Professor Andrew Roe

Professor of Molecular Microbiology, Director of Research (Bacteriology)

telephone: 01413302980
email: Andrew.Roe@glasgow.ac.uk

Room B214, GBRC/ Sir Graeme Davis Building, University Place, Glasgow, G12 8TA

Biography

A University of Aberdeen Microbiology graduate, Professor Andrew Roe arrived at the University of Glasgow as a new lecturer in 2006 after completing his PhD.

His PhD, with Professor Ian Booth, looked at the effect of weak acids on bacterial physiology: how and why food preservatives like acetic acid and benzoic acid work to prevent food spoilage.

This was followed by postdoctoral work with Professor David Gally exploring bacterial virulence, working on the 'emerging' pathogen - E. coli O157:H7, the classic burger bug.

His career progression within the Institute of Infection, Immunity & Inflammation saw Andrew start his own research group, focusing on Escherichia coli, which he considered an exciting and challenging chance to explore new areas.

Promotion to Professor followed in 2018 before the appointment as Head of Bacteriology in the summer of 2020 - a role in which supporting early career researchers and developing the next generation of microbiologists will be areas of particular focus.

Research interests

Regulation and expression of virulence factors in enterohaemorraghic Escherichia coli (EHEC) O157:H7.

Research Group Home Page

Personal Profile on ResearchGate

Publications

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Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001

Number of items: 92.

2024

Roe, A. (2024) Aurodox inhibits type III secretion in multiple Gram-negative pathogens. Open Biology, (Accepted for Publication)

Wale, K. R., O'Boyle, N., McHugh, R. , Serrano, E. , Mark, D. , Douce, G. R. , Connolly, J. P.R. and Roe, A. J. (2024) A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens. PLoS Pathogens, 20(10), e101245. (doi: 10.1371/journal.ppat.1012451) (PMID:39405360) (PMCID:PMC11508082)

Tucker, S. K., McHugh, R. E. and Roe, A. (2024) One problem, multiple potential targets: where are we now in the development of small molecule inhibitors against Shiga toxin? Cellular Signalling, 121, 111253. (doi: 10.1016/j.cellsig.2024.111253) (PMID:38852937)

Rimbi, P. T., O'Boyle, N., Douce, G. R. , Pizza, M., Rosini, R. and Roe, A. J. (2024) Enhancing a multi-purpose artificial urine for culture and gene expression studies of uropathogenic Escherichia coli strains. Journal of Applied Microbiology, 135(4), lxae067. (doi: 10.1093/jambio/lxae067) (PMID:38486355)

Addington, E., Sandalli, S. and Roe, A. J. (2024) Current understandings of colibactin regulation. Microbiology, 170(2), 001427. (doi: 10.1099/mic.0.001427) (PMID:38314762)

2023

O'Boyle, N., Douce, G. R. , Farrell, G., Rattray, N. J. W., Schembri, M. A., Roe, A. J. and Connolly, J. P.R. (2023) Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection. Proceedings of the National Academy of Sciences of the United States of America, 120(1), e2212175120. (doi: 10.1073/pnas.2212175120) (PMID:36574699) (PMCID:PMC9910484)

2022

Connolly, J. P.R., Turner, N. C.A., Serrano, E. , Roe, A. J. , Rimbi, P. T., Browning, D. F. and O’Boyle, N. (2022) Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associated Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 119(45), e221029911. (doi: 10.1073/pnas.2210299119) (PMID:36322762) (PMCID:PMC9659370)

McHugh, R. E. , Munnoch, J. T., Braes, R. E., McKean, I. J. W., Giard, J., Taladriz-Sender, A., Peschke, F., Burley, G. A., Roe, A. J. and Hoskisson, P. A. (2022) Biosynthesis of aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Applied and Environmental Microbiology, 88(15), e0069222. (doi: 10.1128/aem.00692-22) (PMID:35867559) (PMCID:PMC9361827)

