Staff
Professor Michael Blatt
- Professor - Regius Professor of Botany [Molecular Biosciences]
- Michael.Blatt@glasgow.ac.uk
Summary of research interests
Ion channel structure and function in plant cell signalling. Mechanisms and roles of membrane trafficking proteins in cellular homeostasis and stress responses of plants.
Professor Richard Cogdell
- Professor - Hooker Chair of Botany [Molecular Biosciences]
- Richard.Cogdell@glasgow.ac.uk
Summary of research interests
The Structure and Function of Purple Bacterial Photosynthetic Membrane Proteins.
Dr Sean Colloms
- Senior Lecturer [Molecular Biosciences]
- Sean.Colloms@glasgow.ac.uk
Summary of research interests
Mechanism, function and applications of enzymes that cut and rejoin DNA.
Professor William Cushley
- Assistant Vice-Principal International [External Relations]
- William.Cushley@glasgow.ac.uk
Professor Paula da Fonseca
- Professor of Cryo-electron Microscopy [Molecular Biosciences]
- Paula.daFonseca@glasgow.ac.uk
Summary of research interests
My research focuses on using cutting edge high resolution cryo-electron microscopy to elucidate the structure and functional mechanisms of proteins and protein complexes.
Professor Gareth Jenkins
- Professor of Plant Cell and Molecular Biology [Molecular Biosciences]
- Gareth.Jenkins@glasgow.ac.uk
Summary of research interests
Cellular and Molecular Mechanisms of Plant Responses to Light, in Particular the Regulation of Gene Expression by UV-B light.
Dr Eirini Kaiserli
- Senior Lecturer [Molecular Biosciences]
- Eirini.Kaiserli@glasgow.ac.uk
Summary of research interests
How nuclear architecture coordinates changes in gene expression and protein organisation to regulate cell growth and survival in response to endogenous and environmental stimuli.
Dr Rucha Karnik
- Senior Royal Society University Research Fellow [Molecular Biosciences]
- Rucha.Karnik@glasgow.ac.uk
Summary of research interests
I study molecular mechanisms that integrate multifactorial stress responses in plants impacting growth, development and immunity. This is fundamental research, important to develop strategies to safeguard agriculture, restrict water use and cope with climate challenges.
Dr Martin Rennie
- Research Associate [Molecular Biosciences]
- Martin.Rennie@glasgow.ac.uk
Dr Clare Rollie
- Lecturer [Molecular Biosciences]
- Clare.Rollie@glasgow.ac.uk
Dr Brian Smith
- Senior Lecturer [Molecular Biosciences]
- Brian.Smith@glasgow.ac.uk
Summary of research interests
NMR spectroscopy for the determination of protein and nucleic acid structure, dynamics and interaction. Methylated DNA binding proteins. Nematode fatty acid binding proteins.
Professor Laura Spagnolo
- Professor of Biophysical Chemistry [Molecular Biosciences]
- Laura.Spagnolo@glasgow.ac.uk
Professor Kostas Tokatlidis
- Cathcart Chair [Molecular Biosciences]
- Kostas.Tokatlidis@glasgow.ac.uk
Summary of research interests
Mitochondria biogenesis (protein targeting/folding/assembly) in health and disease.
Professor Helen Walden
- Professor of Structural Biology [Molecular Biosciences]
- Helen.Walden@glasgow.ac.uk
Summary of research interests
Specificity and disease in the ubiquitin system
Professor Joanna Wilson
- Professor of Molecular Genetics [Molecular Biosciences]
- Joanna.Wilson@glasgow.ac.uk
Summary of research interests
The molecular basis of cancer: oncogenes and tumour suppressor genes at play in malignant disease, how the cellular environment supports or inhibits disease process. Investigating the role of chronic inflammation in carcinogenesis and the underlying mechanisms at work.
Publications
2025
Xu, T., Patitaki, E., Zioutopoulou, A., Kaiserli, E. (2025) Light and high temperatures control epigenomic and epitranscriptomic events in Arabidopsis. Current Opinion in Plant Biology, 83, (doi: 10.1016/j.pbi.2024.102668)
2024
Waghmare, S., Xia, L., Phan Ly, T., Xu, J., Farami, S., Burchmore, R., Blatt, M. R., Karnik, R. (2024) SYNTAXIN OF PLANTS 132 underpins secretion of cargoes associated with salicylic acid signaling and pathogen defense. Plant Physiology, (doi: 10.1093/plphys/kiae541)
Dearlove, E. L., Chatrin, C., Buetow, L., Ahmed, S. F., Schmidt, T., Bushell, M., Smith, B. O., Huang, D. T. (2024) DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids. eLife, 13, (doi: 10.7554/elife.98070)
Waghmare, S., Xia, L., Ly, T. P., Xu, J., Farami, S., Burchmore, R., Blatt, M. R., Karnik, R. (2024) Arabidopsis Syntaxin of Plants 132 underpins secretory traffic of cargoes associated with salicylic acid signalling and pathogen defence. Plant Physiology,
Rennie, M. L., Gundogdu, M., Arkinson, C., Liness, S., Frame, S., Walden, H. (2024) Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01184)
Su, J., He, B., Li, P., Yu, B., Cen, Q., Xia, L., Jing, Y., Wu, F., Karnik, R., Xue, D., Blatt, M. R., Wang, Y. (2024) Overexpression of tonoplast Ca2+‐ATPase in guard cells synergistically enhances stomatal opening and drought tolerance. Journal of Integrative Plant Biology, (doi: 10.1111/jipb.13721)
