Professor Lilach Sheiner

  • Professor (Parasitology)

telephone: +44 (0) 141 330 4797
email: Lilach.Sheiner@glasgow.ac.uk

Ri Iii, 120 University Place, Glasgow, G12 8ta

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-5909-2307

Biography

Research interests

Professor Lilach Sheiner is an expert in eukaryotic parasite cell biology and have been researching apicomplexan parasites (causing e.g. Toxoplasmosis and malaria) since 2005. 

Professor Sheiner's research team aims to understand fundamental mechanisms that underpin parasite survival and virulence and that are divergent from any parallel processes in human and animal. The team’s research is mainly focus on the biology, function and biogenesis of the organelles of endosymbiotic origin - the highly divergent parasite mitochondrion, and the unique parasite plastid (apicoplast). The team is mainly using T. gondii (the causative agent of toxoplasmosis) as a model organism, and recently commenced work with the malaria parasites, Plasmodium spp. 

Lilach and her team developed some of the most widely used tools for Toxoplasma cell biology research1,2 and made substantial contribution to the understanding of the apicoplast (read more). The team is one of the pioneers of Toxoplasma mitochondrial research, who developed critical tools for these studies3,4 and who is making exciting discoveries about parasite mitochondrial biology (read more).

Selected publications

  1. Lilach Sheiner, Jessica L. Demerly, Nicole Poulsen, Wandy L. Beatty, Olivier Lucas, Michael S. Behnke, Michael W. White, Boris Striepen. Published: December 1, 2011 https://doi.org/10.1371/journal.ppat.1002392
  2. Damien Jacot, Sebastian Lourido, Markus Meissner, Lilach Sheiner, Dominique Soldati-Favre, Boris Striepen. Available online 13 March 2020. https://doi.org/10.1016/B978-0-12-815041-2.00020-7
  3. Identification of the Toxoplasma gondii mitochondrial ribosome and characterisation of a protein essential for mitochondrial translation. Lacombe A., Maclean AE., Ovciarikova J., Tottey J., Mühleip A., Fernandes P., Sheiner L. Mol Microbiol. 2019 Oct112(4):1235-1252. doi: 10.1111/mmi.14357.
  4. Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex.Maclean AE., Bridges HR., Silva MF., Ding S., Ovciarikova J., Hirst J., Sheiner L. PLoS Pathog. 2021 Mar 217(3):e1009301. doi: 10.1371/journal.ppat.1009301

 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007
Number of items: 46.

2024

Sheokand, P. K., Pradhan, S., MacLean, A. E., Mühleip, A. and Sheiner, L. (2024) Plasmodium falciparum mitochondrial complex III, the target of atovaquone, is essential for progression to the transmissible sexual stages. International Journal of Molecular Sciences, 25(17), 9239. (doi: 10.3390/ijms25179239)

Maclean, A. E., Sloan, M. A. , Renaud, E. A., Argyle, B. E., Lewis, W. H., Ovciarikova, J., Demolombe, V., Waller, R. F., Besteiro, S. and Sheiner, L. (2024) The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. mBio, (doi: 10.1128/mbio.00872-24) (PMID:39207139) (Early Online Publication)

Ovciarikova, J. et al. (2024) Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. Journal of Cell Biology, 223(4), e202304075. (doi: 10.1083/jcb.202304075) (PMID:38456969)

2023

Elati, H. A.A. , Goerner, A. L., Martorelli Di Genova, B., Sheiner, L. and De Koning, H. P. (2023) Pyrimidine salvage in Toxoplasma gondii as a target for new treatment. Frontiers in Cellular and Infection Microbiology, 13, 1320160. (doi: 10.3389/fcimb.2023.1320160) (PMID:38162577) (PMCID:PMC10755004)

F. Silva, M., Douglas, K., Sandalli, S., MacLean, A. E. and Sheiner, L. (2023) Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex. PLoS Pathogens, 19(12), e1011867. (doi: 10.1371/journal.ppat.1011867) (PMID:38079448) (PMCID:PMC10735183)

2022

MacLean, A. E., Hayward, J. A., Huet, D., van Dooren, G. G. and Sheiner, L. (2022) The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain. Trends in Parasitology, 38(12), pp. 1041-1052. (doi: 10.1016/j.pt.2022.09.008) (PMID:36302692) (PMCID:PMC10434753)

Walsh, D., Katris, N. J., Sheiner, L. and Botté, C. Y. (2022) Toxoplasma metabolic flexibility in different growth conditions. Trends in Parasitology, 38(9), pp. 775-790. (doi: 10.1016/j.pt.2022.06.001) (PMID:35718642)

