Dr Roz Laing

  • Senior Research Fellow (Host-Parasite Interactions & Pathogenesis)

email: Rosalind.Laing@glasgow.ac.uk

Ri Biodiversity Animal Health & Compmed, College of Medical, Veterinary & Life Sciences, Level 2, Room 242, Henry Wellcome Building, University of Glasgow, G61 1QH

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-6191-0759

Biography

I am a Wellcome Clinical Research Career Development Fellow studying drug resistance in parasitic nematodes of veterinary and medical importance

Research interests

Research interests:

Molecular biology of veterinary parasites; population genetics and genomics of parasitic nematodes; genetic basis of parasite drug resistance; drug metabolism; approaches to the diagnosis and control of anthelmintic resistance

 

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010
Number of items: 37.

2024

Brinzer, R. A. , McIntyre, J. R. , Britton, C. and Laing, R. (2024) The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro. International Journal for Parasitology, (doi: 10.1016/j.ijpara.2024.11.004) (PMID:39617094) (Early Online Publication)

Nak-on, S., Campbell, P., Shalaby, M. M., McIntyre, J. , Antonopoulos, A., Chontananarth, T. and Laing, R. (2024) Development of a LAMP detection assay for Dictyocaulus viviparus Bloch, 1782 lungworm: DviLAMP. Frontiers in Veterinary Science, 11, 1454065. (doi: 10.3389/fvets.2024.1454065)

Campbell, P., Forbes, A., McIntyre, J. , Bartoschek, T., Devine, K., O’Neill, K., Laing, R. and Ellis, K. (2024) Inefficacy of ivermectin and moxidectin treatments against Dictyocaulus viviparus in dairy calves. Veterinary Record, (doi: 10.1002/vetr.4265) (PMID:38845174) (Early Online Publication)

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

Antonopoulos, A., Charvet, C. L., Maitland, K. , Doyle, S. R., Neveu, C. and Laing, R. (2024) Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus. International Journal for Parasitology: Drugs and Drug Resistance, 24, 100524. (doi: 10.1016/j.ijpddr.2024.100524) (PMID:38346379) (PMCID:PMC10867575)

Antonopoulos, A. et al. (2024) Real-time single base specific detection of the Haemonchus contortus S168T variant associated with levamisole resistance using loop-primer endonuclease cleavage loop mediated isothermal amplification. Molecular and Cellular Probes, 73, 101946. (doi: 10.1016/j.mcp.2023.101946) (PMID:38097144) (PMCID:PMC10884526)

2023

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

McIntyre, J. , Miskell, L., Morgan, E. R., Lovatt, F. and Laing, R. (2023) Moxidectin use in Scottish sheep flocks suggests a need for clearer product labelling and communication of updated SCOPS guidelines. Veterinary Record, 192(2), e2083. (doi: 10.1002/vetr.2083) (PMID:36030372) (PMCID:PMC10087414)

2022

Antonopoulos, A., Doyle, S. R., Bartley, D. J., Morrison, A. A., Kaplan, R., Howell, S., Neveu, C., Busin, V. , Devaney, E. and Laing, R. (2022) Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus. International Journal for Parasitology: Drugs and Drug Resistance, 20, pp. 17-26. (doi: 10.1016/j.ijpddr.2022.08.001) (PMID:35970104) (PMCID:PMC9399269)

Doyle, S. R. et al. (2022) Genomic landscape of drug response reveals mediators of anthelmintic resistance. Cell Reports, 41(3), 111522. (doi: 10.1016/j.celrep.2022.111522) (PMID:36261007) (PMCID:PMC9597552)

Wit, J. et al. (2022) Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchus contortus field populations. International Journal for Parasitology, 52(10), pp. 677-689. (doi: 10.1016/j.ijpara.2022.07.004) (PMID:36113620)

Laing, R. et al. (2022) Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode. PLoS Pathogens, 18(6), e1010545. (doi: 10.1371/journal.ppat.1010545) (PMID:35696434) (PMCID:PMC9232149)

2020

Doyle, S. R. et al. (2020) Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm. Communications Biology, 3, 656. (doi: 10.1038/s42003-020-01377-3) (PMID:33168940) (PMCID:PMC7652881)

Britton, C. , Laing, R. and Devaney, E. (2020) Small RNAs in parasitic nematodes - forms and functions. Parasitology, 147(8), pp. 855-864. (doi: 10.1017/S0031182019001689) (PMID:31843030) (PMCID:PMC7284814)

2019

Antonopoulos, A., Busin, V. , Laing, R. and Devaney, E. (2019) Levamisole Resistance Markers in Haemonchus Contortus. BAVP Winter Meeting 2019, Moredun Research Institute, Edinburgh, 5-6 Dec 2019.

