Professor Sandosh Padmanabhan
- Pontecorvo Chair of Pharmacogenomics (Cardiovascular & Metabolic Health)
telephone:
01413302228
email:
Sandosh.Padmanabhan@glasgow.ac.uk
Institute of C&MS, Bhf Gcrc, Glasgow G12 8TA
https://orcid.org/0000-0003-3869-5808Biography
Prof Sandosh Padmanabhan completed his MBBS and MD at JIPMER, Pondicherry, India and was awarded the Gold Medal for MD General Medicine in 1995. His PhD (1999-2003) on G-protein signalling in hypertension was awarded the Bellahouston Medal by the University of Glasgow in 2004. He received the Austin Doyle Award from the International Society of Hypertension in 2004. His pharmacogenetic genomewide linkage study led to a BHF Intermediate Fellowship (2006-2009). He was the lead on a genome wide association analysis of Hypertension between 2008 and 2010 resulting in the discovery of a new gene and pathway for hypertension. He was a visiting fellow to the Broad Institute of Harvard and MIT (2010-2012). He is a Fellow of the Royal College of Physicians, the British Hypertension Society and the American Heart Association.
Research interests
Research Theme: Cardiovascular Data Science
My research combines epidemiology and randomised clinical trials incorporating high-throughput genomics and metabolomics in the dissection of cardiovascular traits and drug response. As a principal investigator in the MRC Stratified Medicine consortium on Hypertension (AIM HY), I lead the work strand that aims to discover ancestry and metabolomic markers of antihypertensive drug response in large randomised clinical trials. I co-lead the research on the functional dissection and translation of our GWAS discovered hypertension gene, uromodulin, and this involves salt interventional studies, a range of omics studies and a genotype directed clinical trial. I am a member of Generation Scotland executive, section editor of Physiological Genomics and Cardiovascular Risk Reports, the editorial board of Hypertension and Journal of Hypertension, the meetings committee of the British Pharmacologic Society, the research committee of the Wellcome Trust/Public Health Foundation of India. I chair the educational committee of British Hypertension Society.
Research groups
Publications
2024
Sosenko, F. et al. (2024) Cancer diagnosis after emergency presentation: impact of demographics, cancer types, and pandemic. Academia Oncology, 1(2), pp. 1-8. (doi: 10.20935/AcadOnco7422)
McCallum, L. et al. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, 81(10), pp. 2049-2059. (doi: 10.1161/HYPERTENSIONAHA.124.23122) (PMID:39077768) (PMCID:PMC11460757)
Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)
Morrow, A. et al. (2024) Zibotentan in microvascular angina: a randomized, placebo-controlled, crossover trial. Circulation, (doi: 10.1161/CIRCULATIONAHA.124.069901) (PMID:39217504) (Early Online Publication)
Canning, J. et al. (2024) Methods applied to neonatal dried blood spot samples for secondary research purposes: a scoping review. Critical Reviews in Clinical Laboratory Sciences, (doi: 10.1080/10408363.2024.2360996) (PMID:38855982) (Early Online Publication)
Padmanabhan, S. , Delles, C. and Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81(6), pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371) (PMID:38748763)
Tran, T. Q. B. et al. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6(6), pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005) (PMID:39022171) (PMCID:PMC11250845)
Alsanosi, S. M. and Padmanabhan, S. (2024) Potential applications of artificial intelligence (AI) in managing polypharmacy in Saudi Arabia: a narrative review. Healthcare, 12(7), 788. (doi: 10.3390/healthcare12070788)
McCallum, L., Lip, S. , Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S. and Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11(1), e002535. (doi: 10.1136/openhrt-2023-002535) (PMID:38429056)
Mair, F. S. et al. (2024) Developing SysteMatic: prevention, precision and equity by design for people living with multiple long-term conditions. Journal of Multimorbidity and Comorbidity, 14, pp. 1-9. (doi: 10.1177/26335565241272682)
2023
van de Vegte, Y. J. et al. (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nature Communications, 14(1), 4646. (doi: 10.1038/s41467-023-39521-2) (PMID:37532724) (PMCID:PMC10397318)
Le, N. N., Tran, T. Q. B., Du Toit, C. , Gill, D. and Padmanabhan, S. (2023) Establishing plausibility of cardiovascular adverse effects of immunotherapies using Mendelian randomisation. Frontiers in Cardiovascular Medicine, 10, 1116799. (doi: 10.3389/fcvm.2023.1116799) (PMID:37273876) (PMCID:PMC10235787)
Du Toit, C. et al. (2023) Survey and evaluation of hypertension machine learning research. Journal of the American Heart Association, 12(9), e027896. (doi: 10.1161/JAHA.122.027896) (PMID:37119074) (PMCID:PMC10227215)
Beynon-Cobb, B., Louca, P., Hoorn, E. J., Menni, C. and Padmanabhan, S. (2023) Effect of sodium bicarbonate on systolic blood pressure in CKD: a systematic review and meta-analysis. Clinical Journal of the American Society of Nephrolog, 18(4), pp. 435-445. (doi: 10.2215/CJN.0000000000000119) (PMID:36758154) (PMCID:PMC10103210)
Young, W. J. et al. (2023) Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature Communications, 14, 1411. (doi: 10.1038/s41467-023-36997-w) (PMID:36918541) (PMCID:PMC10015012)
Tran, T. Q. B. et al. (2023) Predictive accuracy and clinical utility of machine learning prediction for classifying blood pressure status. SSRN, (doi: 10.2139/ssrn.4307704)
Garimella, P. S., Du Toit, C. , Le, N. N. and Padmanabhan, S. (2023) A genomic deep field view of hypertension. Kidney International, 103(1), pp. 42-52. (doi: 10.1016/j.kint.2022.09.029) (PMID:36377113)
Padmanabhan, S. , Du Toit, C. and Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. e28. (doi: 10.1017/pcm.2023.17)
Taylor, A. et al. (2023) Long-term usage and improved clinical outcomes with adoption of a COPD digital support service: key findings from the RECEIVER trial. International Journal of Chronic Obstructive Pulmonary Disease, 18, pp. 1301-1318. (doi: 10.2147/COPD.S409116) (PMID:37378275) (PMCID:PMC10292615)
2022
Mary, S. , Boder, P., Padmanabhan, S. , McBride, M. W. , Graham, D. , Delles, C. and Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888) (PMID:36378920) (PMCID:PMC9553220)
Louca, P., Tran, T. Q. B., Du Toit, C. , Christofidou, P., Spector, T. D., Mangino, M., Suhre, K., Padmanabhan, S. and Menni, C. (2022) Machine learning integration of multimodal data identifies key features of blood pressure regulation. EBioMedicine, 84, 104243. (doi: 10.1016/j.ebiom.2022.104243) (PMID:36084617) (PMCID:PMC9463529)
Young, W. J. et al. (2022) Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nature Communications, 13, 5144. (doi: 10.1038/s41467-022-32821-z) (PMID:36050321) (PMCID:PMC9436946)
Lip, S. , Dempster, G., Jain, S., Brooksbank, K., Ghouri, N. , McCallum, L. and Padmanabhan, S. (2022) Underrepresentation of ethnic minorities in hypertension research—a survey of enablers and barriers among South Asian and African communities in Glasgow. Trials, 23, 609. (doi: 10.1186/s13063-022-06542-z) (PMID:35906700) (PMCID:PMC9335986)
Acur, N. , Carbajal Pina, C. and Padmanabhan, S. (2022) Therme & The University of Glasgow Global Wellbeing Centre of Excellence (WellEx), Feasibility Study. Project Report. Founded by The Scottish Inward Investment Catalyst Fund- Interface (Project Number is 318334-02), University of Glasgow and Therme Group.
