomised controlled trial.[see comment]. British Medical Journal, 326(7399), p. 1115.

Gracie, J., Komai-Koma, M., Liew, F., McInnes, I. , Thomson, N., Wei, X. and Xu, D. (2003) Chemoattraction of human T cells by IL-18. Journal of Immunology, 170, pp. 1084-1090. (doi: 10.4049/jimmunol.170.2.1084) (PMID:12517977)

Lalloo, U., Malolepszy, J., Kozma, D., Krofta, K., Ankerst, J., Johansen, B. and Thomson, N. (2003) Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma. Chest, 123, pp. 1480-1487.

Livingston, E. and Thomson, N. (2003) Managing chronic obstructive pulmonary disease. Practitioner, 247, pp. 289-304.

Thomson, N., Chaudhuri, R. and Livingston, E. (2003) Active cigarette smoking and asthma. Clinical and Experimental Allergy, 33(11), pp. 1471-1475.

Thomson, N. and Shepherd, M. (2003) Leukotriene receptor antagonists as add-on therapy tor adults with asthma. Thorax, 58(3), pp. 190-192.

Little, S.A., Sproule, M.W., Cowan, M.D., Macleod, K.J., Robertson, M., Love, J.G., Chalmers, G.W., McSharry, C. and Thomson, N. (2002) High resolution computed tomography assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax, 57(3), pp. 247-253. (doi: 10.1136/thorax.57.3.247)

Chalmers, G., MacLeod, K., Little, S., Thomson, L., McSharry, C. and Thomson, N. (2002) Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax, 57, pp. 226-230.

Little, S., Sproule, M., Cowan, M., MacLeod, K., Robertson, M., Love, J., Chalmers, G., McSharry, C. and Thomson, N. (2002) High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax, 57, pp. 247-253.

Chalmers, G., Clayton, R., Dagg, K., McGrath, J. , Thomson, L. and Thomson, N. (2001) The effect of acute alteration in oxygen tension on the bronchodilator response to salbutamol in vitro and in vivo in man. Pulmonary Pharmacology and Therapeutics, 14, pp. 99-105.

Chalmers, G., Komai-Koma, M., Liew, F., Mckay, A., McSharry, C., Thomson, L. and Thomson, N. (2001) Immuno-regulatory cytokines in asthma: IL-15 and IL-13 in induced sputum. Clinical and Experimental Allergy, 31, pp. 1441-1448.

Chalmers, G., MacLeod, K., Thomson, L., Little, S., McSharry, C. and Thomson, N. (2001) Smoking and airway inflammation in patients with mild asthma. Chest, 120(6), pp. 1917-1922.

Tan, K. S. and Thomson, N. C. (2000) Asthma in pregnancy. American Journal of Medicine, 109(9), pp. 727-733. (doi: 10.1016/S0002-9343(00)00615-X)

Book Sections

Cowan, D. , Smith, A. and Thomson, N. (2014) Drugs that act on the respiratory tract. In: Aronson, J. K. (ed.) Side Effects of Drugs Annual 35. Series: Side Effects of Drugs Annual, 35. Elsevier, pp. 309-326. ISBN 9780444626356 (doi: 10.1016/b978-0-444-62635-6.00016-4)

Conference Proceedings

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2008) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased local Th2 cytokine and chemokine production. In: Scottish Thoracic Society Meeting, Stirling, UK, 26 Oct 2007, p. 50. (doi: 10.1258/rsmsmj.53.2.48)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2007) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased ST2 dependent local Th2 cytokine and chemokine production. In: Winter Meeting of the British-Thoracic-Society, London, UK, 05-07 Dec 2007, A1.