Professor Julia Edgar

  • Professor of Neurobiology, Head of School, Infection & Immunity (Immunology & Infection)

telephone: 01413302082
email: Julia.Edgar@glasgow.ac.uk

B413 Level 4, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-3869-0962

Research interests

Professor Edgar is interested in how disorders of the central nervous system myelin sheath affect axonal health and, in particular, how the oligodendrocyte exerts axonal protection.

Studies investigating the relationship between oligodendrocyte dysfunction and axonal pathology are undertaken in collaboration with the Nave lab at the Max Planck Institute of Experimental Medicine, in Göttingen, Germany.

Their findings demonstrate that normal oligodendrocyte function is required for the long-term support of axonal integrity (Glia 57:1815-1824 and EMBO Mol Med 2:42-50).

Although the mechanisms are still not fully understood, their data indicate that the oligodendrocyte modulates fast axonal transport (reviewd in Journal of Neuroscience 29:12776-12786) and a recent study led by the Nave lab raises the possibility that oligodendrocytes support axonal energy requirements (Nature 485Pages: 517–521).

Their findings have implications for understanding axonal degeneration in neurodegenerative disorders such as multiple sclerosis and the leukodystrophies (reviewed in Current Opinion in Neurobiology 19 498-504).


 

Publications

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Number of items: 67.

2023

Thümmler, K. et al. (2023) Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis? Neuropathology and Applied Neurobiology, 49(5), e12935. (doi: 10.1111/nan.12935) (PMID:37705188)

Schäffner, E. et al. (2023) Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. Nature Neuroscience, 26(7), pp. 1218-1228. (doi: 10.1038/s41593-023-01366-9) (PMID:37386131)

Gamble, A., Suessmilch, M., Bonestroo, A., Merits, A., Graham, G. J. , Cavanagh, J. , Edgar, J. M. and Pingen, M. (2023) Establishing mixed neuronal and glial cell cultures from embryonic mouse brains to study infection and innate immunity. Journal of Visualized Experiments(196), 65331. (doi: 10.3791/65331) (PMID:37458443)

Steyer, A. M. et al. (2023) Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. Glia, 71(3), pp. 509-523. (doi: 10.1002/glia.24290) (PMID:36354016)

de Almeida, M. M.A. et al. (2023) Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. Stem Cell Reports, 18(2), pp. 519-533. (doi: 10.1016/j.stemcr.2022.12.001) (PMID:36608690) (PMCID:PMC9968989)

2022

Baldacchino, K. et al. (2022) Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system. Experimental Neurology, 354, 114113. (doi: 10.1016/j.expneurol.2022.114113) (PMID:35569511)

Crawford, C. L. et al. (2022) SARM1 depletion slows axon degeneration in a CNS model of neurotropic viral infection. Frontiers in Molecular Neuroscience, 15, 860410. (doi: 10.3389/fnmol.2022.860410) (PMID:35493328) (PMCID:PMC9043327)

2021

Edgar, J. M. , McGowan, E., Chapple, K., Möbius, W., Lemgruber, L. , Insall, R. H. , Nave, K.-A. and Boullerne, A. (2021) Rio-Hortega's drawings revisited with fluorescent proteins define a cytoplasm filled channel system of CNS myelin. Journal of Anatomy, 239(6), pp. 1241-1255. (doi: 10.1111/joa.13577)

Berghoff, S. A. et al. (2021) Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Reports, 37(4), 109889. (doi: 10.1016/j.celrep.2021.109889)

Schultz, V. et al. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69(8), pp. 2023-2036. (doi: 10.1002/glia.24010) (PMID:33942402) (PMCID:PMC9216243)

Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)

Berghoff, S. A. et al. (2021) Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience, 24(1), pp. 47-60. (doi: 10.1038/s41593-020-00757-6) (PMID:33349711) (PMCID:PMC7116742)

De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)

2020

Hayden, L. et al. (2020) Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis. Acta Neuropathologica Communications, 8, 135. (doi: 10.1186/s40478-020-01011-7) (PMID:32792006) (PMCID:PMC7427287)

Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)

Edgar, J. M. , Smith, R. S. and Duncan, I. D. (2020) Transmission electron microscopy and morphometry of the CNS white matter. In: Babetto, E. (ed.) Axon Degeneration: Methods and Protocols. Series: Methods in molecular biology (2143). Humana: New York, pp. 233-261. ISBN 9781071605844 (doi: 10.1007/978-1-0716-0585-1_18)

2019

Thümmler, K. et al. (2019) Polarizing receptor activation dissociates Fibroblast Growth Factor 2 mediated inhibition of myelination from its neuroprotective potential. Acta Neuropathologica Communications, 7, 212. (doi: 10.1186/s40478-019-0864-6) (PMID:31856924) (PMCID:PMC6923900)

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)

Wilder-Smith, A. et al. (2019) ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Global Health Action, 12(1), 1666566. (doi: 10.1080/16549716.2019.1666566) (PMID:31640505) (PMCID:PMC6818126)

2018

Stassart, R. M., Möbius, W., Nave, K.-A. and Edgar, J. M. (2018) The axon-myelin unit in development and degenerative disease. Frontiers in Neuroscience, 12, 467. (doi: 10.3389/fnins.2018.00467) (PMID:30050403) (PMCID:PMC6050401)

Konda, P. C. , Edgar, J. , Barnett, S. and Harvey, A. R. (2018) Minimally Invasive Microscopy Using GRIN Lens Microendoscopes. Biophotonics Congress: Biomedical Optics Congress 2018, Hollywood, FL, USA, 03-06 Apr 2018. BTh4C.4. ISBN 9781943580415 (doi: 10.1364/BRAIN.2018.BTh4C.4)

2017

Bahey, N. G., Gadalla, K. K.E. , McGonigal, R. , Bailey, M. E.S. , Edgar, J. M. and Cobb, S. R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi: 10.1016/j.neuroscience.2017.06.061)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi: 10.1038/nn.4425) (PMID:27775720)

Berghoff, S. A. et al. (2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications, 8, 14241. (doi: 10.1038/ncomms14241) (PMID:28117328) (PMCID:PMC5286209)

2015

Lindner, M. et al. (2015) Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain, 138(7), pp. 1875-1893. (doi: 10.1093/brain/awv102) (PMID:25907862) (PMCID:PMC7185739)

2014

Deighton, R. F., Le Bihan, T., Martin, S. F., Gerth, A. M. J., McCulloch, M., Edgar, J. M. , Kerr, L. E., Whittle, I. R. and McCulloch, J. (2014) Interactions among mitochondrial proteins altered in glioblastoma. Journal of Neuro-Oncology, 118(2), pp. 247-256. (doi: 10.1007/s11060-014-1430-5)

Snaidero, N. et al. (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell, 156(1-2), pp. 277-290. (doi: 10.1016/j.cell.2013.11.044) (PMID:24439382) (PMCID:PMC4862569)

Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M. and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15(1), p. 59. (doi: 10.1186/1471-2202-15-59)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

2013

de Monasterio-Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T.L., Kusch, K., Edgar, J.M. , Brophy, P.J. and Werner, H.B. (2013) Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia, 61(11), pp. 1832-1847. (doi: 10.1002/glia.22561)

Barrette, B., Nave, K.-A. and Edgar, J.M. (2013) Molecular triggers of neuroinflammation in mouse models of demyelinating diseases. Biological Chemistry, 394(12), (doi: 10.1515/hsz-2013-0219)

2012

Franklin, R.J.M., ffrench-Constant, C., Edgar, J.M. and Smith, K.J. (2012) Neuroprotection and repair in multiple sclerosis. Nature Reviews Neurology, 8(11), pp. 624-634. (doi: 10.1038/nrneurol.2012.200) (PMID:23026979)