Le, N. N., Tran, T. Q. B., Lip, S. , McCallum, L., McClure, J. , Dominiczak, A. F. , Gill, D. and Padmanabhan, S. (2022) Unravelling the distinct effects of systolic and diastolic blood pressure using Mendelian randomisation. Genes, 13(7), 1226. (doi: 10.3390/genes13071226) (PMID:35886009) (PMCID:PMC9323763)
Lip, S. , McCallum, L., Delles, C. , McClure, J. D. , Guzik, T., Berry, C. , Touyz, R. and Padmanabhan, S. (2022) Rationale and design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR). Open Heart, 9(1), e002057. (doi: 10.1136/openhrt-2022-002057) (PMID:35750422) (PMCID:PMC9234432)
Winkler, T. W. et al. (2022) Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 5, 580. (doi: 10.1038/s42003-022-03448-z) (PMID:35697829) (PMCID:PMC9192715)
Du Toit, C. et al. (2022) Investigating the quality of machine learning research and reporting in hypertension. European Society of Hypertension 31st Annual Meeting, Athens, Greece, 17-21 Jul 2022. e78. (doi: 10.1097/01.hjh.0000835956.81410.5e)
Lucas-Herald, A. K. et al. (2022) Vascular dysfunction and increased cardiovascular risk in hypospadias. European Heart Journal, 43(19), pp. 1832-1845. (doi: 10.1093/eurheartj/ehac112) (PMID:35567552) (PMCID:PMC9113289)
Shaman, J. A., Bousman, C. A., Mitropoulou, C. and Padmanabhan, S. (2022) Editorial: Pharmacogenomics: from bench to bedside and back again. Frontiers in Genetics, 13, 878191. (doi: 10.3389/fgene.2022.878191) (PMID:35360856) (PMCID:PMC8964277)
Nogal, A. et al. (2022) Incremental value of a panel of serum metabolites for predicting risk of atherosclerotic cardiovascular disease. Journal of the American Heart Association, 11(4), e024590. (doi: 10.1161/JAHA.121.024590) (PMID:35156414) (PMCID:PMC9245800)
2021
Morrow, A. et al. (2021) Rationale and design of the Medical Research Council Precision medicine with Zibotentan in microvascular angina (PRIZE) trial MRI sub-study. British Society of Cardiovascular Magnetic Resonance 2021 Annual Meeting, 12 October 2021. A2.1-A2. (doi: 10.1136/heartjnl-2021-BSCMR.3)
Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)
Tran, T. Q. B., Du Toit, C. and Padmanabhan, S. (2021) Artificial intelligence in healthcare-the road to precision medicine. Journal of Hospital Management and Health Policy, 5, 29. (doi: 10.21037/JHMHP-20-132)
Boder, P., Mary, S. , Mark, P. B. , Leiper, J. , Dominiczak, A. F. , Padmanabhan, S. , Rampold, L. and Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)
Clarke, T.-K. et al. (2021) Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. Molecular Psychiatry, 26(8), pp. 4344-4354. (doi: 10.1038/s41380-019-0607-x) (PMID:31767999)
Chen, J. et al. (2021) The trans-ancestral genomic architecture of glycemic traits. Nature Genetics, 53(6), pp. 840-860. (doi: 10.1038/s41588-021-00852-9) (PMID:34059833) (PMCID:PMC7610958)
Fawcett, K. A. et al. (2021) Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Research, 5, 111. (doi: 10.12688/wellcomeopenres.15846.2) (PMID:33728380) (PMCID:PMC7938335)
Shaw, R. J. , Mackay, D. , Pell, J. P. , Padmanabhan, S. , Bailey, D. S. and Smith, D. J. (2021) The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients. Psychological Medicine, 51(7), pp. 1183-1191. (doi: 10.1017/S0033291719004094) (PMID:31973782)
Padmanabhan, S. and Dominiczak, A. F. (2021) Genomics of hypertension: the road to precision medicine. Nature Reviews Cardiology, 18(4), pp. 235-250. (doi: 10.1038/s41569-020-00466-4) (PMID:33219353)
McCallum, L., Brooksbank, K., McConnachie, A. , Aman, A. , Lip, S. , Dawson, J. , MacIntyre, I. M., MacDonald, T. M., Webb, D. J. and Padmanabhan, S. (2021) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD). American Journal of Hypertension, 34(1), pp. 92-99. (doi: 10.1093/ajh/hpaa166) (PMID:33084880) (PMCID:PMC7891239)
2020
Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52(12), pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x) (PMID:33230300) (PMCID:PMC7610439)
Morrow, A. J. et al. (2020) Rationale and design of the Medical Research Council precision medicine with Zibotentan in microvascular angina (PRIZE) trial. American Heart Journal, 229, pp. 70-80. (doi: 10.1016/j.ahj.2020.07.007) (PMID:32942043)
Ford, T. J. et al. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41(34), pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915) (PMID:31972008) (PMCID:PMC7557475)
Louca, P., Mompeo, O., Leeming, E. R., Berry, S. E., Mangino, M., Spector, T. D., Padmanabhan, S. and Menni, C. (2020) Dietary influence on systolic and diastolic blood pressure in the TwinsUK cohort. Nutrients, 12(7), 2130. (doi: 10.3390/nu12072130) (PMID:32708992) (PMCID:PMC7400881)
Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, 2542. (doi: 10.1038/s41467-020-15706-x) (PMID:32439900) (PMCID:PMC7242331)
Lip, S. and Padmanabhan, S. (2020) Genomics of blood pressure and hypertension: extending the mosaic theory toward stratification. Canadian Journal of Cardiology, 36(5), pp. 694-705. (doi: 10.1016/j.cjca.2020.03.001) (PMID:32389342) (PMCID:PMC7237883)
Simpson, J. et al. (2020) Prognostic models derived in PARADIGM-HF and validated in ATMOSPHERE and the Swedish Heart Failure Registry to predict mortality and morbidity in chronic heart failure. JAMA Cardiology, 5(4), pp. 432-441. (doi: 10.1001/jamacardio.2019.5850) (PMID:31995119)
Wigmore, E. M. et al. (2020) Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP. Pharmacogenomics Journal, 20, pp. 329-341. (doi: 10.1038/s41397-019-0067-3) (PMID:30700811) (PMCID:PMC7096334)
2019
Teumer, A. et al. (2019) KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. JCI Insight, 4(23), e131156. (doi: 10.1172/jci.insight.131156) (PMID:31600170) (PMCID:PMC6962032)
Clark, D. W. et al. (2019) Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, 4957. (doi: 10.1038/s41467-019-12283-6) (PMID:31673082) (PMCID:PMC6823371)
Schmidt, A. F. et al. (2019) Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. BMC Cardiovascular Disorders, 19, 240. (doi: 10.1186/s12872-019-1187-z) (PMID:31664920) (PMCID:PMC6820948)
Menni, C. et al. (2019) Metabolomic profiling identifies novel associations with electrolyte and acid-base homeostatic patterns. Scientific Reports, 9, 15088. (doi: 10.1038/s41598-019-51492-3) (PMID:31636301) (PMCID:PMC6803625)
Tin, A. et al. (2019) Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics, 51, pp. 1459-1474. (doi: 10.1038/s41588-019-0504-x) (PMID:31578528)
Lip, S. , Tan, L. E., Jeemon, P., McCallum, L., Dominiczak, A. F. and Padmanabhan, S. (2019) Diastolic blood pressure J-curve phenomenon in a tertiary-care hypertension clinic. Hypertension, 74(4), pp. 767-775. (doi: 10.1161/HYPERTENSIONAHA.119.12787) (PMID:31422693) (PMCID:PMC6756261)
Graham, N. A., Ward, J. , Mackay, D. , Pell, J. , Cavanagh, J. , Padmanabhan, S. and Smith, D. J. (2019) Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank. BMJ Open, 9(9), e024433. (doi: 10.1136/bmjopen-2018-024433) (PMID:31575565) (PMCID:PMC6797415)
Iniesta, R. et al. (2019) Gene variants at loci related to blood pressure account for variation in response to antihypertensive drugs between black and white individuals. Hypertension, 74(3), pp. 614-622. (doi: 10.1161/hypertensionaha.118.12177) (PMID:31327267)
Frangou, S. et al. (2019) Insulin resistance: genetic associations with depression and cognition in population based cohorts. Experimental Neurology, 316, pp. 20-26. (doi: 10.1016/j.expneurol.2019.04.001) (PMID:30965038)
Noordam, R. et al. (2019) Effects of calcium, magnesium, and potassium concentrations on ventricular repolarization in unselected individuals. Journal of the American College of Cardiology, 73(24), pp. 3118-3131. (doi: 10.1016/j.jacc.2019.03.519) (PMID:31221261)
Welsh, P. et al. (2019) Cardiac troponin T and troponin I in the general population: comparing and contrasting their genetic determinants and associations with outcomes. Circulation, 139(24), pp. 2754-2764. (doi: 10.1161/CIRCULATIONAHA.118.038529) (PMID:31014085) (PMCID:PMC6571179)
Wuttke, M. et al. (2019) A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51(6), pp. 957-972. (doi: 10.1038/s41588-019-0407-x) (PMID:31152163) (PMCID:PMC6698888)
Kokubo, Y., Padmanabhan, S. , Iwashima, Y., Yamagishi, K. and Goto, A. (2019) Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines. Environmental Health and Preventive Medicine, 24(1), 19. (doi: 10.1186/s12199-019-0771-2) (PMID:30857519) (PMCID:PMC6410507)
Clarke, T.-K. et al. (2019) Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism. Wellcome Open Research, 3, 11. (doi: 10.12688/wellcomeopenres.13893.2)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. In: Dorobantu, M., Mancia, G., Grassi, G. and Voicu, V. (eds.) Hypertension and Heart Failure. Series: Updates in hypertension and cardiovascular protection. Springer International Publishing, pp. 15-29. ISBN 9783319933191
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genomics of hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer, pp. 171-181. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_16)
2018
