2024

Reis-Cunha, J. L., Pimenta-Carvalho, S. A., Almeida, L. V., Coqueiro-Dos-Santos, A., Marques, C. A. , Black, J. A., Damasceno, J. , McCulloch, R. , Bartholomeu, D. C. and Jeffares, D. C. (2024) Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites. Genome Research, 34(3), pp. 441-453. (doi: 10.1101/gr.278550.123) (PMID:38604731) (PMCID:PMC11067883)

2023

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

Tosi, L. R. O., Denny, P. W., De Oliveira, C. I. and Damasceno, J. D. (2023) Editorial: Leishmania genome variability: impacts on parasite evolution, parasitism and leishmaniases control. Frontiers in Cellular and Infection Microbiology, 13, 1171962. (doi: 10.3389/fcimb.2023.1171962) (PMID:36949811) (PMCID:PMC10025553)

2022

da Silva, R. B., Bertoldo, W. d. R., Naves, L. L., de Vito, F. B., Damasceno, J. D. , Tosi, L. R. O., Machado, C. R. and Pedrosa, A. L. (2022) Specific human ATR and ATM inhibitors modulate single strand DNA formation in Leishmania major exposed to oxidative agent. Frontiers in Cellular and Infection Microbiology, 11, 802613. (doi: 10.3389/fcimb.2021.802613) (PMID:35059327) (PMCID:PMC8763966)

2021

Damasceno, J. D. , Marques, C. A., Black, J., Briggs, E. and McCulloch, R. (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)

2020

Damasceno, J. D. , Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)

Damasceno, J. D. , Reis-Cunha, J., Crouch, K. , Beraldi, D., Lapsley, C., Tosi, L. R.O., Bartholomeu, D. and McCulloch, R. (2020) Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication. PLoS Genetics, 16(7), e1008828. (doi: 10.1371/journal.pgen.1008828) (PMID:32609721) (PMCID:PMC7360064)

de Araujo, C. B. et al. (2020) Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, 21, 414. (doi: 10.1186/s12864-020-06803-8) (PMID:32571205) (PMCID:PMC7310030)

Briggs, E. M., Marques, C. A., Reis-Cunha, J., Black, J., Campbell, S., Damasceno, J. , Bartholomeu, D., Crouch, K. and McCulloch, R. (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)

2019

Damasceno, J. D. , Tosi, L. R.O., Santos, R. E.R.S. and Mottram, J. C. (2019) DiCre-based inducible gene expression. In: Clos, J. (ed.) Leishmania: Methods and Protocols. Series: Methods in molecular biology (1971). Humana Press: New York, NY, pp. 225-235. ISBN 9781493992096 (doi: 10.1007/978-1-4939-9210-2_11)

2018

Damasceno, J. D. , Obonaga, R., Silva, G. L.A., Reis-Cunha, J. L., Duncan, S. M., Bartholomeu, D. C., Mottram, J. C. , McCulloch, R. and Tosi, L. R.O. (2018) Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania. Nucleic Acids Research, 46(22), pp. 11835-11846. (doi: 10.1093/nar/gky1017) (PMID:30380080) (PMCID:PMC6294564)

Trindade, J. B. C. et al. (2018) A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis. EBioMedicine, 36, pp. 83-91. (doi: 10.1016/j.ebiom.2018.09.029) (PMID:30268832) (PMCID:PMC6197651)

2017

da Silva, M. S., Pavani, R. S., Damasceno, J. D. , Marques, C. A. , McCulloch, R. , Tosi, L. R. O. and Elias, M. C. (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11), pp. 858-874. (doi: 10.1016/j.pt.2017.08.002) (PMID:28844718) (PMCID:PMC5662062)

Santos, R. E.R.S., Silva, G. L.A., Santos, E. V., Duncan, S. M., Mottram, J. C. , Damasceno, J. D. and Tosi, L. R.O. (2017) A DiCre recombinase-based system for inducible expression in Leishmania major. Molecular and Biochemical Parasitology, 216, pp. 45-48. (doi: 10.1016/j.molbiopara.2017.06.006) (PMID:28629935)

Damasceno, J. D. , Silva, G. L.A., Tschudi, C. and Tosi, L. R.O. (2017) Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids. Memorias Do Instituto Oswaldo Cruz, 112(8), pp. 572-576. (doi: 10.1590/0074-02760170054) (PMID:28767983) (PMCID:PMC5530550)

2016

Marques, C. A. , Tiengwe, C., Lemgruber Soares, L. , Damasceno, J. D., Scott, A., Paape, D. , Marcello, L. and McCulloch, R. (2016) Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Research, 44(10), pp. 4763-4784. (doi: 10.1093/nar/gkw147) (PMID:26951375) (PMCID:PMC4889932)

Damasceno, J. D., Obonaga, R., Santos, E. V., Scott, A., McCulloch, R. and Tosi, L. R.O. (2016) Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania. Molecular Microbiology, 101(6), pp. 1054-1068. (doi: 10.1111/mmi.13441) (PMID:27301589) (PMCID:PMC5453112)

2015

Damasceno, J. D. , Beverley, S. M. and Tosi, L. R.O. (2015) A transposon-based tool for transformation and mutagenesis in trypanosomatid protozoa. Methods in Molecular Biology, 1201, pp. 235-245. (doi: 10.1007/978-1-4939-1438-8_14) (PMID:25388118) (PMCID:PMC4287265)

