Dr Anneli Cooper
- Research Associate (Host-Parasite Interactions & Pathogenesis)
telephone:
01413306923
email:
Anneli.Cooper@glasgow.ac.uk
SBOHVM, Rm 243 Henry Wellcome Building, 464 Bearsden Road, Glasgow G61 1QH
https://orcid.org/0000-0002-1159-142XResearch interests
Google Scholar - Publications Profile
My research interest lies in understanding the complex co-evolution that has taken place between African trypanosome parasites and their mammalian hosts. My current research focuses on using molecular genetics techniques to investigate genes involved in both parasite infectivity and host defence.
Research groups
Publications
2024
Adamson, W. E. et al. (2024) Phenome-wide analysis reveals epistatic associations between APOL1 variants and chronic kidney disease and multiple other disorders. EBioMedicine, 101, 105000. (doi: 10.1016/j.ebiom.2024.105000) (PMID:38360481) (PMCID:PMC10944146)
Sinton, M. C. et al. (2024) Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 15, 1833. (doi: 10.1038/s41467-024-46299-4) (PMID:38418827) (PMCID:PMC10901872)
2023
Calvo Alvarez, E., Marc Tsagmo Ngoune, J., Sharma, P., Cooper, A. , Camara, A., Travaillé, C., Crouzols, A., MacLeod, A. and Rotureau, B. (2023) FLAgellum Member 8 modulates extravascular distribution of African trypanosomes. PLoS Pathogens, 19(12), e1011220. (doi: 10.1371/journal.ppat.1011220) (PMID:38127941) (PMCID:PMC10769064)
Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)
Quintana, J. F. et al. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, 5279. (doi: 10.1038/s41467-023-40962-y) (PMID:37644007) (PMCID:PMC10465518)
Morales, F. et al. (2023) Individual-specific levels of CTG•CAG somatic instability are shared across multiple tissues in myotonic dystrophy type 1. Human Molecular Genetics, 32(4), pp. 621-631. (doi: 10.1093/hmg/ddac231) (PMID:36099027)
2021
Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)
Camara, M. et al. (2021) Extravascular dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis. Clinical Infectious Diseases, 73(1), pp. 12-20. (doi: 10.1093/cid/ciaa897) (PMID:32638003) (PMCID:PMC8246823)
2020
Kurkiewicz, A. et al. (2020) Towards development of a statistical framework to evaluate myotonic dystrophy type 1 mRNA biomarkers in the context of a clinical trial. PLoS ONE, 15(4), e0231000. (doi: 10.1371/journal.pone.0231000) (PMID:32287265) (PMCID:PMC7156058)
2019
Kaboré, J. W. et al. (2019) Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infection, Genetics and Evolution, 71, pp. 108-115. (doi: 10.1016/j.meegid.2019.03.021) (PMID:30914286)
Chiweshe, S. M. et al. (2019) Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection. PLoS Neglected Tropical Diseases, 13(2), e0007189. (doi: 10.1371/journal.pntd.0007189) (PMID:30779758) (PMCID:PMC6413958)
2018
Cumming, S. A. et al. (2018) De novo repeat interruptions are associated with reduced somatic instability and mild or absent clinical features in myotonic dystrophy type 1. European Journal of Human Genetics, 26(11), pp. 1635-1647. (doi: 10.1038/s41431-018-0156-9) (PMID:29967337) (PMCID:PMC6189127)
Currier, R. B., Cooper, A. , Burrell-Saward, H., MacLeod, A. and Alsford, S. (2018) Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. PLoS Pathogens, 14(1), e1006855. (doi: 10.1371/journal.ppat.1006855) (PMID:29346416) (PMCID:PMC5790291)
2017
Luintel, A., Lowe, P., Cooper, A. , MacLeod, A. , Büscher, P., Brooks, T. and Brown, M. (2017) Case of Nigeria-acquired Human African trypanosomiasis in United Kingdom, 2016. Emerging Infectious Diseases, 23(7), pp. 1225-1227. (doi: 10.3201/eid2307.170695) (PMID:28628444) (PMCID:PMC5512500)