Turnbull, F. , Devaney, E. , Morrison, A. A., Laing, R. and Bartley, D. J. (2019) Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta. International Journal for Parasitology: Drugs and Drug Resistance, 11, pp. 59-69. (doi: 10.1016/j.ijpddr.2019.10.002) (PMID:31622822) (PMCID:PMC6796645)

Rezansoff, A. M. et al. (2019) The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 49(11), pp. 847-858. (doi: 10.1016/j.ijpara.2019.05.012) (PMID:31525371)

Doyle, S. R. et al. (2019) Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole-genome sequencing. Frontiers in Genetics, 10, 826. (doi: 10.3389/fgene.2019.00826) (PMID:31616465) (PMCID:PMC6764475)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Doyle, S. R. et al. (2019) Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. BMC Genomics, 20, p. 218. (doi: 10.1186/s12864-019-5592-6) (PMID:30876405) (PMCID:PMC6420744)

Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)

2018

Matoušková, P. et al. (2018) UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), pp. 420-429. (doi: 10.1016/j.ijpddr.2018.09.005) (PMID:30293057) (PMCID:PMC6174829)

McIntyre, J., Hamer, K., Morrison, A. A., Bartley, D. J., Sargison, N., Devaney, E. and Laing, R. (2018) Hidden in plain sight - multiple resistant species within a strongyle community. Veterinary Parasitology, 258, pp. 79-87. (doi: 10.1016/j.vetpar.2018.06.012) (PMCID:PMC6052248)

Sallé, G. et al. (2018) Transcriptomic profiling of nematode parasites surviving vaccine exposure. International Journal for Parasitology, 48(5), pp. 395-402. (doi: 10.1016/j.ijpara.2018.01.004) (PMID:29534987) (PMCID:PMC5909036)

Doyle, S. R. et al. (2018) A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Genome Biology and Evolution, 10(2), pp. 396-409. (doi: 10.1093/gbe/evx269) (PMID:29267942) (PMCID:PMC5793844)

2017

Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)

Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)

2016

Laing, R. , Maitland, K. , Lecova, L., Skuce, P. J., Tait, A. and Devaney, E. (2016) Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use. International Journal for Parasitology, 46(10), pp. 621-630. (doi: 10.1016/j.ijpara.2016.03.010) (PMID:27179994) (PMCID:PMC5011429)

Rezansoff, A. M., Laing, R. and Gilleard, J. S. (2016) Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus. International Journal for Parasitology, 46(10), pp. 653-661. (doi: 10.1016/j.ijpara.2016.04.007) (PMID:27216082)

Laing, R. , Martinelli, A., Tracey, A., Holroyd, N., Gilleard, J.S. and Cotton, J.A. (2016) Haemonchus contortus: genome structure, organization and comparative genomics. In: Gasser, R. B. and von Samson-Himmelstjerna, G. (eds.) Haemonchus contortus and Haemonchosis – Past, Present and Future Trends. Series: Advances in parasitology (93). Elsevier: Amsterdam, pp. 569-598. ISBN 9780128103951 (doi: 10.1016/bs.apar.2016.02.016)

2015

Laing, R. , Bartley, D. J., Morrison, A. A., Rezansoff, A., Martinelli, A., Laing, S. T. and Gilleard, J. S. (2015) The cytochrome P450 family in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 45(4), pp. 243-251. (doi: 10.1016/j.ijpara.2014.12.001) (PMID:25558056) (PMCID:PMC4365919)

