Professor Martin Bushell

Professor of Cancer Biology (Beatson Institute for Cancer Research)

Publications

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Number of items: 89.

2024

Dearlove, E. L., Chatrin, C., Buetow, L., Ahmed, S. F. , Schmidt, T., Bushell, M. , Smith, B. O. and Huang, D. T. (2024) DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids. eLife, 13, RP98070. (doi: 10.7554/elife.98070) (PMID:39377462)

Ghashghaei, M. et al. (2024) Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis. Nature Communications, 15, 2340. (doi: 10.1038/s41467-024-46665-2) (PMID:38491013) (PMCID:PMC10943099)

2023

Munro, J., Gillen, S. L., Mitchell, L., Laing, S., Karim, S. A., Rink, C. J., Waldron, J. A. and Bushell, M. (2023) Optimisation of sample preparation from primary mouse tissue to maintain RNA integrity for methods examining translational control. Cancers, 15(15), 3985. (doi: 10.3390/cancers15153985) (PMID:37568801) (PMCID:PMC10417042)

Whyte, D. et al. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, 17(7), pp. 1212-1227. (doi: 10.1002/1878-0261.13425) (PMID:36975767) (PMCID:PMC10323901)

May, S. et al. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78(5), pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009) (PMID:36702176)

Schmidt, T. et al. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51(4), pp. 1859-1879. (doi: 10.1093/nar/gkad030) (PMID:36727461) (PMCID:PMC9976904)

2022

Bader, A. S., Luessing, J., Hawley, B. R., Skalka, G. L., Lu, W.-T., Lowndes, N. F. and Bushell, M. (2022) DDX17 is required for efficient DSB repair at DNA:RNA hybrid deficient loci. Nucleic Acids Research, 50(18), pp. 10487-10502. (doi: 10.1093/nar/gkac843) (PMID:36200807) (PMCID:PMC9561282)

Pantaleão, L. C. et al. (2022) Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner. eLife, 11, e69078. (doi: 10.7554/elife.69078) (PMID:35025731) (PMCID:PMC8794468)

2021

Gillen, S. L., Giacomelli, C., Hodge, K., Zanivan, S. , Bushell, M. and Wilczynska, A. (2021) Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization. Genome Biology, 22, 284. (doi: 10.1186/s13059-021-02494-w) (PMID:34615539) (PMCID:PMC8496106)

Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, 4920. (doi: 10.1038/s41467-021-25173-7) (PMID:34389715) (PMCID:PMC8363647)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)

Bushell, M. , Gillen, S. L. and Waldron, J. A. (2021) Codon optimality in cancer. Oncogene, 40, pp. 6309-6320. (doi: 10.1038/s41388-021-02022-x) (PMID:34584217)

2019

Waldron, J. A., Tack, D. C., Ritchey, L. E., Gillen, S. L., Wilczynska, A., Turro, E., Bevilacqua, P. C., Assmann, S. M., Bushell, M. and Le Quesne, J. (2019) mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Genome Biology, 20(1), 300. (doi: 10.1186/s13059-019-1901-2) (PMID:31888698) (PMCID:PMC6936103)

Wilczynska, A. et al. (2019) eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5’UTR. Genome Biology, 20, 262. (doi: 10.1186/s13059-019-1857-2) (PMID:31791371) (PMCID:PMC6886185)

Meijer, H. A., Schmidt, T., Gillen, S. L., Langlais, C., Jukes-Jones, R., de Moor, C. H., Cain, K., Wilczynska, A. and Bushell, M. (2019) DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. Nucleic Acids Research, 47(15), pp. 8224-8238. (doi: 10.1093/nar/gkz509) (PMID:31180491) (PMCID:PMC6736043)

Skalka, G., Hall, H., Somers, J., Bushell, M. , Willis, A. and Malewicz, M. (2019) Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation. Cell Cycle, 18(9), pp. 963-975. (doi: 10.1080/15384101.2019.1601476) (PMID:30973299) (PMCID:PMC6527300)

2018

Marini, A. et al. (2018) TAp73 contributes to the oxidative stress response by regulating protein synthesis. Proceedings of the National Academy of Sciences of the United States of America, 115(24), pp. 6219-6224. (doi: 10.1073/pnas.1718531115) (PMID:29844156) (PMCID:PMC6004440)