Zambelloni, R., Beckham, K. S.H., Wu, H.-J., Elofsson, M., Marquez, R., Gabrielsen, M. and Roe, A. J. (2022) Crystal structures of WrbA, a spurious target of the salicylidene acylhydrazide inhibitors of type III secretion in Gram-negative pathogens, and verification of improved specificity of next-generation compounds. Microbiology, 168(7), 001211. (doi: 10.1099/mic.0.001211) (PMID:35829699)

McHugh, R. E. , Munnoch, J. T., Roe, A. J. and Hoskisson, P. A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

2021

McCreath, G., Whitfield, P. D. , Roe, A. J. , Watson, M. J. and Sim, M. A.B. (2021) A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol. BMC Infectious Diseases, 21, 1204. (doi: 10.1186/s12879-021-06832-y)

Connolly, J. P.R., Turner, N. C.A., Hallam, J., Rimbi, P. T., Flett, T., McCormack, M. J., Roe, A. J. and O'Boyle, N. (2021) D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes. Microbiology, 167(10), 001093. (doi: 10.1099/mic.0.001093) (PMID:34623236)

O'Boyle, N. and Roe, A. J. (2021) Heterogeneity in populations of enterohaemorrhagic Escherichia coli undergoing D-serine adaptation. Current Genetics, 67(2), pp. 221-224. (doi: 10.1007/s00294-020-01130-7) (PMID:33219834)

Mordue, J., O'Boyle, N., Gadegaard, N. and Roe, A. J. (2021) The force awakens: the dark side of mechanosensing in bacterial pathogens. Cellular Signalling, 78, 109867. (doi: 10.1016/j.cellsig.2020.109867) (PMID:33279672)

Connolly, J. P.R., Roe, A. J. and O'Boyle, N. (2021) Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria. Critical Reviews in Microbiology, 47(1), pp. 126-140. (doi: 10.1080/1040841X.2020.1854172) (PMID:33332206)

2020

O'Boyle, N., Connolly, J. P.R., Tucker, N. P. and Roe, A. J. (2020) Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 117(36), pp. 22484-22493. (doi: 10.1073/pnas.2004977117) (PMID:32848072) (PMCID:PMC7486766)

Azmi, L., Bragginton, E. C., Cadby, I. T., Byron, O. , Roe, A. J. , Lovering, A. L. and Gabrielsen, M. (2020) High-resolution structure of the alcohol dehydrogenase domain of the bifunctional bacterial enzyme AdhE. Acta Crystallographica. Section F: Structural Biology Communications, 76(9), pp. 414-421. (doi: 10.1107/S2053230X20010237)

Connolly, J. P.R., O'Boyle, N. and Roe, A. J. (2020) Widespread strain-specific distinctions in chromosomal binding dynamics of a highly conserved Escherichia coli transcription factor. mBio, 11, e01058-20. (doi: 10.1128/mBio.01058-20) (PMID:32576674) (PMCID:PMC7315121)

Kim, G., Yang, J., Jang, J., Choi, J.-S., Roe, A. J. , Byron, O. , Seok, C. and Song, J.-J. (2020) Aldehyde-alcohol dehydrogenase undergoes structural transition to form extended spirosomes for substrate channeling. Communications Biology, 3, 298. (doi: 10.1038/s42003-020-1030-1) (PMID:32523125) (PMCID:PMC7286902)

O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)

Fox, S., Goswami, C. , Holden, M., Connolly, J. P.R., Mordue, J., O'Boyle, N., Roe, A. , Connor, M., Leanord, A. and Evans, T. J. (2020) A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage. Scientific Reports, 10, 4135. (doi: 10.1038/s41598-020-61026-x) (PMID:32139768) (PMCID:PMC7058095)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

Kim, G., Azmi, L., Jang, S., Jung, T., Hebert, H., Roe, A. J. , Byron, O. and Song, J.-J. (2019) Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity. Nature Communications, 10, 4527. (doi: 10.1038/s41467-019-12427-8) (PMID:31586059) (PMCID:PMC6778083)