Lecova, L., Růžičková, M., Laing, R. , Vogel, H., Szotáková, B., Prchal, L., Lamka, J., Vokřál, I., Skálová, L. and Matoušková, P. (2015) Reliable reference gene selection for quantitative real time PCR in Haemonchus contortus. Molecular and Biochemical Parasitology, 201(2), pp. 123-127. (doi: 10.1016/j.molbiopara.2015.08.001) (PMID:26255779)

2013

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi: 10.1186/gb-2013-14-8-r88) (PMID:23985316) (PMCID:PMC4054779)

Saunders, G. I., Wasmuth, J. D., Beech, R., Laing, R. , Hunt, M., Naghra, H., Cotton, J. A. , Berriman, M., Britton, C. and Gilleard, J. S. (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011) (PMID:23416426)

2012

Laing, S.T., Ivens, A., Butler, V., Ravikumar, S.P., Laing, R. , Woods, D.J. and Gilleard, J.S. (2012) The transcriptional response of Caenorhabditis elegans to ivermectin exposure identifies novel genes involved in the response to reduced food intake. PLoS ONE, 7(2), e31367. (doi: 10.1371/journal.pone.0031367) (PMID:22348077) (PMCID:PMC3279368)

2011

Laing, R. et al. (2011) Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans. PLoS ONE, 6(8), e23216. (doi: 10.1371/journal.pone.0023216) (PMID:21858033) (PMCID:PMC3156134)

2010

Laing, S., Ivens, A., Laing, R. , Ravikumar, S., Butler, V., Woods, D.J. and Gilleard, J.S. (2010) Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites. Biochemical Journal, 432(3), pp. 505-514. (doi: 10.1042/BJ20101346)

This list was generated on Sat Dec 21 17:19:11 2024 GMT.
Number of items: 37.

Articles

Brinzer, R. A. , McIntyre, J. R. , Britton, C. and Laing, R. (2024) The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro. International Journal for Parasitology, (doi: 10.1016/j.ijpara.2024.11.004) (PMID:39617094) (Early Online Publication)

Nak-on, S., Campbell, P., Shalaby, M. M., McIntyre, J. , Antonopoulos, A., Chontananarth, T. and Laing, R. (2024) Development of a LAMP detection assay for Dictyocaulus viviparus Bloch, 1782 lungworm: DviLAMP. Frontiers in Veterinary Science, 11, 1454065. (doi: 10.3389/fvets.2024.1454065)

Campbell, P., Forbes, A., McIntyre, J. , Bartoschek, T., Devine, K., O’Neill, K., Laing, R. and Ellis, K. (2024) Inefficacy of ivermectin and moxidectin treatments against Dictyocaulus viviparus in dairy calves. Veterinary Record, (doi: 10.1002/vetr.4265) (PMID:38845174) (Early Online Publication)

Antonopoulos, A., Charvet, C. L., Maitland, K. , Doyle, S. R., Neveu, C. and Laing, R. (2024) Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus. International Journal for Parasitology: Drugs and Drug Resistance, 24, 100524. (doi: 10.1016/j.ijpddr.2024.100524) (PMID:38346379) (PMCID:PMC10867575)

Antonopoulos, A. et al. (2024) Real-time single base specific detection of the Haemonchus contortus S168T variant associated with levamisole resistance using loop-primer endonuclease cleavage loop mediated isothermal amplification. Molecular and Cellular Probes, 73, 101946. (doi: 10.1016/j.mcp.2023.101946) (PMID:38097144) (PMCID:PMC10884526)

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

McIntyre, J. , Miskell, L., Morgan, E. R., Lovatt, F. and Laing, R. (2023) Moxidectin use in Scottish sheep flocks suggests a need for clearer product labelling and communication of updated SCOPS guidelines. Veterinary Record, 192(2), e2083. (doi: 10.1002/vetr.2083) (PMID:36030372) (PMCID:PMC10087414)

Antonopoulos, A., Doyle, S. R., Bartley, D. J., Morrison, A. A., Kaplan, R., Howell, S., Neveu, C., Busin, V. , Devaney, E. and Laing, R. (2022) Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus. International Journal for Parasitology: Drugs and Drug Resistance, 20, pp. 17-26. (doi: 10.1016/j.ijpddr.2022.08.001) (PMID:35970104) (PMCID:PMC9399269)