Articles

Reis-Cunha, J. L., Pimenta-Carvalho, S. A., Almeida, L. V., Coqueiro-Dos-Santos, A., Marques, C. A. , Black, J. A., Damasceno, J. , McCulloch, R. , Bartholomeu, D. C. and Jeffares, D. C. (2024) Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites. Genome Research, 34(3), pp. 441-453. (doi: 10.1101/gr.278550.123) (PMID:38604731) (PMCID:PMC11067883)

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

Tosi, L. R. O., Denny, P. W., De Oliveira, C. I. and Damasceno, J. D. (2023) Editorial: Leishmania genome variability: impacts on parasite evolution, parasitism and leishmaniases control. Frontiers in Cellular and Infection Microbiology, 13, 1171962. (doi: 10.3389/fcimb.2023.1171962) (PMID:36949811) (PMCID:PMC10025553)

da Silva, R. B., Bertoldo, W. d. R., Naves, L. L., de Vito, F. B., Damasceno, J. D. , Tosi, L. R. O., Machado, C. R. and Pedrosa, A. L. (2022) Specific human ATR and ATM inhibitors modulate single strand DNA formation in Leishmania major exposed to oxidative agent. Frontiers in Cellular and Infection Microbiology, 11, 802613. (doi: 10.3389/fcimb.2021.802613) (PMID:35059327) (PMCID:PMC8763966)

Damasceno, J. D. , Marques, C. A., Black, J., Briggs, E. and McCulloch, R. (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)

Damasceno, J. D. , Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)

Damasceno, J. D. , Reis-Cunha, J., Crouch, K. , Beraldi, D., Lapsley, C., Tosi, L. R.O., Bartholomeu, D. and McCulloch, R. (2020) Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication. PLoS Genetics, 16(7), e1008828. (doi: 10.1371/journal.pgen.1008828) (PMID:32609721) (PMCID:PMC7360064)

de Araujo, C. B. et al. (2020) Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, 21, 414. (doi: 10.1186/s12864-020-06803-8) (PMID:32571205) (PMCID:PMC7310030)

Damasceno, J. D. , Obonaga, R., Silva, G. L.A., Reis-Cunha, J. L., Duncan, S. M., Bartholomeu, D. C., Mottram, J. C. , McCulloch, R. and Tosi, L. R.O. (2018) Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania. Nucleic Acids Research, 46(22), pp. 11835-11846. (doi: 10.1093/nar/gky1017) (PMID:30380080) (PMCID:PMC6294564)

Trindade, J. B. C. et al. (2018) A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis. EBioMedicine, 36, pp. 83-91. (doi: 10.1016/j.ebiom.2018.09.029) (PMID:30268832) (PMCID:PMC6197651)

da Silva, M. S., Pavani, R. S., Damasceno, J. D. , Marques, C. A. , McCulloch, R. , Tosi, L. R. O. and Elias, M. C. (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11), pp. 858-874. (doi: 10.1016/j.pt.2017.08.002) (PMID:28844718) (PMCID:PMC5662062)

Santos, R. E.R.S., Silva, G. L.A., Santos, E. V., Duncan, S. M., Mottram, J. C. , Damasceno, J. D. and Tosi, L. R.O. (2017) A DiCre recombinase-based system for inducible expression in Leishmania major. Molecular and Biochemical Parasitology, 216, pp. 45-48. (doi: 10.1016/j.molbiopara.2017.06.006) (PMID:28629935)

Damasceno, J. D. , Silva, G. L.A., Tschudi, C. and Tosi, L. R.O. (2017) Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids. Memorias Do Instituto Oswaldo Cruz, 112(8), pp. 572-576. (doi: 10.1590/0074-02760170054) (PMID:28767983) (PMCID:PMC5530550)

Marques, C. A. , Tiengwe, C., Lemgruber Soares, L. , Damasceno, J. D., Scott, A., Paape, D. , Marcello, L. and McCulloch, R. (2016) Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Research, 44(10), pp. 4763-4784. (doi: 10.1093/nar/gkw147) (PMID:26951375) (PMCID:PMC4889932)

Damasceno, J. D., Obonaga, R., Santos, E. V., Scott, A., McCulloch, R. and Tosi, L. R.O. (2016) Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania. Molecular Microbiology, 101(6), pp. 1054-1068. (doi: 10.1111/mmi.13441) (PMID:27301589) (PMCID:PMC5453112)

Damasceno, J. D. , Beverley, S. M. and Tosi, L. R.O. (2015) A transposon-based tool for transformation and mutagenesis in trypanosomatid protozoa. Methods in Molecular Biology, 1201, pp. 235-245. (doi: 10.1007/978-1-4939-1438-8_14) (PMID:25388118) (PMCID:PMC4287265)

Book Sections

Briggs, E. M., Marques, C. A., Reis-Cunha, J., Black, J., Campbell, S., Damasceno, J. , Bartholomeu, D., Crouch, K. and McCulloch, R. (2020) Next-generation analysis of trypanosomatid genome stability and instability. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in Molecular Biology (2116). Springer, pp. 225-262. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_15)

Damasceno, J. D. , Tosi, L. R.O., Santos, R. E.R.S. and Mottram, J. C. (2019) DiCre-based inducible gene expression. In: Clos, J. (ed.) Leishmania: Methods and Protocols. Series: Methods in molecular biology (1971). Humana Press: New York, NY, pp. 225-235. ISBN 9781493992096 (doi: 10.1007/978-1-4939-9210-2_11)