Koszela, J., Rintala-Dempsey, A., Salzano, G., Pimenta, V., Kamarainen, O., Gabrielsen, M., Parui, A. L., Shaw, G. S., Walden, H. (2024) A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1. bioRxiv, (doi: 10.1101/2024.06.03.597144)
Baena, G., Xia, L., Waghmare, S., Yu, Z., Guo, Y., Blatt, M. R., Zhang, B., Karnik, R. (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, 118, pp. 1036-1053. (doi: 10.1111/tpj.16649)
Cogdell, R. (2024) Reviewers in 2023. Journal of The Royal Society Interface, 21, (doi: 10.1098/rsif.2024.0126)
Tokatlidis, K. (2024) MIMAS is a new giant multifunctional player in the mitochondrial megacomplex playground. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.113874)
Liu, W., Jenkins, G. (2024) Recent advances in UV-B signalling: Interaction of proteins with the UVR8 photoreceptor. Journal of Experimental Botany, (doi: 10.1093/jxb/erae132)
Pal, S., Nare, Z., Rao, V. A., Smith, B. O., Morrison, I., Fitzgerald, E. A., Scott, A., Bingham, M. J., Pesnot, T. (2024) Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS) ChemMedChem, 19, (doi: 10.1002/cmdc.202300590)
Nguyen, T.-H., Blatt, M. R. (2024) Surrounded by luxury: the necessities of subsidiary cells. Plant, Cell and Environment, (doi: 10.1111/pce.14872)
Silva-Alvim, F. A.L., Alvim, J. C., Harvey, A., Blatt, M. R. (2024) Speedy stomata of a C4 plant correlate with enhanced K+ channel gating. Plant, Cell and Environment, 47, pp. 817-831. (doi: 10.1111/pce.14775)
Liu, W., Giuriani, G., Havlikova, A., Li, D., Lamont, D. J., Neugart, S., Velanis, C. N., Petersen, J., Hoecker, U., Christie, J. M., Jenkins, G. (2024) Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation. Nature Communications, 15, (doi: 10.1038/s41467-024-45575-7)
Blatt, M. R. (2024) A charged existence: a century of transmembrane ion transport in plants. Plant Physiology, (doi: 10.1093/plphys/kiad630)
2023
Nguyen, T. B.-A., Lefoulon, C., Nguyen, T.-H., Blatt, M. R., Carroll, W. (2023) Engineering stomata for enhanced carbon capture and water-use efficiency. Trends in Plant Science, 28, pp. 1290-1309. (doi: 10.1016/j.tplants.2023.06.002)
Nguyen, T.-H., Silva-Alvim, F. A. L., Hills, A., Blatt, M. R. (2023) OnGuard3e: a predictive, ecophysiology‐ready tool for gas exchange and photosynthesis research. Plant, Cell and Environment, 46, pp. 3644-3658. (doi: 10.1111/pce.14674)
Quint, M. et al. (2023) 25 years of thermomorphogenesis research: milestones and perspectives. Trends in Plant Science, 28, pp. 1089-1100. (doi: 10.1016/j.tplants.2023.07.001)
Karnik, R., Blatt, M. R. (2023) Analyzing protein–protein interactions using the split-ubiquitin system. Humana Press
Agirre, J. et al. (2023) The CCP 4 suite: integrative software for macromolecular crystallography. Acta Crystallographica. Section D: Structural Biology, D79, pp. 449-461. (doi: 10.1107/S2059798323003595)
Horiuchi, K., Uragami, C., Tao, R., Kosumi, D., Cogdell, R. J., Hashimoto, H. (2023) Excited-state dynamics of all the mono-cis and the major di-cis isomers of β-apo-8′-carotenal as revealed by femtosecond time-resolved transient absorption spectroscopy. Molecules, 28, (doi: 10.3390/molecules28114424)
Deni, I. et al. (2023) Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30, pp. 470-485.e6. (doi: 10.1016/j.chembiol.2023.03.002)
Javitt, A. et al. (2023) The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC. Nature Cancer, 4, pp. 629-647. (doi: 10.1038/s43018-023-00557-4)
Cupellini, L., Qian, P., Nguyen-Phan, T. C., Gardiner, A. T., Cogdell, R. J. (2023) Quantum chemical elucidation of a sevenfold symmetric bacterial antenna complex. Photosynthesis Research, 156, pp. 75-87. (doi: 10.1007/s11120-022-00925-8)
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., Smith, B. O., Kalinina, O. V., Müller, R., Koehnke, J. (2023) Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15, pp. 560-568. (doi: 10.1038/s41557-023-01153-w)
Abioye, J., Lawson‐Williams, M., Lecanda, A., Calhoon, B., McQue, A. L., Colloms, S. D., Stark, W. M., Olorunniji, F. J. (2023) High fidelity one‐pot DNA assembly using orthogonal serine integrases. Biotechnology Journal, 18, (doi: 10.1002/biot.202200411)
Lemonidis, K., Rennie, M. L., Arkinson, C., Chaugule, V. K., Clarke, M., Streetley, J., Walden, H. (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42, (doi: 10.15252/embj.2022111898)
Gallusci, P., Agius, D. R., Moschou, P. N., Dobránszki, J., Kaiserli, E., Martinelli, F. (2023) Deep inside the epigenetic memories of stressed plants. Trends in Plant Science, 28, pp. 142-153. (doi: 10.1016/j.tplants.2022.09.004)
Cannone, G., Kompaniiets, D., Graham, S., White, M. F., Spagnolo, L. (2023) Structure of the Saccharolobus solfataricus type III-D CRISPR effector. Current Research in Structural Biology, 5, (doi: 10.1016/j.crstbi.2023.100098)
McInnes, K. J., van der Hooft, J. J.J., Sharma, A., Herzyk, P., Hundleby, P. A.C., Schoonbeek, H.-J., Amtmann, A., Ridout, C., Jenkins, G. I. (2023) Overexpression of Brassica napus COMT1 in Arabidopsis heightens UV-B-mediated resistance to Plutella xylostella herbivory. Photochemical and Photobiological Sciences, 22, pp. 2341-2356. (doi: 10.1007/s43630-023-00455-9)