Gutierrez Quintana, R. , Edgar, J. , Wessmann, A., Cherubini, G.B. and Penderis, J. (2012) The cutaneous trunci reflex for localising and grading thoracolumbar spinal cord injuries in dogs. Journal of Small Animal Practice, 53(8), pp. 470-475. (doi: 10.1111/j.1748-5827.2012.01244.x) (PMID:22845846)

Funfschilling, U. et al. (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature, 485(7399), pp. 517-521. (doi: 10.1038/nature11007)

Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M. and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7(1), e30775. (doi: 10.1371/journal.pone.0030775) (PMID:22303455) (PMCID:PMC3267745)

Ip, C.W. et al. (2012) Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. PLoS ONE, 7(8), e42554. (doi: 10.1371/journal.pone.0042554) (PMID:22905147) (PMCID:PMC3414455)

2011

Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)

Gruenenfelder, F.I., Thomson, G., Penderis, J. and Edgar, J.M. (2011) Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. Journal of Anatomy, 219(1), pp. 33-43. (doi: 10.1111/j.1469-7580.2011.01363.x)

2010

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)

Edgar, J.M. , McCulloch, M.C., Montague, P., Brown, A., Thilemann, S., Pratola, L., Gruenenfelder, F.I., Griffiths, I. and Nave, K.A. (2010) Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease. EMBO Molecular Medicine, 2(2), pp. 42-50. (doi: 10.1002/emmm.200900057)

2009

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi: 10.1002/jnr.21867)

Edgar, J. M. and Nave, K. A. (2009) The role of CNS glia in preserving axon function. Current Opinion in Neurobiology, 19(5), pp. 498-504. (doi: 10.1016/j.conb.2009.08.003)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)

Morfini, G.A. et al. (2009) Axonal Transport Defects in Neurodegenerative Diseases. Journal of Neuroscience, 29(41), pp. 12776-12786. (doi: 10.1523/JNEUROSCI.3463-09.2009)

2008

Wang, E., Dimova, N., Sperle, K., Huang, Z., Lock, L., McCulloch, M., Edgar, J. , Hobson, G. and Cambi, F. (2008) Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Experimental Neurology, 214(2), pp. 322-330. (doi: 10.1016/j.expneurol.2008.09.001)

Edgar, J.M. , McCulloch, M.C., Thomson, C.E. and Griffith, I.R. (2008) Distribution of mitochondria along small-diameter myelinated central nervous system axons. Journal of Neuroscience Research, 86(10), pp. 2250-2257. (doi: 10.1002/jnr.21672)

2007

da Costa, N., Edgar, J. , Ooi, P., Su, Y., Meissner, J. and Chang, K. (2007) Calcineurin differentially regulates genes in oxidative muscle fibre type fast myosin heavy chain conversion. Cell and Tissue Research, 329, pp. 515-527. (doi: 10.1007/s00441-007-0441-3)

Edgar, J. (2007) Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell and Tissue Research, 329(3), pp. 515-527.

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi: 10.1007/s11064-006-9122-y)

2006

Ooi, P., da Costa, N., Edgar, J. and Chang, K. (2006) Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression. BMC Veterinary Research, 2(1), p. 23. (doi: 10.1186/1746-6148-2-23)

Andrews, H., White, K., Thomson, C., Edgar, J., Bates, D., Griffiths, I., Turnbull, D. and Nichols, P. (2006) Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the shiverer mouse. Journal of Neuroscience Research, 83, pp. 1533-1539. (doi: 10.1002/jnr.20842)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi: 10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J., Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi: 10.1002/glia.20325)

Thomson, C., Hunter, A., Griffiths, I., Edgar, J. and McCulloch, M. (2006) Murine spinal cord explants: A model for evaluating axonal growth and myelination in vitro. Journal of Neuroscience Research, 84, pp. 1703-1715. (doi: 10.1002/jnr.21084)

2005

Montague, P., McCallion, A., Barrie, J., Edgar, J., McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi: 10.1002/glia.20155)

2004

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi: 10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J. and Garbern, J. (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved. Journal of Neuroscience Research, 76(5), pp. 593-598. (doi: 10.1002/jnr.20063)

Edgar, J., McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi: 10.1007/s00401-003-0808-9)

2002

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi: 10.1002/glia.10103) (PMID:12203392)

Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi: 10.1083/jcb.200202124)

2001

Edgar, J. (2001) The fates of cells generated at the end of neurogenesis in developing mouse cortex. Journal of Neurobiology, 48(4), pp. 265-277.