Ovciarikova, J., Oliveira Souza, R. O., Arrizabalaga, G. and Sheiner, L. (2022) Protein control of membrane and organelle dynamics: insights from the divergent eukaryote Toxoplasma gondii. Current Opinion in Cell Biology, 76, 102085. (doi: 10.1016/j.ceb.2022.102085) (PMID:35569259) (PMCID:PMC9586877)

Ovciarikova, J., Shikha, S. and Sheiner, L. (2022) Nuclear interactions: a spotlight on nuclear mitochondrial membrane contact sites. Contact, 5, p. 25152564221096217. (doi: 10.1177/25152564221096217) (PMID:36338149) (PMCID:PMC9623421)

Shikha, S., Ferreira Silva, M. and Sheiner, L. (2022) Identification and validation of Toxoplasma gondii mitoribosomal large subunit components. Microorganisms, 10(5), 863. (doi: 10.3390/microorganisms10050863) (PMID:35630308) (PMCID:PMC9145746)

Campagnaro, G. D., Elati, H. A. A. , Balaska, S., Martin Abril, M. E., Natto, M. J., Hulpia, F., Lee, K., Sheiner, L. , Van Calenbergh, S. and de Koning, H. P. (2022) A Toxoplasma gondii oxopurine transporter binds nucleobases and nucleosides using different binding modes. International Journal of Molecular Sciences, 23(2), 710. (doi: 10.3390/ijms23020710) (PMID:35054895) (PMCID:PMC8776092)

2021

Mallo, N. et al. (2021) Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the ER. Journal of Cell Science, 134(20), jcs255299. (doi: 10.1242/jcs.255299) (PMID:34523684) (PMCID:PMC8572010)

Richtová, J., Sheiner, L. , Gruber, A., Yang, S.-M., Kořený, L., Striepen, B. and Oborník, M. (2021) Using diatom and apicomplexan models to study the heme pathway of Chromera velia. International Journal of Molecular Sciences, 22(12), 6495. (doi: 10.3390/ijms22126495) (PMID:34204357) (PMCID:PMC8233740)

Biddau, M. et al. (2021) Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes. International Journal for Parasitology, 51(6), pp. 441-453. (doi: 10.1016/j.ijpara.2020.10.011) (PMID:33713652) (PMCID:PMC8126644)

Rama, J.-L. R., Mallo, N., Biddau, M. , Fernandes, F., de Miguel, T., Sheiner, L. , Choupina, A. and Lores, M. (2021) Exploring the powerful phytoarsenal of white grape marc against bacteria and parasites causing significant diseases. Environmental Science and Pollution Research, 28(19), pp. 24270-24278. (doi: 10.1007/s11356-019-07472-1) (PMID:31939019)

Maclean, A. E., Bridges, H. R., F. Silva, M., Ding, S., Ovciarikova, J., Hirst, J. and Sheiner, L. (2021) Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex. PLoS Pathogens, 17(3), e1009301. (doi: 10.1371/journal.ppat.1009301) (PMID:33651838) (PMCID:PMC7987180)

Mühleip, A., Kock Flygaard, R., Ovciarikova, J., Lacombe, A., Fernandes, P., Sheiner, L. and Amunts, A. (2021) ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria. Nature Communications, 12, 120. (doi: 10.1038/s41467-020-20381-z) (PMID:33402698) (PMCID:PMC7785744)

2020

Biddau, M. , Ovciarikova, J. and Sheiner, L. (2020) Experimental approaches for examining apicoplast biology. In: Tonkin, C. J. (ed.) Toxoplasma gondii: Methods and Protocols. Series: Methods in molecular biology (2071). Humana Press: New York, NY, pp. 221-243. ISBN 9781493998562 (doi: 10.1007/978-1-4939-9857-9_13)

2019

Lacombe, A., Maclean, A. E., Ovciarikova, J., Tottey, J., Mühleip, A., Fernandes, P. and Sheiner, L. (2019) Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation. Molecular Microbiology, 112(4), pp. 1235-1252. (doi: 10.1111/mmi.14357) (PMID:31339607) (PMCID:PMC6851545)

Sheiner, L. and Harb, O. S. (2019) MeBoP: advanced training in the biology of parasitism for Middle Eastern students. Trends in Parasitology, 35(5), pp. 329-332. (doi: 10.1016/j.pt.2019.03.001) (PMID:30948350)