Connolly, J. P.R., O'Boyle, N., Turner, N., Browning, D. F. and Roe, A. J. (2019) Distinct intra-species virulence mechanisms regulated by a conserved transcription factor. Proceedings of the National Academy of Sciences of the United States of America, 116(39), pp. 19695-19704. (doi: 10.1073/pnas.1903461116) (PMID:31501343) (PMCID:PMC6765310)

Ibáñez-Shimabukuro, M. et al. (2019) Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode. Bioscience Reports, 39(7), BSR2019129. (doi: 10.1042/BSR20191292) (PMID:31273060) (PMCID:PMC6646235)

Irvine, S., Bunk, B., Bayes, H. K., Spröer, C., Connolly, J. P.R., Six, A., Evans, T. J. , Roe, A. J. , Overmann, J. and Walker, D. (2019) Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model. Microbial Genomics, 5(4), (doi: 10.1099/mgen.0.000262) (PMID:30920365) (PMCID:PMC6521587)

Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)

McHugh, R. E. , O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

2018

Scott, N. A. et al. (2018) Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Science Translational Medicine, 10(464), eaao4755. (doi: 10.1126/scitranslmed.aao4755) (PMID:30355800) (PMCID:PMC6548564)

Blum, S. E. et al. (2018) Postgenomics characterization of an essential genetic determinant of mammary pathogenic Escherichia coli. mBio, 9(2), e00423-18. (doi: 10.1128/mBio.00423-18) (PMID:29615502) (PMCID:PMC5885034)

O'Boyle, N., Connolly, J. P.R. and Roe, A. J. (2018) Tracking elusive cargo: Illuminating spatio-temporal type 3 effector protein dynamics using reporters. Cellular Microbiology, 20(1), e12797. (doi: 10.1111/cmi.12797) (PMID:29087624) (PMCID:PMC5765406)

Connolly, J. P.R. et al. (2018) Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nature Communications, 9, 4187. (doi: 10.1038/s41467-018-06701-4) (PMID:30305622) (PMCID:PMC6180029)

2017

Zambelloni, R., Connolly, J. P.R., Huerta Uribe, A. , Burgess, K., Marquez, R. and Roe, A. J. (2017) Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition. Molecular Microbiology, 105(4), pp. 606-619. (doi: 10.1111/mmi.13719) (PMID:28557017) (PMCID:PMC5575525)

2016

Connolly, J. P.R. and Roe, A. J. (2016) Intracellular D-serine accumulation promotes genetic diversity via modulated induction of RecA in enterohemorrhagic Escherichia coli. Journal of Bacteriology, 198(24), pp. 3318-3328. (doi: 10.1128/JB.00548-16) (PMID:27698085) (PMCID:PMC5116935)

Huerta-Uribe, A. et al. (2016) Identification and characterization of novel compounds blocking Shiga toxin expression in Escherichia coli O157:H7. Frontiers in Microbiology, 7, 1930. (doi: 10.3389/fmicb.2016.01930) (PMID:27965652) (PMCID:PMC5127787)

Gawthorne, J. A., Audry, L., McQuitty, C., Dean, P., Christie, J. M. , Enninga, J. and Roe, A. J. (2016) Visualizing translocation and localization of bacterial type III effector proteins using a genetically encoded reporter system. Applied and Environmental Microbiology, 82(9), pp. 2700-2708. (doi: 10.1128/AEM.03418-15) (PMID:25576618) (PMCID:PMC4345375)

Connolly, J. P.R. and Roe, A. J. (2016) When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment. Microbial Cell, 3(4), pp. 181-184. (doi: 10.15698/mic2016.04.494) (PMID:28357351) (PMCID:PMC5349093)

Buckley, A. M., Jukes, C., Candlish, D., Irvine, J. J., Spencer, J., Fagan, R. P., Roe, A. J. , Christie, J. , Fairweather, N. F. and Douce, G. R. (2016) Lighting up Clostridium Difficile: reporting gene expression using fluorescent Lov domains. Scientific Reports, 6, 23463. (doi: 10.1038/srep23463) (PMID:26996606) (PMCID:PMC4800718)

