Mr Derek Wright
- Bioinformatician / Computational Biologist (Virology)
telephone:
01413304019
email:
Derek.Wright@glasgow.ac.uk
Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH
https://orcid.org/0000-0003-0411-4497Research interests
Bioinformatics, computational biology, data science.
Publications
2024
Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)
2023
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Cox, M. et al. (2023) SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies. Nature Reviews Microbiology, 21(2), pp. 112-124. (doi: 10.1038/s41579-022-00809-7) (PMID:36307535) (PMCID:PMC9616429)
2022
Wright, D. W. et al. (2022) Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. Virus Evolution, 8(1), veac023. (doi: 10.1093/ve/veac023) (PMID:35502202) (PMCID:PMC9037374)
2021
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
2020
Bailey, M. H. et al. (2020) Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11, 4748. (doi: 10.1038/s41467-020-18151-y) (PMID:32958763) (PMCID:PMC7505971)
Li, C. H. et al. (2020) Sex differences in oncogenic mutational processes. Nature Communications, 11, 4330. (doi: 10.1038/s41467-020-17359-2) (PMID:32859912) (PMCID:PMC7455744)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et al. (2020) Pan-cancer analysis of whole genomes. Nature, 578(7793), pp. 82-93. (doi: 10.1038/s41586-020-1969-6) (PMID:32025007) (PMCID:PMC7025898)
Jiao, W. et al. (2020) A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nature Communications, 11, 728. (doi: 10.1038/s41467-019-13825-8) (PMID:32024849) (PMCID:PMC7002586)
2018
Livigni, A., O'Hara, L., Polak, M. E., Angus, T., Wright, D. W. , Smith, L. B. and Freeman, T. C. (2018) A graphical and computational modeling platform for biological pathways. Nature Protocols, 13(4), pp. 705-722. (doi: 10.1038/nprot.2017.144) (PMID:29543794)
2016
O’Hara, L. et al. (2016) Modelling the structure and dynamics of biological pathways. PLoS Biology, 14(8), e1002530. (doi: 10.1371/journal.pbio.1002530) (PMID:27509052) (PMCID:PMC4980033)
2015
Lizio, M. et al. (2015) Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biology, 16, 22. (doi: 10.1186/s13059-014-0560-6) (PMID:25723102) (PMCID:PMC4310165)
2014
Wright, D. W. , Angus, T., Enright, A. J. and Freeman, T. C. (2014) Visualisation of BioPAX Networks using BioLayout Express3D. F1000Research, 3, 246. (doi: 10.12688/f1000research.5499.1) (PMID:25949802) (PMCID:PMC4406191)
1999
Evans, M. C.W., Purton, S., Patel, V., Wright, D. , Heathcote, P. and Rigby, S. E.J. (1999) Modification of electron transfer from the quinone electron carrier, A(1), of Photosystem 1 in a site directed mutant D576 double right arrow L within the Fe-S(x) binding site of PsaA and in second site suppressors of the mutation in Chlamydomonas reinhardtii. Photosynthesis Research, 61(1), pp. 33-42. (doi: 10.1023/A:1006205811407)
1995
Hallahan, B. J., Purton, S., Ivison, A., Wright, D. and Evans, M. C. W. (1995) Analysis of the proposed Fe-SX binding region of Photosystem 1 by site directed mutation of PsaA in Chlamydomonas reinhardtii. Photosynthesis Research, 46(1-2), pp. 257-264. (doi: 10.1007/BF00020438) (PMID:24301590)
Articles
Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Cox, M. et al. (2023) SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies. Nature Reviews Microbiology, 21(2), pp. 112-124. (doi: 10.1038/s41579-022-00809-7) (PMID:36307535) (PMCID:PMC9616429)
Wright, D. W. et al. (2022) Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. Virus Evolution, 8(1), veac023. (doi: 10.1093/ve/veac023) (PMID:35502202) (PMCID:PMC9037374)
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
Bailey, M. H. et al. (2020) Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11, 4748. (doi: 10.1038/s41467-020-18151-y) (PMID:32958763) (PMCID:PMC7505971)
Li, C. H. et al. (2020) Sex differences in oncogenic mutational processes. Nature Communications, 11, 4330. (doi: 10.1038/s41467-020-17359-2) (PMID:32859912) (PMCID:PMC7455744)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et al. (2020) Pan-cancer analysis of whole genomes. Nature, 578(7793), pp. 82-93. (doi: 10.1038/s41586-020-1969-6) (PMID:32025007) (PMCID:PMC7025898)
Jiao, W. et al. (2020) A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nature Communications, 11, 728. (doi: 10.1038/s41467-019-13825-8) (PMID:32024849) (PMCID:PMC7002586)
Livigni, A., O'Hara, L., Polak, M. E., Angus, T., Wright, D. W. , Smith, L. B. and Freeman, T. C. (2018) A graphical and computational modeling platform for biological pathways. Nature Protocols, 13(4), pp. 705-722. (doi: 10.1038/nprot.2017.144) (PMID:29543794)
O’Hara, L. et al. (2016) Modelling the structure and dynamics of biological pathways. PLoS Biology, 14(8), e1002530. (doi: 10.1371/journal.pbio.1002530) (PMID:27509052) (PMCID:PMC4980033)
Lizio, M. et al. (2015) Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biology, 16, 22. (doi: 10.1186/s13059-014-0560-6) (PMID:25723102) (PMCID:PMC4310165)
Wright, D. W. , Angus, T., Enright, A. J. and Freeman, T. C. (2014) Visualisation of BioPAX Networks using BioLayout Express3D. F1000Research, 3, 246. (doi: 10.12688/f1000research.5499.1) (PMID:25949802) (PMCID:PMC4406191)
Evans, M. C.W., Purton, S., Patel, V., Wright, D. , Heathcote, P. and Rigby, S. E.J. (1999) Modification of electron transfer from the quinone electron carrier, A(1), of Photosystem 1 in a site directed mutant D576 double right arrow L within the Fe-S(x) binding site of PsaA and in second site suppressors of the mutation in Chlamydomonas reinhardtii. Photosynthesis Research, 61(1), pp. 33-42. (doi: 10.1023/A:1006205811407)
Hallahan, B. J., Purton, S., Ivison, A., Wright, D. and Evans, M. C. W. (1995) Analysis of the proposed Fe-SX binding region of Photosystem 1 by site directed mutation of PsaA in Chlamydomonas reinhardtii. Photosynthesis Research, 46(1-2), pp. 257-264. (doi: 10.1007/BF00020438) (PMID:24301590)
Research datasets
2023
Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]
