Professor David Stott I

Emeritus Professor of Molecular Immunology and Honorary Senior Research Fellow (School of Infection & Immunity)

Institute of Infection, Immunity & Inflammation, University Place, Glasgow G12 8TA

Research interests

We have shown that clusters of B-cells, T-cells and follicular dendritic cells in the target tissues of autoimmune diseases (Sjögren’s syndrome, myasthenia gravis, myositis and psoriatic arthritis) are undergoing an ectopic germinal centre reaction in which B-cells are stimulated by antigen to proliferate, switch on somatic hypermutation and undergo affinity selection. In collaboration with Professors Nick Willcox and Angela Vincent at the Neurosciences Group, Institute of Molecular Medicine, Oxford, antibodies produced by thymic B-cells from a myasthenia gravis patient were cloned, shown to be specific for the acetylcholine receptor and to inhibit receptor signalling. We have also investigated the reactions of lymphocytes infiltrating human breast tumours and identified ectopic germinal centre reactions within the tumours, with selection for B-cells expressing identified Ig V-genes, similar to those in the target tissues of autoimmune diseases. Antibodies expressed by B-cells infiltrating a human breast tumour were cloned and shown to recognise epidermal growth factor receptor-related antigens present on the tumour cells. Following this discovery, in collaboration with a group at Pharmexa, Denmark, we investigated the effects of a recombinant vaccine containing part of the same antigen linked to a tetanus toxin peptide on tumour development in a transgenic mouse model of breast cancer. Prophylactic immunisation with the recombinant antigen completely prevented development of tumours in a B-cell-dependent manner, whereas therapeutic vaccination after small tumours had already developed failed to prevent tumour growth. Research on the inhibitory effects of tumours on the immune response and ways of blocking these effects could facilitate development of this vaccine for therapeutic use. This work has important implications for the development of anti-cancer vaccines.

In collaboration with the Finlay Institute for vaccine research we used a phage display peptide library to clone peptides (mimotopes) that have similar 3-D structures to immunogenic regions of virus proteins. Mimotopes that induce a protective immune response against Hepatitis A virus were identified and have been patented for potential application in vaccines and diagnostic kits. Studies on the development of mimotope vaccines against HAV and Dengue Virus are continuing.

Publications

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Number of items: 95.

2014

Aguilar, A. et al. (2014) Study of peptide mimetics of hepatitis A virus conjugated to keyhole limpet hemocyanin and as multiple antigen peptide system. International Journal of Peptide Research and Therapeutics, 20(1), pp. 33-42. (doi: 10.1007/s10989-013-9364-x)

Mukhopadhyay, A., Dyring, C. and Stott, D. (2014) Comparison of prophylactic and therapeutic immunisation with an ErbB-2 (HER2) fusion protein and immunoglobulin V-gene repertoire analysis in a transgenic mouse model of spontaneous breast cancer. Vaccine, 32(8), pp. 1012-1018. (doi: 10.1016/j.vaccine.2013.10.077)

McIntyre, D., Zuckerman, N. S., Field, M., Mehr, R. and Stott, D. I. (2014) The V_H repertoire and clonal diversification of B cells in inflammatory myopathies. European Journal of Immunology, 44(2), pp. 585-596. (doi: 10.1002/eji.201343315) (PMID:24343314)

2013

Amin, N. et al. (2013) Immunogenicity of NS4b dengue 3 virus mimotope presented to the immune system as multiple antigen peptide system. ISRN Virology, 2013, p. 924057. (doi: 10.5402/2013/924057)

2011

Stott, D.I. and McIntyre, D. (2011) The ectopic germinal centre response in autoimmune disease and Cancer. In: Huang, F.P. (ed.) Autoimmune Disorders - Current Concepts and Advances from Bedside to Mechanistic Insights. InTech: Rijeka, Croatia. ISBN 9789533076539 (doi: 10.5772/37014)

2010

Aguilar, A., Martinez, R., Camacho, F., Amin, N., Alfonso, J.L., Stott, D.I. and Perez, E.L. (2010) Ensayo de neutralización in vitro de aplicación en la evaluación de inmunógenos contra la hepatitis A, obtenidos mediante la tecnología de expresión en fagos filamentosos [In vitro neutralization assay to evaluate new hepatitis A vaccine candidates]. Vaccimonitor, 19(1), pp. 16-19.