Edgar, J. (2001) Radial migration in the cerebral cortex is enhanced by signals from thalamus. European Journal of Neuroscience, 13(9), pp. 1745-1754.

2000

Yool, D. A. , Edgar, J. M. , Montague, P. and Malcolm, S. (2000) The proteolipid protein gene and myelin disorders in man and animal models. Human Molecular Genetics, 9(6), pp. 987-992. (doi: 10.1093/hmg/9.6.987) (PMID:10767322)

This list was generated on Wed Nov 20 20:31:30 2024 GMT.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 67.

Articles

Thümmler, K. et al. (2023) Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis? Neuropathology and Applied Neurobiology, 49(5), e12935. (doi: 10.1111/nan.12935) (PMID:37705188)

Schäffner, E. et al. (2023) Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. Nature Neuroscience, 26(7), pp. 1218-1228. (doi: 10.1038/s41593-023-01366-9) (PMID:37386131)

Gamble, A., Suessmilch, M., Bonestroo, A., Merits, A., Graham, G. J. , Cavanagh, J. , Edgar, J. M. and Pingen, M. (2023) Establishing mixed neuronal and glial cell cultures from embryonic mouse brains to study infection and innate immunity. Journal of Visualized Experiments(196), 65331. (doi: 10.3791/65331) (PMID:37458443)

Steyer, A. M. et al. (2023) Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. Glia, 71(3), pp. 509-523. (doi: 10.1002/glia.24290) (PMID:36354016)

de Almeida, M. M.A. et al. (2023) Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. Stem Cell Reports, 18(2), pp. 519-533. (doi: 10.1016/j.stemcr.2022.12.001) (PMID:36608690) (PMCID:PMC9968989)

Baldacchino, K. et al. (2022) Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system. Experimental Neurology, 354, 114113. (doi: 10.1016/j.expneurol.2022.114113) (PMID:35569511)

Crawford, C. L. et al. (2022) SARM1 depletion slows axon degeneration in a CNS model of neurotropic viral infection. Frontiers in Molecular Neuroscience, 15, 860410. (doi: 10.3389/fnmol.2022.860410) (PMID:35493328) (PMCID:PMC9043327)

Edgar, J. M. , McGowan, E., Chapple, K., Möbius, W., Lemgruber, L. , Insall, R. H. , Nave, K.-A. and Boullerne, A. (2021) Rio-Hortega's drawings revisited with fluorescent proteins define a cytoplasm filled channel system of CNS myelin. Journal of Anatomy, 239(6), pp. 1241-1255. (doi: 10.1111/joa.13577)

Berghoff, S. A. et al. (2021) Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Reports, 37(4), 109889. (doi: 10.1016/j.celrep.2021.109889)

Schultz, V. et al. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69(8), pp. 2023-2036. (doi: 10.1002/glia.24010) (PMID:33942402) (PMCID:PMC9216243)

Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)

Berghoff, S. A. et al. (2021) Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience, 24(1), pp. 47-60. (doi: 10.1038/s41593-020-00757-6) (PMID:33349711) (PMCID:PMC7116742)

De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)

Hayden, L. et al. (2020) Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis. Acta Neuropathologica Communications, 8, 135. (doi: 10.1186/s40478-020-01011-7) (PMID:32792006) (PMCID:PMC7427287)

Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)

Thümmler, K. et al. (2019) Polarizing receptor activation dissociates Fibroblast Growth Factor 2 mediated inhibition of myelination from its neuroprotective potential. Acta Neuropathologica Communications, 7, 212. (doi: 10.1186/s40478-019-0864-6) (PMID:31856924) (PMCID:PMC6923900)

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)