Arnau-Soler, A., Adams, M. J., Generation Scotland, , Major Depressive Disorder Working Group, P. G. C., Hayward, C. and Thomson, P. A. (2018) Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13(12), e0209160. (doi: 10.1371/journal.pone.0209160) (PMID:30571770) (PMCID:PMC6301766)
Kokubo, Y. and Padmanabhan, S. (2018) Necessity of preventing cardiovascular disease by smoke-free policies. Journal of the American Heart Association, 7(23), e011120. (doi: 10.1161/JAHA.118.011120) (PMID:30571604) (PMCID:PMC6405570)
Alghamdi, J., Matou-Nasri, S., Alghamdi, F., Alghamdi, S., Alfadhel, M. and Padmanabhan, S. (2018) Risk of neuropsychiatric adverse effects of lipid-lowering drugs: a Mendelian randomization study. International Journal of Neuropsychopharmacology, 21(12), pp. 1067-1075. (doi: 10.1093/ijnp/pyy060) (PMID:29986042) (PMCID:PMC6276028)
Pulit, S. L. et al. (2018) Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. Neurology Genetics, 4(6), e293. (doi: 10.1212/NXG.0000000000000293) (PMID:30584597) (PMCID:PMC6283455)
Graham, L. A., Aman, A. , Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi: 10.1152/physiolgenomics.00057.2018) (PMID:30216136) (PMCID:PMC6293113)
Welsh, P. et al. (2018) Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort. Clinical Chemistry, 64(11), pp. 1607-1616. (doi: 10.1373/clinchem.2018.292086) (PMID:30126950)
Evangelou, E. et al. (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50, pp. 1412-1425. (doi: 10.1038/s41588-018-0205-x) (PMID:30224653) (PMCID:PMC6284793)
Mukhtar, O. et al. (2018) A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: the comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. American Heart Journal, 204, pp. 102-108. (doi: 10.1016/j.ahj.2018.05.006) (PMID:30092411) (PMCID:PMC6234107)
Rosenthal, E. A. et al. (2018) Rare loss of function variants in candidate genes and risk of colorectal cancer. Human Genetics, 137(10), pp. 795-806. (doi: 10.1007/s00439-018-1938-4) (PMID:30267214) (PMCID:PMC6283057)
Roselli, C. et al. (2018) Multi-ethnic genome-wide association study for atrial fibrillation. Nature Genetics, 50(9), pp. 1225-1233. (doi: 10.1038/s41588-018-0133-9) (PMID:29892015)
Van Setten, J. et al. (2018) PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications, 9, 2904. (doi: 10.1038/s41467-018-04766-9) (PMID:30046033) (PMCID:PMC6060178)
Prins, B. P. et al. (2018) Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology, 19, 87. (doi: 10.1186/s13059-018-1457-6) (PMID:30012220) (PMCID:PMC6048820)
Ford, T. J. et al. (2018) Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial. American Heart Journal, 201, pp. 86-94. (doi: 10.1016/j.ahj.2018.03.010) (PMID:29803987) (PMCID:PMC6018570)
Feitosa, M. F. et al. (2018) Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13(6), e0198166. (doi: 10.1371/journal.pone.0198166) (PMID:29912962) (PMCID:PMC6005576)
Corcoran, D. et al. (2018) Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study. Open Heart, 5(2), e000924. (doi: 10.1136/openhrt-2018-000924) (PMID:30687508) (PMCID:PMC6326326)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2018) Recent findings in the genetics of blood pressure: how to apply in practice or is a moonshot required? Current Hypertension Reports, 20, 54. (doi: 10.1007/s11906-018-0863-1) (PMID:29881931) (PMCID:PMC5992231)
Williams, B. et al. (2018) Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes and Endocrinology, 6(6), pp. 464-475. (doi: 10.1016/S2213-8587(18)30071-8) (PMID:29655877) (PMCID:PMC5966620)
Lin, H. et al. (2018) Common and rare coding genetic variation underlying the electrocardiographic PR interval. Circulation: Genomic and Precision Medicine, 11(5), e002037. (doi: 10.1161/CIRCGEN.117.002037) (PMID:29748316)
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Magnus, M. C., Lawlor, D. A., Iliodromiti, S., Padmanabhan, S. , Nelson, S. M. and Fraser, A. (2018) Age at menarche and cardiometabolic health: a sibling analysis in the Scottish Family Health Study. Journal of the American Heart Association, 7(4), e007780. (doi: 10.1161/JAHA.117.007780) (PMID:29440004) (PMCID:PMC5850196)
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Padmanabhan, S. , Tan, L.-E. and Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. In: Berbari, A.E. and Mancia, G. (eds.) Disorders of Blood Pressure Regulation. Series: Updates in hypertension and cardiovascular protection. Springer, pp. 135-154. ISBN 9783319599175 (doi: 10.1007/978-3-319-59918-2_10)
2017
MacDonald, T. M. et al. (2017) Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. Journal of the American Heart Association, 6(11), e006986. (doi: 10.1161/JAHA.117.006986) (PMID:29151036) (PMCID:PMC5721778)
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Padmanabhan, S. and Joe, B. (2017) Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans. Physiological Reviews, 97(4), pp. 1469-1528. (doi: 10.1152/physrev.00035.2016) (PMID:28931564) (PMCID:PMC6347103)
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Che Roos, N. A., Alsanosi, S. M., Alsieni, M. A., Gupta, M. and Padmanabhan, S. (2017) Antihypertensive Drugs and Risk of Cancer: A Systematic Review and Meta-Analysis of 391, 790 Patients. The American Heart Association's Hypertension 2017 Scientific Sessions, San Francisco, CA, USA, 14-17 Sep 2017. (doi: 10.1161/hyp.70.suppl_1.p129)
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McGinnis, R. et al. (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nature Genetics, 49(8), pp. 1255-1260. (doi: 10.1038/ng.3895) (PMID:28628106)
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Zhang, Z.‐Y. et al. (2017) Novel urinary peptidomic classifier predicts incident heart failure. Journal of the American Heart Association, 6(8), e005432. (doi: 10.1161/JAHA.116.005432) (PMID:28784649) (PMCID:PMC5586413)
van der Hooft, J. J.J. , Wandy, J. , Young, F., Padmanabhan, S. , Gerasimidis, K. , Burgess, K. E.V., Barrett, M. P. and Rogers, S. (2017) Unsupervised discovery and comparison of structural families across multiple samples in untargeted metabolomics. Analytical Chemistry, 89(14), pp. 7569-7577. (doi: 10.1021/acs.analchem.7b01391) (PMID:28621528) (PMCID:PMC5524435)
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Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2017) Genomics of hypertension. Pharmacological Research, 121, pp. 219-229. (doi: 10.1016/j.phrs.2017.04.031) (PMID:28495658)
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Day, F. R. et al. (2017) Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49(6), pp. 834-841. (doi: 10.1038/ng.3841) (PMID:28436984)
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Clarke, T.-K. et al. (2017) Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 174(3), pp. 227-234. (doi: 10.1002/ajmg.b.32478) (PMID:27480393) (PMCID:PMC5363226)
Dominiczak, A. , Delles, C. and Padmanabhan, S. (2017) Genomics and precision medicine for clinicians and scientists in hypertension. Hypertension, 69(4), e10-e13. (doi: 10.1161/HYPERTENSIONAHA.116.08252) (PMID:28193712)
Menni, C., Metrustry, S. J., Ehret, G., Dominiczak, A. F. , Chowienczyk, P., Spector, T. D., Padmanabhan, S. and Valdes, A. M. (2017) Molecular pathways associated with blood pressure and hexadecanedioate levels. PLoS ONE, 9(4), e0175479. (doi: 10.1371/journal.pone.0175479) (PMID:28403188) (PMCID:PMC5389832)
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Schulz, C. and Padmanabhan, S. (2017) Methods to assess genetic risk prediction. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 27-40. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_2)
Tsiropoulou, S., McBride, M. and Padmanabhan, S. (2017) Urine metabolomics in hypertension research. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 61-68. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_5)
Jeemon, P., Harikrishnan, S., Sanjay, G., Sivasubramonian, S., Lekha, T.R., Padmanabhan, S. , Tandon, N. and Prabhakaran, D. (2017) A PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction (PROLIFIC Study): design and rationale of a family based randomized controlled trial in individuals with family history of premature coronary heart disease. BMC Public Health, 17, 10. (doi: 10.1186/s12889-016-3928-6) (PMID:28056897) (PMCID:PMC5217619)
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2016
Zeng, Y. et al. (2016) Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression. EBioMedicine, 14, pp. 161-167. (doi: 10.1016/j.ebiom.2016.11.003) (PMID:27838479) (PMCID:PMC5161419)
Gillespie, J., Beverland, I. J., Hamilton, S. and Padmanabhan, S. (2016) Development, evaluation, and comparison of land use regression modeling methods to estimate residential exposure to nitrogen dioxide in a cohort study. Environmental Science and Technology, 50(20), pp. 11085-11093. (doi: 10.1021/acs.est.6b02089) (PMID:27618146)
Boal, A. H., Smith, D. J. , Mccallum, L., Muir, S., Touyz, R. M. , Dominiczak, A. F. and Padmanabhan, S. (2016) Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders. Hypertension, 68(5), pp. 1132-1138. (doi: 10.1161/HYPERTENSIONAHA.116.08188) (PMID:27733585) (PMCID:PMC5058642)