2009

Amin, N. et al. (2009) Identification of dengue-specific B-cell epitopes by phage-display random peptide library. Malaysian Journal of Medical Sciences, 16(4), pp. 4-14.

2008

Yang, C.-H., Tian, L., Ling, G.-S., Trendell‐Smith, N. J., Ma, L., Lo, C.-K., Stott, D. I., Liew, F. Y. and Huang, F.-P. (2008) Correction: Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL‐2versusIL‐15. European Journal of Immunology, 38(7), p. 2046. (doi: 10.1002/eji.200890028)

Yang, C.-H., Tian, L., Ling, G.-S., Trendell-Smith, N. J., Ma, L., Lo, C.-K., Stott, D. I., Liew, F. Y. and Huang, F.-P. (2008) Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15. European Journal of Immunology, 38(6), pp. 1664-1676. (doi: 10.1002/eji.200838190)

2007

Loughlin, P.M., Cooke, T.G., George, W.D., Gray, A.J., Stott, D.I. and Going, J.J. (2007) Quantifying tumour-infiltrating lymphocyte subsets: a practical immuno-histochemical method. Journal of Immunological Methods, 321(1-2), pp. 32-40. (doi: 10.1016/j.jim.2007.01.012)

Larralde, O.G., Martinez, R., Camacho, F., Amin, N., Aguilar, A., Talavera, A., Stott, D.I. and Perez, E.M. (2007) Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity. Journal of Virological Methods, 140(1-2), pp. 49-58. (doi: 10.1016/j.jviromet.2006.10.015)

2006

Steiman-Shimony, A., Edelman, H., Hutzler, A., Barak, M., Zuckerman, N.S., Shahaf, G., Dunn-Walters, D., Stott, D.I., Abraham, R.S. and Mehr, R. (2006) Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection. Cellular Immunology, 244(2), pp. 130-136. (doi: 10.1016/j.cellimm.2007.01.009)

Darlow, J.M. and Stott, D.I. (2006) Gene conversion in human rearranged immunoglobulin genes. Immunogenetics, 58(7), pp. 511-522. (doi: 10.1007/s00251-006-0113-6)

Steiman-Shimony, A., Edelman, H., Barak, M., Shahaf, G., Dunn-Walters, D., Stott, D.I., Abraham, R.S. and Mehr, R. (2006) Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases. Autoimmunity Reviews, 5(4), pp. 242-251. (doi: 10.1016/j.autrev.2005.07.008)

2005

Darlow, J.M. and Stott, D.I. (2005) V_H replacement in rearranged immunoglobulin genes. Immunology, 114(2), pp. 155-165. (doi: 10.1111/j.1365-2567.2004.02084.x)

Darlow, J.M. and Stott, D.I. (2005) V-H replacement in rearranged immunoglobulin genes. Immunology, 114(2), pp. 155-165. (doi: 10.1111/j.1365-2567.2004.02084.x)

Darlow, J.M. and Stott, D.I. (2005) VH replacement in immunoglobulin genes. Immunology, 114(2), pp. 155-165. (doi: 10.1111/j.1365-2567.2004.02084.x)

Ma, L. et al. (2005) Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains. European Journal of Immunology, 35, pp. 3364-3375. (doi: 10.1002/eji.200535192)

Simsa, P., Teillaud, J.L., Stott, D.I., Toth, J. and Kotlan, B. (2005) Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma. Pathology and Oncology Research, 11(2), pp. 92-97.

2004

Darlow, J.M., Farrell, A.M. and Stott, D.I. (2004) Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4. Immunology, 111(2), pp. 212-222. (doi: 10.1111/j.0019-2805.2003.01790.x)

05819161.0-1223-CU2005000011 (2004) Peptides which Mimic the Antigenic Regions of the Hepatitis A Virus. .

2004-0270 (2004) Peptidos Que Mimetizan Las Regiones Antigenicas Del Virus De La Hepatitis A. .

2003

Nzula, S., Going, J.J. and Stott, D.I. (2003) Antigen-driven clonal proliferation, somatic hypermutation and selection of B-lymphocytes infiltrating human ductal breast carcinoma. Cancer Research, 63(12), pp. 3275-3280.