Connolly, J. P. R., Gabrielsen, M. , Goldstone, R. J., Grinter, R., Wang, D., Cogdell, R. J. , Walker, D. , Smith, D. G. E. and Roe, A. J. (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12(1), e1005359. (doi: 10.1371/journal.ppat.1005359) (PMID:26727373) (PMCID:PMC4699771)

2015

Dean, P., Quitard, S., Bulmer, D. M., Roe, A. and Kenny, B. (2015) Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment. Scientific Reports, 5, 17359. (doi: 10.1038/srep17359) (PMID:26612456) (PMCID:PMC4661573)

Rey, B. M.F. et al. (2015) Diversity in the structures and ligand binding sites of nematode fatty acid and retinol binding proteins revealed by Na-FAR-1 from Necator americanus. Biochemical Journal, 471(3), pp. 403-414. (doi: 10.1042/BJ20150068) (PMID:26318523) (PMCID:PMC4613501)

Buckley, A. M., Petersen, J., Roe, A. J. , Douce, G. R. and Christie, J. M. (2015) LOV-based reporters for fluorescence imaging. Current Opinion in Chemical Biology, 27, pp. 39-45. (doi: 10.1016/j.cbpa.2015.05.011) (PMID:26087123)

Connolly, J.P., Finlay, B.B. and Roe, A.J. (2015) From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli. Frontiers in Microbiology, 6, 568. (doi: 10.3389/fmicb.2015.00568) (PMID:26097473) (PMCID:PMC4456613)

Connolly, J. P.R., Goldstone, R. J., Burgess, K., Cogdell, R. J. , Beatson, S. A., Vollmer, W., Smith, D. G.E. and Roe, A. (2015) The host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9, pp. 1039-1051. (doi: 10.1038/ismej.2014.242) (PMID:25526369) (PMCID:PMC4366372)

Zambelloni, R., Marquez, R. and Roe, A. J. (2015) Development of antivirulence compounds: a biochemical review. Chemical Biology and Drug Design, 85(1), pp. 43-55. (doi: 10.1111/cbdd.12430)

2014

Beckham, K. S.H. and Roe, A. J. (2014) From screen to target: insights and approaches for the development of anti-virulence compounds. Frontiers in Cellular and Infection Microbiology, 4(139), (doi: 10.3389/fcimb.2014.00139)

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi: 10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

2013

Dunne, K.A. et al. (2013) Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive escherichia coli (AIEC) in immune cells. PLoS ONE, 8(7), e68386. (doi: 10.1371/journal.pone.0068386) (PMID:23861899) (PMCID:PMC3701656)

Gabrielsen, M. , Roe, A.J. and McLuskey, K. (2013) High-throughput methods for the detection of protein overexpression using fluorescence markers. Methods in Cell Biology, 113, pp. 189-208. (doi: 10.1016/B978-0-12-407239-8.00010-0)

Othman, S., Roe, A.J. , Parton, R. and Coote, J.G. (2013) Use of a dual reporter plasmid to demonstrate bactofection with an attenuated aroa- derivative of Pasteurella multocida b:2. PLoS ONE, 8(8), e71524. (doi: 10.1371/journal.pone.0071524) (PMID:23951183) (PMCID:PMC3741130)

2012

Tahoun, A. et al. (2012) Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion. Cell Host and Microbe, 12(5), pp. 645-656. (doi: 10.1016/j.chom.2012.10.009)

Gabrielsen, M. , Rey-Burusco, M.F., Griffiths, K., Roe, A.J. , Cooper, A., Smith, B.O. , Kennedy, M.W. and Corsico, B. (2012) Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematodeNecator americanus. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(7), pp. 835-838. (doi: 10.1107/S1744309112023597) (PMID:22750878) (PMCID:PMC3388935)

Beckham, K. S.H., Byron, O. , Roe, A. J. and Gabrielsen, M. (2012) The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(5), pp. 522-526. (doi: 10.1107/S1744309112011487) (PMID:22691780) (PMCID:PMC3374505)

Christie, J.M. , Gawthorne, J., Young, G., Fraser, N.J. and Roe, A.J. (2012) LOV to BLUF: flavoprotein contributions to the optogenetic toolkit. Molecular Plant, (doi: 10.1093/mp/sss020) (PMID:22431563)