Lu, W.-T., Hawley, B. R., Skalka, G. L., Baldock, R. A., Smith, E. M., Bader, A. S., Malewicz, M., Watts, F. Z., Wilczynska, A. and Bushell, M. (2018) Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair. Nature Communications, 9, 532. (doi: 10.1038/s41467-018-02893-x) (PMID:29416038) (PMCID:PMC5803274)

2017

Chernova, T. et al. (2017) Long-fiber carbon nanotubes replicate asbestos-induced mesothelioma with disruption of the tumor suppressor gene Cdkn2a ( Ink4a/Arf ). Current Biology, 27(21), 3302-3314.e6. (doi: 10.1016/j.cub.2017.09.007) (PMID:29112861) (PMCID:PMC5681354)

Halliday, M. et al. (2017) Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain, 140(6), pp. 1768-1783. (doi: 10.1093/brain/awx074) (PMID:28430857) (PMCID:PMC5445255)

Hawley, B. R., Lu, W.-T., Wilczynska, A. and Bushell, M. (2017) The emerging role of RNAs in DNA damage repair. Cell Death and Differentiation, 24(4), pp. 580-587. (doi: 10.1038/cdd.2017.16) (PMID:28234355) (PMCID:PMC5384027)

Fletcher, C. E., Godfrey, J. D., Shibakawa, A., Bushell, M. and Bevan, C. L. (2017) A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis. Nucleic Acids Research, 45(5), pp. 2809-2828. (doi: 10.1093/nar/gkw938) (PMID:27907888) (PMCID:PMC5389555)

Bastide, A. et al. (2017) RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3. Current Biology, 27(5), pp. 638-650. (doi: 10.1016/j.cub.2017.01.047) (PMID:28238655) (PMCID:PMC5344685)

2016

Alfaradhi, M. Z., Kusinski, L. C., Fernandez-Twinn, D. S., Pantaleão, L. C., Carr, S. K., Ferland-McCollough, D., Yeo, G. S. H., Bushell, M. and Ozanne, S. E. (2016) Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology, 157(11), pp. 4246-4256. (doi: 10.1210/en.2016-1314) (PMID:27583789) (PMCID:PMC5086532)

Chernova, T. et al. (2016) Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease. Cell Death and Differentiation, 23(7), pp. 1152-1164. (doi: 10.1038/cdd.2015.165) (PMID:26891694) (PMCID:PMC4946883)

Martin-Gronert, M. S., Fernandez-Twinn, D. S., Bushell, M. , Siddle, K. and Ozanne, S. E. (2016) Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia, 59(6), pp. 1266-1275. (doi: 10.1007/s00125-016-3905-8) (PMID:26965244) (PMCID:PMC4861755)

Sbarrato, T. et al. (2016) A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment. Cell Death and Disease, 7(6), e2249. (doi: 10.1038/cddis.2016.148) (PMID:27253413) (PMCID:PMC5143378)

Hall, A. E., Lu, W.-T., Godfrey, J. D., Antonov, A. V., Paicu, C., Moxon, S., Dalmay, T., Wilczynska, A., Muller, P. A. J. and Bushell, M. (2016) The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death and Disease, 7(4), e2184. (doi: 10.1038/cddis.2016.91) (PMID:27054339) (PMCID:PMC4855670)

2015

Mura, M. et al. (2015) LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene, 34(39), pp. 5025-5036. (doi: 10.1038/onc.2014.428) (PMID:25531318) (PMCID:PMC4430325)

Somers, J. et al. (2015) A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy. Genes and Development, 29(18), pp. 1891-1896. (doi: 10.1101/gad.261867.115) (PMID:26338418) (PMCID:PMC4579346)

Nolte-’t Hoen, E. N. M., Van Rooij, E., Bushell, M. , Zhang, C.-Y., Dashwood, R. H., James, W. P. T., Harris, C. and Baltimore, D. (2015) The role of microRNA in nutritional control. Journal of Internal Medicine, 278(2), pp. 99-109. (doi: 10.1111/joim.12372) (PMID:25832550)

