Dr David Alexander Dickie
- Affiliate (School of Cardiovascular & Metabolic Health)
https://orcid.org/0000-0002-9443-8403Biography
David is a Stroke Association Research Fellow working on improving the utility of brain MRI in stroke and dementia. He has a BSc (Hons) in Technology Business Studies from the University of Strathclyde, a MSc in Industrial Engineering from The University of Iowa, and a PhD in Clinical Science from The University of Edinburgh. His main interest is in developing automated assessments of brain health from MRI for predicting stroke outcome, cognitive impairment and dementia.
Research interests
- Stroke
- Dementia
- Brain MRI
- Cognition
- Functional status
- Outcome prediction
Publications
2024
Watt, J. K., Dickie, D. A. , Ho, F. K., Lyall, D. M. , Dawson, J. , Quinn, T. J. and European Prevention of Alzheimer's Disease (EPAD) Consortium, (2024) Validation of the brain health index in the European Prevention of Alzheimer's Dementia cohort. Cerebral Circulation - Cognition and Behavior, 6, p. 100214. (doi: 10.1016/j.cccb.2024.100214) (PMID:38595911) (PMCID:PMC11002803)
MacDonald, A. S. et al. (2024) Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST. Journal of Human Hypertension, 38, pp. 307-313. (doi: 10.1038/s41371-024-00906-5) (PMID:38438602) (PMCID:PMC11001576)
2023
Kimberley, T. J., Prudente, C. N., Engineer, N. D., Dickie, D. A. , Bisson, T. A. and Van de Winckel, A. (2023) Vagus nerve stimulation paired with mobility training in chronic ischemic stroke: a case report. Physical Therapy and Rehabilitation Journal, 103(12), pzad097. (doi: 10.1093/ptj/pzad097) (PMID:37669130) (PMCID:PMC10748760)
Watt, J. K., Dickie, D. A. , Lyall, D. , Ward, J. , Ho, F., Dawson, J. and Quinn, T. J. (2023) Normative values of the brain health index in UK biobank. Neuroimage: Reports, 3(3), 100176. (doi: 10.1016/j.ynirp.2023.100176)
Dawson, J. et al. (2023) Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial. EClinicalMedicine, 57, 101863. (doi: 10.1016/j.eclinm.2023.101863) (PMID:36864979) (PMCID:PMC9972492)
2022
Jochems, A. C. C. et al. (2022) Contribution of white matter hyperintensities to ventricular enlargement in older adults. NeuroImage: Clinical, 34, 103019. (doi: 10.1016/j.nicl.2022.103019) (PMID:35490587) (PMCID:PMC9062739)
2021
Moreton, F. C., Cullen, B. , Dickie, D. A. , Lopez Gonzalez, R., Santosh, C., Delles, C. and Muir, K. W. (2021) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up. European Journal of Neurology, 28(1), pp. 220-228. (doi: 10.1111/ene.14534) (PMID:32931073)
2020
Dickie, D. A. , Gardner, K., Wagener, A., Wyss, A., Arba, F., Wardlaw, J. M. and Dawson, J. (2020) Cortical thickness, white matter hyperintensities, and cognition after stroke. International Journal of Stroke, 15(1), pp. 46-54. (doi: 10.1177/1747493019851291) (PMID:31088224)
Shi, Y., Thrippleton, M. J., Blair, G. W., Dickie, D. A. , Marshall, I., Hamilton, I., Doubal, F. N., Chappell, F. and Wardlaw, J. M. (2020) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism, 40(1), pp. 85-99. (doi: 10.1177/0271678X18803956) (PMID:30295558)
2019
Dickie, D. A. , Kimberley, T. J., Pierce, D., Engineer, N., Tarver, W. B. and Dawson, J. (2019) An exploratory study of predictors of response to vagus nerve stimulation paired with upper-limb rehabilitation after ischemic stroke. Scientific Reports, 9, 15902. (doi: 10.1038/s41598-019-52092-x) (PMID:31685853) (PMCID:PMC6828969)
Wyss, A., Dawson, J. , Arba, F., Wardlaw, J. M. and Dickie, D. A. (2019) Combining neurovascular and neurodegenerative magnetic resonance imaging measures in stroke. Stroke, 50(5), pp. 1136-1139. (doi: 10.1161/STROKEAHA.118.024181) (PMID:31009345)
