Dr Nicholas Graham
- Honorary lecturer (School of Health & Wellbeing)
email:
Nicholas.Graham@glasgow.ac.uk
Mental Health and Wellbeing, University of Glasgow, 1st Floor, Admin building, Gartnavel Royal Hospital
Publications
2024
Hill, N., Graham, N. and Forrester, R. L. (2024) Routine sensitive enquiry of adult interpersonal trauma in community mental health teams: an audit of the initial assessment tool. Community Mental Health Journal, 60, pp. 691-698. (doi: 10.1007/s10597-023-01220-z) (PMID:38363438) (PMCID:PMC11001718)
2023
Strawbridge, R. J. and Graham, N. (2023) Dissecting the genetic relationship between schizophrenia and cardiovascular disease. American Journal of Psychiatry, 180(11), pp. 785-786. (doi: 10.1176/appi.ajp.20230714) (PMID:37908093)
Forsyth, L., Aman, A. , Cullen, B. , Graham, N., Lyall, D. M. , Lyall, L. M., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2023) Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank. Journal of Affective Disorders, 339, pp. 943-953. (doi: 10.1016/j.jad.2023.07.052) (PMID:37487843)
Ward, J. et al. (2023) Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Advances, (doi: 10.1182/bloodadvances.2023010562) (PMID:37399490) (In Press)
2022
Aman, A. , Slob, E. A.W., Ward, J. , Cullen, B. , Graham, N., Lyall, D. M. , Sattar, N. and Strawbridge, R. J. (2022) Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization. PLoS ONE, 17(12), e0279381. (doi: 10.1371/journal.pone.0279381) (PMID:36580462) (PMCID:PMC9799310)
Hay, R., Cullen, B. , Graham, N., Lyall, D. M. , Aman, A. , Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2022) Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank. European Journal of Human Genetics, 30(12), pp. 1380-1390. (doi: 10.1038/s41431-022-01107-9) (PMID:35501368) (PMCID:PMC9712543)
2021
Burt, O., Johnston, K. J.A., Graham, N., Cullen, B. , Lyall, D. M. , Lyall, L. M., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2021) Genetic variation in the ASTN2 locus in cardiovascular, metabolic and psychiatric traits: evidence for pleiotropy rather than shared biology. Genes, 12(8), 1194. (doi: 10.3390/genes12081194) (PMID:34440368) (PMCID:PMC8391428)
Shaw, R. , Cullen, B. , Graham, N., Lyall, D. , Mackay, D. , Okolie, C., Pearsall, R., Ward, J. , John, A. and Smith, D. (2021) Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: a nine-year follow up of the UK Biobank cohort. Journal of Affective Disorders, 279, pp. 316-323. (doi: 10.1016/j.jad.2020.10.026) (PMID:33096330)
Strawbridge, R. J. et al. (2021) The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Scientific Reports, 11, 632. (doi: 10.1038/s41598-020-79964-x) (PMID:33436761) (PMCID:PMC7804422)
2020
Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)
Ward, J. et al. (2020) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, 25(11), pp. 3091-3099. (doi: 10.1038/s41380-019-0439-8) (PMID:31168069) (PMCID:PMC7116257)
Davis, K. A.S. et al. (2020) Mental health in UK Biobank – development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis. BJPsych Open, 6(2), e18. (doi: 10.1192/bjo.2019.100) (PMID:32026800) (PMCID:PMC7176892)
Strawbridge, R. J. et al. (2020) Carotid intima-media thickness: novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(2), pp. 446-461. (doi: 10.1161/ATVBAHA.119.313226) (PMID:31801372) (PMCID:PMC6975521)
2019
Ward, J. et al. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. Translational Psychiatry, 9, 327. (doi: 10.1038/s41398-019-0635-y) (PMID:31797917) (PMCID:PMC6892870)
Graham, N. A., Ward, J. , Mackay, D. , Pell, J. , Cavanagh, J. , Padmanabhan, S. and Smith, D. J. (2019) Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank. BMJ Open, 9(9), e024433. (doi: 10.1136/bmjopen-2018-024433) (PMID:31575565) (PMCID:PMC6797415)
Lyall, D. M. et al. (2019) Assessing for interaction between APOE ε4, sex and lifestyle on cognitive abilities. Neurology, 92, e2691-e2698. (doi: 10.1212/WNL.0000000000007551) (PMID:31028125) (PMCID:PMC6556094)
Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi: 10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)
Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi: 10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)
2018
