2024

Rios, F. J. et al. (2024) Mechanisms of vascular inflammation and potential therapeutic targets: a position paper from the ESH Working Group on Small Arteries. Hypertension, 81(6), pp. 1218-1232. (doi: 10.1161/hypertensionaha.123.22483) (PMID:38511317)

Jandeleit-Dahm, K. A. M., Kankanamalage, H. R., Dai, A., Meister, J., Lopez-Trevino, S., Cooper, M. E., Touyz, R. M. , Kennedy, C. R. J. and Jha, J. C. (2024) Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes. Antioxidants, 13(4), 396. (doi: 10.3390/antiox13040396) (PMID:38671844) (PMCID:PMC11047703)

Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, 32. (doi: 10.1038/s43856-024-00455-5) (PMID:38418616) (PMCID:PMC10901805)

Tobias, E. S. et al. (2024) SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine, 84, pp. 345-349. (doi: 10.1007/s12020-024-03701-x) (PMID:38400880)

2023

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7(4), pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2023) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, 601(22), pp. 4923-4936. (doi: 10.1113/JP282054) (PMID:35306667) (PMCID:PMC10953460)

Lucas-Herald, A. K. et al. (2023) Effects of sex hormones on vascular reactivity in boys with hypospadias. Journal of Clinical Endocrinology and Metabolism, (doi: 10.1210/clinem/dgad525) (PMID:37672642) (Early Online Publication)

Schigt, H. et al. (2023) Expanding the phenotypic spectrum of Kenny-Caffey syndrome: a case series and systematic literature review. Journal of Clinical Endocrinology and Metabolism, 108(9), e754-e768. (doi: 10.1210/clinem/dgad147) (PMID:36916904) (PMCID:PMC10438882)

Whelton, P. K., Flack, J. M., Jennings, G. L. R., Schutte, A. E., Wang, J.-G. and Touyz, R. M. (2023) Editors’ commentary on the 2023 ESH management of arterial hypertension guidelines. Hypertension, 80(9), pp. 1795-1799. (doi: 10.1161/HYPERTENSIONAHA.123.21592) (PMID:37354199)

Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)

Morris, H. E., Neves, K. B. , Nilsen, M., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)

Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)

Camargo, L. L. and Touyz, R. M. (2023) Phenotype-specific induced pluripotent stem cell–derived vascular smooth muscle cells to model vascular disease: implications of differentiation protocols. Hypertension, 80(4), pp. 754-756. (doi: 10.1161/HYPERTENSIONAHA.123.20871) (PMID:36921028)

Touyz, R. M. and Harrison, D. G. (2023) Hope for resistant hypertension through BrigHTN and PRECISION. Nature Reviews Nephrology, 19(4), pp. 216-217. (doi: 10.1038/s41581-023-00676-2) (PMID:36658403)

Chapman, N. et al. (2023) Arterial hypertension in women: state of the art and knowledge gaps. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.122.20448) (PMID:36919603) (Early Online Publication)

Cohen, J. B., Brown, N. J., Brown, S.-A., Dent, S., van Dorst, D. C.H., Herrmann, S. M., Lang, N. N. , Oudit, G. Y. and Touyz, R. M. (2023) Cancer therapy–related hypertension: a scientific statement from the American Heart Association. Hypertension, 80(3), e46-e57. (doi: 10.1161/HYP.0000000000000224) (PMID:36621810)

Neves, K. B. , Alves‐Lopes, R. , Montezano, A. C. and Touyz, R. M. (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)

Chen, J. Y., Chew, K. S., Mary, S. , Boder, P., Bagordo, D., Rossi, G. P., Touyz, R. M. , Delles, C. and Rossitto, G. (2023) Skin-specific mechanisms of body fluid regulation in hypertension. Clinical Science, 137(3), pp. 239-250. (doi: 10.1042/CS20220609) (PMID:36648486)

Schutte, A. E. et al. (2023) Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension. Cardiovascular Research, 119(2), pp. 381-409. (doi: 10.1093/cvr/cvac130) (PMID:36219457) (PMCID:PMC9619669)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10(1), e002192. (doi: 10.1136/openhrt-2022-002192) (PMID:36822817) (PMCID:PMC9950584)

2022

Lucas-Herald, A. K. and Touyz, R. M. (2022) Androgen and androgen receptors as determinants of vascular sex differences across the lifespan. Canadian Journal of Cardiology, 38(12), pp. 1854-1864. (doi: 10.1016/j.cjca.2022.09.018) (PMID:36156286)

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

Touyz, R. M. (2022) TRPV4 channel–regulated microdomains define a new paradigm in hypertension. Circulation, 146(7), pp. 565-568. (doi: 10.1161/CIRCULATIONAHA.122.060980) (PMID:35969652)

Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)

Lip, S. , McCallum, L., Delles, C. , McClure, J. D. , Guzik, T., Berry, C. , Touyz, R. and Padmanabhan, S. (2022) Rationale and design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR). Open Heart, 9(1), e002057. (doi: 10.1136/openhrt-2022-002057) (PMID:35750422) (PMCID:PMC9234432)

Chen, J., Chen, X., Dominiczak, A. F. , Carey, R. M., Laffer, C. L., Elijovich, F., Taler, S. J., Dudenbostel, T., Touyz, R. M. and Wang, J.-G. (2022) A rare disease leading to hypertension. Hypertension, 79(6), pp. 1147-1152. (doi: 10.1161/HYPERTENSIONAHA.122.18678) (PMID:35300529)

Jha, J. C. et al. (2022) Independent of renox, NOX5 promotes renal inflammation and fibrosis in diabetes by activating ROS-sensitive pathways. Diabetes, 71(6), pp. 1282-1298. (doi: 10.2337/db21-1079) (PMID:35275988)

Morrow, A. J. et al. (2022) A multisystem, cardio-renal investigation of post-COVID-19 illness. Nature Medicine, 28(6), pp. 1303-1313. (doi: 10.1038/s41591-022-01837-9) (PMID:35606551) (PMCID:PMC9205780)

Lucas-Herald, A. K. et al. (2022) Vascular dysfunction and increased cardiovascular risk in hypospadias. European Heart Journal, 43(19), pp. 1832-1845. (doi: 10.1093/eurheartj/ehac112) (PMID:35567552) (PMCID:PMC9113289)

Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)

Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

Dobbin, S. J.H. , Herrmann, S. M.S., Lang, N. N. , Herrmann, J. and Touyz, R. M. (2022) Hypertension and renal disease before anti-cancer therapies. In: Herrmann, J. (ed.) Cardio-Oncology Practice Manual: A Companion to Braunwald's Heart Disease. Elsevier: Philadelphia, PA, pp. 111-122. ISBN 9780323681353 (doi: 10.1016/B978-0-323-68135-3.00020-9)

Herrmann, S. M.S., Dobbin, S. J.H. , Herrmann, J., Touyz, R. M. and Lang, N. N. (2022) Hypertension and renal disease during anti-cancer therapies. In: Herrmann, J. (ed.) Cardio-Oncology Practice Manual: A Companion to Braunwald's Heart Disease. Elsevier: Philadelphia, PA, pp. 185-199. ISBN 9780323681353 (doi: 10.1016/B978-0-323-68135-3.00029-5)

Lang, N. N. , Dobbin, S. J.H. , Herrmann, S. M.S., Herrmann, J. and Touyz, R. M. (2022) Hypertension and renal failure prevention and management after cancer therapy. In: Herrmann, J. (ed.) Cardio-Oncology Practice Manual: A Companion to Braunwald's Heart Disease. Elsevier: Philadelphia, PA, pp. 286-291. ISBN 9780323681353 (doi: 10.1016/B978-0-323-68135-3.00041-6)

Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36(2), pp. 120-125. (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (PMCID:PMC8850193)

Lopez, A.-G., Dominiczak, A. F. , Touyz, R. , Schlaich, M., de Freminville, J.-B. and Amar, L. (2022) Hypertension with negative metaiodobenzylguanidine scintigraphy. Hypertension, 79(2), pp. 474-478. (doi: 10.1161/HYPERTENSIONAHA.121.18012) (PMID:34879700)

2021

Lang, N. N. and Touyz, R. M. (2021) Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity. Clinical Science, 135(23), pp. 2661-2663. (doi: 10.1042/CS20210986) (PMID:34881389) (PMCID:PMC8672202)

Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)

Berry, C. et al. (2021) Post-COVID-19 illness trajectory: a multisystem investigation [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1053331/v1)

Rush, C. J. et al. (2021) Prevalence of coronary artery disease and coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction. JAMA Cardiology, 6(10), pp. 1130-1143. (doi: 10.1001/jamacardio.2021.1825) (PMID:34160566) (PMCID:PMC8223134)

Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)

Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)

Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)

Rossitto, G. et al. (2021) High sodium intake, glomerular hyperfiltration and protein catabolism in patients with essential hypertension. Cardiovascular Research, 117(5), pp. 1372-1381. (doi: 10.1093/cvr/cvaa205) (PMID:33053160) (PMCID:PMC8064429)

Wolf, F. I. et al. (2021) The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19. Magnesium Research, 34(2), pp. 90-92. (doi: 10.1684/mrh.2021.0479) (PMID:34524085)

Griendling, K. K., Camargo, L. L., Rios, F. , Alves-Lopes, R., Montezano, A. C. and Touyz, R. M. (2021) Oxidative stress and hypertension. Circulation Research, 128(7), pp. 993-1020. (doi: 10.1161/CIRCRESAHA.121.318063) (PMID:33793335)

Touyz, R. M. and Schiffrin, E. L. (2021) A compendium on hypertension: new advances and future impact. Circulation Research, 128(7), pp. 803-807. (doi: 10.1161/CIRCRESAHA.121.319181) (PMID:33793329)

Cameron, A. C., Neves, K. B. , White, J., Touyz, R. M. and Lang, N. N. (2021) Reply: Cisplatin-associated aortic thrombosis: a review of cases reported to the FDA adverse event reporting system. JACC: CardioOncology, 3(1), p. 166. (doi: 10.1016/j.jaccao.2021.01.005)

Neves, K. B. , Morris, H., Alves-Lopes, R., Muir, K. W. , Moreton, F., Delles, C. , Montezano, A. C. and Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)

Wardlaw, J. M. et al. (2021) Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: protocol. European Stroke Journal, 6(1), pp. 89-101. (doi: 10.1177/2396987320953312) (PMID:33817339) (PMCID:PMC7995325)

Connelly, P. J. , Clark, A., Touyz, R. M. and Delles, C. (2021) Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review. Journal of Hypertension, 39(2), pp. 223-230. (doi: 10.1097/HJH.0000000000002632) (PMID:32809982) (PMCID:PMC7810409)

Kuriakose, J., Montezano, A. C. and Touyz, R. M. (2021) ACE-2/Ang (1-7)/Mas axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical Science, 135(2), pp. 387-407. (doi: 10.1042/CS20200480) (PMID:33511992) (PMCID:PMC7846970)

Dobbin, S. J.H. , Petrie, M. C. , Myles, R. C. , Touyz, R. M. and Lang, N. N. (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135(1), pp. 71-100. (doi: 10.1042/CS20200305) (PMID:33404052) (PMCID:PMC7812690)

2020

Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116(14), pp. 2185-2196. (doi: 10.1093/cvr/cvaa209) (PMID:32702087) (PMCID:PMC7454350)

Anagnostopoulou, A., Camargo, L. L. , Rodrigues, D., Montezano, A. C. and Touyz, R. M. (2020) Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells. Scientific Reports, 10, 17818. (doi: 10.1038/s41598-020-73751-4) (PMID:33082354) (PMCID:PMC7575553)

Qin, J.-J. et al. (2020) Redefining cardiac biomarkers in predicting mortality and adverse outcomes of inpatients with COVID-19. Hypertension, 76(4), pp. 1104-1112. (doi: 10.1161/HYPERTENSIONAHA.120.15528) (PMID:32673499) (PMCID:PMC7375179)

Ford, T. J. et al. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41(34), pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915) (PMID:31972008) (PMCID:PMC7557475)

Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)

Haas, A. V. et al. (2020) The interplay between statins, caveolin-1, and aldosterone. Hypertension, 76(3), pp. 962-967. (doi: 10.1161/HYPERTENSIONAHA.120.14777) (PMID:32755411) (PMCID:PMC7418929)

Zhao, G.-J. et al. (2020) Ca2+-dependent NOX5 (NADPH oxidase 5) exaggerates cardiac hypertrophy through reactive oxygen species production. Hypertension, 76(3), pp. 827-838. (doi: 10.1161/HYPERTENSIONAHA.120.15558)

Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)

Guzik, T. J. et al. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116(10), pp. 1666-1687. (doi: 10.1093/cvr/cvaa106) (PMID:32352535) (PMCID:PMC7197627)

Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)

McFall, A. et al. (2020) UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), pp. 1402-1414. (doi: 10.1177/0271678X20910552) (PMID:32151228) (PMCID:PMC7307003)

Dobbin, S. J.H. et al. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, 22(7), pp. 1276-1277. (doi: 10.1002/ejhf.1847) (PMID:32379945)

Bernal, J., Valdés-Hernández, M., Escudero, J., Sakka, E., Armitage, P. A., Makin, S., Touyz, R. M. and Wardlaw, J. M. (2020) Examining the relationship between semiquantitative methods analysing concentration-time and enhancement-time curves from dynamic-contrast enhanced magnetic resonance imaging and cerebrovascular dysfunction in small vessel disease. Journal of Imaging, 6(6), 43. (doi: 10.3390/jimaging6060043)

Zhang, P. et al. (2020) Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circulation Research, 126(12), pp. 1671-1681. (doi: 10.1161/circresaha.120.317134) (PMID:32302265) (PMCID:PMC7265882)

Touyz, R. M. , Feldman, R. D., Harrison, D. G. and Schiffrin, E. L. (2020) A new look at the mosaic theory of hypertension. Canadian Journal of Cardiology, 36(5), pp. 591-592. (doi: 10.1016/j.cjca.2020.03.025) (PMID:32389334)

Cosentino, F. et al. (2020) Guía ESC 2019 sobre diabetes, prediabetes y enfermedad cardiovascular, en colaboración con la European Association for the Study of Diabetes (EASD) [2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD]. Revista Española de Cardiología, 73(5), 404.e1-404.e59. (doi: 10.1016/j.recesp.2019.11.024)

Doehner, W. et al. (2020) Cardiovascular care of patients with stroke and high risk of stroke: the need for interdisciplinary action: a consensus report from the European Society of Cardiology Cardiovascular Round Table. European Journal of Preventive Cardiology, 27(7), pp. 682-692. (doi: 10.1177/2047487319873460) (PMID:31569966) (PMCID:PMC7227126)

Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)

Bautista-Niño, P. K. et al. (2020) Local endothelial DNA repair defect causes aging-resembling endothelial-specific dysfunction. Clinical Science, 134(7), pp. 727-746. (doi: 10.1042/cs20190124) (PMID:32202295)

Deliyanti, D., Alrashdi, S. F., Touyz, R. , Kennedy, C. R., Jha, J. C., Cooper, M. E., Jandeleit-Dahm, K. A. and Wilkinson-Berka, J. L. (2020) Nox (NADPH Oxidase) 1, Nox4, and Nox5 promote vascular permeability and neovascularization in retinopathy. Hypertension, 75(4), pp. 1091-1101. (doi: 10.1161/hypertensionaha.119.14100) (PMID:32114846)

Delles, C. , Li, H. and Touyz, R. M. (2020) ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19. Clinical Science, 134(7), pp. 747-750. (doi: 10.1042/CS20200363)

Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2020) Lessons learned from RAG-1-deficient mice in hypertension. Hypertension, 75(4), pp. 935-937. (doi: 10.1161/hypertensionaha.119.14406) (PMID:32078397)

Rodríguez, J. E. et al. (2020) The α1D-adrenoreceptor antagonist BMY 7378 reverses cardiac hypertrophy in spontaneously hypertensive rats. Journal of Hypertension, 38(8), pp. 1496-1503. (doi: 10.1097/HJH.0000000000002412) (PMID:32195823)