Wilder-Smith, A. et al. (2019) ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Global Health Action, 12(1), 1666566. (doi: 10.1080/16549716.2019.1666566) (PMID:31640505) (PMCID:PMC6818126)

Stassart, R. M., Möbius, W., Nave, K.-A. and Edgar, J. M. (2018) The axon-myelin unit in development and degenerative disease. Frontiers in Neuroscience, 12, 467. (doi: 10.3389/fnins.2018.00467) (PMID:30050403) (PMCID:PMC6050401)

Bahey, N. G., Gadalla, K. K.E. , McGonigal, R. , Bailey, M. E.S. , Edgar, J. M. and Cobb, S. R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi: 10.1016/j.neuroscience.2017.06.061)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi: 10.1038/nn.4425) (PMID:27775720)

Berghoff, S. A. et al. (2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications, 8, 14241. (doi: 10.1038/ncomms14241) (PMID:28117328) (PMCID:PMC5286209)

Lindner, M. et al. (2015) Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain, 138(7), pp. 1875-1893. (doi: 10.1093/brain/awv102) (PMID:25907862) (PMCID:PMC7185739)

Deighton, R. F., Le Bihan, T., Martin, S. F., Gerth, A. M. J., McCulloch, M., Edgar, J. M. , Kerr, L. E., Whittle, I. R. and McCulloch, J. (2014) Interactions among mitochondrial proteins altered in glioblastoma. Journal of Neuro-Oncology, 118(2), pp. 247-256. (doi: 10.1007/s11060-014-1430-5)

Snaidero, N. et al. (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell, 156(1-2), pp. 277-290. (doi: 10.1016/j.cell.2013.11.044) (PMID:24439382) (PMCID:PMC4862569)

Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M. and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15(1), p. 59. (doi: 10.1186/1471-2202-15-59)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

de Monasterio-Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T.L., Kusch, K., Edgar, J.M. , Brophy, P.J. and Werner, H.B. (2013) Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia, 61(11), pp. 1832-1847. (doi: 10.1002/glia.22561)

Barrette, B., Nave, K.-A. and Edgar, J.M. (2013) Molecular triggers of neuroinflammation in mouse models of demyelinating diseases. Biological Chemistry, 394(12), (doi: 10.1515/hsz-2013-0219)

Franklin, R.J.M., ffrench-Constant, C., Edgar, J.M. and Smith, K.J. (2012) Neuroprotection and repair in multiple sclerosis. Nature Reviews Neurology, 8(11), pp. 624-634. (doi: 10.1038/nrneurol.2012.200) (PMID:23026979)

Gutierrez Quintana, R. , Edgar, J. , Wessmann, A., Cherubini, G.B. and Penderis, J. (2012) The cutaneous trunci reflex for localising and grading thoracolumbar spinal cord injuries in dogs. Journal of Small Animal Practice, 53(8), pp. 470-475. (doi: 10.1111/j.1748-5827.2012.01244.x) (PMID:22845846)

Funfschilling, U. et al. (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature, 485(7399), pp. 517-521. (doi: 10.1038/nature11007)

Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M. and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7(1), e30775. (doi: 10.1371/journal.pone.0030775) (PMID:22303455) (PMCID:PMC3267745)

Ip, C.W. et al. (2012) Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. PLoS ONE, 7(8), e42554. (doi: 10.1371/journal.pone.0042554) (PMID:22905147) (PMCID:PMC3414455)

Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)

Gruenenfelder, F.I., Thomson, G., Penderis, J. and Edgar, J.M. (2011) Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. Journal of Anatomy, 219(1), pp. 33-43. (doi: 10.1111/j.1469-7580.2011.01363.x)

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)

Edgar, J.M. , McCulloch, M.C., Montague, P., Brown, A., Thilemann, S., Pratola, L., Gruenenfelder, F.I., Griffiths, I. and Nave, K.A. (2010) Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease. EMBO Molecular Medicine, 2(2), pp. 42-50. (doi: 10.1002/emmm.200900057)

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi: 10.1002/jnr.21867)