Faller, W. et al. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature, 517(7535), pp. 497-500. (doi: 10.1038/nature13896) (PMID:25383520) (PMCID:PMC4304784)

Wilczynska, A. and Bushell, M. (2015) The complexity of miRNA-mediated repression. Cell Death and Differentiation, 22(1), pp. 22-33. (doi: 10.1038/cdd.2014.112) (PMID:25190144) (PMCID:PMC4262769)

2014

Fonseca, B. D., Smith, E. M., Yelle, N., Alain, T., Bushell, M. and Pause, A. (2014) The ever-evolving role of mTOR in translation. Seminars in Cell and Developmental Biology, 36, pp. 102-112. (doi: 10.1016/j.semcdb.2014.09.014) (PMID:25263010)

Lu, W.-T. and Bushell, M. (2014) Old case, new leads: miRNA links Kaposi’s sarcoma-associated herpesvirus with sepsis. Cell Death and Disease, 5(12), e1560. (doi: 10.1038/cddis.2014.516) (PMID:25476908) (PMCID:PMC4454161)

Meijer, H. A., Smith, E. M. and Bushell, M. (2014) Regulation of miRNA strand selection: follow the leader? Biochemical Society Transactions, 42(4), pp. 1135-1140. (doi: 10.1042/BST20140142) (PMID:25110015)

Fernandez-Twinn, D. S., Alfaradhi, M. Z., Martin-Gronert, M. S., Duque-Guimaraes, D. E., Piekarz, A., Ferland-McCollough, D., Bushell, M. and Ozanne, S. E. (2014) Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. Molecular Metabolism, 3(3), pp. 325-333. (doi: 10.1016/j.molmet.2014.01.007) (PMID:24749062) (PMCID:PMC3986586)

Horvilleur, E. et al. (2014) A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma. Leukemia, 28(5), pp. 1092-1102. (doi: 10.1038/leu.2013.295) (PMID:24135829) (PMCID:PMC4017261)

Kamenska, A., Lu, W.-T., Kubacka, D., Broomhead, H., Minshall, N., Bushell, M. and Standart, N. (2014) Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Nucleic Acids Research, 42(5), pp. 3298-3313. (doi: 10.1093/nar/gkt1265) (PMID:24335285) (PMCID:PMC3950672)

Lu, W.-T., Wilczynska, A., Smith, E. and Bushell, M. (2014) The diverse roles of the eIF4A family: you are the company you keep. Biochemical Society Transactions, 42(1), pp. 166-172. (doi: 10.1042/BST20130161) (PMID:24450646)

King, H.A. et al. (2014) Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death and Differentiation, 21(1), pp. 161-171. (doi: 10.1038/cdd.2013.135) (PMID:24141718) (PMCID:PMC3857619)

2013

Dhiraj, D. K., Chrysanthou, E., Mallucci, G. R. and Bushell, M. (2013) miRNAs-19b, -29b-2* and -339-5p show an early and sustained up-regulation in ischemic models of stroke. PLoS ONE, 8(12), e83717. (doi: 10.1371/journal.pone.0083717) (PMID:24376737) (PMCID:PMC3869799)

Meijer, H.A., Kong, Y.W., Lu, W.T., Wilczynska, A., Spriggs, R.V., Robinson, S.W., Godfrey, J.D., Willis, A.E. and Bushell, M. (2013) Translational repression and eIF4A2 activity are critical for MicroRNA-mediated gene regulation. Science, 340(6128), pp. 82-85. (doi: 10.1126/science.1231197) (PMID:23559250)

2012

Ferland-McCollough, D. et al. (2012) Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death and Differentiation, 19(6), pp. 1003-1012. (doi: 10.1038/cdd.2011.183) (PMID:22223106) (PMCID:PMC3354052)

Kong, Y. W., Ferland-McCollough, D., Jackson, T. J. and Bushell, M. (2012) microRNAs in cancer management. Lancet Oncology, 13(6), e249-e258. (doi: 10.1016/S1470-2045(12)70073-6) (PMID:22652233)