Abdul-Rahim, A. H. , Dickie, D. A. , Selvarajah, J. R., Lees, K. R. and Quinn, T. J. (2019) Stroke aetiological classification reliability and effect on trial sample size: systematic review, meta-analysis and statistical modelling. Trials, 20, 107. (doi: 10.1186/s13063-019-3222-x) (PMID:30736833) (PMCID:PMC6368715)
Findlay, M. D., Dawson, J. , Dickie, D. A. , Forbes, K. P., McGlynn, D., Quinn, T. and Mark, P. B. (2019) Investigating the relationship between cerebral blood flow and cognitive function in hemodialysis patients. Journal of the American Society of Nephrology, 30(10194), pp. 147-158. (doi: 10.1681/ASN.2018050462) (PMID:30530658) (PMCID:PMC6317612)
2018
Kimberley, T. J. et al. (2018) Vagus nerve stimulation paired with upper limb rehabilitation after chronic stroke. Stroke, 49(11), pp. 2789-2792. (doi: 10.1161/strokeaha.118.022279) (PMID:30355189)
Dickie, D. A. , Valdés Hernández, M. d. C., Makin, S. D., Staals, J., Wiseman, S. J., Bastin, M. E. and Wardlaw, J. M. (2018) The brain health index: towards a combined measure of neurovascular and neurodegenerative structural brain injury. International Journal of Stroke, 13(8), pp. 849-856. (doi: 10.1177/1747493018770222) (PMID:29672236)
Cox, S. R. et al. (2018) Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936. Neurobiology of Aging, 69, pp. 274-282. (doi: 10.1016/j.neurobiolaging.2018.05.029) (PMID:29933100) (PMCID:PMC6075468)
Dawson, J. et al. (2018) Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) – Protocol for a randomised double blind placebo-controlled clinical trial. European Stroke Journal, 3(3), pp. 281-290. (doi: 10.1177/2396987318771426) (PMID:30246149) (PMCID:PMC6120121)
Lewis, G. J., Dickie, D. A. , Cox, S. R., Karama, S., Evans, A. C., Starr, J. M., Bastin, M. E., Wardlaw, J. M. and Deary, I. J. (2018) Widespread associations between trait conscientiousness and thickness of brain cortical regions. NeuroImage, 176, pp. 22-28. (doi: 10.1016/j.neuroimage.2018.04.033) (PMID:29665419) (PMCID:PMC5986708)
Marshall, I. et al. (2018) Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265(8), pp. 1795-1802. (doi: 10.1007/s00415-018-8903-y) (PMID:29846780) (PMCID:PMC6060762)
Qin, C., Guerrero, R., Bowles, C., Chen, L., Dickie, D. A. , Valdes-Hernandez, M. d. C., Wardlaw, J. and Rueckert, D. (2018) A large margin algorithm for automated segmentation of white matter hyperintensity. Pattern Recognition, 77, pp. 150-159. (doi: 10.1016/j.patcog.2017.12.016)
Ritchie, S. J. et al. (2018) Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume. Neurobiology of Aging, 62, pp. 146-158. (doi: 10.1016/j.neurobiolaging.2017.10.005) (PMID:29149632) (PMCID:PMC5759896)
Wiseman, S. J. et al. (2018) Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. Human Brain Mapping, 39(2), pp. 622-632. (doi: 10.1002/hbm.23857) (PMID:29139161) (PMCID:PMC5813175)
Pinter, D. et al. (2018) Predictors of gait speed and its change over three years in community-dwelling older people. Aging, 10(1), pp. 144-153. (doi: 10.18632/aging.101365) (PMID:29356686) (PMCID:PMC5811248)
Cox, S. R. et al. (2018) Brain cortical characteristics of lifetime cognitive ageing. Brain Structure and Function, 223(1), pp. 509-518. (doi: 10.1007/s00429-017-1505-0) (PMID:28879544) (PMCID:PMC5772145)
Dickie, D. A. et al. (2018) Blood pressure variability and leukoaraiosis in acute ischemic stroke. International Journal of Stroke, 13(5), pp. 473-480. (doi: 10.1177/1747493017729267) (PMID:28872448)
Guerrero, R. et al. (2018) White matter hyperintensity and stroke lesion segmentation and differentiation using convolutional neural networks. NeuroImage: Clinical, 17, pp. 918-934. (doi: 10.1016/j.nicl.2017.12.022) (PMID:29527496) (PMCID:PMC5842732)