Edgar, J. M. and Nave, K. A. (2009) The role of CNS glia in preserving axon function. Current Opinion in Neurobiology, 19(5), pp. 498-504. (doi: 10.1016/j.conb.2009.08.003)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)

Morfini, G.A. et al. (2009) Axonal Transport Defects in Neurodegenerative Diseases. Journal of Neuroscience, 29(41), pp. 12776-12786. (doi: 10.1523/JNEUROSCI.3463-09.2009)

Wang, E., Dimova, N., Sperle, K., Huang, Z., Lock, L., McCulloch, M., Edgar, J. , Hobson, G. and Cambi, F. (2008) Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Experimental Neurology, 214(2), pp. 322-330. (doi: 10.1016/j.expneurol.2008.09.001)

Edgar, J.M. , McCulloch, M.C., Thomson, C.E. and Griffith, I.R. (2008) Distribution of mitochondria along small-diameter myelinated central nervous system axons. Journal of Neuroscience Research, 86(10), pp. 2250-2257. (doi: 10.1002/jnr.21672)

da Costa, N., Edgar, J. , Ooi, P., Su, Y., Meissner, J. and Chang, K. (2007) Calcineurin differentially regulates genes in oxidative muscle fibre type fast myosin heavy chain conversion. Cell and Tissue Research, 329, pp. 515-527. (doi: 10.1007/s00441-007-0441-3)

Edgar, J. (2007) Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell and Tissue Research, 329(3), pp. 515-527.

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi: 10.1007/s11064-006-9122-y)

Ooi, P., da Costa, N., Edgar, J. and Chang, K. (2006) Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression. BMC Veterinary Research, 2(1), p. 23. (doi: 10.1186/1746-6148-2-23)

Andrews, H., White, K., Thomson, C., Edgar, J., Bates, D., Griffiths, I., Turnbull, D. and Nichols, P. (2006) Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the shiverer mouse. Journal of Neuroscience Research, 83, pp. 1533-1539. (doi: 10.1002/jnr.20842)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi: 10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J., Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi: 10.1002/glia.20325)

Thomson, C., Hunter, A., Griffiths, I., Edgar, J. and McCulloch, M. (2006) Murine spinal cord explants: A model for evaluating axonal growth and myelination in vitro. Journal of Neuroscience Research, 84, pp. 1703-1715. (doi: 10.1002/jnr.21084)

Montague, P., McCallion, A., Barrie, J., Edgar, J., McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi: 10.1002/glia.20155)

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi: 10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J. and Garbern, J. (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved. Journal of Neuroscience Research, 76(5), pp. 593-598. (doi: 10.1002/jnr.20063)

Edgar, J., McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi: 10.1007/s00401-003-0808-9)

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi: 10.1002/glia.10103) (PMID:12203392)

Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi: 10.1083/jcb.200202124)

Edgar, J. (2001) The fates of cells generated at the end of neurogenesis in developing mouse cortex. Journal of Neurobiology, 48(4), pp. 265-277.

Edgar, J. (2001) Radial migration in the cerebral cortex is enhanced by signals from thalamus. European Journal of Neuroscience, 13(9), pp. 1745-1754.

Yool, D. A. , Edgar, J. M. , Montague, P. and Malcolm, S. (2000) The proteolipid protein gene and myelin disorders in man and animal models. Human Molecular Genetics, 9(6), pp. 987-992. (doi: 10.1093/hmg/9.6.987) (PMID:10767322)

Book Sections

Edgar, J. M. , Smith, R. S. and Duncan, I. D. (2020) Transmission electron microscopy and morphometry of the CNS white matter. In: Babetto, E. (ed.) Axon Degeneration: Methods and Protocols. Series: Methods in molecular biology (2143). Humana: New York, pp. 233-261. ISBN 9781071605844 (doi: 10.1007/978-1-0716-0585-1_18)