Melatti, C., Pieperhoff, M., Lemgruber, L. , Pohl, E., Sheiner, L. and Meissner, M. (2019) A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. PLoS Pathogens, 15(4), e1007512. (doi: 10.1371/journal.ppat.1007512) (PMID:30947298) (PMCID:PMC6448817)

Biddau, M. and Sheiner, L. (2019) Targeting the apicoplast in malaria. Biochemical Society Transactions, 47(4), pp. 973-983. (doi: 10.1042/BST20170563) (PMID:31383817)

2018

Mbekeani, A. J., Stanley, W. A., Kalel, V. C., Dahan, N., Zalckvar, E., Sheiner, L. , Schliebs, W., Erdmann, R., Pohl, E. and Denny, P. W. (2018) Functional analyses of a putative, membrane-bound, peroxisomal protein import mechanism from the apicomplexan protozoan Toxoplasma gondii. Genes, 9(9), 434. (doi: 10.3390/genes9090434) (PMID:30158461) (PMCID:PMC6162456)

Mallo, N., Fellows, J., Johnson, C. and Sheiner, L. (2018) Protein import into the endosymbiotic organelles of apicomplexan parasites. Genes, 9(8), 412. (doi: 10.3390/genes9080412) (PMID:30110980) (PMCID:PMC6115763)

Biddau, M. et al. (2018) Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii. PLoS Pathogens, 14(2), e1006836. (doi: 10.1371/journal.ppat.1006836) (PMID:29470517) (PMCID:PMC5823475)

2017

Ovciarikova, J., Lemgruber, L. , Stilger, K. L., Sullivan, W. J. and Sheiner, L. (2017) Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii. Scientific Reports, 7, 42746. (doi: 10.1038/srep42746) (PMID:28202940) (PMCID:PMC5311943)

2015

Sheiner, L. et al. (2015) Toxoplasma gondii Toc75 functions in import of stromal but not peripheral apicoplast proteins. Traffic, 16(12), pp. 1254-1269. (doi: 10.1111/tra.12333) (PMID:26381927)

Williams, M. J., Alonso, H., Enciso, M., Egarter, S., Sheiner, L. , Meissner, M. , Striepen, B., Smith, B. J. and Tonkin, C. J. (2015) Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility. mBio, 6(5), e00845-15. (doi: 10.1128/mBio.00845-15) (PMID:26374117) (PMCID:PMC4600101)

2014

Daher, W., Morlon-Guyot, J., Sheiner, L. , Lentini, G., Berry, L., Tawk, L., Dubremetz, J.-F., Wengelnik, K., Striepen, B. and Lebrun, M. (2014) Lipid kinases are essential for apicoplast homeostasis inToxoplasma gondii. Cellular Microbiology, 17(4), pp. 559-578. (doi: 10.1111/cmi.12383)

Jacot, D., Meissner, M. , Sheiner, L. , Soldati-Favre, D. and Striepen, B. (2014) Genetic manipulation of toxoplasma gondii. In: Weiss, L.M. and Kim, K. (eds.) Toxoplasma Gondii. Elsevier Academic Press: Burlington, VT, pp. 577-611. ISBN 9780123965363 (doi: 10.1016/B978-0-12-396481-6.00017-9)

Sheiner, L. and Striepen, B. (2014) The apicoplast: a parasite’s symbiont. In: Theg, S. M. and Wollman, F.-A. (eds.) Plastid Biology. Series: Advances in plant biology (5). Springer New York: New York, pp. 209-238. ISBN 9781493911356 (doi: 10.1007/978-1-4939-1136-3_8)

2013

Sheiner, L. , Vaidya, A.B. and McFadden, G.I. (2013) The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. Current Opinion in Microbiology, 16(4), pp. 452-458. (doi: 10.1016/j.mib.2013.07.003)

Sheiner, L. and Striepen, B. (2013) Protein sorting in complex plastids. Biochimica et Biophysica Acta: Molecular Cell Research, 1833(2), pp. 352-359. (doi: 10.1016/j.bbamcr.2012.05.030)

2012

Francia, M.E., Jordan, C.N., Patel, J.D., Sheiner, L. , Demerly, J.L., Fellows, J.D., de Leon, J.C., Morrissette, N.S., Dubremetz, J.-F. and Striepen, B. (2012) Cell division in apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biology, 10(12), e1001444. (doi: 10.1371/journal.pbio.1001444) (PMID:23239939)

MacRae, J.I., Sheiner, L. , Nahid, A., Tonkin, C., Striepen, B. and McConville, M.J. (2012) Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host and Microbe, 12(5), pp. 682-692. (doi: 10.1016/j.chom.2012.09.013)