2022
Seale, M., Zhdanov, O., Soons, M. B., Cummins, C., Kroll, E., Blatt, M. R., Zare-Behtash, H., Busse, A., Mastropaolo, E., Bullock, J. M., Viola, I. M., Nakayama, N. (2022) Environmental morphing enables informed dispersal of the dandelion diaspore. eLife, 11, (doi: 10.7554/eLife.81962)
Elvers, I., Nguyen Phan, T. C., Gardiner, A. T., Hunter, C. N., Cogdell, R. J., Köhler, J. (2022) Phasor analysis reveals multicomponent fluorescence kinetics in the LH2 complex from Marichromatium purpuratum. Journal of Physical Chemistry B, 126, pp. 10335-10346. (doi: 10.1021/acs.jpcb.2c04983)
Duan, H.-G., Jha, A., Chen, L., Tiwari, V., Cogdell, R. J., Ashraf, K., Prokhorenko, V. I., Thorwart, M., Miller, R. J. D. (2022) Quantum coherent energy transport in the Fenna–Matthews–Olson complex at low temperature. Proceedings of the National Academy of Sciences of the United States of America, 119, pp. e2212630119. (doi: 10.1073/pnas.2212630119)
Kowalczyk, D., Nakasone, M. A., Smith, B. O., Huang, D. T. (2022) Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function. Life Science Alliance, 5, (doi: 10.26508/lsa.202201472)
Lieberman-Lazarovich, M., Kaiserli, E., Bucher, E., Mladenov, V. (2022) Natural and induced epigenetic variation for crop improvement. Current Opinion in Plant Biology, 70, (doi: 10.1016/j.pbi.2022.102297)
Wu, F., Finkelstein-Shapiro, D., Wang, M., Rosenkampff, I., Yartsev, A., Pascher, T., Nguyen- Phan, T. C., Cogdell, R., Börjesson, K., Pullerits, T. (2022) Optical cavity-mediated exciton dynamics in photosynthetic light harvesting 2 complexes. Nature Communications, 13, (doi: 10.1038/s41467-022-34613-x)
Horaruang, W., Klejchová, M., Carroll, W., Silva-Alvim, F. A.L., Waghmare, S., Papanatsiou, M., Amtmann, A., Hills, A., Alvim, J. C., Blatt, M. R., Zhang, B. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8, pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2)
Fang, W., Vellutini, E., Perrella, G., Kaiserli, E. (2022) TANDEM ZINC-FINGER/PLUS3 regulates phytochrome B abundance and signaling to fine-tune hypocotyl growth. Plant Cell, 34, pp. 4213-4231. (doi: 10.1093/plcell/koac236)
Gracie, J., Zamberlan, F., Andrews, I. B., Smith, B. O., Peveler, W. J. (2022) Growth of plasmonic nanoparticles for aging cask-matured whisky. ACS Applied Nano Materials, 5, pp. 15362-15368. (doi: 10.1021/acsanm.2c03406)
Miguel-Romero, L., Alqasmi, M., Bacarizo, J., Tan, J. A., Cogdell, R. J., Chen, J., Byron, O., Christie, G. E., Marina, A., Penadés, J. R. (2022) Non-canonical Staphylococcus aureus pathogenicity island repression. Nucleic Acids Research, 50, pp. 11109-11127. (doi: 10.1093/nar/gkac855)
Qian, P., Nguyen-Phan, T. C., Gardiner, A. T., Croll, T. I., Roszak, A. P., Southall, J., Jackson, P. J., Vasilev, C., Castro-Hartmann, P., Sader, K., Hunter, C. N., Cogdell, R. J. (2022) Cryo-EM structures of light-harvesting 2 complexes from Rhodopseudomonas palustris reveal the molecular origin of absorption tuning. Proceedings of the National Academy of Sciences of the United States of America, 117, (doi: 10.1073/pnas.2210109119)
Yan, S., Wilson, J. (2022) The Action of the Epstein-Barr Virus Oncogene LMP1 in Chronic Inflammation and Tumourigenesis.
Patitaki, E., Schivre, G., Zioutopoulou, A., Perrella, G., Bourbousse, C., Barneche, F., Kaiserli, E. (2022) Light, chromatin, action: nuclear events regulating light signaling in Arabidopsis. New Phytologist, 236, pp. 333-349. (doi: 10.1111/nph.18424)
Rennie, M. L., Arkinson, C., Chaugule, V. K., Walden, H. (2022) Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Science Advances, 8, (doi: 10.1126/sciadv.abq6353)
Ryan, S. M., Ruscher, R., Johnston, W. A., Pickering, D. A., Kennedy, M. W., Smith, B. O., Jones, L., Buitrago, G., Field, M. A., Esterman, A. J., McHugh, C. P., Browne, D. J., Cooper, M. M., Ryan, R. Y. M., Doolan, D. L., Engwerda, C. R., Miles, K., Mitreva, M., Croese, J., Rahman, T., Alexandrov, K., Giacomin, P. R., Loukas, A. (2022) Novel antiinflammatory biologics shaped by parasite–host coevolution. Proceedings of the National Academy of Sciences of the United States of America, 119, (doi: 10.1073/pnas.2202795119)
Hogrel, G., Guild, A., Graham, S., Rickman, H., Grüschow, S., Bertrand, Q., Spagnolo, L., White, M. F. (2022) Cyclic nucleotide-induced helical structure activates a TIR immune effector. Nature, 608, pp. 808-812. (doi: 10.1038/s41586-022-05070-9)
Lemonidis, K., Arkinson, C., Rennie, M. L., Walden, H. (2022) Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination. FEBS Journal, 289, pp. 4811-4829. (doi: 10.1111/febs.16077)
Caccavale, E., Johnson, M. P., Brijbassi, S., Andreazza, A. C., Tokatlidis, K. (2022) Mitochondria and Us: from exploration to global collective. Biochemist, 44, pp. 22-28. (doi: 10.1042/bio_2022_122)
Wilson, J. (2022) Mouse Models of EBV Associated Disease, From Understanding Mechanism to Pre-clinical Model.