Moreno, J. A. et al. (2012) Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature, 485(7399), pp. 507-511. (doi: 10.1038/nature11058) (PMID:22622579) (PMCID:PMC3378208)

2011

Kress, T. R., Cannell, I. G., Brenkman, A. B., Samans, B., Gaestel, M., Roepman, P., Burgering, B. M., Bushell, M. , Rosenwald, A. and Eilers, M. (2011) The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Molecular Cell, 41(4), pp. 445-457. (doi: 10.1016/j.molcel.2011.01.023) (PMID:21329882)

2010

Ferland-McCollough, D., Ozanne, S. E., Siddle, K., Willis, A. E. and Bushell, M. (2010) The involvement of microRNAs in Type 2 diabetes. Biochemical Society Transactions, 38(6), pp. 1565-1570. (doi: 10.1042/BST0381565) (PMID:21118127)

Spriggs, K. A., Bushell, M. and Willis, A. E. (2010) Translational regulation of gene expression during conditions of cell stress. Molecular Cell, 40(2), pp. 228-237. (doi: 10.1016/j.molcel.2010.09.028) (PMID:20965418)

Burrows, C. et al. (2010) The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Research, 38(16), pp. 5542-5553. (doi: 10.1093/nar/gkq294) (PMID:20430826) (PMCID:PMC2938220)

Cannell, I. and Bushell, M. (2010) Regulation of Myc by miR-34c: a mechanism to prevent genomic instability? Cell Cycle, 9(14), pp. 2798-2802. (doi: 10.4161/cc.9.14.12182) (PMID:20603603)

James, V. et al. (2010) LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences of the United States of America, 107(28), pp. 12499-12504. (doi: 10.1073/pnas.0914987107) (PMID:20616046) (PMCID:PMC2906597)

Cobbold, L.C., Wilson, L.A., Sawicka, K., King, H.A., Kondrashov, A.V., Spriggs, K.A., Bushell, M. and Willis, A.E. (2010) Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1. Oncogene, 29(19), pp. 2884-2891. (doi: 10.1038/onc.2010.31) (PMID:20190818)

Lou, J. J. W., Chua, Y. L., Chew, E. H., Gao, J., Bushell, M. and Hagen, T. (2010) Inhibition of hypoxia-inducible factor-1α (HIF-1α) protein synthesis by DNA damage inducing agents. PLoS ONE, 5(5), e10522. (doi: 10.1371/journal.pone.0010522) (PMID:20479887) (PMCID:PMC2866540)

Cannell, I. G. et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proceedings of the National Academy of Sciences of the United States of America, 107(12), pp. 5375-5380. (doi: 10.1073/pnas.0910015107) (PMID:20212154) (PMCID:PMC2851793)

Garrey, J. L., Lee, Y.-Y., Au, H. H.T. A., Bushell, M. and Jan, E. (2010) Host and viral translational mechanisms during cricket paralysis virus infection. Journal of Virology, 84(2), pp. 1124-1138. (doi: 10.1128/JVI.02006-09) (PMID:19889774) (PMCID:PMC2798387)

Le Quesne, J. P.C., Spriggs, K. A., Bushell, M. and Willis, A. E. (2010) Dysregulation of protein synthesis and disease. Journal of Pathology, 220(2), pp. 140-151. (doi: 10.1002/path.2627) (PMID:19827082)

2009

Spriggs, K. A., Cobbold, L. C., Ridley, S. H., Coldwell, M., Bottley, A., Bushell, M. , Willis, A. E. and Siddle, K. (2009) The human insulin receptor mRNA contains a functional internal ribosome entry segment. Nucleic Acids Research, 37(17), pp. 5881-5893. (doi: 10.1093/nar/gkp623) (PMID:19654240) (PMCID:PMC2761284)

Spriggs, K. A. et al. (2009) Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Molecular and Cellular Biology, 29(6), pp. 1565-1574. (doi: 10.1128/MCB.01283-08) (PMID:19124605) (PMCID:PMC2648239)

Kondrashov, A. V., Spriggs, K. A., Bushell, M. and Willis, A. E. (2009) Co-ordinated regulation of translation following DNA damage. Cell Cycle, 8(19), pp. 3067-3068. (doi: 10.4161/cc.8.19.9467) (PMID:19755844)

