2024

Churchhouse, A. M.D. et al. (2024) Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression. Oncogene, 43(42), pp. 3094-3107. (doi: 10.1038/s41388-024-03135-9) (PMID:39242821)

Kumar, S. et al. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, 64. (doi: 10.1038/s41421-024-00681-0) (PMID:38834551) (PMCID:PMC11150427)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1) (PMID:38816652) (Early Online Publication)

Sumaria, N. et al. (2024) Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms. Nature Immunology, (doi: 10.1038/s41590-024-01855-4) (PMID:38802512) (Early Online Publication)

Lupo, F. and Coffelt, S. B. (2024) Stressed out neutrophils drive metastasis. Immunity, 57(4), pp. 840-842. (doi: 10.1016/j.immuni.2024.03.013) (PMID:38599176)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)

2023

Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)

Quintana, J. F. et al. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, 5279. (doi: 10.1038/s41467-023-40962-y) (PMID:37644007) (PMCID:PMC10465518)

Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11(8), pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644) (PMID:37309673) (PMCID:PMC10398359)

Coffelt, S. B. and Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4(3), pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Edwards, S. C. et al. (2023) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220(2), e20211431. (doi: 10.1084/jem.20211431) (PMID:36480166) (PMCID:PMC9732671)

2022

van Wagensveld, L. et al. (2022) Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer. Cancers, 14(23), 5965. (doi: 10.3390/cancers14235965) (PMID:36497449) (PMCID:PMC9738162)

Lawrence, M., Wiesheu, R. and Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, 106213. (doi: 10.1016/j.biocel.2022.106213) (PMID:35447350)

Curio, S. et al. (2022) NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1(1), kyac002. (doi: 10.1093/discim/kyac002) (PMID:36277678) (PMCID:PMC9580227)

Paterson, K., Paterson, S., Mulholland, T., Coffelt, S.B. and Zagnoni, M. (2022) Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy. IEEE Open Journal of Engineering in Medicine and Biology, 3, pp. 86-95. (doi: 10.1109/OJEMB.2022.3178302) (PMID:35813488) (PMCID:PMC9252335)

2021

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Paterson, K., Zanivan, S. , Glasspool, R., Coffelt, S.B. and Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21(12), pp. 2306-2329. (doi: 10.1039/D0LC01305F) (PMID:34085677) (PMCID:PMC8204114)

McFarlane, A. J., Fercoq, F., Coffelt, S. B. and Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131(6), e143759. (doi: 10.1172/JCI143759) (PMID:33720040)

Edwards, S. C., Hoevenaar, W. H.M. and Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5) (PMID:33262520)

2020

Coffelt, S. B. , Kabelitz, D., Silva-Santos, B., Kuball, J., Born, W. and Bank, I. (2020) Editorial: γδ T Cells in Cancer. Frontiers in Immunology, 11, 602411. (doi: 10.3389/fimmu.2020.602411) (PMID:33329597) (PMCID:PMC7714948)

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J. and Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298(1), pp. 198-217. (doi: 10.1111/imr.12916) (PMID:32840001)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S. , Blyth, K. and Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12(8), 2181. (doi: 10.3390/nu12082181) (PMID:32708052) (PMCID:PMC7469024)

Muthalagu, N. et al. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10(6), pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620) (PMID:32200350) (PMCID:PMC7611248)

2019

Wellenstein, M. D. et al. (2019) Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis. Nature, 572, pp. 538-542. (doi: 10.1038/s41586-019-1450-6) (PMID:31367040) (PMCID:PMC6707815)

Mackey, J. B.G., Coffelt, S. B. and Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, 1912. (doi: 10.3389/fimmu.2019.01912) (PMID:31474989) (PMCID:PMC6702268)

Silva-Santos, B., Mensurado, S. and Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19(7), pp. 392-404. (doi: 10.1038/s41568-019-0153-5) (PMID:31209264)