Adams, C. L., Macleod, M. K.L. , Milner-White, E. J., Aitken, R., Garside, P. and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108(3), pp. 274-287. (doi: 10.1046/j.1365-2567.2003.01583.x) (PMID:12603593)

Fraser, N.L.W., Rowley, G., Field, M. and Stott, D.I. (2003) The V_H gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus. Arthritis Research and Therapy, 5, pp. 114-121. (doi: 10.1186/ar627)

Fraser, N.L.W., Rowley, G., Field, M. and Stott, D.I. (2003) The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus. Arthritis Research and Therapy, 5, R114-R121. (doi: 10.1186/ar627)

Nzula, S., Going, J.J. and Stott, D.I. (2003) The role of B lymphocytes in breast cancer: a review and current status. Cancer Therapy, 1, pp. 353-362.

Shiono, H. et al. (2003) Scenarios for autoimmunization of T and B cells in myasthenia gravis. Annals of the New York Academy of Sciences, 998, pp. 237-256. (doi: 10.1196/annals.1254.026)

Sims, G.P., Willcox, N. and Stott, D.I. (2003) The autoantibody repertoire in myasthenia gravis. In: Zouali, M. (ed.) Frontiers in Autoimmunity. Series: NATO science series. Series I, life and behavioural sciences, 1. IOS Press: Amsterdam, pp. 100-125. ISBN 9781586033613

Stott, D.I. and Berek, C. (2003) An antigen-driven B-cell response within the salivary glands of patients with Sjögren's syndrome. MCFA Annals, II, pp. 108-116.

2002

Matthews, I., Sims, G., Ledwidge, S., Stott, D., Beeson, D., Wilcox, N. and Vincent, A. (2002) Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen. Laboratory Investigation, 82(10), pp. 1407-1417. (doi: 10.1097/01.LAB.0000032379.63784.9C) (PMID:12379775)

Darlow, J.M. and Stott, D.I. (2002) Get the balance right. Nature Immunology, 3, p. 1113. (doi: 10.1038/ni1202-1113)

Stott, D.I. and Berek, C. (2002) An antigen-driven B-cell response within the salivary glands of patients with Sjögren’s syndrome. Annals of the Marie Curie Fellowship Association, 2, pp. 108-116.

2001

Sims, G.P., Shiono, H., Willcox, N. and Stott, D.I. (2001) Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis. Journal of Immunology, 167(4), pp. 1935-1944.

2000

Herbert, W.J., Wilkinson, P.C. and Stott, D.I. (2000) Immunológia Szótár [Hungarian translation]. Medicina Könyvkiadó: Budapest, Hungary. ISBN 9632424484

Stott, D.I. (2000) Immunoblotting, dot-blotting, and ELISPOT assays: methods and applications. Journal of Immunoassay, 21(2-3), pp. 273-296.

Stott, D.I. and Goodridge, H. (2000) Antibodies, cells, cytokines and signals. Immunology News, 7, pp. 66-69.

Stott, D.I. and Sims, G.P. (2000) Application of scFv-phage display to analysis of B-cell clones proliferating in the salivary glands of a patient with Sjögren's syndrome. Disease Markers, 16(1-2), pp. 21-23.

1999

Huggins, M.L., Huang, F.P., Xu, D., Lindop, G. and Stott, D.I. (1999) Modulation of autoimmune disease in the MRL-lpr/lpr mouse by IL-2 and TGF-b1 gene therapy using attenuated Salmonella typhimurium as gene carrier. Lupus, 8, pp. 29-38. (doi: 10.1191/096120399678847308)

1998

Stott, D.I., Hiepe, F., Hummel, M., Steinhauser, G. and Berek, C. (1998) Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease, the salivary glands of patients with Sjögren's syndrome. Journal of Clinical Investigation, 102(5), pp. 938-946. (doi: 10.1172/JCI3234)

Stott, D.I., Hiepe, F., Hummel, M., Steinhauser, G. and Berek, C. (1998) Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome. Journal of Clinical Investigation, 102(5), pp. 938-946. (doi: 10.1172/JCI3234)

Niedbala, W.G. and Stott, D.I. (1998) A comparison of three methods for production of human hybridomas secreting autoantibodies. Hybridoma, 17(3), pp. 299-304.

1997

Huggins, M.L., Huang, F.P., Xu, D., Lindop, G. and Stott, D.I. (1997) Modulation of the autoimmune response in lupus mice by oral administration of attenuated Salmonella typhimurium expressing the IL-2 and TGF-b genes. Annals of the New York Academy of Sciences, 815, pp. 499-502. (doi: 10.1111/j.1749-6632.1997.tb52114.x)

1996

Huang, F.P., Feng, G.J., Lindop, G., Stott, D.I. and Liew, F.Y. (1996) The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. Journal of Experimental Medicine, 183(4), pp. 1447-1459.