Rios, F. J. et al. (2020) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, 116(3), pp. 721-735. (doi: 10.1093/cvr/cvz164) (PMID:31250885) (PMCID:PMC7252442)

Bernal, J., Valdes-Hernandez, M. d. C., Escudero, J., Viksne, L., Heye, A. K., Armitage, P. A., Makin, S., Touyz, R. and Wardlaw, J. M. (2020) Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease. Magnetic Resonance Imaging, 66, pp. 240-247. (doi: 10.1016/j.mri.2019.11.001) (PMID:31730881) (PMCID:PMC7049910)

Cameron, A. C., Welsh, P. , Neves, K. B. , Newby, D., Touyz, R. M. and Lang, N. (2020) Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension, 38(2), pp. 257-265. (doi: 10.1097/HJH.0000000000002230) (PMID:31449168) (PMCID:PMC7197298)

Ford, T. J. et al. (2020) 1-year outcomes of angina management guided by invasive coronary function testing (CorMicA). JACC: Cardiovascular Interventions, 13(1), pp. 33-45. (doi: 10.1016/j.jcin.2019.11.001) (PMID:31709984)

Wheeler, D. C. et al. (2020) 2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. European Heart Journal, 41(2), pp. 255-323. (doi: 10.1093/eurheartj/ehz486) (PMID:31497854)

Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)

Llorens-Cortes, C. and Touyz, R. M. (2020) Evolution of a new class of antihypertensive drugs. Hypertension, 75(1), pp. 6-15. (doi: 10.1161/hypertensionaha.119.12675) (PMID:31786978)

2019

Morris, H., Neves, K. B. , Montezano, A. C., Maclean, M. R. and Touyz, R. (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)

Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)

Cameron, A. C. et al. (2019) Progressive hypertension and severe left ventricular outflow tract obstruction. Hypertension, 74(6), pp. 1216-1225. (doi: 10.1161/hypertensionaha.119.13343) (PMID:31587571)

Connelly, P. J. , Freel, E. M., Perry, C., Ewan, J., Touyz, R. M. , Currie, G. and Delles, C. (2019) Gender-affirming hormone therapy, vascular health and cardiovascular disease in transgender adults. Hypertension, 74(6), pp. 1266-1274. (doi: 10.1161/HYPERTENSIONAHA.119.13080) (PMID:31656099) (PMCID:PMC6887638)

Ford, T. J. et al. (2019) Ischemia and no obstructive coronary artery disease: prevalence and correlates of coronary vasomotion disorders. Circulation: Cardiovascular Interventions, 12(12), e008126. (doi: 10.1161/CIRCINTERVENTIONS.119.008126) (PMID:31833416) (PMCID:PMC6924940)

Kelleher, J. et al. (2019) Patient-specific iPSC model of a genetic vascular dementia syndrome reveals failure of mural cells to stabilize capillary structures. Stem Cell Reports, 13(5), pp. 817-831. (doi: 10.1016/j.stemcr.2019.10.004) (PMID:31680059) (PMCID:PMC6893064)

Mach, F. et al. (2019) 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Atherosclerosis, 290, pp. 140-205. (doi: 10.1016/j.atherosclerosis.2019.08.014) (PMID:31591002)

Arendse, L. B., Danser, A. H. J., Poglitsch, M., Touyz, R. M. , Burnett Jr, J. C., Llorens-Cortes, C., Ehlers, M. R. and Sturrock, E. D. (2019) Novel therapeutic approaches targeting the renin angiotensin system and associated peptides in hypertension and heart failure. Pharmacological Reviews, 71(4), pp. 539-570. (doi: 10.1124/pr.118.017129) (PMID:31537750) (PMCID:PMC6782023)

Sagan, A. et al. (2019) T cells are dominant population in human abdominal aortic aneurysms and their infiltration in the perivascular tissue correlates with disease severity. Frontiers in Immunology, 10, 1979. (doi: 10.3389/fimmu.2019.01979) (PMID:31552015) (PMCID:PMC6736986)

Cacciottolo, T. M. et al. (2019) Scientific business abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland. QJM: An International Journal of Medicine, 112(9), pp. 724-729. (doi: 10.1093/qjmed/hcz175) (PMID:31505685)

Jha, J. C., Dai, A., Holterman, C. E., Cooper, M. E., Touyz, R. M. , Kennedy, C. R. and Jandeleit-Dahm, K. (2019) Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse. Diabetologia, 62(9), pp. 1712-1726. (doi: 10.1007/s00125-019-4924-z) (PMID:31222503)

Touyz, R. M. and Lang, N. N. (2019) Hypertension and antiangiogenesis: the Janus face of VEGF inhibitors. JACC: CardioOncology, 1(1), pp. 37-40. (doi: 10.1016/j.jaccao.2019.08.010)

Neves, K. B. and Touyz, R. M. (2019) Extracellular vesicles as biomarkers and biovectors in primary aldosteronism. Hypertension, 74(2), pp. 250-252. (doi: 10.1161/hypertensionaha.119.13088) (PMID:31230536)

Beaney, T. et al. (2019) May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension. European Heart Journal, 40(25), pp. 2006-2017. (doi: 10.1093/eurheartj/ehz300) (PMID:31041440) (PMCID:PMC6600128)

Lerman, L. O. et al. (2019) Animal models of hypertension: a scientific statement from the American Heart Association. Hypertension, 73(6), e87-e120. (doi: 10.1161/HYP.0000000000000090) (PMID:30866654) (PMCID:PMC6740245)

Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and De Lucca Camargo, L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi: 10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)

Alves-Lopes, R., Neves, K. B. and Touyz, R. M. (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi: 10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)

Touyz, R. M. (2019) Hypertension guidelines: effect of blood pressure targets. Canadian Journal of Cardiology, 35(5), pp. 564-569. (doi: 10.1016/j.cjca.2019.03.014) (PMID:31030859)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Zou, Z.-G., Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2019) TRPM7, magnesium and signaling. International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., Belin de Chantemele, E. J., Tostes, R. C. and Touyz, R. M. (2019) Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress. Life Sciences, 221, pp. 29-34. (doi: 10.1016/j.lfs.2019.01.043) (PMID:30721707) (PMCID:PMC6686670)

Touyz, R. M. and De Lucca Camargo, L. (2019) Microglia, the missing link in the brain-gut-hypertension axis. Circulation Research, 124(5), pp. 671-673. (doi: 10.1161/CIRCRESAHA.119.314718) (PMID:30817265)

Touyz, R. M. , Anagnostopoulou, A., De Lucca Camargo, L. , Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi: 10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)

Berry, C. , Sidik, N., Pereira, A. C., Ford, T. J. , Touyz, R. M. , Kaski, J.-C. and Hainsworth, A. H. (2019) Small-vessel disease in the heart and brain: current knowledge, unmet therapeutic need, and future directions. Journal of the American Heart Association, 8(3), e011104. (doi: 10.1161/JAHA.118.011104) (PMID:30712442) (PMCID:PMC6405580)

Kerr, D. M.I., Brooksbank, K. J.M., Taylor, R. G., Pinel, K., Rios, F. J. , Touyz, R. M. and Delles, C. (2019) Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study. Journal of Hypertension, 37(1), pp. 154-166. (doi: 10.1097/HJH.0000000000001890) (PMID:30063637)

Touyz, R. M. and Delles, C. (Eds.) (2019) Textbook of Vascular Medicine. Springer: Cham. ISBN 9783030164805

Alves-Lopes, R. , Touyz, R. M. and Montezano, A. C. (2019) Cell biology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 23-30. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_3)

Cameron, A.C., Dominiczak, A.F. and Touyz, R.M. (2019) Hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer Nature Switzerland: Cham, Switzerland, pp. 331-341. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_31)

Cameron, A. C., Rossitto, G., Lang, N. N. and Touyz, R. M. (2019) Antihypertensive drugs and vascular health. In: Zimlichman, R., Julius, S. and Mancia, G. (eds.) Prehypertension and Cardiometabolic Syndrome. Series: Updates in hypertension and cardiovascular protection. Springer, pp. 585-605. ISBN 9783319753096 (doi: 10.1007/978-3-319-75310-2_37)

Cameron, A. C., Touyz, R. M. and Lang, N. N. (2019) Vascular biology of cancer chemotherapeutic drugs. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 259-268. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_24)

de Lucca Camargo, L. and Touyz, R. M. (2019) Reactive oxygen species. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 127-136. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_12)

Kennedy, S. and Touyz, R. M. (2019) Anatomy and pharmacology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 3-11. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_1)

Neves, K. B. and Touyz, R. M. (2019) Vascular signaling. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 83-91. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_8)

Rios, F. J. , Touyz, R. M. , Montezano, A. C. and Burger, D. (2019) Microparticles and exosomes in cell-cell communication. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 159-168. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_15)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2019) Aldosterone and ion channels. In: Litwack, G. (ed.) Aldosterone. Series: Vitamins and hormones. Elsevier, pp. 105-131. ISBN 9780128177822 (doi: 10.1016/bs.vh.2018.10.004)

2018

Ford, T. J. et al. (2018) Stratified medical therapy using invasive coronary function testing in angina: CorMicA trial. Journal of the American College of Cardiology, 72(23 PtA), pp. 2841-2855. (doi: 10.1016/j.jacc.2018.09.006) (PMID:30266608)

Ford, T. J. et al. (2018) Systemic microvascular dysfunction in microvascular and vasospastic angina. European Heart Journal, 39(46), pp. 4086-4097. (doi: 10.1093/eurheartj/ehy529) (PMID:30165438) (PMCID:PMC6284165)

Dobbin, S. J.H. , Cameron, A. C., Petrie, M. C. , Jones, R. J. , Touyz, R. M. and Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104(24), pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726) (PMID:30228246) (PMCID:PMC6268130)

Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)

Rossitto, G., Touyz, R. M. , Petrie, M. C. and Delles, C. (2018) Much Ado about N...atrium: modelling tissuesodium as a highly sensitive marker of subclinicaland localized oedema. Clinical Science, 132(24), pp. 2609-2613. (doi: 10.1042/CS20180575) (PMID:30545897) (PMCID:PMC6365627)

Alves-Lopes, R. and Touyz, R. M. (2018) PARP-1 (poly[ADP-ribose] polymerase-1): a novel target in aortic aneurysm. Hypertension, 72(5), pp. 1087-1089. (doi: 10.1161/HYPERTENSIONAHA.118.11830) (PMID:30354832) (PMCID:PMC6218001)

Bader, M., Alenina, N., Young, D., Santos, R. A.S. and Touyz, R. M. (2018) The meaning of mas. Hypertension, 72(5), pp. 1072-1075. (doi: 10.1161/hypertensionaha.118.10918) (PMID:30354821) (PMCID:PMC6217935)

Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Poulter, N. R., Castillo, R., Charchar, F. J., Schlaich, M. P., Schutte, A. E., Tomaszewski, M., Touyz, R. M. and Wang, J.-G. (2018) Are the American Heart Association/American College of Cardiology high blood pressure guidelines fit for global purpose?: Thoughts from the International Society of Hypertension. Hypertension, 72(2), pp. 260-262. (doi: 10.1161/HYPERTENSIONAHA.118.11452) (PMID:29967044)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Ford, T. J. et al. (2018) Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial. American Heart Journal, 201, pp. 86-94. (doi: 10.1016/j.ahj.2018.03.010) (PMID:29803987) (PMCID:PMC6018570)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Bursztyn, M., Touyz, R. M. , Laffer, C. L., Carey, R. M. and Dominiczak, A. F. (2018) Case of severe hypertension and nephrotic range proteinuria. Hypertension, 71(6), pp. 956-961. (doi: 10.1161/HYPERTENSIONAHA.118.11045) (PMID:29610267)

Corcoran, D. et al. (2018) Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study. Open Heart, 5(2), e000924. (doi: 10.1136/openhrt-2018-000924) (PMID:30687508) (PMCID:PMC6326326)

Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Touyz, R. M. , Herrmann, S. M.S. and Herrmann, J. (2018) Vascular toxicities with VEGF inhibitor therapies-focus on hypertension and arterial thrombotic events. Journal of the American Society of Hypertension, 12(6), pp. 409-425. (doi: 10.1016/j.jash.2018.03.008) (PMID:29703600) (PMCID:PMC6168784)

Touyz, R. M. and Herrmann, J. (2018) Cardiotoxicity with vascular endothelial growth factor inhibitor therapy. npj Precision Oncology, 2(1), 13. (doi: 10.1038/s41698-018-0056-z)

Rossitto, G. and Touyz, R. (2018) Dr Giacomo Rossitto interviews Professor Rhian Touyz, on the translational applications of vascular smooth muscle cell biology in cardiovascular disease. [Audio]

George, M. J. et al. (2018) Resistant hypertension: trials and tribulations. Hypertension, 71(5), pp. 772-780. (doi: 10.1161/HYPERTENSIONAHA.118.10864) (PMID:29610269)

Petrie, J. R. , Guzik, T. J. and Touyz, R. M. (2018) Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Canadian Journal of Cardiology, 34(5), pp. 575-584. (doi: 10.1016/j.cjca.2017.12.005) (PMID:29459239) (PMCID:PMC5953551)

Berra, E. et al. (2018) Management of a pregnant woman with fibromuscular dysplasia. Hypertension, 71(4), pp. 540-547. (doi: 10.1161/HYPERTENSIONAHA.118.10819) (PMID:29483231)

Egea, J. et al. (2018) Corrigendum to “European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162]. Redox Biology, 14, pp. 694-696. (doi: 10.1016/j.redox.2017.10.001) (PMID:29107648)

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi: 10.1042/CS20171620) (PMID:29712883)

Liu, P., Zhang, S., Gao, J., Lin, Y., Shi, G., He, W., Touyz, R. M. , Yan, L. and Huang, H. (2018) Downregulated serum 14, 15-epoxyeicosatrienoic acid is associated with abdominal aortic calcification in patients with primary aldosteronism. Hypertension, 71(4), pp. 592-598. (doi: 10.1161/HYPERTENSIONAHA.117.10644) (PMID:29440332)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , De Lucca Camargo, L. , Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi: 10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)

Jae, S. Y., Bunsawat, K., Choi, Y.-H., Kim, Y. S., Touyz, R. M. , Park, J. B. and Franklin, B. A. (2018) Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension. Journal of Clinical Hypertension, 20(3), pp. 551-556. (doi: 10.1111/jch.13219) (PMID:29457335)

Nguyen Dinh Cat, A. et al. (2018) Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling. Scientific Reports, 8, 2952. (doi: 10.1038/s41598-018-21087-5) (PMID:29440699) (PMCID:PMC5811612)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi: 10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2018) Aldosterone, SGK1, and ion channels in the kidney. Clinical Science, 132(2), pp. 173-183. (doi: 10.1042/CS20171525) (PMID:29352074) (PMCID:PMC5817097)

Touyz, R. M. and Montezano, A. C. (2018) Angiotensin-(1–7) and vascular function: the clinical context. Hypertension, 71(1), pp. 68-69. (doi: 10.1161/HYPERTENSIONAHA.117.10406) (PMID:29203630)

2017

Silva, S. D., Jara, Z. P., Peres, R., Lima, L. S., Scavone, C., Montezano, A. C., Touyz, R. M. , Casarini, D. E. and Michelini, L. C. (2017) Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction. PLoS ONE, 12(12), e0189535. (doi: 10.1371/journal.pone.0189535) (PMID:29232407) (PMCID:PMC5726656)

Savoia, C. and Touyz, R. (2017) Hypertension, diabetes mellitus, and excess cardiovascular risk importance of baseline systolic blood pressure. Hypertension, 70(5), pp. 882-883. (doi: 10.1161/HYPERTENSIONAHA.117.09764) (PMID:28847887)

Savoia, C., Volpe, M., Grassi, G., Borghi, C., Rosei, E. A. and Touyz, R. M. (2017) Personalized medicine—a modern approach for the diagnosis and management of hypertension. Clinical Science, 131(22), pp. 2671-2685. (doi: 10.1042/CS20160407) (PMID:29109301) (PMCID:PMC5736921)