Gabrielsen, M. , Beckham, K.S., Feher, V.A., Zetterstrom, C.E., Wang, D., Muller, S., Elofsson, M., Amaro, R.E., Byron, O. and Roe, A.J. (2012) Structural characterisation of Tpx from yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PLoS ONE, 7(2), e32217. (doi: 10.1371/journal.pone.0032217) (PMID:22384182) (PMCID:PMC3288085)

Gabrielsen, M. , Beckham, K.S.H., Cogdell, R.J. , Byron, O. and Roe, A.J. (2012) FolX from Pseudomonas aeruginosa is octameric in both crystal and solution. FEBS Letters, 586(8), pp. 1160-1165. (doi: 10.1016/j.febslet.2012.03.031) (PMID:22575651) (PMCID:PMC3405516)

Gabrielsen, M. , Beckham, K.S.H. and Roe, A.J. (2012) High-throughput methods for the identification of protein purification conditions using a cleavable tag system. Methods in Cell Biology, 112, pp. 93-110. (doi: 10.1016/B978-0-12-405914-6.00005-6)

Gabrielsen, M. , Riboldi-Tunnicliffe, A., Ibáñez-Shimabukuro, M., Griffiths, K., Roe, A.J. , Cooper, A., Smith, B. , Córsico, B. and Kennedy, M.W. (2012) Useable diffraction data from a multiple microdomain-containing crystal of Ascaris suum As-p18 fatty-acid-binding protein using a microfocus beamline. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68, pp. 939-941. (doi: 10.1107/S1744309112026553) (PMID:22869127) (PMCID:PMC3412778)

Gabrielsen, M. , Riboldi-Tunnicliffe, A., Ibáñez-Shimabukuro, M., Griffiths, K., Roe, A.J. , Cooper, A., Smith, B.O. , Córsico, B. and Kennedy, M.W. (2012) Useable diffraction data from a multiple microdomain-containing crystal ofAscaris suumAs-p18 fatty-acid-binding protein using a microfocus beamline. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(8), pp. 939-941. (doi: 10.1107/S1744309112026553) (PMID:22869127) (PMCID:PMC3412778)

Gawthorne, J.A., Reddick, L.E., Akpunarlieva, S.N., Beckham, K.S.H., Christie, J.M. , Alto, N.M., Gabrielsen, M. and Roe, A.J. (2012) Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification. PLoS ONE, 7(12), e52962. (doi: 10.1371/journal.pone.0052962) (PMID:23300834) (PMCID:PMC3531456)

Schmidt, E.E., Holmes, A., Lindestam Arlehamn, C.S., Wang, D., Mitchell, T.J., Evans, T.J. and Roe, A.J. (2012) Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2. PLoS ONE, 7(3), e33408. (doi: 10.1371/journal.pone.0033408) (PMID:22428045) (PMCID:PMC3299786)

Xuefang, X. et al. (2012) Lysogeny with Shiga toxin 2-encoding bacteriophages represses type III secretion in enterohemorrhagic Escherichia coli. PLoS Pathogens, 8(5), e1002672. (doi: 10.1371/journal.ppat.1002672)

2011

Gabrielsen, M. , Kroner, F., Black, I., Isaacs, N.W., Roe, A.J. and McLuskey, K. (2011) High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins. Molecular Membrane Biology, 28(7-8), pp. 445-453. (doi: 10.3109/09687688.2011.628954) (PMID:22034843)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi: 10.1074/jbc.M111.233858) (PMID:21724850) (PMCID:PMC3191033)

Tree, J.J. et al. (2011) Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7. Molecular Microbiology, 80(5), pp. 1349-1365. (doi: 10.1111/j.1365-2958.2011.07650.x) (PMID:21492263) (PMCID:PMC7099609)

2010

Gabrielsen, M. , Zetterström, C.E., Wang, D., Beckham, K.S.H., Elofsson, M., Isaacs, N.W. and Roe, A. (2010) Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 66(12), pp. 1606-1609. (doi: 10.1107/S1744309110039679) (PMID:21139206) (PMCID:PMC2998365)