Sampels, V., Hartmann, A., Dietrich, I., Coppens, I., Sheiner, L. , Striepen, B., Herrmann, A., Lucius, R. and Gupta, N. (2012) Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. Journal of Biological Chemistry, 287(20), pp. 16289-16299. (doi: 10.1074/jbc.M112.347138)

2011

Sheiner, L. , Demerly, J.L., Poulsen, N., Beatty, W.L., Lucas, O., Behnke, M.S., White, M.W. and Striepen, B. (2011) A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor. PLoS Pathogens, 7(12), e1002392. (doi: 10.1371/journal.ppat.1002392)

2010

Agrawal, S., Nair, S., Sheiner, L. and Striepen, B. (2010) The Apicoplast: An ancient algal endosymbiont of Apicomplexa. In: de Souza, W. (ed.) Structures and Organelles in Pathogenic Protists. Series: Microbiology monographs (17). Springer. ISBN 9783642128639

Lorestani, A., Sheiner, L. , Yang, K., Robertson, S.D., Sahoo, N., Brooks, C.F., Ferguson, D.J.P., Striepen, B. and Gubbels, M.-J. (2010) A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis. PLoS ONE, 5(8), e12302. (doi: 10.1371/journal.pone.0012302) (PMID:20808817) (PMCID:PMC2924399)

Pino, P., Aeby, E., Foth, B.J., Sheiner, L. , Soldati, T., Schneider, A. and Soldati-Favre, D. (2010) Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNAMet formylation in Apicomplexa. Molecular Microbiology, 76(3), pp. 706-718. (doi: 10.1111/j.1365-2958.2010.07128.x)

Sheiner, L. , Santos, J.M., Klages, N., Parussini, F., Jemmely, N., Friedrich, N., Ward, G.E. and Soldati-Favre, D. (2010) Toxoplasma gondii transmembrane microneme proteins and their modular design. Molecular Microbiology, 77(4), pp. 912-929. (doi: 10.1111/j.1365-2958.2010.07255.x)

2008

Sheiner, L. , Dowse, T.J. and Soldati-Favre, D. (2008) Identification of trafficking determinants for polytopic rhomboid proteases in toxoplasma gondii. Traffic, 9(5), pp. 665-677. (doi: 10.1111/j.1600-0854.2008.00736.x)

Goldshmidt, H., Sheiner, L. , Butikofer, P., Roditi, I., Uliel, S., Gunzel, M., Engstler, M. and Michaeli, S. (2008) Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei. Journal of Biological Chemistry, 283(46), pp. 32085-32098. (doi: 10.1074/jbc.M801499200)

Sheiner, L. and Soldati-Favre, D. (2008) Protein trafficking inside Toxoplasma gondii. Traffic, 9(5), pp. 636-646. (doi: 10.1111/j.1600-0854.2008.00713.x)

2007

Lustig, Y., Sheiner, L. , Vagima, Y., Goldshmidt, H., Das, A., Bellofatto, V. and Michaeli, S. (2007) Spliced-leader RNA silencing: a novel stress-induced mechanism in Trypanosoma brucei. EMBO Reports, 8(4), pp. 408-413. (doi: 10.1038/sj.embor.7400930)

Pino, P., Foth, B.J., Kwok, L.-Y., Sheiner, L. , Schepers, R., Soldati, T. and Soldati-Favre, D. (2007) Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii. PLoS Pathogens, 3(8), e115. (doi: 10.1371/journal.ppat.0030115)

This list was generated on Thu Nov 7 21:14:17 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 46.

Articles

Sheokand, P. K., Pradhan, S., MacLean, A. E., Mühleip, A. and Sheiner, L. (2024) Plasmodium falciparum mitochondrial complex III, the target of atovaquone, is essential for progression to the transmissible sexual stages. International Journal of Molecular Sciences, 25(17), 9239. (doi: 10.3390/ijms25179239)

Maclean, A. E., Sloan, M. A. , Renaud, E. A., Argyle, B. E., Lewis, W. H., Ovciarikova, J., Demolombe, V., Waller, R. F., Besteiro, S. and Sheiner, L. (2024) The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. mBio, (doi: 10.1128/mbio.00872-24) (PMID:39207139) (Early Online Publication)

Ovciarikova, J. et al. (2024) Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. Journal of Cell Biology, 223(4), e202304075. (doi: 10.1083/jcb.202304075) (PMID:38456969)