Surendran, P. et al. (2016) Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics, 48(10), pp. 1151-1161. (doi: 10.1038/ng.3654) (PMID:27618447) (PMCID:PMC5056636)
van der Harst, P. et al. (2016) 52 genetic loci influencing myocardial mass. Journal of the American College of Cardiology, 68(13), pp. 1435-1448. (doi: 10.1016/j.jacc.2016.07.729) (PMID:27659466) (PMCID:PMC5478167)
Alharf, A.A., Cleland, S., Webster, J., McInnes, G.T. and Padmanabhan, S. (2016) Microalbuminuria in subjects with hypertension attending specialist blood pressure clinics. Journal of Human Hypertension, 30(9), pp. 527-533. (doi: 10.1038/jhh.2015.116) (PMID:26674756)
Van Der Hooft, J. , Padmanabhan, S. , Burgess, K. and Barrett, M. (2016) Erratum to: Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. Metabolomics, 12(8), 139. (doi: 10.1007/s11306-016-1078-6)
Yaghootkar, H. et al. (2016) Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension, and heart disease. Diabetes, 65(8), pp. 2448-2460. (doi: 10.2337/db15-1671) (PMID:27207519)
Sung, Y. J. et al. (2016) An empirical comparison of joint and stratified frameworks for studying G × E interactions: systolic blood pressure and smoking in the CHARGE gene-lifestyle interactions working group. Genetic Epidemiology, 40(5), pp. 404-415. (doi: 10.1002/gepi.21978) (PMID:27230302)
Van Der Hooft, J. J.J. , Padmanabhan, S. , Burgess, K. E.V. and Barrett, M. P. (2016) Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. Metabolomics, 12, 125. (doi: 10.1007/s11306-016-1064-z) (PMID:27471437) (PMCID:PMC4932139)
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Hewitt, J., Walters, M. , Padmanabhan, S. and Dawson, J. (2016) Cohort profile of the UK Biobank: diagnosis and characteristics of cerebrovascular disease. BMJ Open, 6(3), e009161. (doi: 10.1136/bmjopen-2015-009161) (PMID:27006341) (PMCID:PMC4809076)
Lip, S. , Jeemon, P., Mccallum, L., Dominiczak, A. F. , McInnes, G. T. and Padmanabhan, S. (2016) Contrasting mortality risks among subgroups of treated hypertensive patients developing new-onset diabetes. European Heart Journal, 374(12), (doi: 10.1093/eurheartj/ehv557) (PMID:26508167)
Clarke, T.-K. et al. (2016) Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population. Molecular Psychiatry, 21(3), pp. 419-425. (doi: 10.1038/mp.2015.12) (PMID:25754080) (PMCID:PMC4759203)
MacIsaac, R., Janek, S., Higgins, P., Walters, M. R. , Padmanabhan, S. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2016) Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension, 67(3), pp. 535-540. (doi: 10.1161/HYPERTENSIONAHA.115.06344) (PMID:26865199)
Clarke, T.-K. et al. (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addiction Biology, 21(2), pp. 469-480. (doi: 10.1111/adb.12245) (PMID:25865819) (PMCID:PMC4600406)
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Padmanabhan, S. and Touyz, R. M. (2016) Precision medicine in hypertension. Biochemist, 38(1), pp. 35-38. (doi: 10.1042/BIO03801035)
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2015
Solbu, M. D., Thomson, P. C., Macpherson, S., Findlay, M. D., Stevens, K. K., Patel, R. K., Padmanabhan, S. , Jardine, A. G. and Mark, P. B. (2015) Serum phosphate and social deprivation independently predict all-cause mortality in chronic kidney disease. BMC Nephrology, 16, 194. (doi: 10.1186/s12882-015-0187-1) (PMID:26627078) (PMCID:PMC4666082)
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Day, F. R. et al. (2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47(11), pp. 1294-1303. (doi: 10.1038/ng.3412) (PMID:26414677)
Gong, Y. et al. (2015) PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension, 33(11), pp. 2278-2285. (doi: 10.1097/hjh.0000000000000714) (PMID:26425837)
Patel, R., Jeemon, P., Stevens, K., Mccallum, L., Hastie, C. , Schneider, A., Jardine, A. , Mark, P. and Padmanabhan, S. (2015) Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. Journal of Hypertension, 33(10), pp. 2046-2053. (doi: 10.1097/hjh.0000000000000659) (PMID:26431193)
Morris, R. W. et al. (2015) Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1. BMJ Open, 5(8), e008808. (doi: 10.1136/bmjopen-2015-008808) (PMID:26264275) (PMCID:PMC4538266)
Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi: 10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)
Quinn, T. J. , Alghamdi, J., Padmanabhan, S. , Porteous, D. J., Smith, B. H., Hocking, L., Deary, I. J., Gallacher, J., Messow, M. and Stott, D. J. (2015) Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age, 37(4), p. 80. (doi: 10.1007/s11357-015-9820-y) (PMID:26228839) (PMCID:26228839)
Joshi, P. K. et al. (2015) Directional dominance on stature and cognition in diverse human populations. Nature, 523(7561), pp. 459-462. (doi: 10.1038/nature14618) (PMID:26131930)
Mccallum, L. et al. (2015) Longitudinal blood pressure control, long-term mortality and predictive utility of serum liver enzymes and bilirubin in hypertensive patients. Hypertension, 66(1), pp. 37-43. (doi: 10.1161/HYPERTENSIONAHA.114.04915) (PMID:25941342) (PMCID:PMC4461392)
Chittani, M. et al. (2015) TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. Journal of Hypertension, 33(6), pp. 1301-1309. (doi: 10.1097/HJH.0000000000000541) (PMID:25695618)
Clarke, T.-K. et al. (2015) Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index. Translational Psychiatry, 5(6), e592. (doi: 10.1038/tp.2015.83) (PMID:26125155) (PMCID:PMC4490293)
Lip, S. , Carlin, C., McCallum, L., Touyz, R.H. , Dominiczak, A.F. and Padmanabhan, S. (2015) Incidence and prognosis of cancer associated with digoxin and common antihypertensive drugs. Journal of Hypertension, 33(Supl 1), e45. (doi: 10.1097/01.hjh.0000467465.54504.ae) (PMID:26102824)
Fulton, R. L., Walters, M. R. , Morton, R., Touyz, R. M. , Dominiczak, A. F. , Morrison, D. S., Padmanabhan, S. , Meredith, P. A., McInnes, G. T. and Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65(5), 1008-U596. (doi: 10.1161/HYPERTENSIONAHA.114.04945) (PMID:25801870)
Menni, C. et al. (2015) Metabolomic study of carotid–femoral pulse-wave velocity in women. Journal of Hypertension, 33(4), pp. 791-796. (doi: 10.1097/HJH.0000000000000467) (PMID:25490711) (PMCID:PMC4354457)
McCallum, L., Lip, S. and Padmanabhan, S. (2015) The hidden hand of chloride in hypertension. Pflügers Archiv - European Journal of Physiology, 467(3), pp. 595-603. (doi: 10.1007/s00424-015-1690-8) (PMID:25619794) (PMCID:PMC4325190)
Padmanabhan, S. , Caulfield, M. and Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116(6), pp. 937-959. (doi: 10.1161/CIRCRESAHA.116.303647) (PMID:25767282)
Wade, K. H. et al. (2015) Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. American Journal of Clinical Nutrition, 101(1), pp. 202-209. (doi: 10.3945/ajcn.114.092981) (PMID:25527764) (PMCID:PMC4266888)
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Boal, A., Smith, D. , Muir, S., Touyz, R. M. , Dominiczak, A. F. and Padmanabhan, S. (2015) Antihypertensive therapy and risk of admissions for mood disorders. Journal of Hypertension, 33(Supp 1), e128. (doi: 10.1097/01.hjh.0000467697.82617.32) (PMID:26102733)
Lip, S. , McCallum, L., Touyz, R.H. , Dominiczak, A.F. and Padmanabhan, S. (2015) Clinical implications of the diastolic blood pressure 'J Curve' in treated hypertensive patients. Journal of Hypertension, 33(Supl 1), e87. (doi: 10.1097/01.hjh.0000467584.81358.e3) (PMID:26102953)
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2014
Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S. , McCallum, L., Walters, M. R. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5), pp. 1102-1107. (doi: 10.1161/HYPERTENSIONAHA.114.03953) (PMID:25135183)
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2013
Rosenthal, E. A., Ranchalis, J., Crosslin, D. R., Burt, A., Brunzell, J. D., Motulsky, A. G., Nickerson, D. A., Wijsman, E. M., Jarvik, G. P. and Padmanabhan, S. (2013) Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. American Journal of Human Genetics, 93(6), pp. 1035-1045. (doi: 10.1016/j.ajhg.2013.10.019)
Menni, C., Mangino, M., Zhang, F., Clement, G., Snieder, H., Padmanabhan, S. and Spector, T.D. (2013) Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults. Journal of Hypertension, 31(12), pp. 2356-2361. (doi: 10.1097/HJH.0b013e32836523c1)
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Norton, N. et al. (2013) Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circulation: Cardiovascular Genetics, 6(2), pp. 144-153. (doi: 10.1161/CIRCGENETICS.111.000062)
Fu, W. et al. (2013) Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature, 493(7431), pp. 216-220. (doi: 10.1038/nature11690)
Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., Padmanabhan, S. , Delles, C. , Dominiczak, A. F. and Hastie, C. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22(1), pp. 184-201. (doi: 10.1093/hmg/dds396) (PMID:23001569) (PMCID:PMC3522401)
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McDonough, C.W., Gong, Y., Padmanabhan, S. , Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F. , Cooper-DeHoff, R.M. and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62(1), pp. 48-54. (doi: 10.1161/HYPERTENSIONAHA.111.00823)