Conference or Workshop Item

Konda, P. C. , Edgar, J. , Barnett, S. and Harvey, A. R. (2018) Minimally Invasive Microscopy Using GRIN Lens Microendoscopes. Biophotonics Congress: Biomedical Optics Congress 2018, Hollywood, FL, USA, 03-06 Apr 2018. BTh4C.4. ISBN 9781943580415 (doi: 10.1364/BRAIN.2018.BTh4C.4)

This list was generated on Wed Nov 20 20:31:30 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Defining the role KIF21B in glia
    Multiple Sclerosis Society
    2024 - 2027
     
  • Modernising the Electron Microscopy capabilities at the University of Glasgow
    Medical Research Council
    2022 - 2023
     
  • Functional models of axo-glial signalling for understanding axonal degeneration in progressive multiple sclerosis
    Multiple Sclerosis Society
    2020 - 2023
     
  • The myelinic channel in inflammatory disease
    Multiple Sclerosis Society
    2019 - 2019
     
  • Pro-inflammatory feedback loops in progressive multiple sclerosis: a role for the intrathecal antibody repertoire
    Multiple Sclerosis Society
    2016 - 2019
     
  • ZikaPLAN
    European Commission
    2016 - 2019
     
  • The role of the myelinic channel in axonal support
    Multiple Sclerosis Society
    2016 - 2019
     
  • Assocation studies with Guillain-Barre syndrome and neurotropism
    Medical Research Council
    2016 - 2017
     
  • response to MRC ZIKA call
    Medical Research Council
    2016 - 2017
     
  • A high throughput to identify small molecules
    Multiple Sclerosis Society
    2014 - 2015
     
  • Development of a in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination
    National Centre for the Replacement of Animals Research
    2013 - 2014
     
  • An examination of demyelinated, dystrophic axons
    ELA Foundation
    2011 - 2012
     
  • An investigation of the role of microglia/macrophages in axonal damage, in the context of demyelination
    Multiple Sclerosis Society
    2009 - 2011
     
  • The development of an in vitro assay to test the consequences of the acute ablation of myelin proteins on axonal integrity.
    Multiple Sclerosis Society
    2008 - 2009
     
  • The mechanisms and markers of axonal damage in myelin abnormalities
    Multiple Sclerosis Society
    2005 - 2009
     

Teaching

  • BVMS Level 1
  • BSc Veterinary Biosciences Levels 1 and 3
  • BSc Neuroscience Levels 2, 3 and 4
  • BSc Immunology Level 3
  • MSc courses in ‘Brain Sciences’ and ‘Immunology and Inflammatory Disease’
  • Intercalated BSc Med Sci (Neuroscience)

 

Course/Programme Coordination

  • Post Graduate Taught Convenor for 3Is: 2016-present
  • Course coordinator Immunology Level 3A: 2015-present
  • Course coordinator MSc course in ‘in vitro and analytical techniques in neuroscience’: 2015-2018
  • Deputy Programme Director MSc programme in Infection Biology: 2015-16

Professional activities & recognition

Prizes, awards & distinctions

  • 2024: Organising Committee Member, 8th International Molecular Mechanisms of Axon Degeneration meeting, Washington DC
  • 2022: Best paper J Anatomy 2021 (Council of the Anatomical Society)
  • 2021: Member MS Society Edinburgh Centre for MS Research (MS Society)
  • 2018: Organiser (with M Coleman, Cambridge) 7th International Molecular Mechanisms of Axonal Degeneration meeting, Luss, Scotland
  • 2017: Invited local organising committee member, XIII European Meeting on Glial Cells in Health and Disease, Edinburgh
  • 2017: Member of team awarded MVLS College Teaching Excellence Award (University of Glasgow, Scotland)
  • 2013: Associate Staff Scientist, Department of Neurogenetics, Max Planck Institute for Experimental Medicine (Göttingen, Germany)
  • 1995: Prize PhD Studentship, University of Edinburgh (Wellcome Trust)

Research fellowships

  • 2011 - 2013: Göttingen, Germany - Department of Neurogenetics, Max Planck Institute for Experimental Medicine
  • 2005 - 2009: Multiple Sclerosis Society (Scotland) - Junior Fellowship