Elati, H. A.A. , Goerner, A. L., Martorelli Di Genova, B., Sheiner, L. and De Koning, H. P. (2023) Pyrimidine salvage in Toxoplasma gondii as a target for new treatment. Frontiers in Cellular and Infection Microbiology, 13, 1320160. (doi: 10.3389/fcimb.2023.1320160) (PMID:38162577) (PMCID:PMC10755004)

F. Silva, M., Douglas, K., Sandalli, S., MacLean, A. E. and Sheiner, L. (2023) Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex. PLoS Pathogens, 19(12), e1011867. (doi: 10.1371/journal.ppat.1011867) (PMID:38079448) (PMCID:PMC10735183)

MacLean, A. E., Hayward, J. A., Huet, D., van Dooren, G. G. and Sheiner, L. (2022) The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain. Trends in Parasitology, 38(12), pp. 1041-1052. (doi: 10.1016/j.pt.2022.09.008) (PMID:36302692) (PMCID:PMC10434753)

Walsh, D., Katris, N. J., Sheiner, L. and Botté, C. Y. (2022) Toxoplasma metabolic flexibility in different growth conditions. Trends in Parasitology, 38(9), pp. 775-790. (doi: 10.1016/j.pt.2022.06.001) (PMID:35718642)

Ovciarikova, J., Oliveira Souza, R. O., Arrizabalaga, G. and Sheiner, L. (2022) Protein control of membrane and organelle dynamics: insights from the divergent eukaryote Toxoplasma gondii. Current Opinion in Cell Biology, 76, 102085. (doi: 10.1016/j.ceb.2022.102085) (PMID:35569259) (PMCID:PMC9586877)

Ovciarikova, J., Shikha, S. and Sheiner, L. (2022) Nuclear interactions: a spotlight on nuclear mitochondrial membrane contact sites. Contact, 5, p. 25152564221096217. (doi: 10.1177/25152564221096217) (PMID:36338149) (PMCID:PMC9623421)

Shikha, S., Ferreira Silva, M. and Sheiner, L. (2022) Identification and validation of Toxoplasma gondii mitoribosomal large subunit components. Microorganisms, 10(5), 863. (doi: 10.3390/microorganisms10050863) (PMID:35630308) (PMCID:PMC9145746)

Campagnaro, G. D., Elati, H. A. A. , Balaska, S., Martin Abril, M. E., Natto, M. J., Hulpia, F., Lee, K., Sheiner, L. , Van Calenbergh, S. and de Koning, H. P. (2022) A Toxoplasma gondii oxopurine transporter binds nucleobases and nucleosides using different binding modes. International Journal of Molecular Sciences, 23(2), 710. (doi: 10.3390/ijms23020710) (PMID:35054895) (PMCID:PMC8776092)

Mallo, N. et al. (2021) Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the ER. Journal of Cell Science, 134(20), jcs255299. (doi: 10.1242/jcs.255299) (PMID:34523684) (PMCID:PMC8572010)

Richtová, J., Sheiner, L. , Gruber, A., Yang, S.-M., Kořený, L., Striepen, B. and Oborník, M. (2021) Using diatom and apicomplexan models to study the heme pathway of Chromera velia. International Journal of Molecular Sciences, 22(12), 6495. (doi: 10.3390/ijms22126495) (PMID:34204357) (PMCID:PMC8233740)

Biddau, M. et al. (2021) Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes. International Journal for Parasitology, 51(6), pp. 441-453. (doi: 10.1016/j.ijpara.2020.10.011) (PMID:33713652) (PMCID:PMC8126644)

Rama, J.-L. R., Mallo, N., Biddau, M. , Fernandes, F., de Miguel, T., Sheiner, L. , Choupina, A. and Lores, M. (2021) Exploring the powerful phytoarsenal of white grape marc against bacteria and parasites causing significant diseases. Environmental Science and Pollution Research, 28(19), pp. 24270-24278. (doi: 10.1007/s11356-019-07472-1) (PMID:31939019)

Maclean, A. E., Bridges, H. R., F. Silva, M., Ding, S., Ovciarikova, J., Hirst, J. and Sheiner, L. (2021) Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex. PLoS Pathogens, 17(3), e1009301. (doi: 10.1371/journal.ppat.1009301) (PMID:33651838) (PMCID:PMC7987180)

Mühleip, A., Kock Flygaard, R., Ovciarikova, J., Lacombe, A., Fernandes, P., Sheiner, L. and Amunts, A. (2021) ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria. Nature Communications, 12, 120. (doi: 10.1038/s41467-020-20381-z) (PMID:33402698) (PMCID:PMC7785744)