2017
Ritchie, S. J. et al. (2017) Risk and protective factors for structural brain ageing in the eighth decade of life. Brain Structure and Function, 222(8), pp. 3477-3490. (doi: 10.1007/s00429-017-1414-2) (PMID:28424895) (PMCID:PMC5676817)
MacPherson, S. E., Cox, S. R., Dickie, D. A. , Karama, S., Starr, J. M., Evans, A. C., Bastin, M. E., Wardlaw, J. M. and Deary, I. J. (2017) Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults. Cortex, 95, pp. 92-103. (doi: 10.1016/j.cortex.2017.07.021) (PMID:28865241) (PMCID:PMC5637162)
Valdés Hernández, M. D. C. et al. (2017) Metric to quantify white matter damage on brain magnetic resonance images. Neuroradiology, 59(10), pp. 951-962. (doi: 10.1007/s00234-017-1892-1) (PMID:28815362) (PMCID:PMC5596039)
Cox, S. R. et al. (2017) Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76. Neurobiology of Aging, 54, pp. 54-58. (doi: 10.1016/j.neurobiolaging.2017.02.014) (PMID:28324763) (PMCID:PMC5407886)
Shenkin, S. D. et al. (2017) Improving data availability for brain image biobanking in healthy subjects: practice-based suggestions from an international multidisciplinary working group. NeuroImage, 153, pp. 399-409. (doi: 10.1016/j.neuroimage.2017.02.030) (PMID:28232121) (PMCID:PMC5798604)
Shi, Y., Thrippleton, M., Blair, G., Marshall, I., Hamilton, I., Dickie, D. , Doubal, F. and Wardlaw, J. (2017) Cerebral Blood Flow in Patients with White Matter Hyperintensities and Effect of Co-variates. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function and the 13th International Conference on Quantification of Brain Function with PET, Berlin, Germany, 01-04 Apr 2017. (doi: 10.1177/0271678X17695982)
Pinter, D. et al. (2017) Impact of small vessel disease in the brain on gait and balance. Scientific Reports, 7, 41637. (doi: 10.1038/srep41637) (PMID:28134332) (PMCID:PMC5278543)
Dickie, D. A. , Shenkin, S. D., Anblagan, D., Lee, J., Blesa Cabez, M., Rodriguez, D., Boardman, J. P., Waldman, A., Job, D. E. and Wardlaw, J. M. (2017) Whole brain magnetic resonance image atlases: a systematic review of existing atlases and caveats for use in population imaging. Frontiers in Neuroinformatics, 11, 1. (doi: 10.3389/fninf.2017.00001) (PMID:28154532) (PMCID:PMC5244468)
Job, D. E. et al. (2017) A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS). NeuroImage, 144, pp. 299-304. (doi: 10.1016/j.neuroimage.2016.01.027) (PMID:26794641)
Luciano, M. et al. (2017) Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort. Neurology, 88(5), pp. 449-455. (doi: 10.1212/WNL.0000000000003559) (PMID:28053008) (PMCID:PMC5278943)
Bowles, C., Qin, C., Guerrero, R., Gunn, R., Hammers, A., Dickie, D. A. , Valdés Hernández, M., Wardlaw, J. and Rueckert, D. (2017) Brain lesion segmentation through image synthesis and outlier detection. NeuroImage: Clinical, 16, pp. 643-658. (doi: 10.1016/j.nicl.2017.09.003) (PMID:29868438) (PMCID:PMC5984574)
2016
Danso, S. O., Job, D. E., Gonzalez, D. R., Dickie, D. A. , Palmer, J., Ure, J., Bath, P. M., Sandercock, P. A. G. and Wardlaw, J. M. (2016) Developing an integrated image bank and metadata for large-scale research in cerebrovascular disease: our experience from the Stroke Image Bank Project. Frontiers in ICT, 3, 32. (doi: 10.3389/fict.2016.00032)
Cox, S. R. et al. (2016) Associations between education and brain structure at age 73 years, adjusted for age 11 IQ. Neurology, 87(17), pp. 1820-1826. (doi: 10.1212/WNL.0000000000003247) (PMID:27664981) (PMCID:PMC5089529)
Dickie, D. A. et al. (2016) Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936. Neurobiology of Aging, 42, pp. 116-123. (doi: 10.1016/j.neurobiolaging.2016.03.011) (PMID:27143428) (PMCID:PMC4869590)
