Mrs Jennifer Barrie
- Senior Research Technician (Immunology & Infection)
telephone:
01413300735
email:
Jennifer.Barrie@glasgow.ac.uk
CRG/Cavanagh, School Infection and Immunity, B310 SGDB, Glasgow G12 8TA
Publications
2023
Cunningham, M. E. , McGonigal, R. , Barrie, J. A., Campbell, C. I., Yao, D. and Willison, H. J. (2023) Axolemmal nanoruptures arising from paranodal membrane injury induce secondary axon degeneration in murine Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 28(1), pp. 17-31. (doi: 10.1111/jns.12532) (PMID:36710500)
McGonigal, R. , Cunningham, M. E. , Smyth, D., Chou, M., Barrie, J. A., Wilkie, A., Campbell, C., Saatman, K. E., Lunn, M. and Willison, H. J. (2023) The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 28(1), pp. 4-16. (doi: 10.1111/jns.12520) (PMID:36335586)
2022
Cunningham, M. E. , McGonigal, R. , Barrie, J. A., Yao, D. and Willison, H. J. (2022) Real time imaging of intra-axonal calcium flux in an explant mouse model of axonal Guillain-Barré syndrome. Experimental Neurology, 355, 114127. (doi: 10.1016/j.expneurol.2022.114127) (PMID:35640716) (PMCID:PMC7614209)
McGonigal, R. , Campbell, C. I., Barrie, J. A., Yao, D., Cunningham, M. E. , Crawford, C. L., Rinaldi, S., Rowan, E. G. and Willison, H. J. (2022) Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model. Journal of Clinical Investigation, 132(14), e158524. (doi: 10.1172/JCI158524) (PMID:35671105) (PMCID:PMC9282931)
Campbell, C. I., McGonigal, R. , Barrie, J. A., Delaere, J., Bracke, L., Cunningham, M. E. , Yao, D., Delahaye, T., Van de Walle, I. and Willison, H. J. (2022) Complement inhibition prevents glial nodal membrane injury in a GM1 antibody-mediated mouse model. Brain Communications, 4(6), fcac306. (doi: 10.1093/braincomms/fcac306) (PMID:36523267) (PMCID:PMC9746686)
2021
Schultz, V. et al. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69(8), pp. 2023-2036. (doi: 10.1002/glia.24010) (PMID:33942402) (PMCID:PMC9216243)
McGonigal, R. , Barrie, J. A., Yao, D., Black, L. E. , McLaughlin, M. and Willison, H. J. (2021) Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice. Journal of Neurochemistry, 158(2), pp. 217-232. (doi: 10.1111/jnc.15365) (PMID:33864399)
Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)
2020
Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)
2019
McGonigal, R. , Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)
2018
Meehan, G. R. , McGonigal, R. , Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)
2017
Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)
2016
Cunningham, M. , McGonigal, R. , Meehan, G. R. , Barrie, J. A., Yao, D., Halstead, S. K. and Willison, H. J. (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)
McGonigal, R. , Cunningham, M. E. , Yao, D., Barrie, J. A., Sankaranarayanan, S., Fewou, S. N., Furukawa, K., Yednock, T. A. and Willison, H. J. (2016) C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy. Acta Neuropathologica Communications, 4, 23. (doi: 10.1186/s40478-016-0291-x) (PMID:26936605) (PMCID:PMC4776408)
2014
Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)
2012
Rupp, A., Morrison, I., Barrie, J.A., Halstead, S.K., Townson, K.H., Greenshields, K.N. and Willison, H.J. (2012) Motor nerve terminal destruction and regeneration following anti-ganglioside antibody and complement-mediated injury: An in and ex vivo imaging study in the mouse. Experimental Neurology, 233(2), pp. 836-848. (doi: 10.1016/j.expneurol.2011.12.010)
2011
Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)
2010
Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)
Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)
2009
Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)
2005
Thomson, C.E., Vouyiouklis, D.A., Barrie, J.A., Wease, K.N. and Montague, P. (2005) Plp gene regulation in the developing murine optic nerve: Correlation with oligodendroglial process alignment along the axons. Developmental Neuroscience, 27, pp. 27-36. (doi: 10.1159/000084530)
1998
Montague, P., Barrie, J. A., Thomson, C. E., Kirkham, D., McCallion, A. S., Davies, R. W., Kennedy, P. G. E. and Griffiths, I. R. (1998) Cytoskeletal and nuclear localization of myelin oligodendrocytic basic protein isoforms. European Journal of Neuroscience, 10(4), pp. 1321-1328. (doi: 10.1046/j.1460-9568.1998.00143.x)
1997
Dickinson, P.J., Griffiths, I.R., Barrie, J.A., Kyriakides, E., Pollock, G.F. and Barnett, S.C. (1997) Expression of the dm-20 isoform of the plp gene in olfactory nerve ensheathing cells: evidence from developmental studies. Journal of Neurocytology, 26(3), pp. 181-189. (doi: 10.1023/A:1018584013739) (PMID:9192285)
1992
Fanarraga, M.L., Griffiths, I.R., McCulloch, M.C., Barrie, J.A., Kennedy, P.G.E. and Brophy, P.J. (1992) Rumpshaker: an X-linked mutation causing hypomyelination: developmental differences in myelination and glial cells between the optic nerve and spinal cord. Glia, 5(3), pp. 161-170. (doi: 10.1002/glia.440050302)
Articles