O'Connor, T. D., Kiezun, A., Bamshad, M., Rich, S. S., Smith, J. D., Turner, E., Leal, S. M., Akey, J. M. and Padmanabhan, S. (2013) Fine-scale patterns of population stratification confound rare variant association tests. PLoS ONE, 8(7), e65834. (doi: 10.1371/journal.pone.0065834) (PMID:23861739) (PMCID:PMC3701690)
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Sridhar, G.R., Duggirala, R. and Padmanabhan, S. (2013) Emerging face of genetics, genomics and diabetes. International Journal of Diabetes in Developing Countries, 33(4), pp. 183-185. (doi: 10.1007/s13410-013-0164-9)
Turner, S.T. et al. (2013) Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension, 62, pp. 391-397. (doi: 10.1161/HYPERTENSIONAHA.111.00436)
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2012
van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492(7429), pp. 369-375. (doi: 10.1038/nature11677) (PMID:23222517) (PMCID:PMC3623669)
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Padmanabhan, S. , Newton-Cheh, C. and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28(8), pp. 397-408. (doi: 10.1016/j.tig.2012.04.001)
Padmanabhan, S. and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, A. E. and Mancia, G. (eds.) Special Issues in Hypertension. Springer Milan: Milan, pp. 439-452. ISBN 9788847026001 (doi: 10.1007/978-88-470-2601-8_33)
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2011
Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89(6), pp. 688-700. (doi: 10.1016/j.ajhg.2011.10.013)
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2010
Timpson, N.J. et al. (2010) Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. American Journal of Clinical Nutrition, 92(2), pp. 375-382. (doi: 10.3945/ajcn.2010.29438) (PMID:20519558) (PMCID:PMC3605792)
Paul, L., Hastie, C. E. , Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F. , McInnes, G. T. and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55(2), pp. 567-574. (doi: 10.1161/HYPERTENSIONAHA.109.144808)
Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi: 10.1016/j.bbadis.2009.12.006)
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Hastie, C. E. , Padmanabhan, S. and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010(509581), (doi: 10.4061/2010/509581)
Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C. and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212(1), pp. 1-8. (doi: 10.1016/j.atherosclerosis.2010.01.029)
Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28(10), pp. 2007-2009. (doi: 10.1097/HJH.0b013e32833f2f56)
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Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi: 10.1097/HJH.0b013e32833594d7)
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2009
Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85(5), pp. 628-642. (doi: 10.1016/j.ajhg.2009.10.014)
Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M. and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94(11), pp. 4324-4333. (doi: 10.1210/jc.2009-1406)
Padmanabhan, S. , Hastie, C. , Sainsbury, C., McBride, M. W. , Connell, J. M. and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi: 10.1142/S1793351X09000665)
Dominiczak, A. F. , Delles, C. and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940. (doi: 10.1097/HJH.0b013e328329fca3) (PMCID:PMC2709222)
Padmanabhan, S. (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27(8), pp. 1521-1523.
Padmanabhan, S. , Menni, C., Prabhakaran, D. and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97(3), pp. 385-391.
Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L. and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27(4), pp. 730-735. (doi: 10.1097/HJH.0b013e328324ed58)
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2008
Delles, C., McBride, M.W., Padmanabhan, S. and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi: 10.1016/j.tem.2008.07.010)
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Padmanabhan, S. , Melander, O., Hastie, C., Menni, C., Delles, C. , Connell, J. M. and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi: 10.1097/HJH.0b013e3282ff634f)
Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A. and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26, S113-S113.
Hastie, C., Padmanabhan, S., Slack, R., Isles, C. and Pell, J. (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22(10), pp. 717-718.
Padmanabhan, S. , Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G. and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26, S18-S18.
2007
Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S. , Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E. and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116(17), pp. 1915-1924. (doi: 10.1161/CIRCULATIONAHA.107.710293)
2006
Padmanabhan, S. et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47(3), pp. 603-608. (doi: 10.1161/01.HYP.0000197947.62601.9d)
2005
Whiteley, L., Padmanabhan, S. , Hole, D. and Isles, C. (2005) Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care, 28(7), pp. 1588-1593.
2004
Charchar, F., Padmanabhan, S. , Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A. , Connell, J.M., Watt, G.C.M., Dominiczak, A.F. and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22(S1), S58-S59.
Padmanabhan, S. , Connell, J.M.C., Dominiczak, A.F. , Inglis, G., Macfarlane, P.W. and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22(S1), S180-S181.
2003
Swan, L., Birnie, D., Padmanabhan, S. , Inglis, G., Connell, J. and Hillis, W. (2003) The genetic determination of left ventricular mass in healthy adults. European Heart Journal, 24, 579-U9. (doi: 10.1016/S0195-668X(02)00524-9)
Tomaszewski, M., Charchar, F.J., Padmanabhan, S. , Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17(6), pp. 379-380. (doi: 10.1038/sj.jhh.1001559)
2002
Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39(2), pp. 353-356. (doi: 10.1161/hy0202.103413)
Stanton, T., Inglis, G.C., Padmanabhan, S. , Dominiczak, A.F. , Jardine, A.G. and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15(5), pp. 512-518.
1994
Dutta, T. K., Padmanabhan, S. , Hamide, A. and Ramesh, J. (1994) Localised tetanus mimicking incomplete transverse myelitis. Lancet, 343(8903), pp. 983-984. (doi: 10.1016/S0140-6736(94)90111-2)
Articles
Sosenko, F. et al. (2024) Cancer diagnosis after emergency presentation: impact of demographics, cancer types, and pandemic. Academia Oncology, 1(2), pp. 1-8. (doi: 10.20935/AcadOnco7422)
McCallum, L. et al. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, 81(10), pp. 2049-2059. (doi: 10.1161/HYPERTENSIONAHA.124.23122) (PMID:39077768) (PMCID:PMC11460757)
Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)
Morrow, A. et al. (2024) Zibotentan in microvascular angina: a randomized, placebo-controlled, crossover trial. Circulation, (doi: 10.1161/CIRCULATIONAHA.124.069901) (PMID:39217504) (Early Online Publication)
Canning, J. et al. (2024) Methods applied to neonatal dried blood spot samples for secondary research purposes: a scoping review. Critical Reviews in Clinical Laboratory Sciences, (doi: 10.1080/10408363.2024.2360996) (PMID:38855982) (Early Online Publication)
Padmanabhan, S. , Delles, C. and Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81(6), pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371) (PMID:38748763)
Tran, T. Q. B. et al. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6(6), pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005) (PMID:39022171) (PMCID:PMC11250845)
Alsanosi, S. M. and Padmanabhan, S. (2024) Potential applications of artificial intelligence (AI) in managing polypharmacy in Saudi Arabia: a narrative review. Healthcare, 12(7), 788. (doi: 10.3390/healthcare12070788)
McCallum, L., Lip, S. , Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S. and Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11(1), e002535. (doi: 10.1136/openhrt-2023-002535) (PMID:38429056)
Mair, F. S. et al. (2024) Developing SysteMatic: prevention, precision and equity by design for people living with multiple long-term conditions. Journal of Multimorbidity and Comorbidity, 14, pp. 1-9. (doi: 10.1177/26335565241272682)
van de Vegte, Y. J. et al. (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nature Communications, 14(1), 4646. (doi: 10.1038/s41467-023-39521-2) (PMID:37532724) (PMCID:PMC10397318)
Le, N. N., Tran, T. Q. B., Du Toit, C. , Gill, D. and Padmanabhan, S. (2023) Establishing plausibility of cardiovascular adverse effects of immunotherapies using Mendelian randomisation. Frontiers in Cardiovascular Medicine, 10, 1116799. (doi: 10.3389/fcvm.2023.1116799) (PMID:37273876) (PMCID:PMC10235787)
Du Toit, C. et al. (2023) Survey and evaluation of hypertension machine learning research. Journal of the American Heart Association, 12(9), e027896. (doi: 10.1161/JAHA.122.027896) (PMID:37119074) (PMCID:PMC10227215)
Beynon-Cobb, B., Louca, P., Hoorn, E. J., Menni, C. and Padmanabhan, S. (2023) Effect of sodium bicarbonate on systolic blood pressure in CKD: a systematic review and meta-analysis. Clinical Journal of the American Society of Nephrolog, 18(4), pp. 435-445. (doi: 10.2215/CJN.0000000000000119) (PMID:36758154) (PMCID:PMC10103210)