Dickie, D. A. et al. (2016) Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects. Stroke, 47(2), pp. 410-416. (doi: 10.1161/STROKEAHA.115.011229) (PMID:26696646) (PMCID:PMC5633325)
2015
Dickie, D. A. , Mikhael, S., Job, D. E., Wardlaw, J. M., Laidlaw, D. H. and Bastin, M. E. (2015) Permutation and parametric tests for effect sizes in voxel-based morphometry of gray matter volume in brain structural MRI. Magnetic Resonance Imaging, 33(10), pp. 1299-1305. (doi: 10.1016/j.mri.2015.07.014) (PMID:26253778) (PMCID:PMC4658290)
Ritchie, S. J. et al. (2015) Brain volumetric changes and cognitive ageing during the eighth decade of life. Human Brain Mapping, 36(12), pp. 4910-4925. (doi: 10.1002/hbm.22959) (PMID:26769551) (PMCID:PMC4832269)
Dickie, D. A. , Job, D. E., Gonzalez, D. R., Shenkin, S. D. and Wardlaw, J. M. (2015) Use of brain MRI atlases to determine boundaries of age-related pathology: the importance of statistical method. PLoS ONE, 10(5), e0127939. (doi: 10.1371/journal.pone.0127939) (PMID:26023913) (PMCID:PMC4449178)
2014
del C. Valdés Hernández, M., Glatz, A., Kiker, A. J., Dickie, D. A. , Aribisala, B. S., Royle, N. A., Muñoz Maniega, S., Bastin, M. E., Deary, I. J. and Wardlaw, J. M. (2014) Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images. Journal of Magnetic Resonance Imaging, 40(2), pp. 324-333. (doi: 10.1002/jmri.24348) (PMID:24923620)
2013
Dickie, D. A. , Job, D. E., Gonzalez, D. R., Shenkin, S. D., Ahearn, T. S., Murray, A. D. and Wardlaw, J. M. (2013) Variance in brain volume with advancing age: implications for defining the limits of normality. PLoS ONE, 8(12), e84093. (doi: 10.1371/journal.pone.0084093) (PMID:24367629) (PMCID:PMC3868601)
Valdés Hernández, M. d. C., Morris, Z., Dickie, D. A. , Royle, N. A., Muñoz Maniega, S., Aribisala, B. S., Bastin, M. E., Deary, I. J. and Wardlaw, J. M. (2013) Close correlation between quantitative and qualitative assessments of white matter lesions. Neuroepidemiology, 40(1), pp. 13-22. (doi: 10.1159/000341859) (PMID:23075702)
Articles
Watt, J. K., Dickie, D. A. , Ho, F. K., Lyall, D. M. , Dawson, J. , Quinn, T. J. and European Prevention of Alzheimer's Disease (EPAD) Consortium, (2024) Validation of the brain health index in the European Prevention of Alzheimer's Dementia cohort. Cerebral Circulation - Cognition and Behavior, 6, p. 100214. (doi: 10.1016/j.cccb.2024.100214) (PMID:38595911) (PMCID:PMC11002803)
MacDonald, A. S. et al. (2024) Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST. Journal of Human Hypertension, 38, pp. 307-313. (doi: 10.1038/s41371-024-00906-5) (PMID:38438602) (PMCID:PMC11001576)
Kimberley, T. J., Prudente, C. N., Engineer, N. D., Dickie, D. A. , Bisson, T. A. and Van de Winckel, A. (2023) Vagus nerve stimulation paired with mobility training in chronic ischemic stroke: a case report. Physical Therapy and Rehabilitation Journal, 103(12), pzad097. (doi: 10.1093/ptj/pzad097) (PMID:37669130) (PMCID:PMC10748760)
Watt, J. K., Dickie, D. A. , Lyall, D. , Ward, J. , Ho, F., Dawson, J. and Quinn, T. J. (2023) Normative values of the brain health index in UK biobank. Neuroimage: Reports, 3(3), 100176. (doi: 10.1016/j.ynirp.2023.100176)
Dawson, J. et al. (2023) Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial. EClinicalMedicine, 57, 101863. (doi: 10.1016/j.eclinm.2023.101863) (PMID:36864979) (PMCID:PMC9972492)
Jochems, A. C. C. et al. (2022) Contribution of white matter hyperintensities to ventricular enlargement in older adults. NeuroImage: Clinical, 34, 103019. (doi: 10.1016/j.nicl.2022.103019) (PMID:35490587) (PMCID:PMC9062739)