Powley, I. R. et al. (2009) Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes. Genes and Development, 23(10), pp. 1207-1220. (doi: 10.1101/gad.516509) (PMID:19451221) (PMCID:PMC2685536)

2008

Cannell, I. G., Kong, Y. W. and Bushell, M. (2008) How do microRNAs regulate gene expression? Biochemical Society Transactions, 36(6), pp. 1224-1231. (doi: 10.1042/BST0361224) (PMID:19021530)

Sawicka, K., Bushell, M. , Spriggs, K. A. and Willis, A. E. (2008) Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. Biochemical Society Transactions, 36(4), pp. 641-647. (doi: 10.1042/BST0360641) (PMID:18631133)

Kong, Y. W. et al. (2008) The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proceedings of the National Academy of Sciences of the United States of America, 105(26), pp. 8866-8871. (doi: 10.1073/pnas.0800650105) (PMID:18579786) (PMCID:PMC2449332)

Grabowska, A.M., Berry, C.A., Hughes, J., Bushell, M. , Willis, A.E. and Watson, S.A. (2008) A gastrin transcript expressed in gastrointestinal cancer cells contains an internal ribosome entry site. British Journal of Cancer, 98(10), pp. 1696-1703. (doi: 10.1038/sj.bjc.6604326) (PMID:18392051) (PMCID:PMC2391123)

Bushell, M. , Stoneley, M., Spriggs, K. A. and Willis, A. E. (2008) SF2/ASF TORCs up translation. Molecular Cell, 30(3), pp. 262-263. (doi: 10.1016/j.molcel.2008.04.007) (PMID:18471971)

Dobbyn, H.C., Hill, K., Hamilton, T.L., Spriggs, K.A., Pickering, B.M., Coldwell, M.J., de Moor, C.H., Bushell, M. and Willis, A.E. (2008) Regulation of BAG-1 IRES-mediated translation following chemotoxic stress. Oncogene, 27(8), pp. 1167-1174. (doi: 10.1038/sj.onc.1210723) (PMID:17700523) (PMCID:PMC2570717)

Cobbold, L. C., Spriggs, K. A., Haines, S. J., Dobbyn, H. C., Hayes, C., de Moor, C. H., Lilley, K. S., Bushell, M. and Willis, A. E. (2008) Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Molecular and Cellular Biology, 28(1), pp. 40-49. (doi: 10.1128/MCB.01298-07) (PMID:17967896) (PMCID:PMC2223313)

Spriggs, K. A., Stoneley, M., Bushell, M. and Willis, A. E. (2008) Re-programming of translation following cell stress allows IRES-mediated translation to predominate. Biology of the Cell, 100(1), pp. 27-38. (doi: 10.1042/BC20070098) (PMID:18072942)

2007

Meijer, H. A., Bushell, M. , Hill, K., Gant, T. W., Willis, A. E., Jones, P. and de Moor, C. H. (2007) A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells. Nucleic Acids Research, 35(19), e132. (doi: 10.1093/nar/gkm830) (PMID:17933768) (PMCID:PMC2095794)

2006

Bushell, M. , Stoneley, M., Kong, Y. W., Hamilton, T. L., Spriggs, K. A., Dobbyn, H. C., Qin, X., Sarnow, P. and Willis, A. E. (2006) Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. Molecular Cell, 23(3), pp. 401-412. (doi: 10.1016/j.molcel.2006.06.012) (PMID:16885029)

Hamilton, T.L., Stoneley, M., Spriggs, K.A. and Bushell, M. (2006) TOPs and their regulation. Biochemical Society Transactions, 34(1), pp. 12-16. (doi: 10.1042/BST0340012) (PMID:16246169)

2005

Spriggs, K.A., Bushell, M. , Mitchell, S.A. and Willis, A.E. (2005) Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-acting factors. Cell Death and Differentiation, 12(6), pp. 585-591. (doi: 10.1038/sj.cdd.4401642) (PMID:15900315)