Lacombe, A., Maclean, A. E., Ovciarikova, J., Tottey, J., Mühleip, A., Fernandes, P. and Sheiner, L. (2019) Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation. Molecular Microbiology, 112(4), pp. 1235-1252. (doi: 10.1111/mmi.14357) (PMID:31339607) (PMCID:PMC6851545)

Sheiner, L. and Harb, O. S. (2019) MeBoP: advanced training in the biology of parasitism for Middle Eastern students. Trends in Parasitology, 35(5), pp. 329-332. (doi: 10.1016/j.pt.2019.03.001) (PMID:30948350)

Melatti, C., Pieperhoff, M., Lemgruber, L. , Pohl, E., Sheiner, L. and Meissner, M. (2019) A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. PLoS Pathogens, 15(4), e1007512. (doi: 10.1371/journal.ppat.1007512) (PMID:30947298) (PMCID:PMC6448817)

Biddau, M. and Sheiner, L. (2019) Targeting the apicoplast in malaria. Biochemical Society Transactions, 47(4), pp. 973-983. (doi: 10.1042/BST20170563) (PMID:31383817)

Mbekeani, A. J., Stanley, W. A., Kalel, V. C., Dahan, N., Zalckvar, E., Sheiner, L. , Schliebs, W., Erdmann, R., Pohl, E. and Denny, P. W. (2018) Functional analyses of a putative, membrane-bound, peroxisomal protein import mechanism from the apicomplexan protozoan Toxoplasma gondii. Genes, 9(9), 434. (doi: 10.3390/genes9090434) (PMID:30158461) (PMCID:PMC6162456)

Mallo, N., Fellows, J., Johnson, C. and Sheiner, L. (2018) Protein import into the endosymbiotic organelles of apicomplexan parasites. Genes, 9(8), 412. (doi: 10.3390/genes9080412) (PMID:30110980) (PMCID:PMC6115763)

Biddau, M. et al. (2018) Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii. PLoS Pathogens, 14(2), e1006836. (doi: 10.1371/journal.ppat.1006836) (PMID:29470517) (PMCID:PMC5823475)

Ovciarikova, J., Lemgruber, L. , Stilger, K. L., Sullivan, W. J. and Sheiner, L. (2017) Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii. Scientific Reports, 7, 42746. (doi: 10.1038/srep42746) (PMID:28202940) (PMCID:PMC5311943)

Sheiner, L. et al. (2015) Toxoplasma gondii Toc75 functions in import of stromal but not peripheral apicoplast proteins. Traffic, 16(12), pp. 1254-1269. (doi: 10.1111/tra.12333) (PMID:26381927)

Williams, M. J., Alonso, H., Enciso, M., Egarter, S., Sheiner, L. , Meissner, M. , Striepen, B., Smith, B. J. and Tonkin, C. J. (2015) Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility. mBio, 6(5), e00845-15. (doi: 10.1128/mBio.00845-15) (PMID:26374117) (PMCID:PMC4600101)

Daher, W., Morlon-Guyot, J., Sheiner, L. , Lentini, G., Berry, L., Tawk, L., Dubremetz, J.-F., Wengelnik, K., Striepen, B. and Lebrun, M. (2014) Lipid kinases are essential for apicoplast homeostasis inToxoplasma gondii. Cellular Microbiology, 17(4), pp. 559-578. (doi: 10.1111/cmi.12383)

Sheiner, L. , Vaidya, A.B. and McFadden, G.I. (2013) The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. Current Opinion in Microbiology, 16(4), pp. 452-458. (doi: 10.1016/j.mib.2013.07.003)

Sheiner, L. and Striepen, B. (2013) Protein sorting in complex plastids. Biochimica et Biophysica Acta: Molecular Cell Research, 1833(2), pp. 352-359. (doi: 10.1016/j.bbamcr.2012.05.030)

Francia, M.E., Jordan, C.N., Patel, J.D., Sheiner, L. , Demerly, J.L., Fellows, J.D., de Leon, J.C., Morrissette, N.S., Dubremetz, J.-F. and Striepen, B. (2012) Cell division in apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biology, 10(12), e1001444. (doi: 10.1371/journal.pbio.1001444) (PMID:23239939)

MacRae, J.I., Sheiner, L. , Nahid, A., Tonkin, C., Striepen, B. and McConville, M.J. (2012) Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host and Microbe, 12(5), pp. 682-692. (doi: 10.1016/j.chom.2012.09.013)