Moreton, F. C., Cullen, B. , Dickie, D. A. , Lopez Gonzalez, R., Santosh, C., Delles, C. and Muir, K. W. (2021) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up. European Journal of Neurology, 28(1), pp. 220-228. (doi: 10.1111/ene.14534) (PMID:32931073)
Dickie, D. A. , Gardner, K., Wagener, A., Wyss, A., Arba, F., Wardlaw, J. M. and Dawson, J. (2020) Cortical thickness, white matter hyperintensities, and cognition after stroke. International Journal of Stroke, 15(1), pp. 46-54. (doi: 10.1177/1747493019851291) (PMID:31088224)
Shi, Y., Thrippleton, M. J., Blair, G. W., Dickie, D. A. , Marshall, I., Hamilton, I., Doubal, F. N., Chappell, F. and Wardlaw, J. M. (2020) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism, 40(1), pp. 85-99. (doi: 10.1177/0271678X18803956) (PMID:30295558)
Dickie, D. A. , Kimberley, T. J., Pierce, D., Engineer, N., Tarver, W. B. and Dawson, J. (2019) An exploratory study of predictors of response to vagus nerve stimulation paired with upper-limb rehabilitation after ischemic stroke. Scientific Reports, 9, 15902. (doi: 10.1038/s41598-019-52092-x) (PMID:31685853) (PMCID:PMC6828969)
Wyss, A., Dawson, J. , Arba, F., Wardlaw, J. M. and Dickie, D. A. (2019) Combining neurovascular and neurodegenerative magnetic resonance imaging measures in stroke. Stroke, 50(5), pp. 1136-1139. (doi: 10.1161/STROKEAHA.118.024181) (PMID:31009345)
Abdul-Rahim, A. H. , Dickie, D. A. , Selvarajah, J. R., Lees, K. R. and Quinn, T. J. (2019) Stroke aetiological classification reliability and effect on trial sample size: systematic review, meta-analysis and statistical modelling. Trials, 20, 107. (doi: 10.1186/s13063-019-3222-x) (PMID:30736833) (PMCID:PMC6368715)
Findlay, M. D., Dawson, J. , Dickie, D. A. , Forbes, K. P., McGlynn, D., Quinn, T. and Mark, P. B. (2019) Investigating the relationship between cerebral blood flow and cognitive function in hemodialysis patients. Journal of the American Society of Nephrology, 30(10194), pp. 147-158. (doi: 10.1681/ASN.2018050462) (PMID:30530658) (PMCID:PMC6317612)
Kimberley, T. J. et al. (2018) Vagus nerve stimulation paired with upper limb rehabilitation after chronic stroke. Stroke, 49(11), pp. 2789-2792. (doi: 10.1161/strokeaha.118.022279) (PMID:30355189)
Dickie, D. A. , Valdés Hernández, M. d. C., Makin, S. D., Staals, J., Wiseman, S. J., Bastin, M. E. and Wardlaw, J. M. (2018) The brain health index: towards a combined measure of neurovascular and neurodegenerative structural brain injury. International Journal of Stroke, 13(8), pp. 849-856. (doi: 10.1177/1747493018770222) (PMID:29672236)
Cox, S. R. et al. (2018) Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936. Neurobiology of Aging, 69, pp. 274-282. (doi: 10.1016/j.neurobiolaging.2018.05.029) (PMID:29933100) (PMCID:PMC6075468)
Dawson, J. et al. (2018) Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) – Protocol for a randomised double blind placebo-controlled clinical trial. European Stroke Journal, 3(3), pp. 281-290. (doi: 10.1177/2396987318771426) (PMID:30246149) (PMCID:PMC6120121)
Lewis, G. J., Dickie, D. A. , Cox, S. R., Karama, S., Evans, A. C., Starr, J. M., Bastin, M. E., Wardlaw, J. M. and Deary, I. J. (2018) Widespread associations between trait conscientiousness and thickness of brain cortical regions. NeuroImage, 176, pp. 22-28. (doi: 10.1016/j.neuroimage.2018.04.033) (PMID:29665419) (PMCID:PMC5986708)
Marshall, I. et al. (2018) Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265(8), pp. 1795-1802. (doi: 10.1007/s00415-018-8903-y) (PMID:29846780) (PMCID:PMC6060762)