Grant committees & research advisory boards

  • 2024: Deutsche Forschungsgemeinschaft, Research Unit review panel member
  • 2020 - ongoing: Motor Neuron Disease, Scotand, Chair, Scientific Advisory Panel
  • 2020 - ongoing: Multiple Sclerosis Society, Treatment Advisory Committee of the UK MS Society OCTOPUS clinical trial for progressive MS
  • 2019 - 2020: Motor Neuron Disease, Scotand, Funding review panel
  • 2017 - ongoing: Multiple Sclerosis Society, Funding review panel

Professional & learned societies

  • 2011: Fellow, Higher Education Academy

Selected international presentations

  • 2024: Discussion leader, Myelin Conference GRC (Ventura, California, USA)
  • 2023: Invited speaker, European Glial Cell Meeting (Berlin, Germany)
  • 2023: Invited speaker, Department of Neuropathology, Charité Universitaetsmedizin Berlin (Berlin, Germany)
  • 2023: Keynote speaker, Northern Connections MS (Edinburgh, UK)
  • 2023: Invited speaker, Neurotrauma 2023 (Austin, Texas)
  • 2022: Invited speaker, Gordon Conference (Myelin) (Il Ciocco, Italy)
  • 2021: Invited speaker, Northern Ireland MS Research Network symposium (Online forum)
  • 2020: Symposium organiser and Speaker, FENS 2020 (Virtual Forum)
  • 2019: Invited seminar speaker (Roslin Institute, Edinburgh, UK)
  • 2019: Debate panel member (MS Frontiers, Bath, UK)
  • 2019: Invited seminar speaker, Galway Neuroscience Centre (NUI Galway, Ireland)
  • 2019: Invited speaker (MS Frontiers, Bath, UK)
  • 2018: Invited speaker, University of Leipzig Neurosciences Seminar series (Leipzig, Germany)
  • 2017: Invited (Biomed Central) Video Abstract of our manuscript "Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected" Cumberworth et al., 2017 in Acta Neuropathologica Communications ()
  • 2016: Invited co-discussant, Gordon Research Conference on Myelin (Il Ciocco, Italy)
  • 2015: Invited speaker, MS Frontiers (London, England, UK)
  • 2016: Invited oral presentation and session chair, 6th Molecular Mechanisms of Axonal Degeneration meeting (Maine, USA)
  • 2015: Invited speaker, 5th Obergurgl Optic Nerve meeting (Obergurgl, Austria)
  • 2015: Invited speaker, British Neuroscience Association Meeting (Edinburgh, Scotland, UK)
  • 2014: Invited speaker Franco-Scottish seminar: Towards repair in multiple sclerosis (Edinburgh, Scotland, UK)
  • 2014: Invited speaker, International Scientific Conference organised by The Myelin Project (Edinburgh, Scotland, UK)
  • 2013: Invited presentation, ISN/ASN Myelin Satellite Meeting (Cancun, Mexico)
  • 2010: Invited speaker, Anatomical Society of Great Britain and Ireland (Portsmouth, England, UK)
  • 2010: Invited speaker, British Society for Immunology annual conference (Liverpool, England, UK)
  • 2009: Invited speaker, Society for Neuroscience (Chicago, Illinois, USA)
  • 2008: Invited speaker, Myelin Gordon Conference (Il Chioco, Italy)
  • 2007: Invited speaker, MRI of Brain Connectivity and Microstructure (Dead Sea resort, Israel)
  • 2006: Invited speaker, Molecular and Cellular Mechanisms of Axon Degeneration Meeting (Cambridge, England, UK)
  • 2005: Invited speaker, Euroconference on Intra-neuronal Transport and Communication (Barcelona, Spain)

A head and shoulder profile shot of Dr Julia Edgar

Homepage image from the Axo-Glial Research Group website

Axo-Glial Group

We study the functions of the cells that form myelinated axons and aim to understand why they are so susceptible.

Our work provided the first functional demonstration that myelinating cells support axonal transport.

Click here to visit our website.