Salvagno, C. et al. (2019) Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology, 21(4), pp. 511-521. (doi: 10.1038/s41556-019-0298-1) (PMID:30886344) (PMCID:PMC6451630)

2018

Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636) (PMCID:PMC6881183)

2017

Rumney, R. M.H., Coffelt, S. B. , Neale, T. A., Dhayade, S., Tozer, G. M. and Miller, G. (2017) PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development. PLoS ONE, 12(12), e0188591. (doi: 10.1371/journal.pone.0188591) (PMID:29220404) (PMCID:PMC5722323)

Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)

Carron, E. C., Homra, S., Rosenberg, J., Coffelt, S. B. , Kittrell, F., Zhang, Y., Creighton, C. J., Fuqua, S. A., Medina, D. and Machado, H. L. (2017) Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget, 8(31), pp. 50731-50746. (doi: 10.18632/oncotarget.14913) (PMID:28159924)

van Baal, J.O.A.M., Van de Vijver, K.K., Coffelt, S.B. , van der Noort, V., van Driel, W.J., Kenter, G.G., Buist, M.R. and Lok, C.A.R. (2017) Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 124(3), pp. 486-494. (doi: 10.1111/1471-0528.14425) (PMID:27860146)

Kersten, K. et al. (2017) Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. OncoImmunology, 6(8), e1334744. (doi: 10.1080/2162402X.2017.1334744) (PMID:28919995) (PMCID:PMC5593698)

2016

Coffelt, S. B. , Wellenstein, M. D. and de Visser, K. E. (2016) Neutrophils in cancer: neutral no more. Nature Reviews Cancer, 16(7), pp. 431-446. (doi: 10.1038/nrc.2016.52) (PMID:27282249)

Coffelt, S. B. and de Visser, K. E. (2016) Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor. Immunity, 44(4), pp. 722-724. (doi: 10.1016/j.immuni.2016.03.014) (PMID:27096314)

Coffelt, S. B. and de Visser, K. E. (2016) Systemic inflammation: Cancer's long-distance reach to maximize metastasis. OncoImmunology, 5(2), e1075694. (doi: 10.1080/2162402X.2015.1075694) (PMID:27057449) (PMCID:PMC4801429)

Rahat, M. A., Coffelt, S. , Granot, Z., Muthana, M. and Amedei, A. (2016) Macrophages and neutrophils: regulation of the inflammatory microenvironment in autoimmunity and cancer. Mediators of Inflammation, 2016, 5894347. (doi: 10.1155/2016/5894347) (PMID:27725789) (PMCID:PMC5048028)

2015

Doornebal, C. W., Vrijland, K., Hau, C.-S., Coffelt, S. B. , Ciampricotti, M., Jonkers, J., de Visser, K. E. and Hollmann, M. W. (2015) Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer. Pain, 156(8), pp. 1424-1432. (doi: 10.1097/j.pain.0000000000000136) (PMID:25734987)

Coffelt, S. B. et al. (2015) IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature, 522(7556), pp. 345-348. (doi: 10.1038/nature14282) (PMID:25822788) (PMCID:PMC4475637)

Coffelt, S. B. and de Visser, K. E. (2015) Immune-mediated mechanisms influencing the efficacy of anticancer therapies. Trends in Immunology, 36(4), pp. 198-216. (doi: 10.1016/j.it.2015.02.006) (PMID:25857662)

2014

Al-ofi, E., Coffelt, S. B. and Anumba, D. O. (2014) Fibrinogen, an endogenous ligand of Toll-like receptor 4, activates monocytes in pre-eclamptic patients. Journal of Reproductive Immunology, 103, pp. 23-28. (doi: 10.1016/j.jri.2014.02.004) (PMID:24661950)

Coffelt, S. B. and de Visser, K. E. (2014) Cancer: Inflammation lights the way to metastasis. Nature, 507(7490), pp. 48-49. (doi: 10.1038/nature13062) (PMID:24572360)