Qin, C., Guerrero, R., Bowles, C., Chen, L., Dickie, D. A. , Valdes-Hernandez, M. d. C., Wardlaw, J. and Rueckert, D. (2018) A large margin algorithm for automated segmentation of white matter hyperintensity. Pattern Recognition, 77, pp. 150-159. (doi: 10.1016/j.patcog.2017.12.016)
Ritchie, S. J. et al. (2018) Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume. Neurobiology of Aging, 62, pp. 146-158. (doi: 10.1016/j.neurobiolaging.2017.10.005) (PMID:29149632) (PMCID:PMC5759896)
Wiseman, S. J. et al. (2018) Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. Human Brain Mapping, 39(2), pp. 622-632. (doi: 10.1002/hbm.23857) (PMID:29139161) (PMCID:PMC5813175)
Pinter, D. et al. (2018) Predictors of gait speed and its change over three years in community-dwelling older people. Aging, 10(1), pp. 144-153. (doi: 10.18632/aging.101365) (PMID:29356686) (PMCID:PMC5811248)
Cox, S. R. et al. (2018) Brain cortical characteristics of lifetime cognitive ageing. Brain Structure and Function, 223(1), pp. 509-518. (doi: 10.1007/s00429-017-1505-0) (PMID:28879544) (PMCID:PMC5772145)
Dickie, D. A. et al. (2018) Blood pressure variability and leukoaraiosis in acute ischemic stroke. International Journal of Stroke, 13(5), pp. 473-480. (doi: 10.1177/1747493017729267) (PMID:28872448)
Guerrero, R. et al. (2018) White matter hyperintensity and stroke lesion segmentation and differentiation using convolutional neural networks. NeuroImage: Clinical, 17, pp. 918-934. (doi: 10.1016/j.nicl.2017.12.022) (PMID:29527496) (PMCID:PMC5842732)
Ritchie, S. J. et al. (2017) Risk and protective factors for structural brain ageing in the eighth decade of life. Brain Structure and Function, 222(8), pp. 3477-3490. (doi: 10.1007/s00429-017-1414-2) (PMID:28424895) (PMCID:PMC5676817)
MacPherson, S. E., Cox, S. R., Dickie, D. A. , Karama, S., Starr, J. M., Evans, A. C., Bastin, M. E., Wardlaw, J. M. and Deary, I. J. (2017) Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults. Cortex, 95, pp. 92-103. (doi: 10.1016/j.cortex.2017.07.021) (PMID:28865241) (PMCID:PMC5637162)
Valdés Hernández, M. D. C. et al. (2017) Metric to quantify white matter damage on brain magnetic resonance images. Neuroradiology, 59(10), pp. 951-962. (doi: 10.1007/s00234-017-1892-1) (PMID:28815362) (PMCID:PMC5596039)
Cox, S. R. et al. (2017) Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76. Neurobiology of Aging, 54, pp. 54-58. (doi: 10.1016/j.neurobiolaging.2017.02.014) (PMID:28324763) (PMCID:PMC5407886)
Shenkin, S. D. et al. (2017) Improving data availability for brain image biobanking in healthy subjects: practice-based suggestions from an international multidisciplinary working group. NeuroImage, 153, pp. 399-409. (doi: 10.1016/j.neuroimage.2017.02.030) (PMID:28232121) (PMCID:PMC5798604)
Pinter, D. et al. (2017) Impact of small vessel disease in the brain on gait and balance. Scientific Reports, 7, 41637. (doi: 10.1038/srep41637) (PMID:28134332) (PMCID:PMC5278543)
Dickie, D. A. , Shenkin, S. D., Anblagan, D., Lee, J., Blesa Cabez, M., Rodriguez, D., Boardman, J. P., Waldman, A., Job, D. E. and Wardlaw, J. M. (2017) Whole brain magnetic resonance image atlases: a systematic review of existing atlases and caveats for use in population imaging. Frontiers in Neuroinformatics, 11, 1. (doi: 10.3389/fninf.2017.00001) (PMID:28154532) (PMCID:PMC5244468)
Job, D. E. et al. (2017) A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS). NeuroImage, 144, pp. 299-304. (doi: 10.1016/j.neuroimage.2016.01.027) (PMID:26794641)
Luciano, M. et al. (2017) Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort. Neurology, 88(5), pp. 449-455. (doi: 10.1212/WNL.0000000000003559) (PMID:28053008) (PMCID:PMC5278943)