Skiba, D.S. et al. (2017) Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. British Journal of Pharmacology, 174(22), pp. 4055-4069. (doi: 10.1111/bph.13685) (PMID:27935022) (PMCID:PMC5659999)

Kolisek, M., Touyz, R. M. , Romani, A. and Barbagallo, M. (2017) Magnesium and other biometals in oxidative medicine and redox biology. Oxidative Medicine and Cellular Longevity, 2017, 7428796. (doi: 10.1155/2017/7428796) (PMID:29109833)

Egea, J. et al. (2017) European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology, 13, pp. 94-162. (doi: 10.1016/j.redox.2017.05.007) (PMID:28577489)

Guzik, T. J. and Touyz, R. M. (2017) Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension, 70(4), pp. 660-667. (doi: 10.1161/HYPERTENSIONAHA.117.07802) (PMID:28784646)

Jha, J.C. et al. (2017) NADPH oxidase-Nox5 accelerates renal injury in a mouse model of diabetic nephropathy. Journal of the American Society of Nephrology, 66(10), pp. 2691-2703. (doi: 10.2337/db16-1585) (PMID:28747378)

Zhang, K., Zhang, Y., Feng, W., Chen, R., Chen, J., Touyz, R. M. , Wang, J. and Huang, H. (2017) Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), pp. 1933-1943. (doi: 10.1161/ATVBAHA.117.309161) (PMID:28860220)

Martínez-Revelles, S. et al. (2017) Lysyl oxidase induces vascular oxidative stress and contributes to arterial stiffness and abnormal elastin structure in hypertension: role of p38MAPK. Antioxidants and Redox Signaling, 27(7), pp. 379-397. (doi: 10.1089/ars.2016.6642) (PMID:28010122)

Touyz, R. M. , Lang, N. N. , Herrmann, J., van den Meiracker, A. H. and Danser, A.H. J. (2017) Recent advances in hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition. Hypertension, 70(2), pp. 220-226. (doi: 10.1161/HYPERTENSIONAHA.117.08856) (PMID:28630211) (PMCID:PMC5509510)

Valinsky, W. C., Touyz, R. M. and Shrier, A. (2017) Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells. Biochimica et Biophysica Acta: General Subjects, 1861(8), pp. 2007-2019. (doi: 10.1016/j.bbagen.2017.05.004) (PMID:28483640) (PMCID:PMC5482324)

Guzik, T. J., Skiba, D. S., Touyz, R. M. and Harrison, D. G. (2017) The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovascular Research, 113(9), pp. 1009-1023. (doi: 10.1093/cvr/cvx108) (PMID:28838042) (PMCID:PMC5852626)

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. and MacLean, M. R. (2017) Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(7), pp. 1361-1370. (doi: 10.1161/ATVBAHA.116.308929) (PMID:28473438) (PMCID:PMC5478178)

Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi: 10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Calvet, D., Amar, L., Rossi, G. P., Laurent, S., Dominiczak, A. F. , Turc, G., Jennings, G., Guzik, T. and Touyz, R. M. (2017) Case of asymptomatic carotid artery stenosis in a hypertensive patient. Hypertension, 69(6), pp. 985-991. (doi: 10.1161/HYPERTENSIONAHA.117.09330) (PMID:28461597)

Lee, C. J., Kim, B.-K., Yoon, K. B., Lee, H.-Y., Dominiczak, A. F. , Touyz, R. M. , Jennings, G. L.R., Cho, E. J., Hering, D. and Park, S. (2017) Case of refractory hypertension controlled by repeated renal denervation and celiac plexus block: a case of refractory sympathetic overload. Hypertension, 69(6), pp. 978-984. (doi: 10.1161/HYPERTENSIONAHA.117.09260) (PMID:28416585)

Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)

Gray, S. P., Jha, J. C., Kennedy, K., Van Bommel, E., Chew, P., Szyndralewiez, C., Touyz, R. M. , Schmidt, H. H.H.W., Cooper, M. E. and Jandeleit-Dahm, K. A.M. (2017) Combined Nox1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia, 60(5), pp. 927-937. (doi: 10.1007/s00125-017-4215-5) (PMID:28160092)

Touyz, R. M. (2017) Clinical Science-linking basic science to disease mechanisms. Clinical Science, 131(7), pp. 511-513. (doi: 10.1042/CS20170139) (PMID:28302913)

Amar, L. et al. (2017) Case of primary aldosteronism with discordant hormonal and computed tomographic findings. Hypertension, 69(4), pp. 529-535. (doi: 10.1161/HYPERTENSIONAHA.116.08751) (PMID:28193708)

Friederich-Persson, M., Nguyen Dinh Cat, A., Persson, P., Montezano, A. C. and Touyz, R. M. (2017) Brown adipose tissue regulates small artery function through NADPH oxidase 4-derived hydrogen peroxide and redox-sensitive protein kinase G-1α. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(3), pp. 455-465. (doi: 10.1161/atvbaha.116.308659) (PMID:28062507)

Callera, G.E., Bruder-Nascimento, T. and Touyz, R.M. (2017) Assessment of caveolae/lipid rafts in isolated cells. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 251-269. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_20)

Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of human macrophages. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 311-320. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_24)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Cunha, A. R., D'El-Rei, J., Medeiros, F., Umbelino, B., Oigman, W., Touyz, R. M. and Neves, M. F. (2017) Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. Journal of Hypertension, 35(1), pp. 89-97. (doi: 10.1097/HJH.0000000000001129) (PMID:27759579)

Touyz, R. M. and Schiffrin, E. L. (Eds.) (2017) Hypertension: Methods and Protocols. Series: Methods in molecular biology. Humana Press: New York. ISBN 9781493966233

Cameron, A. C., Lang, N. N. and Touyz, R. M. (2017) Cardiovascular complications from cancer therapy: hypertension-focus on vascular endothelial growth factor inhibitors. In: Herrmann, J. (ed.) Clinical Cardio-oncology. Elesvier: Amsterdam, pp. 185-211. ISBN 9780323442275 (doi: 10.1016/B978-0-323-44227-5.00010-7)

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)

Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of murine macrophages. In: Touyz, R. M. and Shiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology. Humana Press, pp. 297-309. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_23)

Tsiropoulou, S. and Touyz, R. M. (2017) Assessment of protein carbonylation and protein tyrosine phosphatase (PTP) oxidation in vascular smooth muscle cells (VSMCs) using immunoblotting approaches. In: Thatcher, S. E. (ed.) The Renin-Angiotensin-Aldosterone System: Methods and Protocols. Series: Methods in molecular biology (1614). Springer, pp. 31-46. ISBN 9781493970285 (doi: 10.1007/978-1-4939-7030-8_3)

2016

Fattah, C. et al. (2016) Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction. Journal of the American College of Cardiology, 68(24), pp. 2652-2666. (doi: 10.1016/j.jacc.2016.09.946) (PMID:27978950) (PMCID:PMC5158000)

Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Yogi, A., Savoia, C. and Touyz, R. M. (2016) c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension. Hypertension, 68(5), pp. 1179-1190. (doi: 10.1161/HYPERTENSIONAHA.116.07699) (PMID:27620391)

Campbell, N. R.C. et al. (2016) 2016 dietary salt fact sheet and call to action: the World Hypertension League, International Society of Hypertension, and the International Council of Cardiovascular Prevention and Rehabilitation. Journal of Clinical Hypertension, 18(11), pp. 1082-1085. (doi: 10.1111/jch.12894) (PMID:27515460)

Simplicio, J. A., Hipólito, U. V., Tavares do Vale, G., Callera, G. E., Pereira, C. A., Touyz, R. M. , de Cássia Tostes, R. and Tirapelli, C. R. (2016) Acute ethanol intake induces NAD(P)H oxidase activation and RhoA translocation in resistance arteries. Arquivos Brasileiros de Cardiologia, 107(5), pp. 427-436. (doi: 10.5935/abc.20160147) (PMID:27812679) (PMCID:PMC5137387)

Callera, G. et al. (2016) Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas. Bioscience Reports, 36(5), e00398. (doi: 10.1042/BSR20160344) (PMID:27612496) (PMCID:PMC5091470)

Boal, A. H., Smith, D. J. , Mccallum, L., Muir, S., Touyz, R. M. , Dominiczak, A. F. and Padmanabhan, S. (2016) Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders. Hypertension, 68(5), pp. 1132-1138. (doi: 10.1161/HYPERTENSIONAHA.116.08188) (PMID:27733585) (PMCID:PMC5058642)

Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

Cameron, A. C., Lang, N. N. and Touyz, R. M. (2016) Drug treatment of hypertension: focus on vascular health. Drugs, 76(16), pp. 1529-1550. (doi: 10.1007/s40265-016-0642-8) (PMID:27667708)

Onwubere, B. et al. (2016) Report of the International Society of Hypertension (ISH) Hypertension Teaching Seminar organized by the ISH Africa Regional Advisory Group: Maputo, Mozambique, 2016. Journal of Hypertension, 34(10), pp. 2105-2107. (doi: 10.1097/hjh.0000000000001062) (PMID:27467769)

Touyz, R. , Anagnostopoulou, A., De Lucca Camargo, L. and Montezano, A. (2016) Novel biosensors reveal a shift in the redox paradigm from oxidative to reductive stress in heart disease. Circulation Research, 119(9), pp. 969-971. (doi: 10.1161/circresaha.116.309854) (PMID:27737937)

Bruder-Nascimento, T. et al. (2016) Renoprotective effects of atorvastatin in diabetic mice: downregulation of RhoA and upregulation of Akt/GSK3. PLoS ONE, 11(9), e0162731. (doi: 10.1371/journal.pone.0162731) (PMID:27649495) (PMCID:PMC5029810)

Valinsky, W. C., Jolly, A., Miquel, P., Touyz, R. M. and Shrier, A. (2016) Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7). Journal of Biological Chemistry, 291(38), pp. 20163-20172. (doi: 10.1074/jbc.M116.735175) (PMID:27466368) (PMCID:PMC5025699)

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. and Touyz, R. M. (2016) Nicotinamide adenine dinucleotide phosphate oxidase–mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells. Hypertension, 68(3), pp. 796-808. (doi: 10.1161/HYPERTENSIONAHA.116.07668) (PMID:27402919) (PMCID:PMC4978604)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)

Tsiropoulou, S., Montezano, A., Scott, A., Burchmore, R.J. and Touyz, R.M. (2016) PS 07-14 vascular protein oxidation and redox proteomics in hypertension. Journal of Hypertension, 34, e287. (doi: 10.1097/01.hjh.0000500678.85921.bc)

Griendling, K. K., Touyz, R. M. , Zweier, J. L., Dikalov, S., Chilian, W., Yeong-Renn, C., Harrison, D. G. and Bhatnagar, A. (2016) Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American heart association. Circulation Research, 119(5), e39-e75. (doi: 10.1161/RES.0000000000000110) (PMID:27418630) (PMCID:PMC5446086)

Weber, M. A., Poulter, N. R., Schutte, A. E., Burrell, L. M., Horiuchi, M., Prabhakaran, D., Ramirez, A. J., Wang, J.-G., Schiffrin, E. L. and Touyz, R. (2016) Is it time to reappraise blood pressure thresholds and targets? Statement from the international society of hypertension - a global perspective. Hypertension, 68(2), pp. 266-268. (doi: 10.1161/HYPERTENSIONAHA.116.07818) (PMID:27354426)

Campbell, N. R. et al. (2016) High blood pressure 2016: why prevention and control are urgent and important. The World Hypertension League, International Society of Hypertension, World Stroke Organization, International Diabetes Foundation, International Council of Cardiovascular Prevention and Rehabilitation, International Society of Nephrology. Journal of Clinical Hypertension, 18(8), pp. 714-717. (doi: 10.1111/jch.12840) (PMID:27316336)

Nguyen Dinh Cat, A. et al. (2016) Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction: role of redox-sensitive PKG-1 and Rho kinase. Diabetes, 65(8), pp. 2392-2403. (doi: 10.2337/db15-1627) (PMID:27207514)

Touyz, R. (2016) Lower is better in hypertension, but how low should blood pressure be targeted? Journal of the American Society of Hypertension, 10(8), pp. 621-622. (doi: 10.1016/j.jash.2016.06.028) (PMID:27436128) (PMCID:PMC4990139)

Nguyen Dinh Cat, A., Friederich-Persson, M., White, A. and Touyz, R. M. (2016) Adipocytes, aldosterone and obesity-related hypertension. Molecular Endocrinology, 57(1), F7-F21. (doi: 10.1530/JME-16-0025) (PMID:27357931)

Campbell, N. R.C. et al. (2016) A call to regulate manufacture and marketing of blood pressure devices and cuffs: a position statement from the World Hypertension League, International Society of Hypertension and Supporting Hypertension Organizations. Journal of Clinical Hypertension, 18(5), pp. 378-380. (doi: 10.1111/jch.12782) (PMID:26852890)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi: 10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., De Lucca Camargo, L. , Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi: 10.1124/jpet.115.230748) (PMID:26941168)

Touyz, R. M. and Dominiczak, A. F. (2016) Hypertension guidelines: is it time to reappraise blood pressure thresholds and targets? Hypertension, 67(4), pp. 688-689. (doi: 10.1161/hypertensionaha.116.07090) (PMID:26962205)

Johansen, A. K. Z., Dean, A., Morecroft, I., Hood, K., Nilsen, M., Loughlin, L., Anagnostopoulou, A., Touyz, R. M. , White, K. and MacLean, M. R. (2016) The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation. Pulmonary Circulation, 6(1), pp. 82-92. (doi: 10.1086/685023) (PMID:27162617) (PMCID:PMC4860551)

MacIsaac, R., Janek, S., Higgins, P., Walters, M. R. , Padmanabhan, S. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2016) Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension, 67(3), pp. 535-540. (doi: 10.1161/HYPERTENSIONAHA.115.06344) (PMID:26865199)

Antunes, T. T., Callera, G. E., He, Y., Yogi, A., Ryazanov, A. G., Ryazanov, L. V., Zhai, A., Stewart, D. J., Shrier, A. and Touyz, R. (2016) Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension. Hypertension, 67, pp. 763-773. (doi: 10.1161/HYPERTENSIONAHA.115.07021) (PMID:26928801) (PMCID:PMC4786473)

Padmanabhan, S. and Touyz, R. M. (2016) Precision medicine in hypertension. Biochemist, 38(1), pp. 35-38. (doi: 10.1042/BIO03801035)

Currie, G. , Delles, C. , Touyz, R. M. , Staessen, J. A., Dominiczak, A. F. , Jennings, G. L. R. and Wang, J.-G. (2016) A woman with treatment-resistant hypertension. Hypertension, 67(2), pp. 243-250. (doi: 10.1161/HYPERTENSIONAHA.115.06756) (PMID:26711735)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi: 10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Touyz, R. M. and Dominiczak, A. F. (2016) Successes of SPRINT, but still some hurdles to cross. Hypertension, 67, pp. 268-269. (doi: 10.1161/HYPERTENSIONAHA.115.06725) (PMID:26556815)

Touyz, R. (2016) Protecting the heart in obesity: role of ACE2 and Its partners. Diabetes, 65(1), pp. 19-21. (doi: 10.2337/dbi15-0014) (PMID:26696636)

Aguado, A. et al. (2016) Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Journal of Hypertension, 34(2), pp. 253-265. (doi: 10.1097/hjh.0000000000000801) (PMID:26682942)

Burger, D., Turner, M., Munkonda, M. N. and Touyz, R. M. (2016) Endothelial microparticle-derived reactive oxygen species: role in endothelial signaling and vascular function. Oxidative Medicine and Cellular Longevity, 2016, 5047954. (doi: 10.1155/2016/5047954) (PMID:27313830) (PMCID:PMC4893592)

Gray, S. P. et al. (2016) Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodelling significance. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(2), pp. 295-307. (doi: 10.1161/atvbaha.115.307012) (PMID:26715682)

Rios, F. J. , Montezano, A. C., Antunes, T. T. and Touyz, R. M. (2016) Magnesium, vascular function, and hypertension. In: Collins, J. F. (ed.) Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Academic Press, pp. 353-364. ISBN 9780128021682 (doi: 10.1016/B978-0-12-802168-2.00029-4)