Cunningham, M. E. , McGonigal, R. , Barrie, J. A., Campbell, C. I., Yao, D. and Willison, H. J. (2023) Axolemmal nanoruptures arising from paranodal membrane injury induce secondary axon degeneration in murine Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 28(1), pp. 17-31. (doi: 10.1111/jns.12532) (PMID:36710500)
McGonigal, R. , Cunningham, M. E. , Smyth, D., Chou, M., Barrie, J. A., Wilkie, A., Campbell, C., Saatman, K. E., Lunn, M. and Willison, H. J. (2023) The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 28(1), pp. 4-16. (doi: 10.1111/jns.12520) (PMID:36335586)
Cunningham, M. E. , McGonigal, R. , Barrie, J. A., Yao, D. and Willison, H. J. (2022) Real time imaging of intra-axonal calcium flux in an explant mouse model of axonal Guillain-Barré syndrome. Experimental Neurology, 355, 114127. (doi: 10.1016/j.expneurol.2022.114127) (PMID:35640716) (PMCID:PMC7614209)
McGonigal, R. , Campbell, C. I., Barrie, J. A., Yao, D., Cunningham, M. E. , Crawford, C. L., Rinaldi, S., Rowan, E. G. and Willison, H. J. (2022) Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model. Journal of Clinical Investigation, 132(14), e158524. (doi: 10.1172/JCI158524) (PMID:35671105) (PMCID:PMC9282931)
Campbell, C. I., McGonigal, R. , Barrie, J. A., Delaere, J., Bracke, L., Cunningham, M. E. , Yao, D., Delahaye, T., Van de Walle, I. and Willison, H. J. (2022) Complement inhibition prevents glial nodal membrane injury in a GM1 antibody-mediated mouse model. Brain Communications, 4(6), fcac306. (doi: 10.1093/braincomms/fcac306) (PMID:36523267) (PMCID:PMC9746686)
Schultz, V. et al. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69(8), pp. 2023-2036. (doi: 10.1002/glia.24010) (PMID:33942402) (PMCID:PMC9216243)
McGonigal, R. , Barrie, J. A., Yao, D., Black, L. E. , McLaughlin, M. and Willison, H. J. (2021) Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice. Journal of Neurochemistry, 158(2), pp. 217-232. (doi: 10.1111/jnc.15365) (PMID:33864399)
Schultz, V. et al. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13(1), 91. (doi: 10.3390/v13010091) (PMID:33440758) (PMCID:PMC7827345)
Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)
McGonigal, R. , Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)
Meehan, G. R. , McGonigal, R. , Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)
Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)
Cunningham, M. , McGonigal, R. , Meehan, G. R. , Barrie, J. A., Yao, D., Halstead, S. K. and Willison, H. J. (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)
McGonigal, R. , Cunningham, M. E. , Yao, D., Barrie, J. A., Sankaranarayanan, S., Fewou, S. N., Furukawa, K., Yednock, T. A. and Willison, H. J. (2016) C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy. Acta Neuropathologica Communications, 4, 23. (doi: 10.1186/s40478-016-0291-x) (PMID:26936605) (PMCID:PMC4776408)
Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)
Rupp, A., Morrison, I., Barrie, J.A., Halstead, S.K., Townson, K.H., Greenshields, K.N. and Willison, H.J. (2012) Motor nerve terminal destruction and regeneration following anti-ganglioside antibody and complement-mediated injury: An in and ex vivo imaging study in the mouse. Experimental Neurology, 233(2), pp. 836-848. (doi: 10.1016/j.expneurol.2011.12.010)
Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)
Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)
Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)
Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)
Thomson, C.E., Vouyiouklis, D.A., Barrie, J.A., Wease, K.N. and Montague, P. (2005) Plp gene regulation in the developing murine optic nerve: Correlation with oligodendroglial process alignment along the axons. Developmental Neuroscience, 27, pp. 27-36. (doi: 10.1159/000084530)
Montague, P., Barrie, J. A., Thomson, C. E., Kirkham, D., McCallion, A. S., Davies, R. W., Kennedy, P. G. E. and Griffiths, I. R. (1998) Cytoskeletal and nuclear localization of myelin oligodendrocytic basic protein isoforms. European Journal of Neuroscience, 10(4), pp. 1321-1328. (doi: 10.1046/j.1460-9568.1998.00143.x)
Dickinson, P.J., Griffiths, I.R., Barrie, J.A., Kyriakides, E., Pollock, G.F. and Barnett, S.C. (1997) Expression of the dm-20 isoform of the plp gene in olfactory nerve ensheathing cells: evidence from developmental studies. Journal of Neurocytology, 26(3), pp. 181-189. (doi: 10.1023/A:1018584013739) (PMID:9192285)
Fanarraga, M.L., Griffiths, I.R., McCulloch, M.C., Barrie, J.A., Kennedy, P.G.E. and Brophy, P.J. (1992) Rumpshaker: an X-linked mutation causing hypomyelination: developmental differences in myelination and glial cells between the optic nerve and spinal cord. Glia, 5(3), pp. 161-170. (doi: 10.1002/glia.440050302)
Research datasets
2022
McGonigal, R. , Cunningham, M. , Smyth, D., Chou, M., Barrie, J., Wilkie, A., Campbell, C., Saatman, K. E., Lunn, M. and Willison, H. (2022) The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome. [Data Collection]
2020
Schultz, V. , Cumberworth, S., Gu, N., Johnson, N., Donald, C. , McCanney, G., Barrie, J., Da Silva Filipe, A. , Linington, C. , Willison, H. , Edgar, J., Barnett, S. and Kohl, A. (2020) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. [Data Collection]