Cooper, A. et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, e25461. (doi: 10.7554/eLife.25461) (PMID:28537557) (PMCID:PMC5495568)
Hamilton, M. J. et al. (2017) Correction: Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: A multicentre cohort follow-up study. PLoS ONE, 12(4), e0175615. (doi: 10.1371/journal.pone.0175615) (PMID:28384345) (PMCID:PMC5383318)
Hamilton, M. et al. (2017) Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: a multicentre cohort follow-up study. PLoS ONE, 12(3), e0174166. (doi: 10.1371/journal.pone.0174166) (PMID:28323905) (PMCID:PMC5360313)
2016
Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)
Cooper, A. , Capewell, P. , Clucas, C. , Veitch, N. , Weir, W. , Thomson, R., Raper, J. and MacLeod, A. (2016) A primate APOL1 variant that kills Trypanosoma brucei gambiense. PLoS Neglected Tropical Diseases, 10(8), e0004903. (doi: 10.1371/journal.pntd.0004903) (PMID:27494254) (PMCID:PMC4975595)
Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi: 10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)
2015
Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. and MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi: 10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)
Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. , Vaikkinen, H., Morrison, L., Tait, A. and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi: 10.1007/978-1-4939-1438-8_5) (PMID:25388109)
2013
Capewell, P. , Clucas, C. , DeJesus, E., Kieft, R., Hajduk, S., Veitch, N. , Steketee, P.C., Cooper, A. , Weir, W. and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi: 10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)
Capewell, P. , Cooper, A. , Duffy, C.W., Tait, A., Turner, C.M.R., Gibson, W., Mehlitz, D. and MacLeod, A. (2013) Human and animal trypanosomes in Côte d'Ivoire form a single breeding population. PLoS ONE, 8(7), e67852. (doi: 10.1371/journal.pone.0067852) (PMID:23844111) (PMCID:PMC3699513)
Duffy, C.W., MacLean, L., Sweeney, L., Cooper, A. , Turner, C.M.R., Tait, A., Sternberg, J., Morrison, L.J. and MacLeod, A. (2013) Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci. PLoS Neglected Tropical Diseases, 7(11), e2526. (doi: 10.1371/journal.pntd.0002526)
2011
Tait, A., Morrison, L.J., Duffy, C.W., Cooper, A. , Turner, C.M.R. and MacLeod, A. (2011) Trypanosome genetics: Populations, phenotypes and diversity. Veterinary Parasitology, 181(1), pp. 61-68. (doi: 10.1016/j.vetpar.2011.04.024)
2008
Cooper, A. , Tait, A., Sweeney, L., Tweedie, A., Morrison, L., Turner, C.M.R. and MacLeod, A. (2008) Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map. Genome Biology, 9(6), R103. (doi: 10.1186/gb-2008-9-6-r103)
2007
MacLean, L., Odiit, M., MacLeod, A. , Morrison, L., Sweeney, L., Cooper, A., Kennedy, P.G.E. and Sternberg, J.M. (2007) Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response. Journal of Infectious Diseases, 196(11), pp. 1620-1628. (doi: 10.1086/522011)
2005
Faulkner, L., Cooper, A. , Fantino, C., Altmann, D. M. and Sriskandan, S. (2005) The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm. Journal of Immunology, 175(10), pp. 6870-6877. (doi: 10.4049/jimmunol.175.10.6870)