Young, W. J. et al. (2023) Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature Communications, 14, 1411. (doi: 10.1038/s41467-023-36997-w) (PMID:36918541) (PMCID:PMC10015012)
Tran, T. Q. B. et al. (2023) Predictive accuracy and clinical utility of machine learning prediction for classifying blood pressure status. SSRN, (doi: 10.2139/ssrn.4307704)
Garimella, P. S., Du Toit, C. , Le, N. N. and Padmanabhan, S. (2023) A genomic deep field view of hypertension. Kidney International, 103(1), pp. 42-52. (doi: 10.1016/j.kint.2022.09.029) (PMID:36377113)
Padmanabhan, S. , Du Toit, C. and Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. e28. (doi: 10.1017/pcm.2023.17)
Taylor, A. et al. (2023) Long-term usage and improved clinical outcomes with adoption of a COPD digital support service: key findings from the RECEIVER trial. International Journal of Chronic Obstructive Pulmonary Disease, 18, pp. 1301-1318. (doi: 10.2147/COPD.S409116) (PMID:37378275) (PMCID:PMC10292615)
Mary, S. , Boder, P., Padmanabhan, S. , McBride, M. W. , Graham, D. , Delles, C. and Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888) (PMID:36378920) (PMCID:PMC9553220)
Louca, P., Tran, T. Q. B., Du Toit, C. , Christofidou, P., Spector, T. D., Mangino, M., Suhre, K., Padmanabhan, S. and Menni, C. (2022) Machine learning integration of multimodal data identifies key features of blood pressure regulation. EBioMedicine, 84, 104243. (doi: 10.1016/j.ebiom.2022.104243) (PMID:36084617) (PMCID:PMC9463529)
Young, W. J. et al. (2022) Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nature Communications, 13, 5144. (doi: 10.1038/s41467-022-32821-z) (PMID:36050321) (PMCID:PMC9436946)
Lip, S. , Dempster, G., Jain, S., Brooksbank, K., Ghouri, N. , McCallum, L. and Padmanabhan, S. (2022) Underrepresentation of ethnic minorities in hypertension research—a survey of enablers and barriers among South Asian and African communities in Glasgow. Trials, 23, 609. (doi: 10.1186/s13063-022-06542-z) (PMID:35906700) (PMCID:PMC9335986)
Le, N. N., Tran, T. Q. B., Lip, S. , McCallum, L., McClure, J. , Dominiczak, A. F. , Gill, D. and Padmanabhan, S. (2022) Unravelling the distinct effects of systolic and diastolic blood pressure using Mendelian randomisation. Genes, 13(7), 1226. (doi: 10.3390/genes13071226) (PMID:35886009) (PMCID:PMC9323763)
Lip, S. , McCallum, L., Delles, C. , McClure, J. D. , Guzik, T., Berry, C. , Touyz, R. and Padmanabhan, S. (2022) Rationale and design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR). Open Heart, 9(1), e002057. (doi: 10.1136/openhrt-2022-002057) (PMID:35750422) (PMCID:PMC9234432)
Winkler, T. W. et al. (2022) Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 5, 580. (doi: 10.1038/s42003-022-03448-z) (PMID:35697829) (PMCID:PMC9192715)
Lucas-Herald, A. K. et al. (2022) Vascular dysfunction and increased cardiovascular risk in hypospadias. European Heart Journal, 43(19), pp. 1832-1845. (doi: 10.1093/eurheartj/ehac112) (PMID:35567552) (PMCID:PMC9113289)
Shaman, J. A., Bousman, C. A., Mitropoulou, C. and Padmanabhan, S. (2022) Editorial: Pharmacogenomics: from bench to bedside and back again. Frontiers in Genetics, 13, 878191. (doi: 10.3389/fgene.2022.878191) (PMID:35360856) (PMCID:PMC8964277)
Nogal, A. et al. (2022) Incremental value of a panel of serum metabolites for predicting risk of atherosclerotic cardiovascular disease. Journal of the American Heart Association, 11(4), e024590. (doi: 10.1161/JAHA.121.024590) (PMID:35156414) (PMCID:PMC9245800)
Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)
Tran, T. Q. B., Du Toit, C. and Padmanabhan, S. (2021) Artificial intelligence in healthcare-the road to precision medicine. Journal of Hospital Management and Health Policy, 5, 29. (doi: 10.21037/JHMHP-20-132)
Boder, P., Mary, S. , Mark, P. B. , Leiper, J. , Dominiczak, A. F. , Padmanabhan, S. , Rampold, L. and Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)
Clarke, T.-K. et al. (2021) Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. Molecular Psychiatry, 26(8), pp. 4344-4354. (doi: 10.1038/s41380-019-0607-x) (PMID:31767999)
Chen, J. et al. (2021) The trans-ancestral genomic architecture of glycemic traits. Nature Genetics, 53(6), pp. 840-860. (doi: 10.1038/s41588-021-00852-9) (PMID:34059833) (PMCID:PMC7610958)
Fawcett, K. A. et al. (2021) Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Research, 5, 111. (doi: 10.12688/wellcomeopenres.15846.2) (PMID:33728380) (PMCID:PMC7938335)
Shaw, R. J. , Mackay, D. , Pell, J. P. , Padmanabhan, S. , Bailey, D. S. and Smith, D. J. (2021) The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients. Psychological Medicine, 51(7), pp. 1183-1191. (doi: 10.1017/S0033291719004094) (PMID:31973782)
Padmanabhan, S. and Dominiczak, A. F. (2021) Genomics of hypertension: the road to precision medicine. Nature Reviews Cardiology, 18(4), pp. 235-250. (doi: 10.1038/s41569-020-00466-4) (PMID:33219353)
McCallum, L., Brooksbank, K., McConnachie, A. , Aman, A. , Lip, S. , Dawson, J. , MacIntyre, I. M., MacDonald, T. M., Webb, D. J. and Padmanabhan, S. (2021) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD). American Journal of Hypertension, 34(1), pp. 92-99. (doi: 10.1093/ajh/hpaa166) (PMID:33084880) (PMCID:PMC7891239)
Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52(12), pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x) (PMID:33230300) (PMCID:PMC7610439)
Morrow, A. J. et al. (2020) Rationale and design of the Medical Research Council precision medicine with Zibotentan in microvascular angina (PRIZE) trial. American Heart Journal, 229, pp. 70-80. (doi: 10.1016/j.ahj.2020.07.007) (PMID:32942043)
Ford, T. J. et al. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41(34), pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915) (PMID:31972008) (PMCID:PMC7557475)
Louca, P., Mompeo, O., Leeming, E. R., Berry, S. E., Mangino, M., Spector, T. D., Padmanabhan, S. and Menni, C. (2020) Dietary influence on systolic and diastolic blood pressure in the TwinsUK cohort. Nutrients, 12(7), 2130. (doi: 10.3390/nu12072130) (PMID:32708992) (PMCID:PMC7400881)
Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, 2542. (doi: 10.1038/s41467-020-15706-x) (PMID:32439900) (PMCID:PMC7242331)
Lip, S. and Padmanabhan, S. (2020) Genomics of blood pressure and hypertension: extending the mosaic theory toward stratification. Canadian Journal of Cardiology, 36(5), pp. 694-705. (doi: 10.1016/j.cjca.2020.03.001) (PMID:32389342) (PMCID:PMC7237883)
Simpson, J. et al. (2020) Prognostic models derived in PARADIGM-HF and validated in ATMOSPHERE and the Swedish Heart Failure Registry to predict mortality and morbidity in chronic heart failure. JAMA Cardiology, 5(4), pp. 432-441. (doi: 10.1001/jamacardio.2019.5850) (PMID:31995119)
Wigmore, E. M. et al. (2020) Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP. Pharmacogenomics Journal, 20, pp. 329-341. (doi: 10.1038/s41397-019-0067-3) (PMID:30700811) (PMCID:PMC7096334)
Teumer, A. et al. (2019) KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. JCI Insight, 4(23), e131156. (doi: 10.1172/jci.insight.131156) (PMID:31600170) (PMCID:PMC6962032)
Clark, D. W. et al. (2019) Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, 4957. (doi: 10.1038/s41467-019-12283-6) (PMID:31673082) (PMCID:PMC6823371)
Schmidt, A. F. et al. (2019) Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. BMC Cardiovascular Disorders, 19, 240. (doi: 10.1186/s12872-019-1187-z) (PMID:31664920) (PMCID:PMC6820948)
Menni, C. et al. (2019) Metabolomic profiling identifies novel associations with electrolyte and acid-base homeostatic patterns. Scientific Reports, 9, 15088. (doi: 10.1038/s41598-019-51492-3) (PMID:31636301) (PMCID:PMC6803625)
Tin, A. et al. (2019) Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics, 51, pp. 1459-1474. (doi: 10.1038/s41588-019-0504-x) (PMID:31578528)
Lip, S. , Tan, L. E., Jeemon, P., McCallum, L., Dominiczak, A. F. and Padmanabhan, S. (2019) Diastolic blood pressure J-curve phenomenon in a tertiary-care hypertension clinic. Hypertension, 74(4), pp. 767-775. (doi: 10.1161/HYPERTENSIONAHA.119.12787) (PMID:31422693) (PMCID:PMC6756261)
Graham, N. A., Ward, J. , Mackay, D. , Pell, J. , Cavanagh, J. , Padmanabhan, S. and Smith, D. J. (2019) Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank. BMJ Open, 9(9), e024433. (doi: 10.1136/bmjopen-2018-024433) (PMID:31575565) (PMCID:PMC6797415)
Iniesta, R. et al. (2019) Gene variants at loci related to blood pressure account for variation in response to antihypertensive drugs between black and white individuals. Hypertension, 74(3), pp. 614-622. (doi: 10.1161/hypertensionaha.118.12177) (PMID:31327267)
Frangou, S. et al. (2019) Insulin resistance: genetic associations with depression and cognition in population based cohorts. Experimental Neurology, 316, pp. 20-26. (doi: 10.1016/j.expneurol.2019.04.001) (PMID:30965038)
Noordam, R. et al. (2019) Effects of calcium, magnesium, and potassium concentrations on ventricular repolarization in unselected individuals. Journal of the American College of Cardiology, 73(24), pp. 3118-3131. (doi: 10.1016/j.jacc.2019.03.519) (PMID:31221261)