Tsiropoulou, S., Dulak-Lis, M., Montezano, A. C. and Touyz, R. M. (2016) Biomarkers of oxidative stress in human hypertension. In: Andreadis, E. A. (ed.) Hypertension and Cardiovascular Disease. Springer, pp. 151-170. ISBN 9783319395975 (doi: 10.1007/978-3-319-39599-9_11)

2015

Cameron, A. C., Touyz, R. M. and Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32(7), pp. 852-862. (doi: 10.1016/j.cjca.2015.12.023) (PMID:26968393) (PMCID:PMC4989034)

Kolisek, M., Montezano, A., Sponder, G., Anagnostopoulou, A., Vormann, J., Touyz, R. M. and Aschenbach, J. R. (2015) PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases. Clinical Science, 129(12), pp. 1143-1150. (doi: 10.1042/cs20150355) (PMID:26453619)

Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)

Pagano, P. J., Griendling, K. K., Miller, F. J., Laurindo, F. R.M. and Touyz, R. (2015) Chemiluminescence and the Nox1-Nox2-Nox4 triple knockout. Antioxidants and Redox Signaling, 23(15), pp. 1246-1247. (doi: 10.1089/ars.2015.6382) (PMID:26054248)

Tsiropoulou, S., Montezano, A.C., Scott, A., Burchmore, R.J. and Touyz, R. (2015) 41 Vascular protein oxidation and redox proteomics in human hypertension. Heart, 101(Suppl), A13-A14. (doi: 10.1136/heartjnl-2015-308734.41)

Hipólito, U. V., Callera, G. E., Simplicio, J. A., De Martinis, B. S., Touyz, R. M. and Tirapelli, C. R. (2015) Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake. Life Sciences, 141, pp. 99-107. (doi: 10.1016/j.lfs.2015.09.006) (PMID:26386369)

Messaoudi, S. et al. (2015) Endothelial Gata5 transcription factor regulates blood pressure. Nature Communications, 6, 8835. (doi: 10.1038/ncomms9835) (PMID:26617239) (PMCID:PMC4696516)

Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi: 10.1042/cs20140758) (PMID:25967696)

Gallardo-Ortíz, I.A., Rodríguez-Hernández, S.N., López-Guerrero, J.J., Del Valle-Mondragón, L., López-Sánchez, P., Touyz, R.M. and Villalobos-Molina, R. (2015) Role of α1D-adrenoceptors in vascular wall hypertrophy during angiotensin II-induced hypertension. Autonomic and Autacoid Pharmacology, 35(3), pp. 17-31. (doi: 10.1111/aap.12035) (PMID:26845248)

Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., De Lucca Camargo, L. and Touyz, R. M. (2015) Redox signaling, Nox5 and vascular remodeling in hypertension. Current Opinion in Nephrology and Hypertension, 24(5), pp. 425-433. (doi: 10.1097/MNH.0000000000000153) (PMID:26197203) (PMCID:PMC4727501)

Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi: 10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)

Burger, D., Viñas, J. L., Akbari, S., Dehak, H., Knoll, W., Gutsol, A., Carter, A., Touyz, R. M. , Allan, D. S. and Burns, K. D. (2015) Human endothelial colony-fForming cells protect against acute kidney injury. American Journal of Pathology, 185(8), pp. 2309-2323. (doi: 10.1016/j.ajpath.2015.04.010) (PMID:26073035)

Urbanet, R. et al. (2015) Adipocyte mineralocorticoid receptor activation leads to metabolic syndrome and induction of prostaglandin D2 synthase. Hypertension, 66(1), pp. 149-157. (doi: 10.1161/hypertensionaha.114.04981) (PMID:25966493)

Harvey, A., Montezano, A. C. and Touyz, R. M. (2015) Vascular biology of ageing—implications in hypertension. Journal of Molecular and Cellular Cardiology, 83, pp. 112-121. (doi: 10.1016/j.yjmcc.2015.04.011) (PMID:25896391) (PMCID:PMC4534766)

Lip, S. , Carlin, C., McCallum, L., Touyz, R.H. , Dominiczak, A.F. and Padmanabhan, S. (2015) Incidence and prognosis of cancer associated with digoxin and common antihypertensive drugs. Journal of Hypertension, 33(Supl 1), e45. (doi: 10.1097/01.hjh.0000467465.54504.ae) (PMID:26102824)

Feldman, R. D., Anderson, T. J. and Touyz, R. M. (2015) Metabolic syndrome sinkholes: what to do when Occam's razor gets blunted. Canadian Journal of Cardiology, 31(5), pp. 601-604. (doi: 10.1016/j.cjca.2014.12.035) (PMID:25936488)

Fulton, R. L., Walters, M. R. , Morton, R., Touyz, R. M. , Dominiczak, A. F. , Morrison, D. S., Padmanabhan, S. , Meredith, P. A., McInnes, G. T. and Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65(5), 1008-U596. (doi: 10.1161/HYPERTENSIONAHA.114.04945) (PMID:25801870)

Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M. and Touyz, R. M. (2015) Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Canadian Journal of Cardiology, 31(5), pp. 631-641. (doi: 10.1016/j.cjca.2015.02.008) (PMID:25936489)

Campbell, N., Touyz, R. , Lackland, D., Redburn, K. and Niebylski, M. (2015) Celebrate world hypertension day (WHD) on May 17, 2015, and contribute to improving awareness of yypertension. Journal of Clinical Hypertension, 17(4), pp. 317-318. (doi: 10.1111/jch.12542) (PMID:25808252)

Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi: 10.1124/jpet.114.221002) (PMID:25617244)

Zimmerman, D. L., Zimpelmann, J., Xiao, F., Gutsol, A., Touyz, R. and Burns, K. D. (2015) The effect of angiotensin-(1-7) in mouse unilateral ureteral obstruction. American Journal of Pathology, 185(3), pp. 729-740. (doi: 10.1016/j.ajpath.2014.11.013) (PMID:25625676)

Touati, S., Montezano, A. C., Meziri, F., Riva, C., Touyz, R. M. and Laurant, P. (2015) Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun N-terminal kinase downregulation in obese rats. Clinical and Experimental Pharmacology and Physiology, 42(2), pp. 179-185. (doi: 10.1111/1440-1681.12338) (PMID:25399833)

Boal, A., Smith, D. , Muir, S., Touyz, R. M. , Dominiczak, A. F. and Padmanabhan, S. (2015) Antihypertensive therapy and risk of admissions for mood disorders. Journal of Hypertension, 33(Supp 1), e128. (doi: 10.1097/01.hjh.0000467697.82617.32) (PMID:26102733)

Chignalia, A. Z., Oliveira, M. A., Debbas, V., Dull, R. O., Laurindo, F. R.M., Touyz, R. M. , Carvalho, M. H. C., Fortes, Z. B. and Tostes, R. C. (2015) Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clinical Science, 129(1), pp. 39-48. (doi: 10.1042/CS20140548) (PMID:25700020)

Lip, S. , McCallum, L., Touyz, R.H. , Dominiczak, A.F. and Padmanabhan, S. (2015) Clinical implications of the diastolic blood pressure 'J Curve' in treated hypertensive patients. Journal of Hypertension, 33(Supl 1), e87. (doi: 10.1097/01.hjh.0000467584.81358.e3) (PMID:26102953)

Montezano, A. C., Nguyen Dinh Cat, A. and Touyz, R. M. (2015) Mas signaling: resolved and unresolved issues. In: Unger, T., Steckelings, U. M. and dos Santos, R. A.S. (eds.) The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. Academic Press, pp. 169-179. ISBN 9780128013649 (doi: 10.1016/B978-0-12-801364-9.00023-7)

Silva, M. A.B., Bruder-Nascimento, T., Cau, S. B.A., Lopes, R. A.M. , Mestriner, F. L.A.C., Fais, R. S., Touyz, R. M. and Tostes, R. C. (2015) Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Frontiers in Physiology, 6, 269. (doi: 10.3389/fphys.2015.00269)

Touyz, R. M. (2015) The neuroimmune axis in the kidney. Circulation Research, 117(6), pp. 487-489. (doi: 10.1161/circresaha.115.307176) (PMID:26316603)

Touyz, R. M. and Montezano, A. C. (2015) Hypertensive vasculopathy. In: Lanzer, P. (ed.) PanVascular Medicine. Springer, pp. 1595-1618. ISBN 9783642370779 (doi: 10.1007/978-3-642-37078-6_51)

Welsh, P. , Preiss, D. and Touyz, R. M. (2015) Biomarkers of hypertension and cardiovascular disease. In: Peplow, P., Adams, J. and Young, T. (eds.) Cardiovascular and Metabolic Disease: Scientific Discoveries and New Therapies. Series: RSC Drug discovery series. Royal Society of Chemistry, pp. 117-136. ISBN 9781782620464 (doi: 10.1039/9781782622390-00117)

Welsh, P. , Preiss, D. , Tsiropoulou, S., Rios, F. J. , Harvey, A., Dulak-Lis, M. G., Montezano, A. C. and Touyz, R. M. (2015) Biomarkers of vascular inflammation and cardiovascular disease. In: Berbari, A. and Mancia, G. (eds.) Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer: Cham, pp. 115-136. ISBN 9783319145556 (doi: 10.1007/978-3-319-14556-3_9)

2014

Touyz, R. M. , Montezano, A. C., Rios, F. J. and Savoia, C. (2014) Reply to letter by McIntyre et al. Canadian Journal of Cardiology, 30(12), 1733.e3. (doi: 10.1016/j.cjca.2014.10.004)

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S. , McCallum, L., Walters, M. R. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5), pp. 1102-1107. (doi: 10.1161/HYPERTENSIONAHA.114.03953) (PMID:25135183)

Dipchand, A.I., White, M., Manlhiot, C., Pollock-BarZiv, S., Allain-Rooney, T., West, L., He, Y. and Touyz, R.M. (2014) Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. Pediatric Transplantation, 18(7), pp. 764-770. (doi: 10.1111/petr.12337)

Jourd'heuil, D. et al. (2014) An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin ii-induced hypertension: in vivo and in vitro studies. PLoS ONE, 9(11), e111117. (doi: 10.1371/journal.pone.0111117) (PMID:25369284) (PMCID:PMC4219703)

Touyz, R. M. (2014) Linking LOX-1 and arginase II through mitochondria: a novel paradigm in endothelial dysfunction. Circulation Research, 115(4), pp. 412-414. (doi: 10.1161/CIRCRESAHA.114.304550)

Burger, D., Thibodeau, J.-F., Holterman, C.E., Burns, K.D., Touyz, R.M. and Kennedy, C.R.J. (2014) Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury. Journal of the American Society of Nephrology, 25(7), pp. 1401-1407. (doi: 10.1681/ASN.2013070763) (PMID:24676640)

Gonzaga, N. A., Callera, G. E., Yogi, A., Mecawi, A. S., Antunes-Rodrigues, J., Queiroz, R. H., Touyz, R. M. and Tirapelli, C. R. (2014) Acute ethanol intake induces mitogen-activated protein kinase activation, platelet-derived growth factor receptor phosphorylation, and oxidative stress in resistance arteries. Journal of Physiology and Biochemistry, 70(2), pp. 509-523. (doi: 10.1007/s13105-014-0331-6) (PMID:24733165)

Jha, J. C. et al. (2014) Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy. Journal of the American Society of Nephrology, 25(6), pp. 1237-1254. (doi: 10.1681/ASN.2013070810)

Wilkinson-Berka, J. L. et al. (2014) NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxidants and Redox Signaling, 20(17), pp. 2726-2740. (doi: 10.1089/ars.2013.5357)

Montezano, A. C. and Touyz, R. M. (2014) Mammalian target of Rapamycin: a novel pathway in vascular calcification. Canadian Journal of Cardiology, 30(5), pp. 482-484. (doi: 10.1016/j.cjca.2014.03.001)

Small, H. Y., Montezano, A. C., Rios, F. J. , Savoia, C. and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5), pp. 534-543. (doi: 10.1016/j.cjca.2014.02.011)

Holterman, C. E., Thibodeau, J.-F., Towaij, C., Gutsol, A., Montezano, A. C., Parks, R. J., Cooper, M. E., Touyz, R. M. and Kennedy, C. R.J. (2014) Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression. Journal of the American Society of Nephrology, 25(4), pp. 784-797. (doi: 10.1681/ASN.2013040371)

Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J. and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6), p. 431. (doi: 10.1007/s11906-014-0431-2)

Marco, E. et al. (2014) Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice. Diabetologia, 57(3), pp. 633-642. (doi: 10.1007/s00125-013-3118-3)

Vitiello, D. et al. (2014) Changes in cardiopulmonary reserve and peripheral arterial function concomitantly with subclinical inflammation and oxidative stress in patients with heart failure with preserved ejection fraction. International Journal of Vascular Medicine, 2014, 917271. (doi: 10.1155/2014/917271) (PMID:24719767) (PMCID:PMC3955597)

Campbell, N. et al. (2014) The World Hypertension League and International Society of Hypertension call on governments, nongovernmental organizations, and the food industry to work to reduce dietary sodium. Journal of Clinical Hypertension, 16(2), pp. 99-100. (doi: 10.1111/jch.12245)

Campbell, N.R.C. et al. (2014) The International Society of Hypertension and World Hypertension League call on governments, nongovernmental organizations and the food industry to work to reduce dietary sodium. Journal of Hypertension, 32(2), pp. 446-447. (doi: 10.1097/HJH.0000000000000079)

Montezano, A. C. and Touyz, R. M. (2014) Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxidants and Redox Signaling, 20(1), pp. 164-182. (doi: 10.1089/ars.2013.5302)

Bruder-Nascimento, T., Chinnasamy, P., Riascos-Bernal, D.F., Cau, S.B., Callera, G.E., Touyz, R.M. , Tostes, R.C. and Sibinga, N.E.S. (2014) Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. Journal of Molecular and Cellular Cardiology, 66, pp. 18-26. (doi: 10.1016/j.yjmcc.2013.10.013)

Weber, M.A. et al. (2014) Clinical practice guidelines for the management of hypertension in the community a statement by the American society of hypertension and the international society of hypertension. Journal of Hypertension, 32(1), pp. 3-15. (doi: 10.1097/HJH.0000000000000065)

Weber, M. A. et al. (2014) Clinical practice guidelines for the management of hypertension in the community. Journal of Clinical Hypertension, 16(1), pp. 14-26. (doi: 10.1111/jch.12237)

Bruder‑Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T. T., Nguyen Dinh Cat, A., Tostes, R. C. and Touyz, R. M. (2014) Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive nox-dependent pathways. Clinical Science, 128(7), pp. 411-423. (doi: 10.1042/CS20140456)

Burger, D., Reudelhuber, T. L., Mahajan, A., Chibale, K., Sturrock, E. D. and Touyz, R. M. (2014) Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension. Clinical Science, 127(1), pp. 57-63. (doi: 10.1042/CS20130808)

Even, S. E. L., Dulak-Lis, M. G., Touyz, R. M. and Nguyen Dinh Cat, A. (2014) Crosstalk between adipose tissue and blood vessels in cardiometabolic syndrome: implication of steroid hormone receptors (MR/GR). Hormone Molecular Biology and Clinical Investigation, 19(2), pp. 89-101. (doi: 10.1515/hmbci-2014-0013) (PMID:25390018)

Jennings, G. L.R. and Touyz, R. M. (2014) Response to European Society of Hypertension and European Society of Cardiology Guidelines and the muted enthusiasm for home blood pressure monitoring. Hypertension, 63(2), e6. (doi: 10.1161/HYPERTENSIONAHA.113.02423)

Montezano, A. C. and Touyz, R. M. (2014) Reactive oxygen species, vascular disease, and hypertension. In: Laher, I. (ed.) Systems Biology of Free Radicals and Antioxidants. Springer: Berlin, Heidelberg, pp. 1123-1154. ISBN 9783642300172 (doi: 10.1007/978-3-642-30018-9_56)

Touyz, R. M. (2014) Blood pressure regulation and pathology. In: Willis, M. S., Homeister, J. W. and Stone, J. R. (eds.) Cellular and Molecular Pathobiology of Cardiovascular Disease. Academic Press, pp. 257-275. ISBN 9780124052062 (doi: 10.1016/B978-0-12-405206-2.00014-4)

Zimmerman, D. L., Ruzicka, M., Hebert, P., Fergusson, D., Touyz, R. M. and Burns, K. D. (2014) Short daily versus conventional hemodialysis for hypertensive patients: a randomized cross-over study. PLoS ONE, 9(5), e97135. (doi: 10.1371/journal.pone.0097135) (PMID:24875804) (PMCID:PMC4038634)

2013

Thibodeau, J., Nasrallah, R., Carter, A., He, Y., Touyz, R. , Hébert, R.L. and Kennedy, C.R.J. (2013) PTGER1 deletion attenuates renal injury in diabetic mouse models. American Journal of Pathology, 183(6), pp. 1789-1802. (doi: 10.1016/j.ajpath.2013.08.022)

White, M. et al. (2013) Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. Journal of Heart and Lung Transplantation, 32(12), pp. 1222-1232. (doi: 10.1016/j.healun.2013.09.010)

Yogi, A. et al. (2013) Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cellular Signalling, 25(11), pp. 2163-2175. (doi: 10.1016/j.cellsig.2013.07.002)

Sedeek, M., Nasrallah, R., Touyz, R.M. and Hebert, R.L. (2013) NADPH oxidases, reactive oxygen species, and the kidney: friend and foe. Journal of the American Society of Nephrology, 24(10), pp. 1512-1518. (doi: 10.1681/ASN.2012111112)

Nguyen Dinh Cat, A., Montezano, A.C., Burger, D. and Touyz, R.M. (2013) Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxidants and Redox Signaling, 19(10), pp. 1110-1120. (doi: 10.1089/ars.2012.4641)

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Antunes, T., de Cassia Tostes, R., Touyz, R. M. and , (2013) Atorvastatin Inhibits Src/ROS-mediated Redox Sensitive And Pro-Inflammatory Actions of Aldosterone in Vascular Smooth Muscle Cells: Focus on Statins Pleiotropic Effects. Hypertension, 62(3 Sup), A488.