1995

Huang, F. and Stott, D.I. (1995) Dual inhibitory and stimulatory activities in serum from SLE patients and lupus mice that regulate the proliferation of an IL-2-dependent T cell line. Lupus, 4(4), pp. 297-303.

Herbert, W.J., Wilkinson, P.C. and Stott, D.I. (1995) Dictionary of Immunology. Academic Press: London, UK. ISBN 9780127520254

1994

Stott, D.I. (1994) Immunoblotting, dot-blotting, and ELISPOT assays: methods and applications. In: van Oss, C.J. and van Regenmortel, M.H.V. (eds.) Immunochemistry. Marcel Dekker: New York, USA, pp. 925-948. ISBN 9780824791230

1993

Huang, F. and Stott, D.I. (1993) Restoration of an early, progressive defect in responsiveness to T-cell activation in lupus mice by exogenous IL-2. Autoimmunity, 15(1), pp. 19-29. (doi: 10.3109/08916939309004835)

1992

Stott, D.I. (1992) Spectrotypes of anti-DNA antibodies show that anti-DNA-secreting B-cell clones of SLE patients are restricted in number, stable and long lived. Autoimmunity, 12(4), pp. 249-258. (doi: 10.3109/08916939209148467)

1990

Stott, D.I. (1990) Review of: B.A. Baldo and E.R. Tovey (eds.), Protein Blotting. Journal of Immunological Methods, 129(2), p. 294. [Book Review]

Stott, D.I. (1990) Lessons about autoantibody specificity in systemic lupus erythematosus from animal models. Clinical and Experimental Immunology, 81(1), pp. 1-4. (doi: 10.1111/j.1365-2249.1990.tb05282.x)

Stott, D.I., Brighouse, G., Gyotoku, Y. and Lambert, P. (1990) Analysis of the autoimmune response in lupus mice: the behaviour and lifespan of anti-DNA-secreting B-cell clones. Autoimmunity, 8(2), pp. 159-168. (doi: 10.3109/08916939008995734)

1989

Stott, D.I. (1989) Immunoblotting and dot blotting. Journal of Immunological Methods, 119(2), pp. 153-187. (doi: 10.1016/0022-1759(89)90394-3)

Forrester, J.V., Stott, D.I. and Hercus, K.M. (1989) Naturally occurring antibodies to bovine and human retinal S antigens; a comparison between uveitis patients and normal healthy volunteers. British Journal of Ophthalmology, 73(2), pp. 155-159.

Forrester, J.V., Stott, D.I. and Neilson, L.G. (1989) Clonal analysis of antibody secretion in uveitis. In: Secchi, A.G. and Fregona, I.A. (eds.) Modern Trends in Immunology and Immunopathology of the Eye. Masson: Milan, Italy, pp. 31-35. ISBN 9788821418228

1988

Stott, D.I., Hassman, R., Neilson, L. and McGregor, A.M. (1988) Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis. Clinical and Experimental Immunology, 73(2), pp. 269-275.

Stott, D.I., Hassman, R., Neilson, L. and McGregor, A.M. (1988) Isoelectric focusing spectrotypes of anti-thyroglobulin autoantibodies in autoimmune thyroiditis: a PVG rat model. Clinical and Experimental Immunology, 73(2), pp. 269-275.

Stott, D.I. (1988) Reaction to the letter: is that what you mean? Journal of Immunological Methods, 107(1), p. 153. (doi: 10.1016/0022-1759(88)90022-1)

Herbert, W.J., Wilkinson, P.C. and Stott, D.I. (1988) Dictionnaire d’Immunologie [French translation]. Laboratoires Cassenne: Chedigny, France.

Herbert, W.J., Wilkinson, P.C. and Stott, D.I. (1988) Dizionario di Immunologia [Italian translation]. Masson Italia: Milan, Italy.

Stott, D.I. (1988) Review of: J.W. Keyser, Human Plasma Proteins. Disease Markers, 6, pp. 292-293. [Book Review]

Stott, D.I., Merino, J., Schurmans, S. and Lambert, P. (1988) Expression of anti-DNA clonotypes and the role of helper T-lymphocytes during the autoimmune response in mice tolerant to alloantigens. Autoimmunity, 1, pp. 253-266. (doi: 10.3109/08916938809010679)

1987

Herbert, W.J., Wilkinson, P.C. and Stott, D.I. (1987) Dictionary of Immunology [Japanese translation]. Hirokawa Pub. Co: Japan.