2013

Gheryani, N., Coffelt, S. B. , Gartland, A., Rumney, R. M.H., Kiss-Toth, E., Lewis, C. E., Tozer, G. M., Greaves, D. R., Dear, T. N. and Miller, G. (2013) Generation of a novel mouse model for the inducible depletion of macrophages in vivo. genesis, 51(1), pp. 41-49. (doi: 10.1002/dvg.22343) (PMID:22927121)

2012

Al-Ofi, E., Anumba, D.O.C. and Coffelt, S. (2012) OS006. Functional expression of endogenous ligands of Toll like receptor4 on monocytes and placentae from women during normal pregnancy andpre-eclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2(3), p. 178. (doi: 10.1016/j.preghy.2012.04.008) (PMID:26105221)

Wu, W.K.K., Coffelt, S.B. , Cho, C.H., Wang, X.J., Lee, C.W., Chan, F.K.L., Yu, J. and Sung, J.J.Y. (2012) The autophagic paradox in cancer therapy. Oncogene, 31(8), pp. 939-953. (doi: 10.1038/onc.2011.295) (PMID:21765470)

2011

Coffelt, S. B. et al. (2011) Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. Journal of Immunology, 186(7), pp. 4183-4190. (doi: 10.4049/​jimmunol.1002802) (PMID:21368233)

Welford, A. F. et al. (2011) TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. Journal of Clinical Investigation, 121(5), pp. 1969-1973. (doi: 10.1172/JCI44562) (PMID:21490397) (PMCID:PMC3083764)

Muthana, M. et al. (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Research, 71(5), pp. 1805-1815. (doi: 10.1158/0008-5472.CAN-10-2349) (PMID:21233334)

2010

Coffelt, S. B. et al. (2010) Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions. Cancer Research, 70(13), pp. 5270-5280. (doi: 10.1158/0008-5472.CAN-10-0012) (PMID:20530679)

Wu, W. K.K., Wang, G., Coffelt, S. B. , Betancourt, A. M., Lee, C. W., Fan, D., Wu, K., Yu, J., Sung, J. J.Y. and Cho, C. H. (2010) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. International Journal of Cancer, 127(8), pp. 1741-1747. (doi: 10.1002/ijc.25489) (PMID:20521250) (PMCID:PMC2930073)

Coffelt, S. B. , Lewis, C. E., Naldini, L., Brown, J. M., Ferrara, N. and De Palma, M. (2010) Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. American Journal of Pathology, 176(4), pp. 1564-1576. (doi: 10.2353/ajpath.2010.090786) (PMID:20167863) (PMCID:PMC2843445)

2009

Fang, H.-Y. et al. (2009) Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood, 114(4), pp. 844-859. (doi: 10.1182/blood-2008-12-195941) (PMID:19454749) (PMCID:PMC2882173)

Coffelt, S. B. , Tomchuck, S. L., Zwezdaryk, K. J., Danka, E. S. and Scandurro, A. B. (2009) Leucine leucine-37 uses formyl peptide receptor-like 1 to activate signal transduction pathways, stimulate oncogenic gene expression, and enhance the invasiveness of ovarian cancer cells. Molecular Cancer Research, 7(6), pp. 907-915. (doi: 10.1158/1541-7786.MCR-08-0326) (PMID:19491199) (PMCID:PMC2755540)

Coffelt, S. B. et al. (2009) The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells. Proceedings of the National Academy of Sciences of the United States of America, 106(10), pp. 3806-3811. (doi: 10.1073/pnas.0900244106) (PMID:19234121) (PMCID:PMC2656161)

2008

Coffelt, S. B. and Scandurro, A. B. (2008) Tumors sound the alarmin(s). Cancer Research, 68(16), pp. 6482-6485. (doi: 10.1158/0008-5472.CAN-08-0044) (PMID:18701469) (PMCID:PMC2755533)

Murdoch, C., Muthana, M., Coffelt, S. B. and Lewis, C. E. (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nature Reviews Cancer, 8(8), pp. 618-631. (doi: 10.1038/nrc2444) (PMID:18633355)