Bruder-Nascimento, T., Callera, G. E., Montezano, A. C., He, Y., Nguyen Dinh Cat, A., de Cassia Tostes, R. and Touyz, R. M. (2013) Atorvastatin downregulates vascular nox expression and ameliorates oxidative stress-associated inflammatory process in type 2 diabetic Db/db mice. Hypertension, 62(3 Sup), A33.

Callera, G. E., Montezano, A. C., Bruder-Nascimento, T. and Touyz, R. M. (2013) Downregulation of C-terminal Src kinase (csk) and Csk-binding protein (cbp) is associated with increased aldosterone-induced C-src phosphorylation in Shr vascular smooth muscle cells. Hypertension, 62(3 Sup), A350.

Even, S. et al. (2013) The Nox4 inhibitor GKT137831, prevents aldosterone production by adipocytes and protects against adipose tissue inflammation and fibrosis in obese mice. Hypertension, 62(3 Sup), A74.

Hood, K. Y., Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2013) Differential effects of 17ß-estradiol and 16a-hydroxyestrone in oxidative stress and proliferative responses in human pulmonary artery smooth muscle cells - implications in pulmonary arterial hypertension. Hypertension, 62(3 Sup), A263.

Hood, K. Y., Montezano, A. C., Morecroft, I., MacLean, M. R. and Touyz, R. M. (2013) Serotonin signaling through Nox1 in human pulmonary artery smooth muscle cells - implications in vascular remodeling in pulmonary arterial hypertension. Hypertension, 62(3 Sup), A264.

Montezano, A. C. et al. (2013) Nox4 inhibition, by GKT 137831, decreases obesity-associated vascular dysfunction and pro-fibrotic effects. Hypertension, 62(3 Sup), A491.

Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.

Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C., Bruder-Nascimento, T. and Touyz, R. M. (2013) Mineralocorticoid Receptor and Rhoa/rho Kinase Contribute to Vascular Dysfunction in Obese Db/db Mice. Hypertension, 62(3 Sup), A373.

Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., Montezano, A. C., He, Y., Jenkins, C., Carter, A., Jaisser, F. and Touyz, R. M. (2013) Altered vascular reactivity in mice overexpressing adipocyte mineralocorticoid receptors - role of oxidative stress and Rho kinase. Hypertension, 62(3 Sup), A66.

Nguyen Dinh Cat, A., Callera, G. E., Antunes, T. T., Montezano, A. C., Jenkins, C., Touyz, R. M. and He, Y. (2013) Upregulation of the mineralocorticoid system in obesity-associated diabetes leads to increased adipocyte Rho kinase activation and dysregulation of adipocytokines. Hypertension, 62(3 Sup), A372.

Rios, F. J. , Nguyen Dinh Cat, A., Palacios, R. , Carswell, A., Montezano, A. C. and Touyz, R. M. (2013) Torcetrapib and dalcetrapib, CETP inhibitors, induce adipocyte-derived aldosterone and reactive oxygen species formation. Hypertension, 62(3 Sup), A356.

Gray, S.P. et al. (2013) NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation, 127(18), pp. 1888-1902. (doi: 10.1161/CIRCULATIONAHA.112.132159)

Chalmers, J., Arima, H., Harrap, S., Touyz, R.M. and Park, J.B. (2013) Global survey of current practice in management of hypertension as reported by societies affiliated with the international society of hypertension. Journal of Hypertension, 31(5), pp. 1043-1048. (doi: 10.1097/HJH.0b013e32835f7eef)

Touyz, R.M. (2013) Combination antihypertensive treatment with aliskiren and blockers of the renin-angiotensin system—reassurance but with a note of caution. Canadian Journal of Cardiology, 29(5), pp. 521-523. (doi: 10.1016/j.cjca.2013.02.020)

Der Sarkissian, S., Tea, B., Touyz, R.M. , deBlois, D. and Hale, T.M. (2013) Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension, 7(2), pp. 118-127. (doi: 10.1016/j.jash.2013.01.002)

Antunes, T.T., Callera, C. and Touyz, R.M. (2013) Vascular biology of magnesium: implications in cardiovascular disease. In: Watson, R.R., Preedy, V.R. and Zibadi, S. (eds.) Magnesium in Human Health and Disease. Series: Nutrition and health. Humana Press. ISBN 9781627030434

Burger, D., Schock, S., Thompson, C.S., Montezano, A.C., Hakim, A.M. and Touyz, R.M. (2013) Microparticles: biomarkers and beyond. Clinical Science, 124(7), pp. 423-441. (doi: 10.1042/CS20120309)

Jennings, G.L.R. and Touyz, R.M. (2013) Hypertension guidelines: more challenges highlighted by Europe. Hypertension, 62(4), pp. 660-665. (doi: 10.1161/HYPERTENSIONAHA.113.02034)

Montezano, A.C., Antunes, T.T., Callera, G.E. and Touyz, R.M. (2013) Magnesium and vessels. In: Kreitsinger, R., Permyakov, E. and Uversky, V. (eds.) Encyclopedia of Metalloproteins. Springer. ISBN 9781461415329

Montezano, A.C. and Touyz, R.M. (2013) Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling. Circulation Research, 112(12), pp. 1522-1525. (doi: 10.1161/CIRCRESAHA.113.301495)

Sedeek, M. et al. (2013) Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science, 124(3), pp. 191-202. (doi: 10.1042/CS20120330)

Touyz, R.M. and Montezano, A.C. (2013) Vascular function. In: Rosendorff, C. (ed.) Essential Cardiology: Principles and Practice. Springer. ISBN 9781461467045

2012

Yogi, A., Callera, G.E., Mecawi, A.S., Batalhão, M.E., Carnio, E.C., Antunes-Rodrigues, J., Queiroz, R.H., Touyz, R.M. and Tirapelli, C.R. (2012) Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: A role for angiotensin type 1 receptor. Toxicology and Applied Pharmacology, 264(3), pp. 470-478. (doi: 10.1016/j.taap.2012.08.029) (PMID:22982071)

Sedeek, M. et al. (2012) Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies. Journal of Cardiovascular Translational Research, 5(4), pp. 509-518. (doi: 10.1007/s12265-012-9387-2)

Burger, D., Kwart, D. G., Montezano, A. C., Read, N. C., Kennedy, C. R.J., Thompson, C. S. and Touyz, R. M. (2012) Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. Journal of the American Heart Association, 1(3), e001842. (doi: 10.1161/JAHA.112.001842)

Chignalia, A. Z. et al. (2012) Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension, 59(6), pp. 1263-1271. (doi: 10.1161/HYPERTENSIONAHA.111.180620) (PMID:22566500)

Montezano, A.C. and Touyz, R.M. (2012) Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of Medicine, 44(S1), S2-S16. (doi: 10.3109/07853890.2011.653393)

Montezano, A.C. and Touyz, R.M. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinician. Canadian Journal of Cardiology, 28(3), pp. 288-295. (doi: 10.1016/j.cjca.2012.01.017)

Burger, D. and Touyz, R.M. (2012) Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. Journal of the American Society of Hypertension, 6(2), pp. 85-99. (doi: 10.1016/j.jash.2011.11.003)

Briones, A.M. et al. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension, 59(9), pp. 1069-1078. (doi: 10.1161/HYPERTENSIONAHA.111.190223)

Burger, D., Gutsol, A., Carter, A., Allan, D.S., Touyz, R.M. and Burns, K.D. (2012) Human cord blood CD133+ cells exacerbate ischemic acute kidney injury in mice. Nephrology Dialysis Transplantation, 27(10), pp. 3781-3789. (doi: 10.1093/ndt/gfs110)

Burger, D., Veerabhadrappa, P., Charchar, F., Tomaszewski, M., Harrap, S., Carlberg, B. and Touyz, R.M. (2012) Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative. Journal of Hypertension, 30(3), pp. 631-632. (doi: 10.1097/HJH.0b013e32834f8267)

Montezano, A.C. and Touyz, R.M. (2012) Reactive oxygen species and endothelial function - role of nitric oxide synthase uncoupling and nox family Nicotinamide Adenine Dinucleotide Phosphate oxidases. Basic and Clinical Pharmacology and Toxicology, 110(1), pp. 87-94. (doi: 10.1111/j.1742-7843.2011.00785.x)

Montezano, A.C. and Touyz, R.M. (2012) Reactive Oxygen Species and the Cardiovascular System. Series: Integrated systems physiology. Morgan & Claypool. ISBN 9781615043620

Paravicini, T.M., Montezano, A.C., Yusuf, H. and Touyz, R.M. (2012) Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. Journal of the American Society of Hypertension, 6(3), pp. 169-178. (doi: 10.1016/j.jash.2012.01.002)

Rocha, J.T., Hipolito, U.V., Callera, G.E., Yogi, A., Filho, A., Bendhack, L.M., Touyz, R.M. and Tirapelli, C.R. (2012) Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways. Vascular Pharmacology, 56(1-2), pp. 74-83. (doi: 10.1016/j.vph.2011.11.006)

Touyz, R.M. (2012) New insights into mechanisms of hypertension. Current Opinion in Nephrology and Hypertension, 21(2), pp. 119-121. (doi: 10.1097/MNH.0b013e328350a50f)

Touyz, R.M. and Burger, D. (2012) Biomarkers in hypertension. In: Berbari, A.J. and Mancia, G. (eds.) Special issues in Hypertension. Springer, pp. 237-246. ISBN 9788847026001

Touyz, R.M. and Montezano, A.C. (2012) Vascular Nox4: a multifarious NADPH oxidase. Circulation Research, 110(9), pp. 1159-1161. (doi: 10.1161/CIRCRESAHA.112.269068)

Touyz, R.M. and Schiffrin, E.L. (2012) Arterial hypertension. In: Hill, J. and Olson, E.N. (eds.) Muscle: Fundamental Biology and Mechanisms of Disease. Pt. IV. Smooth Muscle. Elsevier, pp. 1301-1311. ISBN 9780123815101

Veerabhadrappa, P., Burger, D., Charchar, F., Tomaszewski, M., Carlberg, B., Harrap, S. and Touyz, R.M. (2012) Council for High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: First New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions. Hypertension, 59(2), pp. 382-383. (doi: 10.1161/HYPERTENSIONAHA.111.185421)

White, M., Montezano, A.C. and Touyz, R.M. (2012) Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease, 6(1), pp. 5-14. (doi: 10.1177/1753944711432901)

2011

Al Ghouleh, I. et al. (2011) Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radical Biology and Medicine, 51(7), pp. 1271-1288. (doi: 10.1016/j.freeradbiomed.2011.06.011)

Chung, Y. et al. (2011) Vascular progenitor recruitment in critically ill patients with acute kidney injury. Clinical and Investigative Medicine, 34(5), E304.

Nguyen Dinh Cat, A. and Touyz, R.M. (2011) A new look at the renin–angiotensin system--focusing on the vascular system. Peptides, 32(10), pp. 2141-2150. (doi: 10.1016/j.peptides.2011.09.010)

Cascino, T., Csanyi, G., Al Ghouleh, I., Montezano, A.C., Touyz, R.M. , Haurani, M.J. and Pagano, P.J. (2011) Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Antioxidants and Redox Signaling, 15(6), pp. 1507-1515. (doi: 10.1089/ars.2010.3631)

Callera, G.E., Yogi, A., Briones, A.M., Montezano, A.C., He, Y., Tostes, R.C.A., Schiffrin, E.L. and Touyz, R.M. (2011) Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovascular Research, 91(4), pp. 720-731. (doi: 10.1093/cvr/cvr131) (PMID:21576132)

Touyz, R.M. and Grassi, G. (2011) Renal biomarkers: novel surrogates of small and large vessel disease? Journal of Hypertension, 29(9), pp. 1700-1702. (doi: 10.1097/HJH.0b013e32834a3ceb)

Burger, D., Montezano, A. C., Nishigaki, N., He, Y., Carter, A. and Touyz, R. M. (2011) Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(8), pp. 1898-1907. (doi: 10.1161/ATVBAHA.110.222703)

Nguyen Dinh Cat, A. and Touyz, R.M. (2011) Cell signaling of angiotensin II on vascular tone: novel mechanisms. Current Hypertension Reports, 13(2), pp. 122-128. (doi: 10.1007/s11906-011-0187-x)

Touati, S., Meziri, F., Devaux, S., Berthelot, A., Touyz, R.M. and Laurant, P. (2011) Exercise reverses metabolic syndrome in high-fat diet-induced obese rats. Medicine and Science in Sports and Exercise, 43(3), pp. 398-407. (doi: 10.1249/MSS.0b013e3181eeb12d)

Touyz, R.M. (2011) Advancement in hypertension pathogenesis: some new concepts. Current Opinion in Nephrology and Hypertension, 20(2), pp. 105-106. (doi: 10.1097/MNH.0b013e328343f526)

Touyz, R.M. , Briones, A.M., Sedeek, M., Burger, D. and Montezano, A.C. (2011) NOX isoforms and reactive oxygen species in vascular health. Molecular Interventions, 11(1), pp. 27-35. (doi: 10.1124/mi.11.1.5)

Briones, A.M., Tabet, F., Callera, G.E., Montezano, A.C., Yogi, A., He, Y., Quinn, M.T., Salaices, M. and Touyz, R.M. (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. Journal of the American Society of Hypertension, 5(3), pp. 137-153. (doi: 10.1016/j.jash.2011.02.001)

Meziri, F., Binda, D., Touati, S., Pellegrin, M., Berthelot, A., Touyz, R.M. and Laurant, P. (2011) Exercise aggravates cardiovascular risks and mortality in rats with disrupted nitric oxide pathway and treated with recombinant human erythropoietin. European Journal of Applied Physiology, 111(8), pp. 1929-1938. (doi: 10.1007/s00421-011-1829-z)

Nguyen Dinh Cat, A., Briones, A.M., Callera, G.E., Yogi, A., He, Y., Montezano, A.C. and Touyz, R.M. (2011) Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension, 58(3), pp. 479-488. (doi: 10.1161/HYPERTENSIONAHA.110.168872)

Rabi, D.M. et al. (2011) The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Canadian Journal of Cardiology, 27(4), 415-433.e2. (doi: 10.1016/j.cjca.2011.03.015)

Savoia, C.,, Burger, D., Nishigaki, N., Montezano, A. and Touyz, R.M. (2011) Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine, 13(e11), pp. 1-25. (doi: 10.1017/S1462399411001815)

Schiffrin, E.L. and Touyz, R.M. (2011) Oxidative stress in arterial hypertension and atherosclerosis. In: Pantopoulos, K. and Schipper, H. (eds.) Principles of Free Radical Biomedicine. Nova Science.