1986

Sinclair, D., Dagg, J.H., Dewar, A.E., Mowat, A.M., Parrott, D.M.V., Stockdill, G. and Stott, D.I. (1986) The incidence, clonal origin and secretory nature of serum paraproteins in chronic lymphocytic leukaemia. British Journal of Haematology, 64(4), pp. 725-735. (doi: 10.1111/j.1365-2141.1986.tb02234.x)

Sinclair, D., Sheehan, T., Parrott, D.M.V. and Stott, D.I. (1986) The incidence of monoclonal gammopathy in a population over 45 years old determined by isoelectric focusing. British Journal of Haematology, 64(4), pp. 745-750. (doi: 10.1111/j.1365-2141.1986.tb02236.x)

Stott, D.I., McLearie, J. and Neilson, L. (1986) Analysis of the clonal origins of autoantibodies against thyroglobulin and DNA in autoimmune thyroiditis and systemic lupus erythematosus. Clinical and Experimental Immunology, 65(3), pp. 520-533.

Sinclair, D., Parrott, D.M.V. and Stott, D.I. (1986) Quantitation of monoclonal immunoglobulins by immuno-isoelectric focusing and its application for monitoring secretory B cell neoplasia. Journal of Immunological Methods, 90(2), pp. 247-255. (doi: 10.1016/0022-1759(86)90082-7)

Sinclair, D., Dagg, J.H., Smith, J.G. and Stott, D.I. (1986) The incidence and possible relevance of Bence-Jones protein in the sera of patients with multiple myeloma. British Journal of Haematology, 62(4), pp. 689-694. (doi: 10.1111/j.1365-2141.1986.tb04092.x)

Sinclair, D. and Stott, D.I. (1986) Immunoisoelectric focusing for detecting, typing, and monitoring serum paraproteins. American Journal of Clinical Pathology, 85(4), pp. 531-532.

Stott, D.I. and McLearie, J. (1986) Isoelectric focusing and reverse immunoblotting of autoantibodies against high molecular weight antigens. Immunological Investigations, 15(2), pp. 113-122. (doi: 10.3109/08820138609094137)

Sinclair, D., Dagg, J.H., Dewar, A.E., Mowat, A.M., Parrott, D.M.V., Stockdill, G. and Stott, D.I. (1986) The incidence, clonal origin and secretory nature of serum paraproteins in chronic lymphocytic leukaemia. In: Hickey, R.C. (ed.) The Yearbook of Cancer. Year Book Medical Publishers: Chicago, IL, USA. ISBN 9780815117940

1985

Stott, D.I. (1985) Autoantibodies and nuclear antigens. Immunology Today, 6(11), pp. 314-315. (doi: 10.1016/0167-5699(85)90118-5)[Book Review]

Stott, D.I., McLearie, J. and Marsden, H.S. (1985) A gel transfer tank for immunoblotting and its application for analysis of nuclear protein antigens. Analytical Biochemistry, 149(2), pp. 454-460. (doi: 10.1016/0003-2697(85)90597-4)

MacGregor, A.N., Stott, D.I. and Kusel, J.R. (1985) Lectin binding to glycoproteins in the surface membrane of Schistosoma mansoni. Molecular and Biochemical Parasitology, 16(2), pp. 163-172. (doi: 10.1016/0166-6851(85)90084-2)

Stott, D.I. (1985) Forbidden clones. Immunology Today, 6(4), pp. 121-11. (doi: 10.1016/0167-5699(85)90075-1)

Herbert, W.J., Wilkinson, P.C. and Stott, D.I. (1985) Dictionary of Immunology. Blackwell Scientific Publications: Oxford, UK. ISBN 9780632009848

Stott, D.I. (1985) Analysis of nuclear and cytoplasmmic protein antigens in systemic rheumatic disease. In: Peeters, H. (ed.) Protides of the Biological Fluids: Proceedings of the Thirty-Third Colloquium. Series: Protides of the biological fluids (33). Pergamon: Oxford, UK. ISBN 9780080332154

1984

Sinclair, D., Dagg, J.H., Mowatt, A.M., Parrott, D.M. and Stott, D.I. (1984) Serum paraproteins in chronic lymphocytic leukaemia. Journal of Clinical Pathology, 37(4), pp. 463-466.