Holmes, A., Muhlen, S., Roe, A.J. and Dean, P. (2010) The EspF effector - a bacterial pathogen's Swiss army knife. Infection and Immunity, 78(11), pp. 4445-4453. (doi: 10.1128/IAI.00635-10) (PMID:20679436) (PMCID:PMC2976335)

2009

Tree, J.J., Wang, D., McInally, C., Mahajan, A., Layton, A., Houghton, I., Elofsson, M., Stevens, M.P., Gally, D.L. and Roe, A.J. (2009) Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7. Infection and Immunity, 77(10), pp. 4209-4220. (doi: 10.1128/IAI.00562-09) (PMID:19635828) (PMCID:PMC2747932)

Tree, J.J., Wolfson, E.B., Wang, D., Roe, A.J. and Gally, D.L. (2009) Controlling injection: regulation of type III secretion in enterohaemorrhagic Escherichia coli. Trends in Microbiology, 17(8), pp. 361-370. (doi: 10.1016/j.tim.2009.06.001)

Mahajan, A. et al. (2009) An investigation of the expression and adhesin function of H7 flagella in the interaction ofEscherichia coliO157: H7 with bovine intestinal epithelium. Cellular Microbiology, 11(1), pp. 121-137. (doi: 10.1111/j.1462-5822.2008.01244.x) (PMID:19016776)

2008

Wang, D., Roe, A.J. , McAteer, S., Shipston, M.J. and Gally, D.L. (2008) Hierarchal type III secretion of translocators and effectors fromEscherichia coliO157:H7 requires the carboxy terminus of SepL that binds to Tir. Molecular Microbiology, 69(6), pp. 1499-1512. (doi: 10.1111/j.1365-2958.2008.06377.x)

2007

Roe, A. J. et al. (2007) Analysis of the expression, regulation and export of NleA-E in Escherichia coli O157: H7. Microbiology, 153, pp. 1350-1360. (doi: 10.1099/mic.0.2006/003707-0)

Roe, A. (2007) Increased adherence and actin pedestal formation by dam-deficient enterohemorrhagic Escherichia coli O157:H7. Molecular Microbiology, 63(5), pp. 1468-1481. (doi: 10.1111/j.1365-2958.2007.05602.x)

2006

Low, A. S., Holden, N., Rosser, T., Roe, A. J. , Constantinidou, C., Hobman, J. L., Smith, D. G.E., Low, J. C. and Gally, D. L. (2006) Analysis of firnbrial gene clusters and their expression in enterohaernorrhagic Escherichia coli O157 : H7. Environmental Microbiology, 8(6), pp. 1033-1047. (doi: 10.1111/j.1462-2920.2006.00995.x)

Spears, K. J., Roe, A. and Gally, D. L. (2006) A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis. FEMS Microbiology Letters, 255(2), pp. 187-202. (doi: 10.1111/j.1574-6968.2006.00119.x)

Roe, A. (2006) Enhancement of bacterial competitive fitness by apramycin resistance plasmids from non-pathogenic Escherichia coli. Biology Letters, 2(3), pp. 463-465. (doi: 10.1098/rsbl.2006.0478)

Roe, A. (2006) Generation of gene deletions and gene replacements in Escherichia coli O157:H7 using a temperature sensitive allelic exchange system. Biological Procedures Online, 8(1), pp. 153-162. (doi: 10.1251/bpo123)

Roe, A. (2006) Demonstration of regulatory cross-talk between P fimbriae and type 1 fimbriae in uropathogenic Escherichia coli. Microbiology: SGM, 152(Pt4), pp. 1143-1153. (doi: 10.1099/mic.0.28677-0)

2005

Naylor, S. A., Roe, A. J. , Nart, P., Spears, K., Smith, D. G.E., Low, J. C. and Gally, D. L. (2005) Escherichia coli O157 : H7 forms attaching and effacing lesions at the terminal rectum of cattle and colonization requires the LEE4 operon. Microbiology, 151(8), pp. 2773-2781. (doi: 10.1099/mic.0.28060-0)