Welsh, P. et al. (2019) Cardiac troponin T and troponin I in the general population: comparing and contrasting their genetic determinants and associations with outcomes. Circulation, 139(24), pp. 2754-2764. (doi: 10.1161/CIRCULATIONAHA.118.038529) (PMID:31014085) (PMCID:PMC6571179)
Wuttke, M. et al. (2019) A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51(6), pp. 957-972. (doi: 10.1038/s41588-019-0407-x) (PMID:31152163) (PMCID:PMC6698888)
Kokubo, Y., Padmanabhan, S. , Iwashima, Y., Yamagishi, K. and Goto, A. (2019) Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines. Environmental Health and Preventive Medicine, 24(1), 19. (doi: 10.1186/s12199-019-0771-2) (PMID:30857519) (PMCID:PMC6410507)
Clarke, T.-K. et al. (2019) Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism. Wellcome Open Research, 3, 11. (doi: 10.12688/wellcomeopenres.13893.2)
Arnau-Soler, A., Adams, M. J., Generation Scotland, , Major Depressive Disorder Working Group, P. G. C., Hayward, C. and Thomson, P. A. (2018) Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13(12), e0209160. (doi: 10.1371/journal.pone.0209160) (PMID:30571770) (PMCID:PMC6301766)
Kokubo, Y. and Padmanabhan, S. (2018) Necessity of preventing cardiovascular disease by smoke-free policies. Journal of the American Heart Association, 7(23), e011120. (doi: 10.1161/JAHA.118.011120) (PMID:30571604) (PMCID:PMC6405570)
Alghamdi, J., Matou-Nasri, S., Alghamdi, F., Alghamdi, S., Alfadhel, M. and Padmanabhan, S. (2018) Risk of neuropsychiatric adverse effects of lipid-lowering drugs: a Mendelian randomization study. International Journal of Neuropsychopharmacology, 21(12), pp. 1067-1075. (doi: 10.1093/ijnp/pyy060) (PMID:29986042) (PMCID:PMC6276028)
Pulit, S. L. et al. (2018) Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. Neurology Genetics, 4(6), e293. (doi: 10.1212/NXG.0000000000000293) (PMID:30584597) (PMCID:PMC6283455)
Graham, L. A., Aman, A. , Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi: 10.1152/physiolgenomics.00057.2018) (PMID:30216136) (PMCID:PMC6293113)
Welsh, P. et al. (2018) Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort. Clinical Chemistry, 64(11), pp. 1607-1616. (doi: 10.1373/clinchem.2018.292086) (PMID:30126950)
Evangelou, E. et al. (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50, pp. 1412-1425. (doi: 10.1038/s41588-018-0205-x) (PMID:30224653) (PMCID:PMC6284793)
Mukhtar, O. et al. (2018) A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: the comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. American Heart Journal, 204, pp. 102-108. (doi: 10.1016/j.ahj.2018.05.006) (PMID:30092411) (PMCID:PMC6234107)
Rosenthal, E. A. et al. (2018) Rare loss of function variants in candidate genes and risk of colorectal cancer. Human Genetics, 137(10), pp. 795-806. (doi: 10.1007/s00439-018-1938-4) (PMID:30267214) (PMCID:PMC6283057)
Roselli, C. et al. (2018) Multi-ethnic genome-wide association study for atrial fibrillation. Nature Genetics, 50(9), pp. 1225-1233. (doi: 10.1038/s41588-018-0133-9) (PMID:29892015)
Van Setten, J. et al. (2018) PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications, 9, 2904. (doi: 10.1038/s41467-018-04766-9) (PMID:30046033) (PMCID:PMC6060178)
Prins, B. P. et al. (2018) Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology, 19, 87. (doi: 10.1186/s13059-018-1457-6) (PMID:30012220) (PMCID:PMC6048820)
Ford, T. J. et al. (2018) Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial. American Heart Journal, 201, pp. 86-94. (doi: 10.1016/j.ahj.2018.03.010) (PMID:29803987) (PMCID:PMC6018570)
Feitosa, M. F. et al. (2018) Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13(6), e0198166. (doi: 10.1371/journal.pone.0198166) (PMID:29912962) (PMCID:PMC6005576)
Corcoran, D. et al. (2018) Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study. Open Heart, 5(2), e000924. (doi: 10.1136/openhrt-2018-000924) (PMID:30687508) (PMCID:PMC6326326)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2018) Recent findings in the genetics of blood pressure: how to apply in practice or is a moonshot required? Current Hypertension Reports, 20, 54. (doi: 10.1007/s11906-018-0863-1) (PMID:29881931) (PMCID:PMC5992231)
Williams, B. et al. (2018) Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes and Endocrinology, 6(6), pp. 464-475. (doi: 10.1016/S2213-8587(18)30071-8) (PMID:29655877) (PMCID:PMC5966620)
Lin, H. et al. (2018) Common and rare coding genetic variation underlying the electrocardiographic PR interval. Circulation: Genomic and Precision Medicine, 11(5), e002037. (doi: 10.1161/CIRCGEN.117.002037) (PMID:29748316)
Sung, Y. J. et al. (2018) A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. American Journal of Human Genetics, 102(3), pp. 375-400. (doi: 10.1016/j.ajhg.2018.01.015) (PMID:29455858)
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Menni, C., Mangino, M., Zhang, F., Clement, G., Snieder, H., Padmanabhan, S. and Spector, T.D. (2013) Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults. Journal of Hypertension, 31(12), pp. 2356-2361. (doi: 10.1097/HJH.0b013e32836523c1)
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McDonough, C.W., Gong, Y., Padmanabhan, S. , Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F. , Cooper-DeHoff, R.M. and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62(1), pp. 48-54. (doi: 10.1161/HYPERTENSIONAHA.111.00823)
O'Connor, T. D., Kiezun, A., Bamshad, M., Rich, S. S., Smith, J. D., Turner, E., Leal, S. M., Akey, J. M. and Padmanabhan, S. (2013) Fine-scale patterns of population stratification confound rare variant association tests. PLoS ONE, 8(7), e65834. (doi: 10.1371/journal.pone.0065834) (PMID:23861739) (PMCID:PMC3701690)
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Sridhar, G.R., Duggirala, R. and Padmanabhan, S. (2013) Emerging face of genetics, genomics and diabetes. International Journal of Diabetes in Developing Countries, 33(4), pp. 183-185. (doi: 10.1007/s13410-013-0164-9)
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Delles, C. and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28(3), pp. 296-304. (doi: 10.1016/j.cjca.2012.02.004)
Jeemon, P. et al. (2012) Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population. Indian Journal of Medical Research, 135(4), pp. 485-493.
Padmanabhan, S. , Newton-Cheh, C. and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28(8), pp. 397-408. (doi: 10.1016/j.tig.2012.04.001)
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Paul, L., Hastie, C. E. , Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F. , McInnes, G. T. and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55(2), pp. 567-574. (doi: 10.1161/HYPERTENSIONAHA.109.144808)
Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi: 10.1016/j.bbadis.2009.12.006)
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Hastie, C. E. , Padmanabhan, S. and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010(509581), (doi: 10.4061/2010/509581)
Lang, C.C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C. and Padmanabhan, S. (2010) Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212(1), pp. 1-8. (doi: 10.1016/j.atherosclerosis.2010.01.029)
Padmanabhan, S. (2010) Antihypertensive pharmacogenetics: missed opportunity. Journal of Hypertension, 28(10), pp. 2007-2009. (doi: 10.1097/HJH.0b013e32833f2f56)
Padmanabhan, S. , Hastie, C. , Prabhakaran, D. and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132(5), pp. 567-78.
Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi: 10.1371/journal.pgen.1001177)
Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi: 10.1097/HJH.0b013e32833594d7)
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Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M. and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94(11), pp. 4324-4333. (doi: 10.1210/jc.2009-1406)
Padmanabhan, S. , Hastie, C. , Sainsbury, C., McBride, M. W. , Connell, J. M. and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi: 10.1142/S1793351X09000665)
Dominiczak, A. F. , Delles, C. and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940. (doi: 10.1097/HJH.0b013e328329fca3) (PMCID:PMC2709222)
Padmanabhan, S. (2009) Genetic causation: the end of parsimony? Journal of Hypertension, 27(8), pp. 1521-1523.
Padmanabhan, S. , Menni, C., Prabhakaran, D. and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97(3), pp. 385-391.
Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L. and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27(4), pp. 730-735. (doi: 10.1097/HJH.0b013e328324ed58)
Delles, C., McBride, M.W., Padmanabhan, S. and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi: 10.1016/j.tem.2008.07.010)
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Padmanabhan, S. , Melander, O., Hastie, C., Menni, C., Delles, C. , Connell, J. M. and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi: 10.1097/HJH.0b013e3282ff634f)
Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A. and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26, S113-S113.