MacLeod, A., Tweedie, A., McLellan, S., Hope, M., Taylor, S., Cooper, A. , Sweeney, L., Turner, C.M.R. and Tait, A. (2005) Erratum: Allelic segregation and independent assortment in T. brucei crosses: Proof that the genetic system is Mendelian and involves meiosis (Molecular and Biochemical Parasitology (2005) 143 (12-19) DOI: 10.1016/j.molbiopara.2005.04.009). Molecular and Biochemical Parasitology, 144(1), p. 131. (doi: 10.1016/j.molbiopara.2005.08.013)
Articles
Adamson, W. E. et al. (2024) Phenome-wide analysis reveals epistatic associations between APOL1 variants and chronic kidney disease and multiple other disorders. EBioMedicine, 101, 105000. (doi: 10.1016/j.ebiom.2024.105000) (PMID:38360481) (PMCID:PMC10944146)
Sinton, M. C. et al. (2024) Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 15, 1833. (doi: 10.1038/s41467-024-46299-4) (PMID:38418827) (PMCID:PMC10901872)
Calvo Alvarez, E., Marc Tsagmo Ngoune, J., Sharma, P., Cooper, A. , Camara, A., Travaillé, C., Crouzols, A., MacLeod, A. and Rotureau, B. (2023) FLAgellum Member 8 modulates extravascular distribution of African trypanosomes. PLoS Pathogens, 19(12), e1011220. (doi: 10.1371/journal.ppat.1011220) (PMID:38127941) (PMCID:PMC10769064)
Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)
Quintana, J. F. et al. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, 5279. (doi: 10.1038/s41467-023-40962-y) (PMID:37644007) (PMCID:PMC10465518)
Morales, F. et al. (2023) Individual-specific levels of CTG•CAG somatic instability are shared across multiple tissues in myotonic dystrophy type 1. Human Molecular Genetics, 32(4), pp. 621-631. (doi: 10.1093/hmg/ddac231) (PMID:36099027)
Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)
Camara, M. et al. (2021) Extravascular dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis. Clinical Infectious Diseases, 73(1), pp. 12-20. (doi: 10.1093/cid/ciaa897) (PMID:32638003) (PMCID:PMC8246823)
Kurkiewicz, A. et al. (2020) Towards development of a statistical framework to evaluate myotonic dystrophy type 1 mRNA biomarkers in the context of a clinical trial. PLoS ONE, 15(4), e0231000. (doi: 10.1371/journal.pone.0231000) (PMID:32287265) (PMCID:PMC7156058)
Kaboré, J. W. et al. (2019) Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infection, Genetics and Evolution, 71, pp. 108-115. (doi: 10.1016/j.meegid.2019.03.021) (PMID:30914286)
Chiweshe, S. M. et al. (2019) Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection. PLoS Neglected Tropical Diseases, 13(2), e0007189. (doi: 10.1371/journal.pntd.0007189) (PMID:30779758) (PMCID:PMC6413958)
Cumming, S. A. et al. (2018) De novo repeat interruptions are associated with reduced somatic instability and mild or absent clinical features in myotonic dystrophy type 1. European Journal of Human Genetics, 26(11), pp. 1635-1647. (doi: 10.1038/s41431-018-0156-9) (PMID:29967337) (PMCID:PMC6189127)
Currier, R. B., Cooper, A. , Burrell-Saward, H., MacLeod, A. and Alsford, S. (2018) Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. PLoS Pathogens, 14(1), e1006855. (doi: 10.1371/journal.ppat.1006855) (PMID:29346416) (PMCID:PMC5790291)
Luintel, A., Lowe, P., Cooper, A. , MacLeod, A. , Büscher, P., Brooks, T. and Brown, M. (2017) Case of Nigeria-acquired Human African trypanosomiasis in United Kingdom, 2016. Emerging Infectious Diseases, 23(7), pp. 1225-1227. (doi: 10.3201/eid2307.170695) (PMID:28628444) (PMCID:PMC5512500)
Cooper, A. et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, e25461. (doi: 10.7554/eLife.25461) (PMID:28537557) (PMCID:PMC5495568)
Hamilton, M. J. et al. (2017) Correction: Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: A multicentre cohort follow-up study. PLoS ONE, 12(4), e0175615. (doi: 10.1371/journal.pone.0175615) (PMID:28384345) (PMCID:PMC5383318)