Sinclair, D., Kumararatne, D.S. and Stott, D.I. (1984) Detection and identification of serum monoclonal immunoglobulin by immunoisoelectric focusing. Limits of sensitivity and use during relapse of multiple myeloma. Journal of Clinical Pathology, 37(3), pp. 255-262.

1983

Sinclair, D., Kumararatne, D.S., Forrester, J.B., Lamont, A. and Stott, D.I. (1983) The application of isoelectric focusing to routine screening for paraproteinaemia. Journal of Immunological Methods, 64(1-2), pp. 147-156. (doi: 10.1016/0022-1759(83)90393-9)

Lincoln, J.C. and Stott, D.I. (1983) Nuclear proteins associated with gene expression in mouse plasmacytoma cell lines. Molecular Immunology, 20(8), pp. 839-850. (doi: 10.1016/0161-5890(83)90080-9)

Stott, D.I. (1983) Levels of immunity. Review of: A. Nisonoff, Introduction to Molecular Immunology. Times Higher Education Supplement, p. 22. [Book Review]

Stott, D.I. (1983) Correlation of patterns of nuclear protein synthesis with differentiation of mitogen-stimulated b-lymphocytes. Immunological Investigations, 12(6), pp. 605-623. (doi: 10.3109/08820138309025441)

1982

Stott, D.I. (1982) Nonhistone chromatin proteins of B-lymphocytes stimulated by lipopolysaccharide. Two-dimensional gel electrophoresis analysis of proteins synthesized and phosphorylated during the initiation of lymphocyte differentiation. Biochimica et Biophysica Acta: General Subjects, 699(3), pp. 247-254.

Stott, D.I. and Williamson, A.R. (1982) Immunoglobulins and histocompatibility antigens. Their structure, function and metabolism. In: Neuberger, A. and van Deenen, L.L.M. (eds.) Protein Metabolism. Series: Comprehensive biochemistry. Elsevier Scientific Pub. Co: Amsterdam, Netherlands. ISBN 9780444803467

1981

Stott, D.I. and Lincoln, J.C. (1981) Nuclear proteins and the control of gene expression in lymphocytes and plasma cells. In: Lefkovits, I., Jerne, N.K., Steinberg, C.M. and Di Lorenzo, C. (eds.) The Immune System. Karger: Basel, Switzerland. ISBN 9783805534086

1980

Stott, D.I. (1980) Non-histone chromatin proteins of B lymphocytes stimulated by lipopolysaccharide, III. De novo synthesis. Biochimica et Biophysica Acta: General Subjects, 610(2), pp. 371-383.

1978

Stott, D.I. and Williamson, A.R. (1978) Non-histone chromatin proteins of B lymphocytes stimulated by lipopolysaccharide. II. Phosphorylation. Biochimica et Biophysica Acta, 521(2), pp. 739-752.

Stott, D.I. and Williamson, A.R. (1978) Nonhistone chromatin proteins of B-lymphocytes stimulated by lipopolysaccharide. I. Synthesis. Biochimica et Biophysica Acta, 521(2), pp. 726-738.

Stott, D.I. (1978) Biosynthesis and assembly of IgM free thiol groups present on cytoplasmic and membrane associated IgM. Immunological Investigations, 7(5), pp. 519-541. (doi: 10.3109/08820137809025482)

1976

Stott, D.I. (1976) Biosynthesis and assembly of IgM. Addition of J chain to intracellular pools of 8S and 19S IgM. Immunochemistry, 13(2), pp. 157-163. (doi: 10.1016/0019-2791(76)90284-6)

1974

Andersson, J., Buxbaum, J., Citronbaum, R., Douglas, S., Forni, L., Melchers, F., Pernis, B. and Stott, D.I. (1974) IgM-producing tumors in the BALB/c mouse: a model for B-cell maturation. Journal of Experimental Medicine, 140(3), pp. 742-763.

1973

Stott, D.I. and Feinstein, A. (1973) Biosynthesis and assembly of IgM. Free thiol groups present on the intracellular subunits. European Journal of Immunology, 3(4), pp. 229-235. (doi: 10.1002/eji.1830030410)

1972

Stott, D.I. (1972) Assembly of immunoglobulin G: the role of the light-chain pool. Biochemical Journal, 130(4), pp. 1151-1152.

Stott, D.I. and Munro, A.J. (1972) The formation of pyrrolid-2-one-5-carboxylic acid at the N-terminus of immunoglobulin G heavy chain. Biochemical Journal, 128(5), pp. 1221-1227.

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