Sampels, V., Hartmann, A., Dietrich, I., Coppens, I., Sheiner, L. , Striepen, B., Herrmann, A., Lucius, R. and Gupta, N. (2012) Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. Journal of Biological Chemistry, 287(20), pp. 16289-16299. (doi: 10.1074/jbc.M112.347138)

Sheiner, L. , Demerly, J.L., Poulsen, N., Beatty, W.L., Lucas, O., Behnke, M.S., White, M.W. and Striepen, B. (2011) A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor. PLoS Pathogens, 7(12), e1002392. (doi: 10.1371/journal.ppat.1002392)

Lorestani, A., Sheiner, L. , Yang, K., Robertson, S.D., Sahoo, N., Brooks, C.F., Ferguson, D.J.P., Striepen, B. and Gubbels, M.-J. (2010) A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis. PLoS ONE, 5(8), e12302. (doi: 10.1371/journal.pone.0012302) (PMID:20808817) (PMCID:PMC2924399)

Pino, P., Aeby, E., Foth, B.J., Sheiner, L. , Soldati, T., Schneider, A. and Soldati-Favre, D. (2010) Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNAMet formylation in Apicomplexa. Molecular Microbiology, 76(3), pp. 706-718. (doi: 10.1111/j.1365-2958.2010.07128.x)

Sheiner, L. , Santos, J.M., Klages, N., Parussini, F., Jemmely, N., Friedrich, N., Ward, G.E. and Soldati-Favre, D. (2010) Toxoplasma gondii transmembrane microneme proteins and their modular design. Molecular Microbiology, 77(4), pp. 912-929. (doi: 10.1111/j.1365-2958.2010.07255.x)

Sheiner, L. , Dowse, T.J. and Soldati-Favre, D. (2008) Identification of trafficking determinants for polytopic rhomboid proteases in toxoplasma gondii. Traffic, 9(5), pp. 665-677. (doi: 10.1111/j.1600-0854.2008.00736.x)

Goldshmidt, H., Sheiner, L. , Butikofer, P., Roditi, I., Uliel, S., Gunzel, M., Engstler, M. and Michaeli, S. (2008) Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei. Journal of Biological Chemistry, 283(46), pp. 32085-32098. (doi: 10.1074/jbc.M801499200)

Sheiner, L. and Soldati-Favre, D. (2008) Protein trafficking inside Toxoplasma gondii. Traffic, 9(5), pp. 636-646. (doi: 10.1111/j.1600-0854.2008.00713.x)

Lustig, Y., Sheiner, L. , Vagima, Y., Goldshmidt, H., Das, A., Bellofatto, V. and Michaeli, S. (2007) Spliced-leader RNA silencing: a novel stress-induced mechanism in Trypanosoma brucei. EMBO Reports, 8(4), pp. 408-413. (doi: 10.1038/sj.embor.7400930)

Pino, P., Foth, B.J., Kwok, L.-Y., Sheiner, L. , Schepers, R., Soldati, T. and Soldati-Favre, D. (2007) Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii. PLoS Pathogens, 3(8), e115. (doi: 10.1371/journal.ppat.0030115)

Book Sections

Biddau, M. , Ovciarikova, J. and Sheiner, L. (2020) Experimental approaches for examining apicoplast biology. In: Tonkin, C. J. (ed.) Toxoplasma gondii: Methods and Protocols. Series: Methods in molecular biology (2071). Humana Press: New York, NY, pp. 221-243. ISBN 9781493998562 (doi: 10.1007/978-1-4939-9857-9_13)

Jacot, D., Meissner, M. , Sheiner, L. , Soldati-Favre, D. and Striepen, B. (2014) Genetic manipulation of toxoplasma gondii. In: Weiss, L.M. and Kim, K. (eds.) Toxoplasma Gondii. Elsevier Academic Press: Burlington, VT, pp. 577-611. ISBN 9780123965363 (doi: 10.1016/B978-0-12-396481-6.00017-9)

Sheiner, L. and Striepen, B. (2014) The apicoplast: a parasite’s symbiont. In: Theg, S. M. and Wollman, F.-A. (eds.) Plastid Biology. Series: Advances in plant biology (5). Springer New York: New York, pp. 209-238. ISBN 9781493911356 (doi: 10.1007/978-1-4939-1136-3_8)

Agrawal, S., Nair, S., Sheiner, L. and Striepen, B. (2010) The Apicoplast: An ancient algal endosymbiont of Apicomplexa. In: de Souza, W. (ed.) Structures and Organelles in Pathogenic Protists. Series: Microbiology monographs (17). Springer. ISBN 9783642128639