Tabet, F., Lambert, G., Cuesta Torres, L.F., Hou, L., Sotirchos, I., Touyz, R.M. , Jenkins, A.J., Barter, P.J. and Rye, K.A. (2011) Lipid-free apolipoprotein A-I and discoidal reconstituted high-density lipoproteins differentially inhibit glucose-induced oxidative stress in human macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(5), pp. 1192-1200. (doi: 10.1161/ATVBAHA.110.222000)

Touyz, R.M. and Briones, A.M. (2011) Reactive oxygen species and vascular biology: implications in human hypertension. Hypertension Research, 34(1), pp. 5-14. (doi: 10.1038/hr.2010.201)

Yogi, A., Callera, G.E., Antunes, T.T., Tostes, R.C. and Touyz, R.M. (2011) Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension. Circulation Journal, 75(2), pp. 237-245. (doi: 10.1253/circj.CJ-10-1021)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D. , McBride, M. , Dominiczak, A. and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4), pp. 809-818. (doi: 10.1161/HYPERTENSIONAHA.110.162719)

Yogi, A., Callera, G.E., OʼConnor, S.E., He, Y., Correa, J.W., Tostes, R.C., Mazur, A. and Touyz, R.M. (2011) Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia. Journal of Hypertension, 29(7), pp. 1400-1410. (doi: 10.1097/HJH.0b013e32834786d6)

2010

Sedeek, M. et al. (2010) Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. American Journal of Physiology: Renal Physiology, 299(6), F1348-F1358. (doi: 10.1152/ajprenal.00028.2010)

Quinn, R.R. et al. (2010) The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 26(5), pp. 241-248.

Montezano, A.C. et al. (2010) Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circulation Research, 106(8), pp. 1363-1373. (doi: 10.1161/CIRCRESAHA.109.216036)

Briones, A.M. and Touyz, R.M. (2010) Oxidative stress and hypertension: current concepts. Current Hypertension Reports, 12(2), pp. 135-142. (doi: 10.1007/s11906-010-0100-z)

Burger, D., Nishigaki, N. and Touyz, R.M. (2010) New insights into molecular mechanisms of hypertension. Current Opinion in Nephrology and Hypertension, 19(2), pp. 160-162. (doi: 10.1097/MNH.0b013e32833680c4)

Yogi, A., OʼConnor, S.E., Callera, G.E., Tostes, R.C. and Touyz, R.M. (2010) Receptor and nonreceptor tyrosine kinases in vascular biology of hypertension. Current Opinion in Nephrology and Hypertension, 19(2), pp. 169-176. (doi: 10.1097/MNH.0b013e3283361c24)

Hackam, D.G. et al. (2010) The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Canadian Journal of Cardiology, 26(5), pp. 249-58.

Montezano, A.C., Burger, D., Ceravolo, G.S., Yusuf, H., Montero, M. and Touyz, R.M. (2010) Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clinical Science, 120(4), pp. 131-141. (doi: 10.1042/CS20100384)

Montezano, A.C., Zimmerman, D., Yusuf, H., Burger, D., Chignalia, A.Z., Wadhera, V., van Leeuwen, F.N. and Touyz, R.M. (2010) Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension, 56(3), pp. 453-462. (doi: 10.1161/HYPERTENSIONAHA.110.152058)

Yogi, A., Callera, G.E., Hipólito, U.V., Silva, C.R., Touyz, R.M. and Tirapelli, C.R. (2010) Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms. Clinical Science, 118(11), pp. 657-668. (doi: 10.1042/CS20090352)

2009

Khan, N.A. et al. (2009) The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 – therapy. Canadian Journal of Cardiology, 25(5), pp. 287-298. (doi: 10.1016/S0828-282X(09)70492-1)

Touyz, R.M. and Montezano, A.C. (2009) Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovascular Research, 81(2), pp. 237-239. (doi: 10.1093/cvr/cvn345) (PMID:19088081)

Yogi, A., Callera, G.E., Tostes, R. and Touyz, R.M. (2009) Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells. American Journal of Physiology: Heart and Circulatory Physiology, 296(2), R201-R207. (doi: 10.1152/ajpregu.90602.2008)

Briones, A.M. and Touyz, R.M. (2009) Moderate exercise decreases inflammation and oxidative stress in hypertension: but what are the mechanisms? Hypertension, 54(6), pp. 1206-1208. (doi: 10.1161/HYPERTENSIONAHA.109.136622)

Callera, G.E., He, Y., Yogi, A., Montezano, A.C., Paravicini, T., Yao, G. and Touyz, R.M. (2009) Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells. Journal of Hypertension, 27(1), pp. 155-166. (doi: 10.1097/HJH.0b013e3283190582)

Fu, A. et al. (2009) Loss of Lkb1 in adult β cells increases β cell mass and enhances glucose tolerance in mice. Cell Metabolism, 10(4), pp. 285-295. (doi: 10.1016/j.cmet.2009.08.008)

Gava, E., Samad-Zadeh, A., Zimpelmann, J., Bahramifarid, N., Kitten, G.T., Santos, R.A., Touyz, R.M. and Burns, K.D. (2009) Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrology Dialysis Transplantation, 24(6), pp. 1766-1773. (doi: 10.1093/ndt/gfn736)

Javeshghani, D., Schiffrin, E.L., Sairam, M.R. and Touyz, R.M. (2009) Potentiation of vascular oxidative stress and nitric oxide-mediated endothelial dysfunction by high-fat diet in a mouse model of estrogen deficiency and hyperandrogenemia. Journal of the American Society of Hypertension, 3(5), pp. 295-305. (doi: 10.1016/j.jash.2009.07.002)

Paravicini, T.M., Yogi, A., Mazur, A. and Touyz, R.M. (2009) Dysregulation of vascular TRPM7 and Annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia. Hypertension, 53(2), pp. 423-429. (doi: 10.1161/HYPERTENSIONAHA.108.124651)

Sedeek, M., Hébert, R.L., Kennedy, C.R., Burns, K.D. and Touyz, R.M. (2009) Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. Current Opinion in Nephrology and Hypertension, 18(2), pp. 122-127. (doi: 10.1097/MNH.0b013e32832923c3)

Takami, K., Touyz, L.Z.G. and Touyz, R.M. (2009) Liquorice alert. British Dental Journal, 207(11), p. 519. (doi: 10.1038/sj.bdj.2009.1090)

Touyz, R.M. and Callera, G.E. (2009) A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy. Circulation Research, 104(1), pp. 9-11. (doi: 10.1161/CIRCRESAHA.108.191288)

Touyz, R.M. , Chignalia, A. and Sedeek, M. (2009) Reactive oxygen species, oxidative stress and hypertension. In: Shah, A. and Laurindo, F. (eds.) Studies on Cardiovascular Disorders. Series: Oxidative stress in applied basic research and clinical practice. Humana Press. ISBN 9781607616009

White, M., Touyz, R.M. , Tessier, Y., Van Le, V., Ross, H. and Sirois, M.G. (2009) A cardiac and a kidney transplant patient above 6000 meters in Bolivia. Wilderness and Environmental Medicine, 20(1), pp. 99-100. (doi: 10.1580/08-WEME-LE-249.1)

White, M., Touyz, R.M. , Tessier, Y., Van Le, V., Ross, H. and Sirois, M.G. (2009) Persistent elevation of VEGF and prostacyclin following poor cardiopulmonary adaptation to high altitude. Wilderness and Environmental Medicine, 20(1), pp. 97-98. (doi: 10.1580/08-WEME-LE-248.1)

Xu, S., He, Y., Vokurkova, M. and Touyz, R.M. (2009) Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of Thioredoxin. Hypertension, 54(2), pp. 427-433. (doi: 10.1161/HYPERTENSIONAHA.109.133983)

2008

Touyz, R.M. (2008) Targeting the ailing endothelium – current concepts and future prospects. Canadian Journal of Cardiology, 24(Sup C), 38C-43C. (doi: 10.1016/S0828-282X(08)71037-7)

Tabet, F., Schiffrin, E. L., Callera, G. E., He, Y., Yao, G., Ostman, A., Kappert, K., Tonks, N. K. and Touyz, R. M. (2008) Redox-Sensitive Signaling by Angiotensin II Involves Oxidative Inactivation and Blunted Phosphorylation of Protein Tyrosine Phosphatase SHP-2 in Vascular Smooth Muscle Cells From SHR. Circulation Research, 103(2), pp. 149-158. (doi: 10.1161/CIRCRESAHA.108.178608)

Ebrahimian, T. and Touyz, R.M. (2008) Thioredoxin in vascular biology: role in hypertension. Antioxidants and Redox Signaling, 10(6), pp. 1127-1136. (doi: 10.1089/ars.2007.1985)

Touyz, R.M. and Schiffrin, E.L. (2008) Reactive oxygen species and hypertension: a complex association. Antioxidants and Redox Signaling, 10(6), pp. 1041-1044. (doi: 10.1089/ars.2007.2012)

Touyz, R.M. (2008) Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. American Journal of Physiology: Heart and Circulatory Physiology, 294(3), H1103-H1118.

Paravicini, T. M. and Touyz, R.M. (2008) NADPH oxidases, reactive oxygen species and hypertension: clinical implications and therapeutic possibilities. Diabetes Care, 31(Supl.2), S170-S180. (doi: 10.2337/dc08-s247)

de Denus, S. et al. (2008) Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan. Annals of Pharmacotherapy, 42(7), pp. 925-932. (doi: 10.1345/aph.1K657)

Ebrahimian, T., Sairam, M.R., Schiffrin, E.L. and Touyz, R.M. (2008) Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. American Journal of Physiology: Heart and Circulatory Physiology, 295(4), H1481-H1488. (doi: 10.1152/ajpheart.00163.2008)

Khan, N.A. et al. (2008) The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy. Canadian Journal of Cardiology, 24(6), pp. 465-475. (doi: 10.1016/S0828-282X(08)70620-2)

Mercure, C., Yogi, A., Callera, G.E., Aranha, A.B., Bader, M., Ferreira, A.J., Santos, R.A.S., Walther, T., Touyz, R.M. and Reudelhuber, T.L. (2008) Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circulation Research, 103(11), pp. 1319-1326. (doi: 10.1161/CIRCRESAHA.108.184911)

Montezano, A.C., Callera, G.E., Yogi, A., He, Y., Tostes, R.C., He, G., Schiffrin, E.L. and Touyz, R.M. (2008) Aldosterone and Angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), pp. 1511-1518. (doi: 10.1161/ATVBAHA.108.168021)

Montezano, A.C. and Touyz, R.M. (2008) Networking between systemic Angiotensin II and cardiac mineralocorticoid receptors. Hypertension, 52(6), pp. 1016-1018. (doi: 10.1161/HYPERTENSIONAHA.108.121269)

Padwal, R.S. et al. (2008) The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 – blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 24(6), pp. 455-463. (doi: 10.1016/S0828-282X(08)70619-6)

Paravicini, T., Najii, S. and Touyz, R.M. (2008) Disturbed Mg++ transporters in hypertension. Journal of Hypertension, 26(12), pp. 2450-2451. (doi: 10.1097/HJH.0b013e328317f029)

Park, Y.M., Lim, B.H., Touyz, R.M. and Park, J.B. (2008) Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat. Journal of Korean Medical Science, 23(6), pp. 1039-1045. (doi: 10.3346/jkms.2008.23.6.1039)

Savoia, C., Touyz, R.M. , Amiri, F. and Schiffrin, E.L. (2008) Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension, 51(2), pp. 432-439. (doi: 10.1161/HYPERTENSIONAHA.107.103267)

Sontia, B., Montezano, A.C., Paravicini, T., Tabet, F. and Touyz, R.M. (2008) Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension, 51(4), pp. 915-921. (doi: 10.1161/HYPERTENSIONAHA.107.100339)

Sontia, B., Mooney, J., Gaudet, L. and Touyz, R.M. (2008) Pseudohyperaldosteronism, liquorice, and hypertension. Journal of Clinical Hypertension, 10(2), pp. 153-157. (doi: 10.1111/j.1751-7176.2008.07470.x)

Tian, T., McBride, M.W., Graham, D., Touyz, R. and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.), S148-S148.

Tostes, R.C., Fortes, Z.B., Callera, G.E., Montezano, A.C., Touyz, R.M. , Webb, R.C. and Carvalho, M.H.C. (2008) Endothelin, sex and hypertension. Clinical Science, 114(2), pp. 85-97. (doi: 10.1042/CS20070169)

Touyz, R.M. (2008) Apocynin, NADPH oxidase, and vascular cells: a complex matter. Hypertension, 51(2), pp. 172-174. (doi: 10.1161/HYPERTENSIONAHA.107.103200)

Viel, E.C., Benkirane, K., Javeshghani, D., Touyz, R.M. and Schiffrin, E.L. (2008) Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. American Journal of Physiology: Heart and Circulatory Physiology, 295(1), H281-H288. (doi: 10.1152/ajpheart.00304.2008)

Yogi, A., Mercure, C., Touyz, J., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Reudelhuber, T. and Touyz, R.M. (2008) Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in Angiotensin II-dependent chronic hypertension. Hypertension, 51(2), pp. 500-506. (doi: 10.1161/HYPERTENSIONAHA.107.103192)

Yzydorczyk, C. et al. (2008) Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood. Hypertension, 52(5), pp. 889-895. (doi: 10.1161/HYPERTENSIONAHA.108.116251)

2007

Sontia, B. and Touyz, R.M. (2007) Magnesium transport in hypertension. Pathophysiology, 14(3-4), pp. 205-211. (doi: 10.1016/j.pathophys.2007.09.005)

Touyz, R.M. (2007) Lifestyle and BP: making a healthy change. Perspectives in Cardiology, 23(7),

Khan, N.A. et al. (2007) The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Canadian Journal of Cardiology, 23(7), pp. 539-550.

Padwal, R.S. et al. (2007) The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 23(7), pp. 529-538.

Tobe, S.W., Touyz, R.M. and Campbell, N.R.C. (2007) The Canadian Hypertension Education Program - a unique Canadian knowledge translation program. Canadian Journal of Cardiology, 23(7), pp. 551-555. (doi: 10.1016/S0828-282X(07)70799-7)

Callera, G., Tostes, R., Savoia, C., Muscara, M.N. and Touyz, R.M. (2007) Vasoactive peptides in cardiovascular (patho)physiology. Expert Review of Cardiovascular Therapy, 5(3), pp. 531-552. (doi: 10.1586/14779072.5.3.531)

Callera, G.E., Montezano, A.C.I., Yogi, A., Tostes, R.C.A. and Touyz, R.M. (2007) Vascular signaling through cholesterol-rich domains: implications in hypertension. Current Opinion in Nephrology and Hypertension, 16(2), pp. 90-104. (doi: 10.1097/MNH.0b013e328040bfbd)

Sontia, B. and Touyz, R.M. (2007) Role of magnesium in hypertension. Archives of Biochemistry and Biophysics, 458(1), pp. 33-39. (doi: 10.1016/j.abb.2006.05.005)

Vokurkova, M., Xu, S. and Touyz, R.M. (2007) Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension. Future Cardiology, 3(1), pp. 53-63. (doi: 10.2217/14796678.3.1.53)

Ciuceis, C., Amiri, F., Iglarz, M., Cohn, J.S., Touyz, R.M. and Schiffrin, E.L. (2007) Synergistic vascular protective effects of combined low doses of PPARα and PPARγ activators in angiotensin II-induced hypertension in rats. British Journal of Pharmacology, 151(1), pp. 45-53. (doi: 10.1038/sj.bjp.0707215)

da Costa Goncalves, A.C. et al. (2007) Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. American Journal of Physiology: Heart and Circulatory Physiology, 293(4), H2588-H2596. (doi: 10.1152/ajpheart.00173.2007)

Ebrahimian, T., He, Y., Schiffrin, E.L. and Touyz, R.M. (2007) Differential regulation of thioredoxin and NAD(P)H oxidase by Angiotensin II in male and female mice. Journal of Hypertension, 25(6), pp. 1263-1271. (doi: 10.1097/HJH.0b013e3280acac60)

Fox, C.H., Timm, E.A., Smith, S.J., Touyz, R.M. , Bush, E.G. and Wallace, P.K. (2007) A method for measuring intracellular free magnesium concentration in platelets using flow cytometry. Magnesium Research, 20(3), pp. 200-207.