Ward, J. et al. (2018) Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts. PLoS ONE, 13(9), e0203896. (doi: 10.1371/journal.pone.0203896) (PMID:30240446) (PMCID:PMC6150505)
Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi: 10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)
Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)
Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi: 10.1016/S2215-0366(18)30139-1) (PMID:29776774)
Celis-Morales, C. A. et al. (2018) Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. British Medical Journal, 361, k1651. (doi: 10.1136/bmj.k1651) (PMID:29739772) (PMCID:PMC5939721)
Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi: 10.1016/j.jad.2017.12.106) (PMID:29329063)
Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi: 10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)
2017
Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi: 10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)
2016
Cullen, B. , Ward, J. , Graham, N. A., Deary, I. J., Pell, J. P. , Smith, D. J. and Evans, J. J. (2016) Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: a systematic review. Journal of Affective Disorders, 205, pp. 165-181. (doi: 10.1016/j.jad.2016.06.063) (PMID:27449549)
Graham, N. and Smith, D. J. (2016) Comorbidity of depression and anxiety disorders in patients with hypertension. Journal of Hypertension, 34(3), pp. 397-398. (doi: 10.1097/HJH.0000000000000850) (PMID:26818922)
Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi: 10.1038/mp.2016.49) (PMID:27067015)
Articles
Hill, N., Graham, N. and Forrester, R. L. (2024) Routine sensitive enquiry of adult interpersonal trauma in community mental health teams: an audit of the initial assessment tool. Community Mental Health Journal, 60, pp. 691-698. (doi: 10.1007/s10597-023-01220-z) (PMID:38363438) (PMCID:PMC11001718)
Strawbridge, R. J. and Graham, N. (2023) Dissecting the genetic relationship between schizophrenia and cardiovascular disease. American Journal of Psychiatry, 180(11), pp. 785-786. (doi: 10.1176/appi.ajp.20230714) (PMID:37908093)
Forsyth, L., Aman, A. , Cullen, B. , Graham, N., Lyall, D. M. , Lyall, L. M., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2023) Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank. Journal of Affective Disorders, 339, pp. 943-953. (doi: 10.1016/j.jad.2023.07.052) (PMID:37487843)
Ward, J. et al. (2023) Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Advances, (doi: 10.1182/bloodadvances.2023010562) (PMID:37399490) (In Press)
Aman, A. , Slob, E. A.W., Ward, J. , Cullen, B. , Graham, N., Lyall, D. M. , Sattar, N. and Strawbridge, R. J. (2022) Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization. PLoS ONE, 17(12), e0279381. (doi: 10.1371/journal.pone.0279381) (PMID:36580462) (PMCID:PMC9799310)
Hay, R., Cullen, B. , Graham, N., Lyall, D. M. , Aman, A. , Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2022) Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank. European Journal of Human Genetics, 30(12), pp. 1380-1390. (doi: 10.1038/s41431-022-01107-9) (PMID:35501368) (PMCID:PMC9712543)
Burt, O., Johnston, K. J.A., Graham, N., Cullen, B. , Lyall, D. M. , Lyall, L. M., Pell, J. P. , Ward, J. , Smith, D. J. and Strawbridge, R. J. (2021) Genetic variation in the ASTN2 locus in cardiovascular, metabolic and psychiatric traits: evidence for pleiotropy rather than shared biology. Genes, 12(8), 1194. (doi: 10.3390/genes12081194) (PMID:34440368) (PMCID:PMC8391428)
Shaw, R. , Cullen, B. , Graham, N., Lyall, D. , Mackay, D. , Okolie, C., Pearsall, R., Ward, J. , John, A. and Smith, D. (2021) Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: a nine-year follow up of the UK Biobank cohort. Journal of Affective Disorders, 279, pp. 316-323. (doi: 10.1016/j.jad.2020.10.026) (PMID:33096330)
Strawbridge, R. J. et al. (2021) The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Scientific Reports, 11, 632. (doi: 10.1038/s41598-020-79964-x) (PMID:33436761) (PMCID:PMC7804422)
Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)
Ward, J. et al. (2020) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, 25(11), pp. 3091-3099. (doi: 10.1038/s41380-019-0439-8) (PMID:31168069) (PMCID:PMC7116257)