Doyle, S. R. et al. (2022) Genomic landscape of drug response reveals mediators of anthelmintic resistance. Cell Reports, 41(3), 111522. (doi: 10.1016/j.celrep.2022.111522) (PMID:36261007) (PMCID:PMC9597552)

Wit, J. et al. (2022) Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchus contortus field populations. International Journal for Parasitology, 52(10), pp. 677-689. (doi: 10.1016/j.ijpara.2022.07.004) (PMID:36113620)

Laing, R. et al. (2022) Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode. PLoS Pathogens, 18(6), e1010545. (doi: 10.1371/journal.ppat.1010545) (PMID:35696434) (PMCID:PMC9232149)

Doyle, S. R. et al. (2020) Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm. Communications Biology, 3, 656. (doi: 10.1038/s42003-020-01377-3) (PMID:33168940) (PMCID:PMC7652881)

Britton, C. , Laing, R. and Devaney, E. (2020) Small RNAs in parasitic nematodes - forms and functions. Parasitology, 147(8), pp. 855-864. (doi: 10.1017/S0031182019001689) (PMID:31843030) (PMCID:PMC7284814)

Turnbull, F. , Devaney, E. , Morrison, A. A., Laing, R. and Bartley, D. J. (2019) Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta. International Journal for Parasitology: Drugs and Drug Resistance, 11, pp. 59-69. (doi: 10.1016/j.ijpddr.2019.10.002) (PMID:31622822) (PMCID:PMC6796645)

Rezansoff, A. M. et al. (2019) The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 49(11), pp. 847-858. (doi: 10.1016/j.ijpara.2019.05.012) (PMID:31525371)

Doyle, S. R. et al. (2019) Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole-genome sequencing. Frontiers in Genetics, 10, 826. (doi: 10.3389/fgene.2019.00826) (PMID:31616465) (PMCID:PMC6764475)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Doyle, S. R. et al. (2019) Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. BMC Genomics, 20, p. 218. (doi: 10.1186/s12864-019-5592-6) (PMID:30876405) (PMCID:PMC6420744)

Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)

Matoušková, P. et al. (2018) UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), pp. 420-429. (doi: 10.1016/j.ijpddr.2018.09.005) (PMID:30293057) (PMCID:PMC6174829)

McIntyre, J., Hamer, K., Morrison, A. A., Bartley, D. J., Sargison, N., Devaney, E. and Laing, R. (2018) Hidden in plain sight - multiple resistant species within a strongyle community. Veterinary Parasitology, 258, pp. 79-87. (doi: 10.1016/j.vetpar.2018.06.012) (PMCID:PMC6052248)

Sallé, G. et al. (2018) Transcriptomic profiling of nematode parasites surviving vaccine exposure. International Journal for Parasitology, 48(5), pp. 395-402. (doi: 10.1016/j.ijpara.2018.01.004) (PMID:29534987) (PMCID:PMC5909036)

Doyle, S. R. et al. (2018) A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Genome Biology and Evolution, 10(2), pp. 396-409. (doi: 10.1093/gbe/evx269) (PMID:29267942) (PMCID:PMC5793844)

Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)

Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)

Laing, R. , Maitland, K. , Lecova, L., Skuce, P. J., Tait, A. and Devaney, E. (2016) Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use. International Journal for Parasitology, 46(10), pp. 621-630. (doi: 10.1016/j.ijpara.2016.03.010) (PMID:27179994) (PMCID:PMC5011429)

Rezansoff, A. M., Laing, R. and Gilleard, J. S. (2016) Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus. International Journal for Parasitology, 46(10), pp. 653-661. (doi: 10.1016/j.ijpara.2016.04.007) (PMID:27216082)

Laing, R. , Bartley, D. J., Morrison, A. A., Rezansoff, A., Martinelli, A., Laing, S. T. and Gilleard, J. S. (2015) The cytochrome P450 family in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 45(4), pp. 243-251. (doi: 10.1016/j.ijpara.2014.12.001) (PMID:25558056) (PMCID:PMC4365919)