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6), pp. 1134-1141. (doi: 10.1161/HYPERTENSIONAHA.107.095349)

Javeshghani, D., Sairam, M.R., Schiffrin, E.L. and Touyz, R.M. (2007) Increased blood pressure, vascular inflammation, and endothelial dysfunction in androgen-deficient follitropin receptor knockout male mice. Journal of the American Society of Hypertension, 1(5), pp. 353-361. (doi: 10.1016/j.jash.2007.06.003)

Montezano, A.C., Amiri, F., Tostes, R.C., Touyz, R.M. and Schiffrin, E.L. (2007) Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Journal of the American Society of Hypertension, 1(2), pp. 150-160. (doi: 10.1016/j.jash.2007.01.005)

Sampaio, W.O., Souza dos Santos, R.A., Faria-Silva, R., da Mata Machado, L.T., Schiffrin, E.L. and Touyz, R.M. (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via akt-dependent pathways. Hypertension, 49(1), pp. 185-192.

Savoia, C., Touyz, R.M. , Volpe, M. and Schiffrin, E.L. (2007) Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension, 49(2), pp. 341-346. (doi: 10.1161/01.HYP.0000253968.95136.b8)

Touyz, R.M. (2007) Reactive oxygen species and mediators of oxidative stress. In: Izzo, J.L. (ed.) Hypertension Primer. Lippincott Williams & Wilkins. ISBN 9780781782050

Touyz, R.M. (2007) Regulation of endothelial nitric oxide synthase by throbin. Hypertension, 49(3), pp. 429-431. (doi: 10.1161/01.HYP.0000255955.75119.1a)

Touyz, R.M. (2007) Vascular remodeling, retinal arteries, and hypertension. Hypertension, 50(4), pp. 603-604. (doi: 10.1161/HYPERTENSIONAHA.107.095638)

Touyz, R.M. , Savoia, C., He, Y., Endemann, D., Pu, Q., Ko, E.A., DeCiuceis, C., Montezano, A.C. and Schiffrin, E.L. (2007) Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade. Journal of the American Society of Hypertension, 1(3), pp. 189-199. (doi: 10.1016/j.jash.2007.01.009)

Touyz, R.M. and Schiffrin, E.L. (2007) Angiotensin II and inflammation. In: Carey, R.M. (ed.) Hypertension and Hormone Mechanisms. Series: Contemporary endocrinology. Humana Press. ISBN 9781588294081

White, M. et al. (2007) Effects of combined candesartan and ACE inhibitors on BNP, markers of inflammation and oxidative stress, and glucose regulation in patients with symptomatic heart failure. Journal of Cardiac Failure, 13(2), pp. 86-94. (doi: 10.1016/j.cardfail.2006.10.013)

Yogi, A., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Schiffrin, E.L. and Touyz, R.M. (2007) Endothelin-1, but not Ang II, activates MAP kinases through c-Src-independent Ras-Raf-dependent pathways in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(9), pp. 1960-1967. (doi: 10.1161/ATVBAHA.107.146746)

Zargham, R., Touyz, R.M. and Thibault, G. (2007) α8 integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype. Atherosclerosis, 195(2), pp. 303-312. (doi: 10.1016/j.atherosclerosis.2007.01.005)

2006

Touyz, R.M. and Schiffrin, E.L. (2006) Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications. Vascular Pharmacology, 45(1), pp. 19-28. (doi: 10.1016/j.vph.2005.11.014)

Touyz, R.M. (2006) Magnesium and hypertension. Current Opinion in Nephrology and Hypertension, 15(2), pp. 141-144. (doi: 10.1097/01.mnh.0000214773.34480.d4)

Callera, G.E., Tostes, R.C., Yogi, A., Montezano, A.C. and Touyz, R.M. (2006) Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clinical Science, 110(2), pp. 243-253. (doi: 10.1042/CS20050307)

Ducharme, A. et al. (2006) Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. Clinical Science, 110(4), pp. 483-489. (doi: 10.1042/CS20050317)

Javeshghani, D., Sairam, M.R., Neves, M.F., Schiffrin, E.L. and Touyz, R.M. (2006) Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension. Journal of Hypertension, 24(7), pp. 1365-1373. (doi: 10.1097/01.hjh.0000234117.25401.f8)

Ko, E.A., Amiri, F., Pandey, N.R., Javeshghani, D., Leibovitz, E., Touyz, R.M. and Schiffrin, E.L. (2006) Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology: Heart and Circulatory Physiology, 292(4), H1789-H1795. (doi: 10.1152/ajpheart.01118.2006)

Paravicini, T.M. and Touyz, R.M. (2006) Redox signaling in hypertension. Cardiovascular Research, 71(2), pp. 247-258. (doi: 10.1016/j.cardiores.2006.05.001)

Savoia, C., Ebrahimian, T., He, Y., Gratton, J., Schiffrin, E.L. and Touyz, R.M. (2006) Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. Journal of Hypertension, 24(12), pp. 2417-2422. (doi: 10.1097/01.hjh.0000251902.85675.7e)

Savoia, C., Touyz, R.M. , Endemann, D., Pu, Q., Ko, E.A., De Ciuceis, C. and Schriffin, E.L. (2006) Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients. Hypertension, 48(2), pp. 271-277. (doi: 10.1161/01.HYP.0000230234.84356.36)

Schiffrin, E.L. and Touyz, R.M. (2006) Oxidative stress in hypertension. In: Bourassa, M. and Tardif, J.-C. (eds.) Antioxidants in Cardiovascular Disease. Series: Developments in cardiovascular medicine (233). Springer. ISBN 9780387295527

Touyz, R.M. (2006) Lipid rafts take center stage in endothelial cell redox signaling by death receptors. Hypertension, 47(1), pp. 16-18. (doi: 10.1161/01.HYP.0000196730.13216.f3)

Touyz, R.M. (2006) Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4), pp. 685-688. (doi: 10.1161/01.ATV.0000216428.90962.60)

Touyz, R.M. , He, Y., Montezano, A.C., Yao, G., Chubanov, V., Gudermann, T. and Callera, G.E. (2006) Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 290(1), R73-R78. (doi: 10.1152/ajpregu.00515.2005)

Xu, S. and Touyz, R.M. (2006) Reactive oxygen species and vascular remodeling in hypertension: still alive. Canadian Journal of Cardiology, 22(11), pp. 947-951.

2005

Tabet, F., Schiffrin, E.L. and Touyz, R.M. (2005) Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats. Journal of Hypertension, 23(11), pp. 2005-2012.

Santos, R.A.,, Ferreira, A.J., Pinheiro, S.V.B., Sampaio, W.O., Touyz, R.M. and Campagnole-Santos, M.J. (2005) Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs. Expert Opinion on Investigational Drugs, 14(8), pp. 1019-1031. (doi: 10.1517/13543784.14.8.1019)

Touyz, R. (2005) Intracellular mechanisms involved in vascular remodeling of resistance arteries in hypertension: role of angiotensin II. Experimental Physiology, 90(4), pp. 449-455. (doi: 10.1113/expphysiol.2005.030080)

Khan, N.A. et al. (2005) The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II - therapy. Canadian Journal of Cardiology, 21(8), pp. 657-672.

Savoia, C., Tabet, F., Yao, G., Schiffrin, E.L. and Touyz, R.M. (2005) Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. Journal of Hypertension, 23(5), pp. 1037-1045.

Beaucage, P., Iglarz, M., Servant, M., Touyz, R.M. and Moreau, P. (2005) Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis. Journal of Hypertension, 23(2), pp. 329-335.

Callera, G. E., Montezano, A.C., Alvaro, Y., Tostes, R.C., He, Y., Schriffin, E. and Touyz, R.M. (2005) c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension, 46(4), pp. 1032-1038. (doi: 10.1161/01.HYP.0000176588.51027.35)

Callera, G.E., Touyz, R.M. , Tostes, R.C., Yogi, A., He, Y., Malkinson, S. and Schriffin, E.L. (2005) Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension, 45(4), pp. 773-779. (doi: 10.1161/01.HYP.0000154365.30593.d3)

Cruzado, M., Risler, N., Miatello, R., Yao, G., Schriffin, E. and Touyz, R.M. (2005) Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. American Journal of Hypertension, 18(1), pp. 81-87. (doi: 10.1016/j.amjhyper.2004.09.001)

De Ciuceis, C., Amiri, F., Brassard, P., Endemann, D.H., Touyz, R.M. and Schriffin, E.L. (2005) Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of Angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in Angiotensin-induced vascular injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(10), pp. 2106-2113. (doi: 10.1161/01.ATV.0000181743.28028.57)

He, Y., Yao, G., Savoia, C. and Touyz, R.M. (2005) Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of Angiotensin II. Circulation Research, 96(2), pp. 207-215. (doi: 10.1161/01.RES.0000152967.88472.3e)

Jamnik, V.K., Gledhill, N., Touyz, R.M. , Campbell, N.R.C., Logan, A.G., Padwal, R. and Petrella, R. (2005) Lifestyle modifications to prevent and manage hypertension for exercise physiologists and fitness professionals. Canadian Journal of Applied Physiology, 30(6), pp. 754-761. (doi: 10.1139/h05-154)

Padwal, R., Campbell, N.R.C. and Touyz, R.M. (2005) Applying the 2005 Canadian Hypertension Education Program recommendations: 3. Lifestyle modifications to prevent and treat hypertension. Canadian Medical Association Journal, 173(7), pp. 749-751. (doi: 10.1503/cmaj.050186)

Schiffrin, E.L. and Touyz, R.M. (2005) Calcium, magnesium, and oxidative stress in hyperaldosteronism. Circulation, 111(7), pp. 830-831. (doi: 10.1161/01.CIR.0000157186.95918.78)

Touyz, R.M. (2005) Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension, 45(4), pp. 530-537. (doi: 10.1161/01.HYP.0000158845.49943.5e)

Touyz, R.M. (2005) Endothelial cell IL-8, a new target for Adiponectin: implications in vascular protection. Circulation Research, 97(12), pp. 1216-1219. (doi: 10.1161/01.RES.0000196745.09234.36)

Touyz, R.M. (2005) Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II [editorial review]. Current Opinion in Nephrology and Hypertension, 14(2), pp. 125-131.

Touyz, R.M. , Yao, G., Quinn, M.T., Pagano, P.J. and Schriffin, E.L. (2005) p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by Angiotensin II. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(3), pp. 512-518. (doi: 10.1161/01.ATV.0000154141.66879.98)

Touyz, R.M. , Yao, G. and Schiffrin, E.L. (2005) Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology, 83(1), pp. 91-97. (doi: 10.1139/y05-006)

2004

Touyz, R.M. , Yao, G., Viel, E., Amiri, F. and Schiffrin, E.L. (2004) Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. Journal of Hypertension, 22(6), pp. 1141-1149.

Touyz, R. M. (2004) Magnesium in clinical medicine. Frontiers in Bioscience, 9, pp. 1278-1293. (doi: 10.2741/1316) (PMID:14977544)

Touyz, R.M. , Campbell, N., Logan, A., Gledhill, N., Petrella, R. and Padwal, R. (2004) The 2004 Canadian recommendations for the management of hypertension: Part III--Lifestyle modifications to prevent and control hypertension. Canadian Journal of Cardiology, 20(1), pp. 55-59.

Amiri, F., Virdis, A.,, Neves, M.F., Iglarz, M., Seidah, N.G., Touyz, R.M. , Reudelhuber, T.L. and Schiffrin, E.L. (2004) Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation, 110(15), pp. 2233-2240. (doi: 10.1161/01.CIR.0000144462.08345.B9)

Callera, G.E., Montezano, A.C., Touyz, R.M. , Zorn, T.M.T., Carvalho, M.H., Fortes, Z.B., Nigro, D., Schriffin, E.L. and Tostes, R.C. (2004) ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension, 43(4), pp. 872-879. (doi: 10.1161/01.HYP.0000117296.30296.14)

Daigle, C., Martens, F.M.A.C., Girardot, D., Dao, H., Touyz, R.M. and Moreau, P. (2004) Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo. BMC Cardiovascular Disorders, 4(6), (doi: 10.1186/1471-2261-4-6)

Endemann, D.H., Pu, Q., De Ciuceis, C., Savoia, C., Virdis, A., Neves, M.F., Touyz, R.M. and Schriffin, E.L. (2004) Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension, 43(2), pp. 399-404. (doi: 10.1161/01.HYP.0000112029.03691.e7)

Endemann, D.H., Touyz, R.M. , Iglarz, M., Savoia, C. and Schiffrin, E.L. (2004) Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension, 43(6), pp. 1252-1257. (doi: 10.1161/01.HYP.0000128031.31572.a3)

Iglarz, M., Touyz, R.M. , Viel, E.C., Amiri, F. and Schiffrin, E.L. (2004) Involvement of oxidative stress in the profibrotic action of aldosterone: interaction with the renin-angiotensin system. American Journal of Hypertension, 17(7), pp. 597-603. (doi: 10.1016/j.amjhyper.2004.04.005)

Lochard, N., Thibault, G., Silversides, D.W., Touyz, R.M. and Reudelhuber, T.L. (2004) Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist. Circulation Research, 94(11), pp. 1451-1457. (doi: 10.1161/01.RES.0000130654.56599.40)

Mabrouk, M.E., Diep, Q.N., Benkirane, K., Touyz, R.M. and Schriffin, E.L. (2004) SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension. American Journal of Physiology: Heart and Circulatory Physiology, 286(5), H1954-H1962. (doi: 10.1152/ajpheart.00134.2003)

Tabet, F., Savoia, C., Schiffrin, E.L. and Touyz, R.M. (2004) Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 44(2), pp. 200-208. (doi: 10.1097/00005344-200408000-00009)

Touyz, R.M. (2004) Magnesium in clinical medicine. In: Maguire, M.E. (ed.) Encyclopedia of Bioscience. McGraw-Hill.

Touyz, R.M. (2004) Reactive oxygen species and angiotensin II signaling in vascular cells – implications in cardiovascular disease. Brazilian Journal of Medical and Biological Research, 37(8), pp. 1263-1273.

Touyz, R.M. (2004) Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension, 44(3), pp. 248-252. (doi: 10.1161/01.HYP.0000138070.47616.9d)

Touyz, R.M. and Schiffren, E.L. (2004) Reactive oxygen species in vascular biology: implications in hypertension. Histochemistry and Cell Biology, 122, pp. 339-352.

Touyz, R.M. and Schiffrin, E.L. (2004) Hypertension and oxidant stress. In: Holtzman, J.L. (ed.) Atherosclerosis and Oxidant Stress. Kluwer Academic.

Virdis, A., Neves, M.F., Amiri, F., Touyz, R.M. and Schiffrin, E.L. (2004) Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. Journal of Hypertension, 22(3), pp. 535-542.

2003

Touyz, R.M. and Yao, G. (2003) Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. Clinical Science, 105(2), pp. 235-242.