Davis, K. A.S. et al. (2020) Mental health in UK Biobank – development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis. BJPsych Open, 6(2), e18. (doi: 10.1192/bjo.2019.100) (PMID:32026800) (PMCID:PMC7176892)
Strawbridge, R. J. et al. (2020) Carotid intima-media thickness: novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(2), pp. 446-461. (doi: 10.1161/ATVBAHA.119.313226) (PMID:31801372) (PMCID:PMC6975521)
Ward, J. et al. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. Translational Psychiatry, 9, 327. (doi: 10.1038/s41398-019-0635-y) (PMID:31797917) (PMCID:PMC6892870)
Graham, N. A., Ward, J. , Mackay, D. , Pell, J. , Cavanagh, J. , Padmanabhan, S. and Smith, D. J. (2019) Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank. BMJ Open, 9(9), e024433. (doi: 10.1136/bmjopen-2018-024433) (PMID:31575565) (PMCID:PMC6797415)
Lyall, D. M. et al. (2019) Assessing for interaction between APOE ε4, sex and lifestyle on cognitive abilities. Neurology, 92, e2691-e2698. (doi: 10.1212/WNL.0000000000007551) (PMID:31028125) (PMCID:PMC6556094)
Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi: 10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)
Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi: 10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)
Ward, J. et al. (2018) Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts. PLoS ONE, 13(9), e0203896. (doi: 10.1371/journal.pone.0203896) (PMID:30240446) (PMCID:PMC6150505)
Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi: 10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)
Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)
Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi: 10.1016/S2215-0366(18)30139-1) (PMID:29776774)
Celis-Morales, C. A. et al. (2018) Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. British Medical Journal, 361, k1651. (doi: 10.1136/bmj.k1651) (PMID:29739772) (PMCID:PMC5939721)
Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi: 10.1016/j.jad.2017.12.106) (PMID:29329063)
Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi: 10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)
Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi: 10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)
Cullen, B. , Ward, J. , Graham, N. A., Deary, I. J., Pell, J. P. , Smith, D. J. and Evans, J. J. (2016) Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: a systematic review. Journal of Affective Disorders, 205, pp. 165-181. (doi: 10.1016/j.jad.2016.06.063) (PMID:27449549)
Graham, N. and Smith, D. J. (2016) Comorbidity of depression and anxiety disorders in patients with hypertension. Journal of Hypertension, 34(3), pp. 397-398. (doi: 10.1097/HJH.0000000000000850) (PMID:26818922)
Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi: 10.1038/mp.2016.49) (PMID:27067015)
Research datasets
2019
Strawbridge, R. , Ward, J., Ferguson, A., Graham, N., Shaw, R. , Cullen, B. , Pearsall, R., Lyall, L., Johnston, K., Niedzwiedz, C. , Pell, J. , Mackay, D. , Martin, J., Lyall, D. , Bailey, M. and Smith, D. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. [Data Collection]
Ferguson, A., Lyall, L., Ward, J., Strawbridge, R. , Cullen, B. , Graham, N., Niedzwiedz, C. , Johnston, K., Mackay, D. , Biello, S. , Pell, J. , Cavanagh, J., McIntosh, A. M., Doherty, A., Bailey, M. , Lyall, D. , Wyse, C. and Smith, D. (2019) Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability. [Data Collection]
Strawbridge, R. , Ward, J., Lyall, L., Tunbridge, E. M., Cullen, B. , Graham, N., Ferguson, A., Johnston, K., Lyall, D. , Mackay, D. , Cavanagh, J., Howard, D. M., Adams, M. J., Deary, I., Escott-Price, V., O’Donovan, M., McIntosh, A. M., Bailey, M. , Pell, J. , Harrison, P. and Smith, D. (2019) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. [Data Collection]
Ward, J., Lyall, L., Bethlehem, R. A. I., Ferguson, A., Strawbridge, R. , Lyall, D. , Cullen, B. , Graham, N., Johnston, K., Bailey, M. , Murray, G. K. and Smith, D. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. [Data Collection]
Ward, J., Tunbridge, E. M., Sandor, C., Lyall, L., Ferguson, A., Strawbridge, R. , Lyall, D. , Cullen, B. , Graham, N., Johnston, K. J.A., Webber, C., Escott-Price, V., O’Donovan, M., Pell, J. , Bailey, M. , Harrison, P. J. and Smith, D. (2019) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. [Data Collection]