Roe, A. (2005) Type III secretion of the Salmonella effector protein SopE is mediated via an n-terminal amino acid signal and not an mRNA sequence (vol 187, pg 1559, 2005). Journal of Bacteriology, 187(15), p. 5505. (doi: 10.1128/JB.187.15.5505.2005)

2004

Porter, M. E., Mitchell, P., Roe, A. J. , Free, A., Smith, D. G.E. and Gally, D. L. (2004) Direct and indirect transcriptional activation of virulence genes by an AraC-like protein, PerA from enteropathogenic Escherichia coli. Molecular Microbiology, 54(4), pp. 1117-1133. (doi: 10.1111/j.1365-2958.2004.04333.x)

Roe, A. J. et al. (2004) Co-ordinate single-cell expression of LEE4- and LEE5-encoded proteins of Escherichia coli O157:H7. Molecular Microbiology, 54(2), pp. 337-352. (doi: 10.1111/j.1365-2958.2004.04277.x)

Roe, A. (2004) Co-ordinate single-cell expression of LEE4- and LEE5-encoded proteins of Escherichia coli O157 : H7. Molecular Microbiology, 54(2), pp. 337-352. (doi: 10.1111/j.1365-2958.2004.04277.x)

Roe, A. (2004) Mutation of toxB and a truncated version of the efa-1 gene in Escherichia coli O157 : H7 influences the expression and secretion of locus of enterocyte effacement-encoded proteins but not intestinal colonization in calves or sheep. Infection and Immunity, 72(9), pp. 5402-5411. (doi: 10.1128/IAI.72.9.5402-5411.2004)

Zhang, L. et al. (2004) Regulators encoded in the Escherichia coli type III secretion system 2 gene cluster influence expression of genes within the locus for enterocyte effacement in enterohemorrhagic E. coli 0157 : H7. Infection and Immunity, 72, pp. 7282-7293. (doi: 10.1128/IAI.72.12.7282-7293.2004)

2003

Roe, A. J. , Yull, H., Naylor, S. W., Woodward, M. J., Smith, D. G.E. and Gally, D. L. (2003) Heterogeneous surface expression of EspA translocon filaments by Escherichia coli O157:H7 is controlled at the posttranscriptional level. Infection and Immunity, 71(10), pp. 5900-5909. (doi: 10.1128/IAI.71.10.5900-5909.2003)

Roe, A. (2003) Heterogeneous surface expression of EspA translocon filaments by Escherichia coli O157 : H7 is controlled at the posttranscriptional level. Infection and Immunity, 71(10), pp. 5900-5909. (doi: 10.1128/IAI.71.10.5900-5909.2003)

Roe, A. (2003) Regulation, secretion and activity of type III-secreted proteins of enterohaemorrhagic Escherichia coli O157. Biochemical Society Transactions, 31(Pt 1), pp. 98-103.

2002

Roe, A. (2002) Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity. Microbiology: SGM, 148(Pt 7), pp. 2215-2222.

2001

McNally, A., Roe, A. J. , Simpson, S., Thomson-Carter, F. M., Hoey, D.E. E., Currie, C., Chakraborty, T., Smith, D. G.E. and Gally, D. L. (2001) Differences in levels of secreted locus of enterocyte effacement proteins between human disease-associated and bovine Escherichia coli O157. Infection and Immunity, 69(8), pp. 5107-5114. (doi: 10.1128/IAI.69.8.5107-5114.2001)

Roe, A. J. , Currie, C., Smith, D. G.E. and Gally, D. L. (2001) Analysis of type 1 fimbriae expression in verotoxigenic Escherichia coli: a comparison between serotypes O157 and O26. Microbiology, 147(1), pp. 145-52. (doi: 10.1099/00221287-147-1-145) (PMID:11160808)

Roe, A. (2001) Analysis of type 1 fimbriae expression in verotoxigenic Escherichia coli: a comparison between serotypes O157 and O26. Microbiology: SGM, 147(Pt1), pp. 145-152.

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