Xiang, S., Coffelt, S. B. , Mao, L., Yuan, L., Cheng, Q. and Hill, S. M. (2008) Period-2: a tumor suppressor gene in breast cancer. Journal of Circadian Rhythms, 6(1), p. 4. (doi: 10.1186/1740-3391-6-4) (PMID:18334030) (PMCID:PMC2365929)

Tomchuck, S. L., Zwezdaryk, K. J., Coffelt, S. B. , Waterman, R. S., Danka, E. S. and Scandurro, A. B. (2008) Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells, 26(1), pp. 99-107. (doi: 10.1634/stemcells.2007-0563) (PMID:17916800) (PMCID:PMC2757778)

2007

Coffelt, S. B. , Waterman, R. S., Florez, L., Bentrup, K. H. z., Zwezdaryk, K. J., Tomchuck, S. L., LaMarca, H. L., Danka, E. S., Morris, C. A. and Scandurro, A. B. (2007) Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion. International Journal of Cancer, 122(5), pp. 1030-1039. (doi: 10.1002/ijc.23186) (PMID:17960624)

Zwezdaryk, K. J., Coffelt, S. B. , Figueroa, Y. G., Liu, J., Phinney, D. G., LaMarca, H. L., Florez, L., Morris, C. B., Hoyle, G. W. and Scandurro, A. B. (2007) Erythropoietin, a hypoxia-regulated factor, elicits a pro-angiogenic program in human mesenchymal stem cells. Experimental Hematology, 35(4), pp. 640-652. (doi: 10.1016/j.exphem.2007.01.044) (PMID:17379074)

Abboud, E. R., Coffelt, S. B. , Figueroa, Y. G., Zwezdaryk, K. J., Nelson, A. B., Sullivan, D. E., Morris, C. B., Tang, Y., Beckman, B. S. and Scandurro, A. B. (2007) Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells. International Journal of Oncology, 30(1), pp. 113-122. (doi: 10.3892/ijo.30.1.113) (PMID:17143519)

Articles

Churchhouse, A. M.D. et al. (2024) Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression. Oncogene, 43(42), pp. 3094-3107. (doi: 10.1038/s41388-024-03135-9) (PMID:39242821)

Kumar, S. et al. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, 64. (doi: 10.1038/s41421-024-00681-0) (PMID:38834551) (PMCID:PMC11150427)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1) (PMID:38816652) (Early Online Publication)

Sumaria, N. et al. (2024) Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms. Nature Immunology, (doi: 10.1038/s41590-024-01855-4) (PMID:38802512) (Early Online Publication)

Lupo, F. and Coffelt, S. B. (2024) Stressed out neutrophils drive metastasis. Immunity, 57(4), pp. 840-842. (doi: 10.1016/j.immuni.2024.03.013) (PMID:38599176)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)

Quintana, J. F. et al. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, 5279. (doi: 10.1038/s41467-023-40962-y) (PMID:37644007) (PMCID:PMC10465518)

Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11(8), pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644) (PMID:37309673) (PMCID:PMC10398359)

Coffelt, S. B. and Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4(3), pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Edwards, S. C. et al. (2023) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220(2), e20211431. (doi: 10.1084/jem.20211431) (PMID:36480166) (PMCID:PMC9732671)

van Wagensveld, L. et al. (2022) Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer. Cancers, 14(23), 5965. (doi: 10.3390/cancers14235965) (PMID:36497449) (PMCID:PMC9738162)

Lawrence, M., Wiesheu, R. and Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, 106213. (doi: 10.1016/j.biocel.2022.106213) (PMID:35447350)

Curio, S. et al. (2022) NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1(1), kyac002. (doi: 10.1093/discim/kyac002) (PMID:36277678) (PMCID:PMC9580227)

Paterson, K., Paterson, S., Mulholland, T., Coffelt, S.B. and Zagnoni, M. (2022) Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy. IEEE Open Journal of Engineering in Medicine and Biology, 3, pp. 86-95. (doi: 10.1109/OJEMB.2022.3178302) (PMID:35813488) (PMCID:PMC9252335)