Liao, X., Jenkins, G. I. (2022) Cysteines have a role in conformation of the UVR8 photoreceptor. Plant Journal, 111, pp. 583-594. (doi: 10.1111/tpj.15841)
Baena, G., Xia, L., Waghmare, S., Karnik, R. (2022) SNARE SYP132 mediates divergent trafficking of H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis. Plant Physiology, 189, pp. 1639-1661. (doi: 10.1093/plphys/kiac149)
Kjeldsen, A., Kay, J. E., Baxter, S., McColm, S., Serrano-Amatriain, C., Parker, S., Robb, E., Arnold, S. A., Gilmour, C., Raper, A., Robertson, G., Fleming, R., Smith, B. O., Fotheringham, I. G., Christie, J. M., Magneschi, L. (2022) The fluorescent protein iLOV as a reporter for screening of high‐yield production of antimicrobial peptides in Pichia pastoris. Microbial Biotechnology, 15, pp. 2126-2139. (doi: 10.1111/1751-7915.14034)
Ledahawsky, L. M., Terzenidou, M. E., Edwards, R., Kline, R. A., Graham, L. C., Eaton, S. L., van der Hoorn, D., Chaytow, H., Huang, Y.‐T., Groen, E. J.N., Motyl, A. A. L., Lamont, D. J., Tokatlidis, K., Wishart, T. M., Gillingwater, T. H. (2022) The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo. FEBS Journal, 289, pp. 3894-3914. (doi: 10.1111/febs.16377)
Wang, Y., Karnik, R., Garcia-Mata, C., Hu, H. (2022) Editorial: transport and membrane traffic in stomatal biology. Frontiers in Plant Science, 13, (doi: 10.3389/fpls.2022.898128)
Torres Cabán, C. C., Yang, M., Lai, C., Yang, L., Subach, F. V., Smith, B. O., Piatkevich, K. D., Boyden, E. S. (2022) Tuning the sensitivity of genetically encoded fluorescent potassium indicators through structure-guided and genome mining strategies. ACS Sensors, 7, pp. 1336-1346. (doi: 10.1021/acssensors.1c02201)
Thu, N. B.A., Amtmann, A., Blatt, M. R., Nguyen, T.-H. (2022) Stomata under salt stress—what can mechanistic modeling tell us? Academic Press
Živković, D., Sanchez Dafun, A., Menneteau, T., Schahl, A., Lise, S., Kervarrec, C., Toste Rêgo, A., da Fonseca, P. C. A., Chavent, M., Pineau, C., Burlet-Schiltz, O., Marcoux, J., Bousquet, M.-P. (2022) Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 119, pp. e2116826119. (doi: 10.1073/pnas.2116826119)
Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)
Zioutopoulou, A., Patitaki, E., O'Donnell, L., Kaiserli, E. (2022) Low fluence ultraviolet-B promotes ultraviolet resistance 8-modulated flowering in Arabidopsis. Frontiers in Plant Science, 13, (doi: 10.3389/fpls.2022.840720)
Dunkerley, K. M., Rintala-Dempsey, A. C., Salzano, G., Tadayon, R., Hadi, D., Barber, K. R., Walden, H., Shaw, G. S. (2022) Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by Parkin. Biochemical Journal, 479, pp. 751-766. (doi: 10.1042/bcj20210741)
Guarino, F., Cicatelli, A., Castiglione, S., Agius, D. R., Orhun, G. E., Fragkostefanakis, S., Leclercq, J., Dobránszki, J., Kaiserli, E., Lieberman-Lazarovich, M., Sõmera, M., Sarmiento, C., Vettori, C., Paffetti, D., Poma, A. M. G., Moschou, P. N., Gašparović, M., Yousefi, S., Vergata, C., Berger, M. M. J., Gallusci, P., Miladinović, D., Martinelli, F. (2022) An epigenetic alphabet of crop adaptation to climate change. Frontiers in Genetics, 13, (doi: 10.3389/fgene.2022.818727)
Kim, J., Nguyen-Phan, T. C., Gardiner, A. T., Yoon, T. H., Cogdell, R. J., Cho, M., Scholes, G. D. (2022) Vibrational modes promoting exciton relaxation in the B850 band of LH2. Journal of Physical Chemistry Letters, 13, pp. 1099-1106. (doi: 10.1021/acs.jpclett.1c03868)
Blatt, M. R., Jezek, M., Lew, V. L., Hills, A. (2022) What can mechanistic models tell us about guard cells, photosynthesis, and water use efficiency? Trends in Plant Science, 27, pp. 166-179. (doi: 10.1016/j.tplants.2021.08.010)
Nakasone, M. A., Majorek, K. A., Gabrielsen, M., Sibbet, G. J., Smith, B. O., Huang, D. T. (2022) Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nature Chemical Biology, 18, pp. 422-431. (doi: 10.1038/s41589-021-00952-x)
Neckebroeck, A., Kelly, S. M., Smith, B. O., Clark, J. S. (2022) Synthesis of the prototypical cyclopropyl dipeptide mimic and evaluation of its turn-inducing capability. Journal of Organic Chemistry, 87, pp. 258-270. (doi: 10.1021/acs.joc.1c02344)