Hastie, C., Padmanabhan, S., Slack, R., Isles, C. and Pell, J. (2008) A study of the 'obesity paradox' across the spectrum of cardiovascular risk. Journal of Human Hypertension, 22(10), pp. 717-718.
Padmanabhan, S. , Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G. and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26, S18-S18.
Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S. , Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E. and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116(17), pp. 1915-1924. (doi: 10.1161/CIRCULATIONAHA.107.710293)
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Charchar, F., Padmanabhan, S. , Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A. , Connell, J.M., Watt, G.C.M., Dominiczak, A.F. and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22(S1), S58-S59.
Padmanabhan, S. , Connell, J.M.C., Dominiczak, A.F. , Inglis, G., Macfarlane, P.W. and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22(S1), S180-S181.
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Book Sections
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. In: Dorobantu, M., Mancia, G., Grassi, G. and Voicu, V. (eds.) Hypertension and Heart Failure. Series: Updates in hypertension and cardiovascular protection. Springer International Publishing, pp. 15-29. ISBN 9783319933191
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genomics of hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer, pp. 171-181. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_16)
Padmanabhan, S. , Tan, L.-E. and Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. In: Berbari, A.E. and Mancia, G. (eds.) Disorders of Blood Pressure Regulation. Series: Updates in hypertension and cardiovascular protection. Springer, pp. 135-154. ISBN 9783319599175 (doi: 10.1007/978-3-319-59918-2_10)
Schulz, C. and Padmanabhan, S. (2017) Methods to assess genetic risk prediction. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 27-40. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_2)
Tsiropoulou, S., McBride, M. and Padmanabhan, S. (2017) Urine metabolomics in hypertension research. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 61-68. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_5)
Alghamdi, J. and Padmanabhan, S. (2014) Fundamentals of complex trait genetics and association studies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 235-257. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00012-8)
Alsanosi, S. M. M., Skiffington, C. and Padmanabhan, S. (2014) Pharmacokinetic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 341-364. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00017-7)
Brown, C. and Padmanabhan, S. (2014) QTc and sudden cardiac death. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 779-806. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00033-5)
Docherty, K. F. and Padmanabhan, S. (2014) Genomics and pharmacogenomics of lipid-lowering therapies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 715-746. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00031-1)
Gong, Y., McDonough, C. W., Padmanabhan, S. and Johnson, J. A. (2014) Hypertension pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 747-778. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00032-3)
McCallum, L., Lip, S. and Padmanabhan, S. (2014) Pharmacodynamic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 365-383. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00018-9)
Padmanabhan, S. (2014) Clinical trials in pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 309-320. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00015-3)
Padmanabhan, S. (2014) Pharmacogenomics and stratified medicine. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 3-25. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00001-3)
Padmanabhan, S. , Caulfield, M. and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, G., Grassi, G. and Redon, J. (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press: Boca Raton, FL, pp. 115-128. ISBN 9781841849973 (doi: 10.1201/b17072-13)
Wang, G. et al. (2013) Genomics of elite sporting performance: what little we know and necessary advances. In: Friedmann, T., Dunlap, J. C. and Goodwin, S. F. (eds.) Advances in Genetics. Academic Press: Amsterdam, pp. 123-49. ISBN 9780124077034
Padmanabhan, S. and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, A. E. and Mancia, G. (eds.) Special Issues in Hypertension. Springer Milan: Milan, pp. 439-452. ISBN 9788847026001 (doi: 10.1007/978-88-470-2601-8_33)
Tomaszewski, M., Padmanabhan, S. , Miller, W.H., Lee, W.K. and Dominiczak, A.F. (2009) Genetic factors. In: Mancia, G., Grassi, G. and Kjeldsen, S. (eds.) Manual of Hypertension of the European Society of Hypertension. Informa Healthcare: London, pp. 84-93. ISBN 9781841846484
Edited Books
Padmanabhan, S. (Ed.) (2014) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London. ISBN 9780123868831
Research Reports or Papers
Acur, N. , Carbajal Pina, C. and Padmanabhan, S. (2022) Therme & The University of Glasgow Global Wellbeing Centre of Excellence (WellEx), Feasibility Study. Project Report. Founded by The Scottish Inward Investment Catalyst Fund- Interface (Project Number is 318334-02), University of Glasgow and Therme Group.
Conference or Workshop Item
Du Toit, C. et al. (2022) Investigating the quality of machine learning research and reporting in hypertension. European Society of Hypertension 31st Annual Meeting, Athens, Greece, 17-21 Jul 2022. e78. (doi: 10.1097/01.hjh.0000835956.81410.5e)
Morrow, A. et al. (2021) Rationale and design of the Medical Research Council Precision medicine with Zibotentan in microvascular angina (PRIZE) trial MRI sub-study. British Society of Cardiovascular Magnetic Resonance 2021 Annual Meeting, 12 October 2021. A2.1-A2. (doi: 10.1136/heartjnl-2021-BSCMR.3)
Che Roos, N. A., Alsanosi, S. M., Alsieni, M. A., Gupta, M. and Padmanabhan, S. (2017) Antihypertensive Drugs and Risk of Cancer: A Systematic Review and Meta-Analysis of 391, 790 Patients. The American Heart Association's Hypertension 2017 Scientific Sessions, San Francisco, CA, USA, 14-17 Sep 2017. (doi: 10.1161/hyp.70.suppl_1.p129)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Optical Stethocsope-based Vital Signal Monitoring using Neuromorphic Chip
Engineering and Physical Sciences Research Council
2023 - 2024
- AF Screening to Prevent Ischaemic StRokE (The ASPIRE Study) - The Role of Blood, ECG and Genetic Biomarkers
Stroke Association
2023 - 2025
- Industry led cross-college digital health innovation opportunity events
Medical Research Council
2022 - 2023
- Mitigation of COVID-19 through cardiovascular pharmacotherapy
British Heart Foundation
2022 - 2025
- Schizophrenia, Heart Attack Outcomes and Receipt of Cardiac Care
Office of the Chief Scientific Adviser
2022 - 2024
- Feasibility Study of Health and Wellbeing Excellence Centre (Therme Group)
Interface
2022 - 2022
- Vascular effects of SARS-CoV-2 infection and long term impact on hypertension
Heart Research UK
2021 - 2024
- Living Lab: Driving Economic Growth in Glasgow through Real-World Implementation of Precision Medicine
UK Research and Innovation
2020 - 2025
- BHF Centre of Excellence
British Heart Foundation (BHF)
2019 - 2024
- Targeting non-communicable diseases through Interactive Health Ecosystems in Indonesia (TANDEM)
British Council
2019 - 2020
- BHF Centre of Excellence
British Heart Foundation
2019 - 2024
- mHealth trial for the management of gestational diabetes & hypertensive disease in pregnancy in India
Medical Research Council
2018 - 2021
- The long term cardiovascular complications associated with hypospadias
Mason Medical Research Foundation
2018 - 2020
- Health Data Research UK: Institute of Health and Biomedical Informatics
Health Data Research UK
2018 - 2023
- Collagen IV variants and their role in intracerebral haemorrhage in the general population
Medical Research Council
2018 - 2021
- Antihypertensives as repurposed treatments for mood disorders: a Scottish national linkage and UK Biobank investigation
Chief Scientist Office
2016 - 2019
- Clinical study of UMOD NKCC2 interaction on salt-sensitivity in hypertension
British Heart Foundation
2016 - 2020
- ISSF Catalyst: Global regulation of gene expression in the Thick Ascending Limb of the Loop of Henle by TNF: implications for salt-uptake and blood pressure regulation
Wellcome Trust
2016 - 2017
- The Scottish Genomes Partnership
Chief Scientist Office
2016 - 2019
- Ancestry and biological informative markers for stratification of hypertension - The AIM HY study
Medical Research Council
2015 - 2020
- Serum Chloride - epidemiology and genetic dissection of a novel marker of cardiovascular risk
British Heart Foundation
2014 - 2018
- Biomarker Discovery 2.0 - Rigorous and Robust Metabolite Characterization using Mass Spectrometry Fragmentation approaches (ISSF Fellowship)
Wellcome Trust
2014 - 2015
- Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
British Heart Foundation
2013 - 2017
- EU-MASCARA - Biomarkers for Cardiovascular Disease
European Commission
2011 - 2015
- InterPregGen
European Commission
2011 - 2016
- A programme for prevention and treatment of resistant hypertension with algorithm based therapy - Pathway Study: British Heart Foundation Award
British Heart Foundation
2010 - 2013
- Genetic dissection of hypertension - SNPs, sequence, Pathways to clinical translation.
British Heart Foundation
2010 - 2011
- Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
British Heart Foundation
2008 - 2011
- Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
British Heart Foundation
2008 - 2011
- High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
British Heart Foundation
2008 - 2009
- Hypertension pharmacogenetics - discovering genetics determinants of blood pressure response
British Heart Foundation
2006 - 2009
Teaching
Prof Sandosh Padmanabhan is the director of the Stratified Medicine and Pharmacological Innovation MSc course.
Research datasets
2020
Padmanabhan, S. , Burgess, K., Van der Hooft, J. J. and Michael, B. (2020) Antihypertensive drug metabolite screening toy dataset for MS/MS application. [Data Collection]