Hamilton, M. et al. (2017) Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: a multicentre cohort follow-up study. PLoS ONE, 12(3), e0174166. (doi: 10.1371/journal.pone.0174166) (PMID:28323905) (PMCID:PMC5360313)
Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)
Cooper, A. , Capewell, P. , Clucas, C. , Veitch, N. , Weir, W. , Thomson, R., Raper, J. and MacLeod, A. (2016) A primate APOL1 variant that kills Trypanosoma brucei gambiense. PLoS Neglected Tropical Diseases, 10(8), e0004903. (doi: 10.1371/journal.pntd.0004903) (PMID:27494254) (PMCID:PMC4975595)
Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi: 10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)
Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. and MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi: 10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)
Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. , Vaikkinen, H., Morrison, L., Tait, A. and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi: 10.1007/978-1-4939-1438-8_5) (PMID:25388109)
Capewell, P. , Clucas, C. , DeJesus, E., Kieft, R., Hajduk, S., Veitch, N. , Steketee, P.C., Cooper, A. , Weir, W. and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi: 10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)
Capewell, P. , Cooper, A. , Duffy, C.W., Tait, A., Turner, C.M.R., Gibson, W., Mehlitz, D. and MacLeod, A. (2013) Human and animal trypanosomes in Côte d'Ivoire form a single breeding population. PLoS ONE, 8(7), e67852. (doi: 10.1371/journal.pone.0067852) (PMID:23844111) (PMCID:PMC3699513)
Duffy, C.W., MacLean, L., Sweeney, L., Cooper, A. , Turner, C.M.R., Tait, A., Sternberg, J., Morrison, L.J. and MacLeod, A. (2013) Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci. PLoS Neglected Tropical Diseases, 7(11), e2526. (doi: 10.1371/journal.pntd.0002526)
Tait, A., Morrison, L.J., Duffy, C.W., Cooper, A. , Turner, C.M.R. and MacLeod, A. (2011) Trypanosome genetics: Populations, phenotypes and diversity. Veterinary Parasitology, 181(1), pp. 61-68. (doi: 10.1016/j.vetpar.2011.04.024)
Cooper, A. , Tait, A., Sweeney, L., Tweedie, A., Morrison, L., Turner, C.M.R. and MacLeod, A. (2008) Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map. Genome Biology, 9(6), R103. (doi: 10.1186/gb-2008-9-6-r103)
MacLean, L., Odiit, M., MacLeod, A. , Morrison, L., Sweeney, L., Cooper, A., Kennedy, P.G.E. and Sternberg, J.M. (2007) Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response. Journal of Infectious Diseases, 196(11), pp. 1620-1628. (doi: 10.1086/522011)
Faulkner, L., Cooper, A. , Fantino, C., Altmann, D. M. and Sriskandan, S. (2005) The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm. Journal of Immunology, 175(10), pp. 6870-6877. (doi: 10.4049/jimmunol.175.10.6870)
MacLeod, A., Tweedie, A., McLellan, S., Hope, M., Taylor, S., Cooper, A. , Sweeney, L., Turner, C.M.R. and Tait, A. (2005) Erratum: Allelic segregation and independent assortment in T. brucei crosses: Proof that the genetic system is Mendelian and involves meiosis (Molecular and Biochemical Parasitology (2005) 143 (12-19) DOI: 10.1016/j.molbiopara.2005.04.009). Molecular and Biochemical Parasitology, 144(1), p. 131. (doi: 10.1016/j.molbiopara.2005.08.013)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Spatially-resolved transcriptomic and proteomic profiling of APOL1-mediated kidney disease
Wellcome Trust
2025 - 2027
- Parasite Street Science
Wellcome Trust
2022 - 2023