Yukihira, N., Uragami, C., Horiuchi, K., Kosumi, D., Gardiner, A. T., Cogdell, R. J., Hashimoto, H. (2022) Intramolecular charge-transfer enhances energy transfer efficiency in carotenoid-reconstituted light-harvesting 1 complex of purple photosynthetic bacteria. Communications Chemistry, 5, (doi: 10.1038/s42004-022-00749-6)
Zhdanov, O., Blatt, M. R., Zare-Behtash, H., Busse, A. (2022) Unidirectional versus bidirectional brushing: simulating wind influence on Arabidopsis thaliana. Quantitative Plant Biology, 3, (doi: 10.1017/qpb.2021.14)
2021
Tokatlidis, K., Eaglesfield, R. (2021) Targeting and insertion of membrane proteins in mitochondria. Frontiers in Cell and Developmental Biology, 9, (doi: 10.3389/fcell.2021.803205)
Blatt, M. (2021) Ae fond fareweel. Plant Physiology, 187, pp. 2341-2343. (doi: 10.1093/plphys/kiab467)
Zioutopoulou, A., Patitaki, E., Xu, T., Kaiserli, E. (2021) The epigenetic mechanisms underlying thermomorphogenesis and heat stress responses in Arabidopsis. Plants, 10, (doi: 10.3390/plants10112439)
Prabhakar, A. T., James, C. D., Das, D., Otoa, R., Day, M., Burgner, J., Fontan, C. T., Wang, X., Wieland, A., Donaldson, M. M., Bristol, M. L., Li, R., Oliver, A. W., Pearl, L. H., Smith, B. O., Glass, S., Morgan, I. M. (2021) CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 interaction with mitotic chromatin and the viral life cycle. mBio, 12, (doi: 10.1128/mbio.01163-21)
Jezek, M., Silva-Alvim, F. A.L., Hills, A., Donald, N., Ishka, M. R., Shadbolt, J., He, B., Lawson, T., Harper, J. F., Wang, Y., Lew, V. L., Blatt, M. R. (2021) Guard cell endomembrane Ca2+-ATPases underpin a ‘carbon memory’ of photosynthetic assimilation that impacts on water-use efficiency. Nature Plants, 7, pp. 1301-1313. (doi: 10.1038/s41477-021-00966-2)
Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10, (doi: 10.3390/cells10092307)
Geldon, S., Fernandez-Vizarra, E., Tokatlidis, K. (2021) Redox-mediated regulation of mitochondrial biogenesis, dynamics and respiratory chain assembly in yeast and human cells. Frontiers in Cell and Developmental Biology, 9, (doi: 10.3389/fcell.2021.720656)
Kakoulidou, I., Avramidou, E. V., Baránek, M., Brunel-Muguet, S., Farrona, S., Johannes, F., Kaiserli, E., Lieberman-Lazarovich, M., Martinelli, F., Mladenov, V., Testillano, P. S., Vassileva, V., Maury, S. (2021) Epigenetics for crop improvement in times of global change. Biology, 10, (doi: 10.3390/biology10080766)
Kim, J., Nguyen-Phan, T. C., Gardiner, A. T., Cogdell, R. J., Scholes, G. D., Cho, M. (2021) Low-frequency vibronic mixing modulates the excitation energy flow in bacterial light-harvesting complex II. Journal of Physical Chemistry Letters, 12, pp. 6292-6298. (doi: 10.1021/acs.jpclett.1c01782)
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2020
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2019
van der Woude, L. C., Perrella, G., Snoek, B. L., van Hoogdalem, M., Novák, O., van Verk, M. C., van Kooten, H. N., Zorn, L. E., Tonckens, R., Dongus, J. A., Praat, M., Stouten, E. A., Proveniers, M. C. G., Vellutini, E., Patitaki, E., Shapulatov, U., Kohlen, W., Balasubramanian, S., Ljung, K., van der Krol, A. R., Smeekens, S., Kaiserli, E., van Zanten, M. (2019) HISTONE DEACETYLASE 9 stimulates auxin-dependent thermomorphogenesis in Arabidopsis thaliana by mediating H2A.Z depletion. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 25343-25354. (doi: 10.1073/pnas.1911694116)
Gundogdu, M., Walden, H. (2019) Structural basis of generic versus specific E2-RING E3 interactions in protein ubiquitination. Protein Science, 28, pp. 1758-1770. (doi: 10.1002/pro.3690)
Waghmare, S., Lefoulon, C., Zhang, B., Lileikyte, E., Donald, N., Blatt, M. (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic. Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919)
Taffet, E. J., Lee, B. G., Toa, Z. S. D., Pace, N., Rumbles, G., Southall, J., Cogdell, R. J., Scholes, G. D. (2019) Carotenoid nuclear reorganization and interplay of bright and dark excited states. Journal of Physical Chemistry B, 123, pp. 8628-8643. (doi: 10.1021/acs.jpcb.9b04027)
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Toste Rêgo, A., da Fonseca, P. C.A. (2019) Characterization of fully recombinant human 20S and 20S-PA200 proteasome complexes. Molecular Cell, 76, pp. 138-147.e5. (doi: 10.1016/j.molcel.2019.07.014)