Bowles, C., Qin, C., Guerrero, R., Gunn, R., Hammers, A., Dickie, D. A. , Valdés Hernández, M., Wardlaw, J. and Rueckert, D. (2017) Brain lesion segmentation through image synthesis and outlier detection. NeuroImage: Clinical, 16, pp. 643-658. (doi: 10.1016/j.nicl.2017.09.003) (PMID:29868438) (PMCID:PMC5984574)
Danso, S. O., Job, D. E., Gonzalez, D. R., Dickie, D. A. , Palmer, J., Ure, J., Bath, P. M., Sandercock, P. A. G. and Wardlaw, J. M. (2016) Developing an integrated image bank and metadata for large-scale research in cerebrovascular disease: our experience from the Stroke Image Bank Project. Frontiers in ICT, 3, 32. (doi: 10.3389/fict.2016.00032)
Cox, S. R. et al. (2016) Associations between education and brain structure at age 73 years, adjusted for age 11 IQ. Neurology, 87(17), pp. 1820-1826. (doi: 10.1212/WNL.0000000000003247) (PMID:27664981) (PMCID:PMC5089529)
Dickie, D. A. et al. (2016) Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936. Neurobiology of Aging, 42, pp. 116-123. (doi: 10.1016/j.neurobiolaging.2016.03.011) (PMID:27143428) (PMCID:PMC4869590)
Dickie, D. A. et al. (2016) Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects. Stroke, 47(2), pp. 410-416. (doi: 10.1161/STROKEAHA.115.011229) (PMID:26696646) (PMCID:PMC5633325)
Dickie, D. A. , Mikhael, S., Job, D. E., Wardlaw, J. M., Laidlaw, D. H. and Bastin, M. E. (2015) Permutation and parametric tests for effect sizes in voxel-based morphometry of gray matter volume in brain structural MRI. Magnetic Resonance Imaging, 33(10), pp. 1299-1305. (doi: 10.1016/j.mri.2015.07.014) (PMID:26253778) (PMCID:PMC4658290)
Ritchie, S. J. et al. (2015) Brain volumetric changes and cognitive ageing during the eighth decade of life. Human Brain Mapping, 36(12), pp. 4910-4925. (doi: 10.1002/hbm.22959) (PMID:26769551) (PMCID:PMC4832269)
Dickie, D. A. , Job, D. E., Gonzalez, D. R., Shenkin, S. D. and Wardlaw, J. M. (2015) Use of brain MRI atlases to determine boundaries of age-related pathology: the importance of statistical method. PLoS ONE, 10(5), e0127939. (doi: 10.1371/journal.pone.0127939) (PMID:26023913) (PMCID:PMC4449178)
del C. Valdés Hernández, M., Glatz, A., Kiker, A. J., Dickie, D. A. , Aribisala, B. S., Royle, N. A., Muñoz Maniega, S., Bastin, M. E., Deary, I. J. and Wardlaw, J. M. (2014) Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images. Journal of Magnetic Resonance Imaging, 40(2), pp. 324-333. (doi: 10.1002/jmri.24348) (PMID:24923620)
Dickie, D. A. , Job, D. E., Gonzalez, D. R., Shenkin, S. D., Ahearn, T. S., Murray, A. D. and Wardlaw, J. M. (2013) Variance in brain volume with advancing age: implications for defining the limits of normality. PLoS ONE, 8(12), e84093. (doi: 10.1371/journal.pone.0084093) (PMID:24367629) (PMCID:PMC3868601)
Valdés Hernández, M. d. C., Morris, Z., Dickie, D. A. , Royle, N. A., Muñoz Maniega, S., Aribisala, B. S., Bastin, M. E., Deary, I. J. and Wardlaw, J. M. (2013) Close correlation between quantitative and qualitative assessments of white matter lesions. Neuroepidemiology, 40(1), pp. 13-22. (doi: 10.1159/000341859) (PMID:23075702)
Conference or Workshop Item
Shi, Y., Thrippleton, M., Blair, G., Marshall, I., Hamilton, I., Dickie, D. , Doubal, F. and Wardlaw, J. (2017) Cerebral Blood Flow in Patients with White Matter Hyperintensities and Effect of Co-variates. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function and the 13th International Conference on Quantification of Brain Function with PET, Berlin, Germany, 01-04 Apr 2017. (doi: 10.1177/0271678X17695982)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Clinical translation of an automated brain MRI health score
Office of the Chief Scientific Adviser
2020 - 2022