Touyz, R.M. (2003) The role of angiotensin II in regulating vascular structural and functional changes in hypertension. Current Hypertension Reports, 5(2), pp. 155-164. (doi: 10.1007/s11906-003-0073-2)

Callera, G.E., Touyz, R.M. , Teixeira, S.A., Muscara, M.N., Carvalho, M.H., Fortes, Z.B., Nigro, D.N., Schiffrin, E.L. and Tostes, R.C. (2003) ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension, 42(4), pp. 811-817. (doi: 10.1161/01.HYP.0000088363.65943.6C)

Fox, C.H., Ramsoomair, D., Carter, C. and Touyz, R.M. (2003) Magnesium disorders. In: Encyclopedia of Endocrinology. UNSPECIFIED.

Iglarz, M., Touyz, R.M. , Amiri, F., Lavoie, M.F., Diep, Q.N. and Schriffin, E.L. (2003) Effect of peroxisome proliferator-activated receptor-α and -γ activators on vascular remodeling in endothelin-dependent hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(1), pp. 45-51. (doi: 10.1161/01.ATV.0000047447.67827.CD)

Iglarz, M., Touyz, R.M. , Viel, E.C., Paradis, P., Amiri, F., Diep, Q.N. and Schiffrin, E.L. (2003) Peroxisome proliferator-activated receptor-α and receptor-γ activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension, 42(4), pp. 737-743. (doi: 10.1161/01.HYP.0000083511.91817.B1)

Javeshghani, D., Touyz, R.M. , Sairam, M.R., Virdis, A., Neves, M.F. and Schiffrin, E.L. (2003) Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension. Hypertension, 42(4), pp. 761-767. (doi: 10.1161/01.HYP.0000085331.22169.3F)

Pu, Q., Neves, M.F., Virdis, A., Touyz, R.M. and Schriffin, E.L. (2003) Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension, 42(1), pp. 49-55. (doi: 10.1161/01.HYP.0000078357.92682.EC)

Schiffrin, E.L. and Touyz, R.M. (2003) Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation? Arteriosclerosis, Thrombosis, and Vascular Biology, 23(5), pp. 707-709. (doi: 10.1161/01.ATV.0000069907.12357.7E)

Schiffrin, E.L. and Touyz, R.M. (2003) Multiple actions of angiotensin II in hypertension. Journal of the American College of Cardiology, 42(5), pp. 911-913. (doi: 10.1016/S0735-1097(03)00845-3)

Touyz, R.M. (2003) Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone? Journal of Hypertension, 21(12), pp. 2235-2238.

Touyz, R.M. (2003) Pressure-induced expression of vascular neuronal nitric oxide synthase: adaptive or maladaptive response in arteries? Journal of Hypertension, 21(5), pp. 863-865.

Touyz, R.M. (2003) Reactive oxygen species and other mediators of oxidative stress. In: Izzo, J.L. and Black, H.R. (eds.) Hypertension Primer: the Essentials of High Blood Pressure. Lippincott Williams & Wilkins, pp. 52-55. ISBN 9780781745093

Touyz, R.M. (2003) Reactive oxygen species in vascular biology: Role in arterial hypertension. Expert Review of Cardiovascular Therapy, 1(1), pp. 91-106.

Touyz, R.M. (2003) Recent advances in intracellular signaling in hypertension. Current Opinion in Nephrology and Hypertension, 12(2), pp. 165-174.

Touyz, R.M. (2003) Role of magnesium in the pathogenesis of hypertension. In: Cittadini, A. and Wolf, F.I. (eds.) Magnesium: From Biochemistry and Cell Physiology to Clinical Implications. Series: Molecular aspects of medicine (24). Elsevier Science, pp. 107-136.

Touyz, R.M. , Cruzado, M., Tabet, F., Yao, G., Salomon, S. and Schiffrin, E.L. (2003) Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation. Canadian Journal of Physiology and Pharmacology, 81(2), pp. 159-167. (doi: 10.1139/y02-164)

Touyz, R.M. , Tabet, F. and Schiffrin, E.L. (2003) Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clinical and Experimental Pharmacology and Physiology, 30(11), pp. 860-866. (doi: 10.1046/j.1440-1681.2003.03930.x)

Touyz, R.M. and Yao, G. (2003) Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. Journal of Hypertension, 21(2), pp. 337-344.

Touyz, R.M. and Yao, G. (2003) Modulation of vascular smooth muscle cell growth by magnesium-role of mitogen-activated protein kinases. Journal of Cellular Physiology, 197(3), pp. 326-335. (doi: 10.1002/jcp.10393)

Touyz, R.M. , Yao, G. and Schriffin, E.L. (2003) c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(6), pp. 981-987. (doi: 10.1161/01.ATV.0000069236.27911.68)

Virdis, A., Iglarz, M., Neves, M.F., Amiri, F., Touyz, R.M. , Rozen, R. and Schriffin, E.L. (2003) Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(8), pp. 1352-1357. (doi: 10.1161/01.ATV.0000083297.47245.DA)

2002

Touyz, R.M. and Berry, C. (2002) Recent advances in angiotensin II signaling. Brazilian Journal of Medical and Biological Research, 35(9), pp. 1001-1015. (doi: 10.1590/S0100-879X2002000900001) (PMID:12219172)

Tostes, R.C.A., Touyz, R.M. , He, G., Chen, X. and Schiffrin, E.L. (2002) Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clinical Science, 103(Sup 48), 25S-30S.

Endemann, D., Touyz, R.M. , Yoa, G. and Schiffrin, E.L. (2002) Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 40(1), pp. 123-132.

Touyz, R.M. , Deschepper, C., Park, J.B., He, G., Chen, X., Neves, M.F.T., Virdis, A. and Schiffrin, E.L. (2002) Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats. Journal of Hypertension, 20(6), pp. 1127-1134. (doi: 10.1097/00004872-200206000-00024)

Zarnke, K.B. et al. (2002) The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Canadian Journal of Cardiology, 18(6), pp. 604-624.

Pu, Q., Touyz, R.M. and Schiffrin, E.L. (2002) Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. Journal of Hypertension, 20(5), pp. 899-907. (doi: 10.1097/00004872-200205000-00025)

Touyz, R.M. (2002) Impaired vasorelaxation in hypertension: beyond the endothelium. Journal of Hypertension, 20(3), pp. 371-373. (doi: 10.1097/00004872-200203000-00007)

Deschepper, C.F., Picard, S., Thibault, G., Touyz, R.M. and Rouleau, J. (2002) Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats. American Journal of Physiology: Heart and Circulatory Physiology, 282(1), H149-H155. (doi: 10.​1152/​ajpheart.​00672.​2001)

Diep, Q.N., Amiri, F., Touyz, R.M. , Cohn, J.S., Endemann, D., Neves, M.F. and Schriffin, E.L. (2002) PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. Hypertension, 40(6), pp. 866-871. (doi: 10.1161/01.HYP.0000037969.41360.CC)

Park, J.B., Touyz, R.M. , Chen, X. and Schriffin, E.L. (2002) Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 15(1), pp. 78-84. (doi: 10.1016/S0895-7061(01)02233-6)

Tostes, R.C.A., Touyz, R.M. , He, G., Ammarguellat, F. and Schiffrin, E.L. (2002) Endothelin a receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 39(6), pp. 892-900. (doi: 10.1097/00005344-200206000-00015)

Touyz, R.M. , Chen, X., Tabet, F., Yao, G., He, G., Quinn, M., Pagano, P.J. and Schriffin, E.L. (2002) Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circulation Research, 90(11), pp. 1205-1213. (doi: 10.1161/01.RES.0000020404.01971.2F)

Touyz, R.M. , Pu, Q., He, G., Chen, X., Yao, G., Neves, M.F. and Viel, E. (2002) Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats. Journal of Hypertension, 20(11), pp. 2221-2232. (doi: 10.1097/00004872-200211000-00022)

Touyz, R.M. , Wu, X.H., He, G., Steven, S. and Schriffin, E.L. (2002) Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased c-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension, 39(2), pp. 479-485. (doi: 10.1161/hy02t2.102909)

Virdis, A., Neves, M.F., Amiri, F., Viel, E., Touyz, R.M. and Schriffin, E.L. (2002) Spironolactone improves Angiotensin-induced vascular changes and oxidative stress. Hypertension, 40(4), pp. 504-510. (doi: 10.1161/01.HYP.0000034738.79310.06)

2001

El Mabrouk, M., Touyz, R.M. and Schiffrin, E.L. (2001) Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR. American Journal of Physiology: Heart and Circulatory Physiology, 281(1), H30-H39.

Diep, Q.N., El Mabrouk, M., Touyz, R.M. and Schiffrin, E.L. (2001) Expression of cell cycle proteins in blood vessels of angiotensin II-inused rats: role of AT(1) receptors. Hypertension, 37(Part 2), pp. 604-608.

Berry, C., Touyz, R. , Dominiczak, A.F., Webb, R.C. and Johns, D.G. (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology: Heart and Circulatory Physiology, 281(6), H2337-H2365.

Chen, X., Touyz, R.M. , Park, J.B. and Schiffrin, E.L. (2001) Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension, 38(3), pp. 606-611. (doi: 10.1161/hy09t1.094005)

McAlister, F.A. et al. (2001) The 2000 Canadian recommendations for the management of hypertension: Part one--therapy. Canadian Journal of Cardiology, 17(5), pp. 543-559.

Touyz, R.M. (2001) Magnesium responsiveness to Ang II and ET-1 in vascular smooth muscle cells from spontaneously hypertensive rats. In: Rayssiguier, Y., Mazur, A. and Durlach, J. (eds.) Advances in Magnesium Research: Nutrition and Health. John Libbey: Eastleigh, England, pp. 341-347. ISBN 9780861966097

Touyz, R.M. , He, G., El Mabrouk, M., Diep, Q., Mardigyan, V. and Schiffrin, E.L. (2001) Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar–Kyoto rats and spontaneously hypertensive rats. Journal of Hypertension, 19(3 Supp), pp. 553-559. (doi: 10.1097/00004872-200103001-00006)

Touyz, R.M. , He, G., El Mabrouk, M. and Schiffrin, E.L. (2001) p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY. Hypertension, 37(Part 2), pp. 574-580.

Touyz, R.M. , He, G., Wu, X.H., Park, J.B., Mabrouk, M.E. and Schiffrin, E.L. (2001) Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension, 38(1), pp. 56-64.

Touyz, R.M. , Mercure, C. and Reudelhuber, T.L. (2001) Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. Journal of Biological Chemistry, 276(17), pp. 13657-13663. (doi: 10.1074/jbc.M008101200)

Touyz, R.M. and Schiffrin, E.L. (2001) Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. Journal of Hypertension, 19(7), pp. 1245-1254. (doi: 10.1097/00004872-200107000-00009)

Touyz, R.M. , Wu, X., He, G., Park, J.B., Chen, X., Vacher, J., Rajapurohitam, V. and Schiffrin, E.L. (2001) Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells. Journal of Hypertension, 19(3), pp. 441-449. (doi: 10.1097/00004872-200103000-00012)

2000

Touyz, R.M. and Schiffren, E.L. (2000) Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacological Reviews, 52(4), pp. 639-672.

Diep, Q.N., Touyz, R.M. and Schiffrin, E.L. (2000) Docosahexaenoic acid, a peroxisome proliferator-activated receptor- ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension, 36(5), pp. 851-855. (doi: 10.1161/01.HYP.36.5.851)

Touyz, R.M. , Turgeon, A. and Schiffrin, E.L. (2000) Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 36(Sup 1), S300-S304.

Touyz, R.M. and Schiffrin, E.L. (2000) Measurement of intracellular free calcium ion concentration in vascular smooth muscle cells using fura-2. In: Wang, D.H. (ed.) Angiotensin Protocols. Series: Methods in molecular medicine (51). Humana Press, pp. 341-353. ISBN 9780896037632 (doi: 10.1385/1-59259-087-X:341)

Touyz, R.M. (2000) Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. Journal of Hypertension, 18(9), pp. 1177-1191.

El Mabrouk, M., Singh, A., Touyz, R.M. and Schiffrin, E.L. (2000) Antiproliferative effect of L-NAME on rat vascular smooth muscle cells. Life Sciences, 67(13), pp. 1613-1623. (doi: 10.1016/S0024-3205(00)00744-X)

Tea, B.-S., Der Sarkissian, S., Touyz, R.M. , Hamet, P. and deBlois, D. (2000) Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension, 35(5), pp. 1069-1073. (doi: 10.1161/01.HYP.35.5.1069)

Schiffrin, E.L., Park, J.B., Intengan, H.D. and Touyz, R.M. (2000) Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation, 101(14), pp. 1653-1659. (doi: 10.1161/01.CIR.101.14.1653)

Touyz, R.M. , Jiang, L. and Sairiam, M.R. (2000) Follicle-stimulating hormone mediated calcium signaling by the alternatively spliced growth factor type I receptor. Biology of Reproduction, 62(4), pp. 1067-1074. (doi: 10.1095/biolreprod62.4.1067)

Fareh, J., Touyz, R.M. , Schiffrin, E.L. and Thibault, G. (2000) Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Journal of Molecular and Cellular Cardiology, 32(4), pp. 665-676. (doi: 10.1006/jmcc.2000.1110)

Touyz, R.M. (2000) Oxidative stress and vascular damage in hypertension. Current Hypertension Reports, 2(1), pp. 98-105. (doi: 10.1007/s11906-000-0066-3)

Touyz, R.M. (2000) Molecular and cellular mechanisms regulating vascular function and structure--implications in the pathogenesis of hypertension. Canadian Journal of Cardiology, 16(9), pp. 1137-1146.

Touyz, R.M. and Schiffrin, E.L. (2000) Measurement of phospholipase D activation in vascular smooth muscle cells. In: Wang, D.H. (ed.) Angiotensin Protocols. Series: Methods in molecular medicine (51). Humana Press, pp. 355-362. ISBN 9780896037632 (doi: 10.1385/1-59259-087-X:355)

1999

Touyz, R.M. and Schiffrin, E.L. (1999) Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. Hypertension, 34(4), pp. 976-982. (doi: 10.1161/01.HYP.34.4.976)

Touyz, R.M. and Schiffrin, E.L. (1999) Activation of the Na+-H+ exchanger modulates angiotensin II stimulated Na+-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension. Hypertension, 34(3), pp. 442-449. (doi: 10.1161/01.HYP.34.3.442)

Touyz, R.M. and Milne, F.J. (1999) Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension, 12(8), pp. 757-765. (doi: 10.1016/S0895-7061(99)00064-3)

Babu, P.S., Jiang, L., Sairam, A.M., Touyz, R.M. and Sairam, M.R. (1999) Structural features and expression of an alternatively spliced growth factor type I receptor for follitropin signaling in the developing ovary. Molecular Cell Biology Research Communications, 2(1), pp. 21-27. (doi: 10.1006/mcbr.1999.0139)

Endemann, D., Touyz, R.M. , Li, J.-S. and Schiffrin, E.L. (1999) Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension, 12(7), pp. 716-723. (doi: 10.1016/S0895-7061(99)00036-9)

Touyz, R.M. , Deng, L.-Y., He, G., Wu, X.-H. and Schiffrin, E.L. (1999) Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases. Journal of Hypertension, 17(7), pp. 907-916.

Touyz, R.M. , El Mabrouk, M., He, G., Wu, X.-H. and Schiffrin, E.L. (1999) Mitogen-activated protein/extracellular signal regulated kinase inhibition attenuates angiotensin II mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circulation Research, 84(5), pp. 505-515. (doi: 10.1161/01.RES.84.5.505)

Touyz, R.M. , He, G., Deng, L.-Y. and Schiffrin, E.L. (1999) Role of extracellular signal-regulated kinases in angiotensin II stimulated contraction of smooth muscle cells from human resistance arteries. Circulation, 99(3), pp. 392-399. (doi: 10.1161/01.CIR.99.3.392)

Touyz, R.M. , Endemann, D., He, G., Li, J.-S. and Schiffrin, E.L. (1999) Role of AT2 receptors in angiotensin II stimulated contraction of small mesenteric arteries in young SHR. Hypertension, 33(1), pp. 366-372. (doi: 10.1161/01.HYP.33.1.366)