Mitchell, S. A., Spriggs, K. A., Bushell, M. , Evans, J. R., Stoneley, M., Le Quesne, J. P.C., Spriggs, R. V. and Willis, A. E. (2005) Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Genes and Development, 19(13), pp. 1556-1571. (doi: 10.1101/gad.339105) (PMID:15998809) (PMCID:PMC1172062)

2004

Bushell, M. , Stoneley, M., Sarnow, P. and Willis, A.E. (2004) Translation inhibition during the induction of apoptosis: RNA or protein degradation? Biochemical Society Transactions, 32(4), pp. 606-610. (doi: 10.1042/BST0320606) (PMID:15270687)

Fraser, C. S., Lee, J. Y., Mayeur, G. L., Bushell, M. , Doudna, J. A. and Hershey, J. W.B. (2004) The j-Subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. Journal of Biological Chemistry, 279(10), pp. 8946-8956. (doi: 10.1074/jbc.M312745200) (PMID:14688252)

2003

Constantinou, C., Bushell, M. , Jeffrey, I. W., Tilleray, V., West, M., Frost, V., Hensold, J. and Clemens, M. J. (2003) p53-induced inhibition of protein synthesis is independent of apoptosis. European Journal of Biochemistry, 270(15), pp. 3122-3132. (doi: 10.1046/j.1432-1033.2003.03687.x) (PMID:12869187)

2002

Horton, L. E., Bushell, M. , Barth-Baus, D., Tilleray, V. J., Clemens, M. J. and Hensold, J. O. (2002) p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene, 21(34), pp. 5325-5334. (doi: 10.1038/sj.onc.1205662) (PMID:12149653)

Jeffrey, I. W., Bushell, M. , Tilleray, V. J., Morley, S. and Clemens, M. J. (2002) Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase. Cancer Research, 62(8), pp. 2272-2280. (PMID:11956083)

Bushell, M. and Sarnow, P. (2002) Hijacking the translation apparatus by RNA viruses. Journal of Cell Biology, 158(3), pp. 395-399. (doi: 10.1083/jcb.200205044) (PMID:12163463) (PMCID:PMC2173839)

2001

Bushell, M. , Wood, W., Carpenter, G., Pain, V. M., Morley, S. J. and Clemens, M. J. (2001) Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4b with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages. Journal of Biological Chemistry, 276(26), pp. 23922-23928. (doi: 10.1074/jbc.M100384200) (PMID:11274152)

2000

Morley, S. J., Jeffrey, I., Bushell, M. , Pain, V. M. and Clemens, M. J. (2000) Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2α, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells. FEBS Letters, 477(3), pp. 229-236. (doi: 10.1016/S0014-5793(00)01805-6) (PMID:10908726)

Bushell, M. , Poncet, D., Marissen, W.E., Flotow, H., Lloyd, R.E., Clemens, M.J. and Morley, S.J. (2000) Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage. Cell Death and Differentiation, 7(7), pp. 628-636. (doi: 10.1038/sj.cdd.4400699) (PMID:10889507)

Clemens, M.J., Bushell, M. , Jeffrey, I.W., Pain, V.M. and Morley, S.J. (2000) Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells. Cell Death and Differentiation, 7(7), pp. 603-615. (doi: 10.1038/sj.cdd.4400695) (PMID:10889505)

Bushell, M. , Wood, W., Clemens, M. J. and Morley, S. J. (2000) Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis. European Journal of Biochemistry, 267(4), pp. 1083-1091. (doi: 10.1046/j.1432-1327.2000.01101.x) (PMID:10672017)

1999

Bushell, M. , McKendrick, L., Jänicke, R. U., Clemens, M. J. and Morley, S. J. (1999) Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis. FEBS Letters, 451(3), pp. 332-336. (doi: 10.1016/S0014-5793(99)00614-6) (PMID:10371215)

1998

Clemens, M. J., Bushell, M. and Morley, S. J. (1998) Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines. Oncogene, 17(22), pp. 2921-2931. (doi: 10.1038/sj.onc.1202227) (PMID:9879998)

Morley, S. J., McKendrick, L. and Bushell, M. (1998) Cleavage of translation initiation factor 4G (eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase. FEBS Letters, 438(1-2), pp. 41-48. (doi: 10.1016/S0014-5793(98)01269-1) (PMID:9821956)

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