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Karki, K. J., Chen, J., Sakurai, A., Shi, Q., Gardiner, A. T., Kühn, O., Cogdell, R. J., Pullerits, T. (2019) Before Förster. Initial excitation in photosynthetic light harvesting. Chemical Science, 10, pp. 7923-7928. (doi: 10.1039/C9SC01888C)
Fillol-Salom, A., Bacarizo Roa, J. L., Alqasmi, M. H. H., Ciges-Tomas, J. R., Martínez-Rubio, R., Roszak, A. W., Cogdell, R. J., Chen, J., Marina, A., Penades, J. R. (2019) Hijacking the hijackers: Escherichia coli pathogenicity islands redirect helper phage packaging for their own benefit. Molecular Cell, 75, pp. 1020-1030.e4. (doi: 10.1016/j.molcel.2019.06.017)
Jurić, I., Hibberd, J. M., Blatt, M., Burroughs, N. J. (2019) Computational modelling predicts substantial carbon assimilation gains for C3 plants with a single-celled C4 biochemical pump. PLoS Computational Biology, 15, (doi: 10.1371/journal.pcbi.1007373)
Ibáñez-Shimabukuro, M., Rey-Burusco, M. F., Gabrielsen, M., Franchini, G. R., Riboldi-Tunnicliffe, A., Roe, A. J., Griffiths, K., Cooper, A., Córsico, B., Kennedy, M. W., Smith, B. O. (2019) Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode. Bioscience Reports, 39, (doi: 10.1042/BSR20191292)
Caceres, C., Spatharis, S., Kaiserli, E., Smeti, E., Flowers, H., Bonachela, J. A. (2019) Temporal phosphate gradients reveal diverse acclimation responses in phytoplankton phosphate uptake. ISME Journal, 13, pp. 2834-2845. (doi: 10.1038/s41396-019-0473-1)
O'Hara, A., Headland, L. R., Díaz-Ramos, L. A., Morales, L. O., Strid, Å., Jenkins, G. I. (2019) Regulation of Arabidopsis gene expression by low fluence rate UV-B independently of UVR8 and stress signaling. Photochemical and Photobiological Sciences, 18, pp. 1675-1684. (doi: 10.1039/C9PP00151D)
Blackman, M. J., Stokes, B. H., Yoo, E., Murithi, J. M., Luth, M. R., Afanasyev, P., da Fonseca, P. C.A., Winzeler, E. A., Ng, C. L., Bogyo, M., Fidock, D. A. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathogens, 15, (doi: 10.1371/journal.ppat.1007722)
Xia, L., Marques-Bueno, M. M., Bruce, C. G., Karnik, R. (2019) Unusual roles of secretory SNARE SYP132 in plasma membrane H+-ATPase traffic and vegetative plant growth. Plant Physiology, 180, pp. 837-858. (doi: 10.1104/pp.19.00266)
Zhao, J., Pokhilko, A., Ebenhöh, O., Rosser, S. J., Colloms, S. D. (2019) A single-input binary counting module based on serine integrase site-specific recombination. Nucleic Acids Research, 47, pp. 4896-4909. (doi: 10.1093/nar/gkz245)
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Rühl, J., Citterio, C., Engelmann, C., Haigh, T., Dzionek, A., Dreyer, J., Khanna, R., Taylor, G. S., Wilson, J. B., Leung, C. S., Munz, C. (2019) Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas. Journal of Clinical Investigation, 129, pp. 2071-2087. (doi: 10.1172/JCI125364)
Ji, H., Wang, S., Cheng, C., Li, R., Wang, Z., Jenkins, G. I., Kong, F., Li, X. (2019) The RCC 1 family protein SAB 1 negatively regulates ABI 5 through multidimensional mechanisms during postgermination in Arabidopsis. New Phytologist, 222, pp. 907-922. (doi: 10.1111/nph.15653)
Papanatsiou, M., Petersen, J., Henderson, L., Wang, Y., Christie, J.M., Blatt, M.R. (2019) Optogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth. Science, 363, pp. 1456-1459. (doi: 10.1126/science.aaw0046)
Edwards, R., Tokatlidis, K. (2019) The yeast voltage-dependent anion channel Porin: more IMPORTant than just metabolite transport. Molecular Cell, 73, pp. 861-862. (doi: 10.1016/j.molcel.2019.02.028)
Conte, E., Mende, L., Grainge, I., Colloms, S. D. (2019) A mini-ISY100 transposon delivery system effective in γ proteobacteria. Frontiers in Microbiology, 10, (doi: 10.3389/fmicb.2019.00280)
Zhao, C. et al. (2019) Evolution of chloroplast retrograde signaling facilitates green plant adaptation to land. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 5015-5020. (doi: 10.1073/pnas.1812092116)
Knuhtsen, A., Whitmore, C., McWhinnie, F. S., McDougall, L., Whiting, R., Smith, B. O., Timperley, C. M., Green, A. C., Kinnear, K. I., Jamieson, A. G. (2019) α-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor. Chemical Science, 10, pp. 1671-1676. (doi: 10.1039/C8SC04198A)