Lecova, L., Růžičková, M., Laing, R. , Vogel, H., Szotáková, B., Prchal, L., Lamka, J., Vokřál, I., Skálová, L. and Matoušková, P. (2015) Reliable reference gene selection for quantitative real time PCR in Haemonchus contortus. Molecular and Biochemical Parasitology, 201(2), pp. 123-127. (doi: 10.1016/j.molbiopara.2015.08.001) (PMID:26255779)

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi: 10.1186/gb-2013-14-8-r88) (PMID:23985316) (PMCID:PMC4054779)

Saunders, G. I., Wasmuth, J. D., Beech, R., Laing, R. , Hunt, M., Naghra, H., Cotton, J. A. , Berriman, M., Britton, C. and Gilleard, J. S. (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011) (PMID:23416426)

Laing, S.T., Ivens, A., Butler, V., Ravikumar, S.P., Laing, R. , Woods, D.J. and Gilleard, J.S. (2012) The transcriptional response of Caenorhabditis elegans to ivermectin exposure identifies novel genes involved in the response to reduced food intake. PLoS ONE, 7(2), e31367. (doi: 10.1371/journal.pone.0031367) (PMID:22348077) (PMCID:PMC3279368)

Laing, R. et al. (2011) Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans. PLoS ONE, 6(8), e23216. (doi: 10.1371/journal.pone.0023216) (PMID:21858033) (PMCID:PMC3156134)

Laing, S., Ivens, A., Laing, R. , Ravikumar, S., Butler, V., Woods, D.J. and Gilleard, J.S. (2010) Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites. Biochemical Journal, 432(3), pp. 505-514. (doi: 10.1042/BJ20101346)

Book Sections

Laing, R. , Martinelli, A., Tracey, A., Holroyd, N., Gilleard, J.S. and Cotton, J.A. (2016) Haemonchus contortus: genome structure, organization and comparative genomics. In: Gasser, R. B. and von Samson-Himmelstjerna, G. (eds.) Haemonchus contortus and Haemonchosis – Past, Present and Future Trends. Series: Advances in parasitology (93). Elsevier: Amsterdam, pp. 569-598. ISBN 9780128103951 (doi: 10.1016/bs.apar.2016.02.016)

Conference or Workshop Item

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

Antonopoulos, A., Busin, V. , Laing, R. and Devaney, E. (2019) Levamisole Resistance Markers in Haemonchus Contortus. BAVP Winter Meeting 2019, Moredun Research Institute, Edinburgh, 5-6 Dec 2019.

This list was generated on Sat Dec 21 17:19:11 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Unravelling the mechanisms of resistance to the macrocyclic lactones in the sheep scab mite, Psoroptes ovis
    Biotechnology and Biological Sciences Research Council
    2024 - 2027
     
  • LEVitate: functional validation of a novel mechanism of levamisole resistance in parasitic nematodes
    Biotechnology and Biological Sciences Research Council
    2022 - 2023
     
  • Transport and trophic effects of migratory ungulates on infectious disease hotspots
    Biotechnology and Biological Sciences Research Council
    2021 - 2025
     
  • BSAS early career award 2020
    British Society of Animal Sciences
    2020 - 2021
     
  • Hitting a moving target: genomic and metabolic approaches to improve anthelmintic use in evolving helminth populations
    Wellcome Trust
    2020 - 2024
     
  • United States-UK partnering award:Co-infection and resistance (CORE)
    Biotechnology and Biological Sciences Research Council
    2016 - 2020
     
  • Monepantel: anthelmintic resistance and the development of tools for sustainable use
    Scottish Government
    2016 - 2019
     
  • The BUG consortium Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasites
    Biotechnology and Biological Sciences Research Council
    2015 - 2020
     

Supervision

  • Campbell, Paul
    Associations between anthelmintic treatment, species composition and genetic diversity of gastrointestinal nematodes on organic and conventional dairy farms in Scotland
  • Karani, Benedict Eboya
    Measuring the impact of treatment regimens on the evolution of anthelmintic resistance.

Research datasets

Jump to: 2022
Number of items: 1.

2022

McIntyre, J. , Miskell, L., Laing, R. , Morgan, E. and Lovatt, F. (2022) Wormer resistance and moxidectin use in Scottish sheep flocks (WORMSS project). [Data Collection]

This list was generated on Sat Dec 21 17:19:13 2024 GMT.