This list was generated on Thu Nov 7 21:14:17 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Structure-function studies of the malaria drug target, mitochondrial respiratory complex III

    2024 - 2027
     
  • Characterization of critical differences between human and parasite respiratory complex II

    2022 - 2025
     
  • Lost in translation. A study of the divergent mitochondrial translation pathway of the parasite Toxoplasma gondii

    2020 - 2024
     
  • How do REDox regulators control Apicoplast functions in the parasites causing TOxoplasmosis and Malaria

    2019 - 2022
     
  • Transgenic T. gondii as a platform for MeCP2 protein delivery to the CNS

    2018 - 2020
     
  • P2D award

    2018 - 2018
     
  • Dissection of the unusual mitochondrial tRNA import translocon of Toxoplasma gondii

    2016 - 2018
     
  • Dance with me? Mechanisms controlling mitochondrion - cell-cycle synchrony in Toxoplasma gondii

    2015 - 2020
     
  • Identification and analysis of essential proteins involved in Toxoplasma gondii mitochondrial tRNA import (ISSF Fellowship)

    2015 - 2015
     
  • Identification and analysis of essential proteins involved in Toxoplasma gondii mitochondrial biogenesis (ISSF Catalyst)

    2014 - 2014
     

Professional activities & recognition

Prizes, awards & distinctions

  • 2021: member (Young Academy of Scotland)
  • 2015: Personal Research Fellowship (Royal Society of Edinburgh)
  • 2013: Lord Kelvin Adam Smith Leadership Fellowship (University of Glasgow)
  • 2013: K99, pathways to independence (National Institutes of Health, Bethesda, Maryland, USA)

Grant committees & research advisory boards

  • 2019: Wellcome Trust, Expert Review Group 5
  • 2020: Academy of Finland, Life12_20 (Cell 1) panel

Professional & learned societies

  • member, Microbiology Society

Selected international presentations

  • 2021: EMBO/FEBS Advanced Course on “Mitochondria in life death and disease” (Budva Montenegro)
  • 2019: EMBO conference: ‘Protein translocation across membranes’ (Costa Brava, Spain)
  • 2019: OrbiMed - Presentation for discussion of plan for commercialization (Herzliya, Israel)
  • 2018: Weizmann Institute of Science. Frontiers in Parasitology (Rehovot, Israel)
  • 2017: Brazilian Protozoology Society Annual meeting. Invited Speaker and Panel Member for Round Table about Genome Editing in Parasitic Protozoa. (Caxambu, Brazil)
  • 2017: University of Strathclyde. Invited seminar speaker. (Glasgow, Scotland)
  • 2017: Ben Gurion University. Invited seminar speaker. (Beer-Sheva, Israel)
  • 2016: University of Kent, School of Biosciences seminar series. Invited seminar speaker. (Canterbury, UK)
  • 2016: Université de Montpellier. Invited international speaker (Montpellier, France)
  • 2016: Max Planck Institute for Developmental Biology and Friedrich Miescher Laboratory International PhD Program annual retreat. Invited Keynote speaker. (Tuebingen, Germany)
  • 2016: Cambridge Parasitology Club seminar series. Invited seminar speaker. (Cambridge, UK)
  • 2015: The University of Edinburgh, Institute of Immunology and Infection Seminar series. Invited seminar speaker. (Edinburgh,UK)
  • 2015: The Francis Crick Institute (NIMR). Invited seminar speaker. (London, UK)
  • 2015: Fiocruz, Instituto Oswaldo Cruiz. Invited seminar speaker. (Rio de Janeiro, Brazil)
  • 2015: Fiocruz Institututo Carlos Chagas. Invited seminar. (Curitiba, Brazil.)
  • 2015: SGM Annual Conference 2015, “Mitochondria and related organelles in microbial eukaryotes” session. Invited speaker. (Birmingham, UK)
  • 2015: University of South Bohemia, Institute of parasitology. Invited seminar speaker. (Ceske Budejovice, Czech Republic.)

A head and shoulders shot of Dr Lilach Sheiner

Related Links

Sheiner Lab website: https://lilachsheiner.wixsite.com/sheinerlab-wtcmp

YAS (Young Academy of Scotland): https://www.youngacademyofscotland.org.uk/members/lilach-sheiner/

meBOP (middle east Biology of Parasitism): https://www.mebop.org/

NERD (Network for Early career Researchers Development): https://www.gla.ac.uk/colleges/mvls/nerd/