Liao, X., Zhang, B., Blatt, M. R., Jenkins, G. I. (2019) A FRET method for investigating dimer/monomer status and conformation of the UVR8 photoreceptor. Photochemical and Photobiological Sciences, 18, pp. 367-374. (doi: 10.1039/C8PP00489G)
Camacho, I. S., Theisen, A., Johannissen, L. O., Díaz-Ramos, L. A., Christie, J. M., Jenkins, G. I., Bellina, B., Barran, P., Jones, A. R. (2019) Native mass spectrometry reveals the conformational diversity of the UVR8 photoreceptor. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 1116-1125. (doi: 10.1073/pnas.1813254116)
Robson, T. M., Aphalo, P. J., Banaś, A. K., Barnes, P. W., Brelsford, C. C., Jenkins, G. I., Kotilainen, T. K., Łabuz, J., Martínez-Abaigar, J., Morales, L. O., Neugart, S., Pieristè, M., Rai, N., Vandenbussche, F., Jansen, M. A. K. (2019) A perspective on ecologically relevant plant-UV research and its practical application. Photochemical and Photobiological Sciences, 18, pp. 970-988. (doi: 10.1039/c8pp00526e)
Kunsel, T., Tiwari, V., Matutes, Y. A., Gardiner, A. T., Cogdell, R. J., Ogilvie, J. P., Jansen, T. L. C. (2019) Simulating fluorescence-detected two-dimensional electronic spectroscopy of multichromophoric systems. Journal of Physical Chemistry B, 123, pp. 394-406. (doi: 10.1021/acs.jpcb.8b10176)
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Purohit, P. K., Edwards, R., Tokatlidis, K., Saini, N. (2019) MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells. RNA Biology, 16, pp. 918-929. (doi: 10.1080/15476286.2019.1600999)
2018
Jackson, M., Marks, L., May, G. H.W., Wilson, J. B. (2018) The genetic basis of disease. Essays In Biochemistry, 62, pp. 643-723. (doi: 10.1042/EBC20170053)
Waghmare, S., Lileikyte, E., Karnik, R., Goodman, J. K., Blatt, M. R., Jones, A. M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178, pp. 1679-1688. (doi: 10.1104/pp.18.00832)
Condos, T. E.C., Dunkerley, K. M., Freeman, E. A., Barber, K. R., Aguirre, J. D., Chaugule, V. K., Xiao, Y., Konermann, L., Walden, H., Shaw, G. S. (2018) Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation. EMBO Journal, (doi: 10.15252/embj.2018100014)
Lefoulon, C., Waghmare, S., Karnik, R., Blatt, M. R. (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41, pp. 2668-2677. (doi: 10.1111/pce.13392)
Arkinson, C., Chaugule, V. K., Toth, R., Walden, H. (2018) Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1. Life Science Alliance, 1, (doi: 10.26508/lsa.201800162)
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Carey, A.-M., Zhang, H., Mieritz, D., Volosin, A., Gardiner, A., Cogdell, R., Yan, H., Seo, D.-K., Lin, S., Woodbury, N. W. (2016) Photocurrent generation by photosynthetic purple bacterial reaction centers interfaced with a porous antimony-doped tin oxide (ATO) electrode. ACS Applied Materials and Interfaces, 8, pp. 25104-25110. (doi: 10.1021/acsami.6b07940)
Heilmann, M., Velanis, C. N., Cloix, C., Smith, B. O., Christie, J. M., Jenkins, G. I. (2016) Dimer/monomer status and in vivo function of salt-bridge mutants of the plant UV-B photoreceptor UVR8. Plant Journal, 88, pp. 71-81. (doi: 10.1111/tpj.13260)
Pokhilko, A., Zhao, J., Ebenhöh, O., Smith, M. C.M., Stark, W. M., Colloms, S. D. (2016) The mechanism of φC31 integrase directionality: experimental analysis and computational modelling. Nucleic Acids Research, 44, pp. 7360-7372. (doi: 10.1093/nar/gkw616)
Papanatsiou, M., Amtmann, A., Blatt, M. R. (2016) Stomatal spacing safeguards stomatal dynamics by facilitating guard cell ion transport independent of the epidermal solute reservoir. Plant Physiology, 172, pp. 254-263. (doi: 10.1104/pp.16.00850)
Morris, R. J., Brandani, G. B., Desai, V., Smith, B. O., Schor, M., MacPhee, C. E. (2016) The conformation of interfacially adsorbed Ranaspumin-2 Is an arrested state on the unfolding pathway. Biophysical Journal, 111, pp. 732-742. (doi: 10.1016/j.bpj.2016.06.006)
Löhner, A., Ashraf, K., Cogdell, R. J., Köhler, J. (2016) Fluorescence-excitation and emission spectroscopy on single FMO complexes. Scientific Reports, 6, (doi: 10.1038/srep31875)
Armfield, K., Liskamp, R., Wilson, J.B. (2016) Therapeutic Approaches to Targetting Epstein-Barr Virus Related Disease.