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Paterson, K., Zanivan, S. , Glasspool, R., Coffelt, S.B. and Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21(12), pp. 2306-2329. (doi: 10.1039/D0LC01305F) (PMID:34085677) (PMCID:PMC8204114)

McFarlane, A. J., Fercoq, F., Coffelt, S. B. and Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131(6), e143759. (doi: 10.1172/JCI143759) (PMID:33720040)

Edwards, S. C., Hoevenaar, W. H.M. and Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5) (PMID:33262520)

Coffelt, S. B. , Kabelitz, D., Silva-Santos, B., Kuball, J., Born, W. and Bank, I. (2020) Editorial: γδ T Cells in Cancer. Frontiers in Immunology, 11, 602411. (doi: 10.3389/fimmu.2020.602411) (PMID:33329597) (PMCID:PMC7714948)

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J. and Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298(1), pp. 198-217. (doi: 10.1111/imr.12916) (PMID:32840001)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S. , Blyth, K. and Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12(8), 2181. (doi: 10.3390/nu12082181) (PMID:32708052) (PMCID:PMC7469024)

Muthalagu, N. et al. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10(6), pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620) (PMID:32200350) (PMCID:PMC7611248)

Wellenstein, M. D. et al. (2019) Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis. Nature, 572, pp. 538-542. (doi: 10.1038/s41586-019-1450-6) (PMID:31367040) (PMCID:PMC6707815)

Mackey, J. B.G., Coffelt, S. B. and Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, 1912. (doi: 10.3389/fimmu.2019.01912) (PMID:31474989) (PMCID:PMC6702268)

Silva-Santos, B., Mensurado, S. and Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19(7), pp. 392-404. (doi: 10.1038/s41568-019-0153-5) (PMID:31209264)

Salvagno, C. et al. (2019) Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology, 21(4), pp. 511-521. (doi: 10.1038/s41556-019-0298-1) (PMID:30886344) (PMCID:PMC6451630)

Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636) (PMCID:PMC6881183)

Rumney, R. M.H., Coffelt, S. B. , Neale, T. A., Dhayade, S., Tozer, G. M. and Miller, G. (2017) PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development. PLoS ONE, 12(12), e0188591. (doi: 10.1371/journal.pone.0188591) (PMID:29220404) (PMCID:PMC5722323)

Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)

Carron, E. C., Homra, S., Rosenberg, J., Coffelt, S. B. , Kittrell, F., Zhang, Y., Creighton, C. J., Fuqua, S. A., Medina, D. and Machado, H. L. (2017) Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget, 8(31), pp. 50731-50746. (doi: 10.18632/oncotarget.14913) (PMID:28159924)

van Baal, J.O.A.M., Van de Vijver, K.K., Coffelt, S.B. , van der Noort, V., van Driel, W.J., Kenter, G.G., Buist, M.R. and Lok, C.A.R. (2017) Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 124(3), pp. 486-494. (doi: 10.1111/1471-0528.14425) (PMID:27860146)

Kersten, K. et al. (2017) Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. OncoImmunology, 6(8), e1334744. (doi: 10.1080/2162402X.2017.1334744) (PMID:28919995) (PMCID:PMC5593698)

Coffelt, S. B. , Wellenstein, M. D. and de Visser, K. E. (2016) Neutrophils in cancer: neutral no more. Nature Reviews Cancer, 16(7), pp. 431-446. (doi: 10.1038/nrc.2016.52) (PMID:27282249)

Coffelt, S. B. and de Visser, K. E. (2016) Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor. Immunity, 44(4), pp. 722-724. (doi: 10.1016/j.immuni.2016.03.014) (PMID:27096314)

Coffelt, S. B. and de Visser, K. E. (2016) Systemic inflammation: Cancer's long-distance reach to maximize metastasis. OncoImmunology, 5(2), e1075694. (doi: 10.1080/2162402X.2015.1075694) (PMID:27057449) (PMCID:PMC4801429)

Rahat, M. A., Coffelt, S. , Granot, Z., Muthana, M. and Amedei, A. (2016) Macrophages and neutrophils: regulation of the inflammatory microenvironment in autoimmunity and cancer. Mediators of Inflammation, 2016, 5894347. (doi: 10.1155/2016/5894347) (PMID:27725789) (PMCID:PMC5048028)

Doornebal, C. W., Vrijland, K., Hau, C.-S., Coffelt, S. B. , Ciampricotti, M., Jonkers, J., de Visser, K. E. and Hollmann, M. W. (2015) Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer. Pain, 156(8), pp. 1424-1432. (doi: 10.1097/j.pain.0000000000000136) (PMID:25734987)

Coffelt, S. B. et al. (2015) IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature, 522(7556), pp. 345-348. (doi: 10.1038/nature14282) (PMID:25822788) (PMCID:PMC4475637)

Coffelt, S. B. and de Visser, K. E. (2015) Immune-mediated mechanisms influencing the efficacy of anticancer therapies. Trends in Immunology, 36(4), pp. 198-216. (doi: 10.1016/j.it.2015.02.006) (PMID:25857662)

Al-ofi, E., Coffelt, S. B. and Anumba, D. O. (2014) Fibrinogen, an endogenous ligand of Toll-like receptor 4, activates monocytes in pre-eclamptic patients. Journal of Reproductive Immunology, 103, pp. 23-28. (doi: 10.1016/j.jri.2014.02.004) (PMID:24661950)

Coffelt, S. B. and de Visser, K. E. (2014) Cancer: Inflammation lights the way to metastasis. Nature, 507(7490), pp. 48-49. (doi: 10.1038/nature13062) (PMID:24572360)

Gheryani, N., Coffelt, S. B. , Gartland, A., Rumney, R. M.H., Kiss-Toth, E., Lewis, C. E., Tozer, G. M., Greaves, D. R., Dear, T. N. and Miller, G. (2013) Generation of a novel mouse model for the inducible depletion of macrophages in vivo. genesis, 51(1), pp. 41-49. (doi: 10.1002/dvg.22343) (PMID:22927121)

Al-Ofi, E., Anumba, D.O.C. and Coffelt, S. (2012) OS006. Functional expression of endogenous ligands of Toll like receptor4 on monocytes and placentae from women during normal pregnancy andpre-eclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2(3), p. 178. (doi: 10.1016/j.preghy.2012.04.008) (PMID:26105221)

Wu, W.K.K., Coffelt, S.B. , Cho, C.H., Wang, X.J., Lee, C.W., Chan, F.K.L., Yu, J. and Sung, J.J.Y. (2012) The autophagic paradox in cancer therapy. Oncogene, 31(8), pp. 939-953. (doi: 10.1038/onc.2011.295) (PMID:21765470)

Coffelt, S. B. et al. (2011) Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. Journal of Immunology, 186(7), pp. 4183-4190. (doi: 10.4049/​jimmunol.1002802) (PMID:21368233)

Welford, A. F. et al. (2011) TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. Journal of Clinical Investigation, 121(5), pp. 1969-1973. (doi: 10.1172/JCI44562) (PMID:21490397) (PMCID:PMC3083764)

Muthana, M. et al. (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Research, 71(5), pp. 1805-1815. (doi: 10.1158/0008-5472.CAN-10-2349) (PMID:21233334)

Coffelt, S. B. et al. (2010) Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions. Cancer Research, 70(13), pp. 5270-5280. (doi: 10.1158/0008-5472.CAN-10-0012) (PMID:20530679)

Wu, W. K.K., Wang, G., Coffelt, S. B. , Betancourt, A. M., Lee, C. W., Fan, D., Wu, K., Yu, J., Sung, J. J.Y. and Cho, C. H. (2010) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. International Journal of Cancer, 127(8), pp. 1741-1747. (doi: 10.1002/ijc.25489) (PMID:20521250) (PMCID:PMC2930073)

Coffelt, S. B. , Lewis, C. E., Naldini, L., Brown, J. M., Ferrara, N. and De Palma, M. (2010) Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. American Journal of Pathology, 176(4), pp. 1564-1576. (doi: 10.2353/ajpath.2010.090786) (PMID:20167863) (PMCID:PMC2843445)

Fang, H.-Y. et al. (2009) Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood, 114(4), pp. 844-859. (doi: 10.1182/blood-2008-12-195941) (PMID:19454749) (PMCID:PMC2882173)

Coffelt, S. B. , Tomchuck, S. L., Zwezdaryk, K. J., Danka, E. S. and Scandurro, A. B. (2009) Leucine leucine-37 uses formyl peptide receptor-like 1 to activate signal transduction pathways, stimulate oncogenic gene expression, and enhance the invasiveness of ovarian cancer cells. Molecular Cancer Research, 7(6), pp. 907-915. (doi: 10.1158/1541-7786.MCR-08-0326) (PMID:19491199) (PMCID:PMC2755540)

Coffelt, S. B. et al. (2009) The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells. Proceedings of the National Academy of Sciences of the United States of America, 106(10), pp. 3806-3811. (doi: 10.1073/pnas.0900244106) (PMID:19234121) (PMCID:PMC2656161)

Coffelt, S. B. and Scandurro, A. B. (2008) Tumors sound the alarmin(s). Cancer Research, 68(16), pp. 6482-6485. (doi: 10.1158/0008-5472.CAN-08-0044) (PMID:18701469) (PMCID:PMC2755533)

Murdoch, C., Muthana, M., Coffelt, S. B. and Lewis, C. E. (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nature Reviews Cancer, 8(8), pp. 618-631. (doi: 10.1038/nrc2444) (PMID:18633355)

Xiang, S., Coffelt, S. B. , Mao, L., Yuan, L., Cheng, Q. and Hill, S. M. (2008) Period-2: a tumor suppressor gene in breast cancer. Journal of Circadian Rhythms, 6(1), p. 4. (doi: 10.1186/1740-3391-6-4) (PMID:18334030) (PMCID:PMC2365929)

Tomchuck, S. L., Zwezdaryk, K. J., Coffelt, S. B. , Waterman, R. S., Danka, E. S. and Scandurro, A. B. (2008) Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells, 26(1), pp. 99-107. (doi: 10.1634/stemcells.2007-0563) (PMID:17916800) (PMCID:PMC2757778)

Coffelt, S. B. , Waterman, R. S., Florez, L., Bentrup, K. H. z., Zwezdaryk, K. J., Tomchuck, S. L., LaMarca, H. L., Danka, E. S., Morris, C. A. and Scandurro, A. B. (2007) Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion. International Journal of Cancer, 122(5), pp. 1030-1039. (doi: 10.1002/ijc.23186) (PMID:17960624)

Zwezdaryk, K. J., Coffelt, S. B. , Figueroa, Y. G., Liu, J., Phinney, D. G., LaMarca, H. L., Florez, L., Morris, C. B., Hoyle, G. W. and Scandurro, A. B. (2007) Erythropoietin, a hypoxia-regulated factor, elicits a pro-angiogenic program in human mesenchymal stem cells. Experimental Hematology, 35(4), pp. 640-652. (doi: 10.1016/j.exphem.2007.01.044) (PMID:17379074)

Abboud, E. R., Coffelt, S. B. , Figueroa, Y. G., Zwezdaryk, K. J., Nelson, A. B., Sullivan, D. E., Morris, C. B., Tang, Y., Beckman, B. S. and Scandurro, A. B. (2007) Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells. International Journal of Oncology, 30(1), pp. 113-122. (doi: 10.3892/ijo.30.1.113) (PMID:17143519)

Conference or Workshop Item

Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)