Maćkowski, S., Czechowski, N., Ashraf, K. U., Szalkowski, M., Lokstein, H., Cogdell, R. J., Kowalska, D. (2016) Origin of bimodal fluorescence enhancement factors of Chlorobaculum tepidumreaction centers on silver island films. FEBS Letters, 590, pp. 2558-2565. (doi: 10.1002/1873-3468.12292)
Kalef-Ezra, E., Kotzamani, D., Zaganas, I., Katrakili, N., Plaitakis, A., Tokatlidis, K. (2016) Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence. Biochemical Journal, 473, pp. 2813-2829. (doi: 10.1042/BCJ20160535)
Findlay, K. M.W., Jenkins, G. I. (2016) Regulation of UVR8 photoreceptor dimer/monomer photo-equilibrium in Arabidopsis plants grown under photoperiodic conditions. Plant Cell and Environment, 39, pp. 1706-1714. (doi: 10.1111/pce.12724)
Vance, S. J., Desai, V., Smith, B. O., Kennedy, M. W., Cooper, A. (2016) Aqueous solubilization of C60 fullerene by natural protein surfactants, latherin and ranaspumin-2. Biophysical Chemistry, 214-15, pp. 27-32. (doi: 10.1016/j.bpc.2016.05.003)
Chatzi, A., Manganas, P., Tokatlidis, K. (2016) Oxidative folding in the mitochondrial intermembrane space: a regulated process important for cell physiology and disease. Biochimica et Biophysica Acta: Molecular Cell Research, 1863, pp. 1298-1306. (doi: 10.1016/j.bbamcr.2016.03.023)
Ashraf, K. U., Josts, I., Mosbahi, K., Kelly, S. M., Byron, O., Smith, B. O., Walker, D. (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor. Structure, 24, pp. 741-749. (doi: 10.1016/j.str.2016.03.017)
Malý, P., Gruber, J. M., Cogdell, R. J., Mančal, T., van Grondelle, R. (2016) Ultrafast energy relaxation in single light-harvesting complexes. Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 2934-2939. (doi: 10.1073/pnas.1522265113)
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Morreale, F. E., Walden, H. (2016) Types of ubiquitin ligases. Cell, 165, pp. 248-248.e1. (doi: 10.1016/j.cell.2016.03.003)
Li, H., O’Donoghue, A. J., van der Linden, W. A., Xie, S. C., Yoo, E., Foe, I. T., Tilley, L., Craik, C. S., da Fonseca, P. C.A., Bogyo, M. (2016) Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature, 530, pp. 233-236. (doi: 10.1038/nature16936)
Ferretti, M., Hendrikx, R., Romero, E., Southall, J., Cogdell, R. J., Novoderezhkin, V. I., Scholes, G. D., van Grondelle, R. (2016) Dark states in the light-harvesting complex 2 revealed by two-dimensional electronic spectroscopy. Scientific Reports, 6, (doi: 10.1038/srep20834)
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Magdaong, N. M., LaFountain, A. M., Hacking, K., Niedzwiedzki, D. M., Gibson, G. N., Cogdell, R., Frank, H. A. (2016) Spectral heterogeneity and carotenoid-to-bacteriochlorophyll energy transfer in LH2 light-harvesting complexes from Allochromatium vinosum. Photosynthesis Research, 127, pp. 171-187. (doi: 10.1007/s11120-015-0165-2)
Henry, S. L., Withers, J. M., Singh, I., Cooper, J. M., Clark, A. W., Burley, G. A., Cogdell, R. J. (2016) DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic and Biomolecular Chemistry, 14, pp. 1359-1362. (doi: 10.1039/c5ob02351c)
Pokhilko, A., Zhao, J., Stark, W. M., Colloms, S. D., Ebenhöh, O. (2016) A simplified mathematical model of directional DNA site-specific recombination by serine integrases. Journal of the Royal Society: Interface, 14, (doi: 10.1098/rsif.2016.0618)
Connolly, J. P. R., Gabrielsen, M., Goldstone, R. J., Grinter, R., Wang, D., Cogdell, R. J., Walker, D., Smith, D. G. E., Roe, A. J. (2016) A highly conserved bacterial d-serine uptake system links host metabolism and virulence. PLoS Pathogens, 12, (doi: 10.1371/journal.ppat.1005359)
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Hashimoto, H., Uragami, C., Cogdell, R. J. (2016) Carotenoids and Photosynthesis. Springer International Publishing
Kosumi, D., Horibe, T., Sugisaki, M., Cogdell, R. J., Hashimoto, H. (2016) Photoprotection mechanism of light-harvesting antenna complex from purple bacteria. Journal of Physical Chemistry B, 120, pp. 951-956. (doi: 10.1021/acs.jpcb.6b00121)
Wientjes, E., Renger, J., Cogdell, R., van Hulst, N. F. (2016) Pushing the photon limit: nanoantennas increase maximal photon stream and total photon number. Journal of Physical Chemistry Letters, 7, pp. 1604-1609. (doi: 10.1021/acs.jpclett.6b00491)
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Postgraduate research students
- Ly Truong Phan Thu *
Engineering stomatal patterning in plants for enhanced water use efficiency - Patitaki Eirini
MVLS DTP - Perkins Nathanael
Understanding the Proteasome and its Evolution / Engineering Plant Rubisco Activase for Thermal Tolerance - Sabha Bassam Hassan A
Using a molecular biology approach to understand the role of heat shock protein co-chaperones in normal physiology and disease. - Van Der Schans Fara
Targeting therapy-resistant cancer cells via mitochondrial biogenesis - Wang Zejia
Unconventional protein import into the mitochondrial intermembrane space as a backup mechanism to sustain Erv1/ALR function under stress conditions - Yu Zhiyi
CO2-sensitive membrane traffic impacts ion transport and stomatal kinetics
Our research aim is to answer fundamental questions related to the structure and function of proteins involved in important biochemical processes. Major topics on this theme include:
- how membrane proteins form structure during biogenesis
- how proteins are trafficked to and from the cell membrane in response to insulin stimulation
- how protein folding is influenced by redox phenomena
- how protein homeostasis is regulated by ubiquitin
There is a strong emphasis on the determination of protein structures using X-ray crystallography, NMR and cryo-EM. Targets of these studies include photosynthetic light harvesting complexes, plant photoreceptors and large multimeric complexes involved in RNA and DNA metabolism. These structural studies are complemented by function studies aimed at elucidating molecular mechanisms of action. Our work is supported by expertise from the Structural Biology and Biophysical Characterisation Facility and the Scottish Centre for Macromolecular Imaging. Multi-omic systems approaches, including next-generation sequencing are provided through Glasgow Polyomics.
Examples of some of the structures that we have determined are illustrated below: