Translational Neuroinflammation Group

Navarro-Gallinad, A., Orlandi, F., Scott, J., Havyarimana, E., Basu, N., Little, M., O'Sullivan, D. (2024) Enabling data linkages for rare diseases in a resilient environment with the SERDIF framework. npj Digital Medicine, 7, (doi: 10.1038/s41746-024-01267-6)

Pugh, D., Patel, D., Dhaun, N., Basu, N., Grayson, P., Macnaught, G., Czopek, A., Bruce, L., Donachie, J., Gallacher, P., Ahlman, M. (2024) 18F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis. Nature Communications, 15, (doi: 10.1038/s41467-024-51613-1)

Gray, S. R., Montoye, A. H.K., Vondrasek, J. D., Neph, S., Siebert, S., Paul, L., Bachmair, E. M., Basu, N. (2024) Associations of physical activity levels with fatigue in people with inflammatory rheumatic disease in the LIFT trial. Rheumatology Advances in Practice,

Lombardo, G., Mondelli, V., Worrell, C., Sforzini, L., Mariani, N., Nikkheslat, N., Nettis, M. A., Kose, M., Zajkowska, Z., Cattaneo, A., Pointon, L., Turner, L., Cowen, P. J., Drevets, W. C., Cavanagh, J., Harrison, N. A., Bullmore, E. T., the NIMA Consortium, , Dazzan, P., Pariante, C. M. (2024) Disturbed sex hormones milieu in males and females with major depressive disorder and low-grade inflammation. Journal of Affective Disorders, 356, pp. 167-176. (doi: 10.1016/j.jad.2024.03.018)

Queirazza, F., Cavanagh, J., Philiastides, M. G., Krishnadas, R. (2024) Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants. Brain, Behavior, and Immunity, 119, pp. 197-210. (doi: 10.1016/j.bbi.2024.03.044)

Kidder, D., Basu, N. (2024) The extinction of primary polyarteritis nodosa: a modern science success story? Arthritis and Rheumatology, 76, pp. 996-998. (doi: 10.1002/art.42851)

Hollick, R. J., James, W. R.G., Nicoll, A., Locock, L., Black, C., Dhaun, N., Egan, A. C., Fluck, N., Laidlaw, L., Lanyon, P. C., Little, M. A., Luqmani, R. A., Moir, L., McBain, M., Basu, N. (2024) Identifying key health system components associated with improved outcomes to inform the reconfiguration of services for adults with rare autoimmune rheumatic diseases: a mixed methods study. Lancet Rheumatology, 6, pp. e361-e373. (doi: 10.1016/S2665-9913(24)00082-1)

Craig, M. T., Bielska, M. H., Jeffery, K. (2024) Mechanisms and implications of gamma oscillation plasticity. Trends in Neurosciences, 47, pp. 398-399. (doi: 10.1016/j.tins.2024.05.002)

Goodyear, C. S. et al. (2024) Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial. Lancet Rheumatology, 6, pp. e339-e351. (doi: 10.1016/S2665-9913(24)00065-1)

Cavanagh, J., Spiller, J., Taylor, D. R. (2024) Assisted dying, moral distress, and conscientious objection. Lancet, 403, pp. 1443-1444. (doi: 10.1016/S0140-6736(23)01910-4)

Michael, B. D. et al. (2024) Author correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15, (doi: 10.1038/s41467-024-47320-6)

Dehsarvi, A., Al-Wasity, S., Stefanov, K., Wiseman, S. J., Ralston, S. H., Wardlaw, J. M., Emsley, R., Bachmair, E.‐M., Cavanagh, J., Waiter, G. D., Basu, N. (2024) Characterizing the neurobiological mechanisms of action of exercise and cognitive–behavioral interventions for rheumatoid arthritis fatigue: a magnetic resonance imaging brain study. Arthritis and Rheumatology, 76, pp. 522-530. (doi: 10.1002/art.42755)

Michael, B. D. et al. (2023) Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14, (doi: 10.1038/s41467-023-42320-4)

Chong, H. Y., McNamee, P., Bachmair, E.-M., Martin, K., Aucott, L., Dhaun, N., Dures, E., Emsley, R., Gray, S. R., Kidd, E., Kumar, V., Lovell, K., MacLennan, G., Norrie, J., Paul, L., Packham, J., Ralston, S. H., Siebert, S., Wearden, A., LIFT study group, , Macfarlane, G., Basu, N. (2023) Cost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases. Rheumatology, 62, pp. 3819-3827. (doi: 10.1093/rheumatology/kead157)

Queirazza, F., Steele, J. D., Krishnadas, R., Cavanagh, J., Philiastides, M. G. (2023) Functional magnetic resonance imaging signatures of Pavlovian and instrumental valuation systems during a modified orthogonalized go/no-go task. Journal of Cognitive Neuroscience, 35, pp. 2089-2109. (doi: 10.1162/jocn_a_02062)

Brock, J., Basu, N., Schlachetzki, J. C. M., Schett, G., McInnes, I. B., Cavanagh, J. (2023) Immune mechanisms of depression in rheumatoid arthritis. Nature Reviews Rheumatology, 19, pp. 790-804. (doi: 10.1038/s41584-023-01037-w)

Sijtsma, M., Marjoram, D., Gallagher, H. L., Grealy, M. A., Brennan, D., Mathias, C., Cavanagh, J., Pollick, F. E. (2023) Major depression and the perception of affective instrumental and expressive gestures: an fMRI investigation. Psychiatry Research: Neuroimaging, 336, (doi: 10.1016/j.pscychresns.2023.111728)

Gisslander, K. et al. (2023) Data quality and patient characteristics in European ANCA associated vasculitis registries – data retrieval by federated querying. Annals of the Rheumatic Diseases, (doi: 10.1136/ard-2023-224571)

Witton, J., Brady, E. S., Craig, M. (2023) Sleep-based neuronal oscillations as a physiological biomarker for Alzheimer's disease: is night time the right time? Neural Regeneration Research, 19, pp. 1417-1418. (doi: 10.4103/1673-5374.386412)

Thümmler, K., Wrzos, C., Franz, J., McElroy, D., Cole, J. J., Hayden, L., Arseni, D., Schwarz, F., Junker, A., Edgar, J. M., Kügler, S., Neef, A., Wolf, F., Stadelmann, C., Linington, C. (2023) Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis? Neuropathology and Applied Neurobiology, 49, (doi: 10.1111/nan.12935)

Andrianova, L., Yanakieva, S., Margetts-Smith, G., Kohli, S., Brady, E. S., Aggleton, J. P., Craig, M. T. (2023) No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation. eLife, 12, (doi: 10.7554/eLife.77364)

Schäffner, E. et al. (2023) Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. Nature Neuroscience, 26, pp. 1218-1228. (doi: 10.1038/s41593-023-01366-9)

Barnes, E. et al. (2023) SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29, pp. 1760-1774. (doi: 10.1038/s41591-023-02414-4)

Gamble, A., Suessmilch, M., Bonestroo, A., Merits, A., Graham, G. J., Cavanagh, J., Edgar, J. M., Pingen, M. (2023) Establishing mixed neuronal and glial cell cultures from embryonic mouse brains to study infection and innate immunity. Journal of Visualized Experiments, (doi: 10.3791/65331)

Brady, E. S., Griffiths, J., Andrianova, L., Bielska, M. H., Saito, T., Saido, T. C., Randall, A. D., Tamagnini, F., Witton, J., Craig, M. T. (2023) Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice. Neurobiology of Disease, 182, pp. 106151. (doi: 10.1016/j.nbd.2023.106151)

Sforzini, L. et al. (2023) Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study. Translational Psychiatry, 13, (doi: 10.1038/s41398-023-02438-x)

Cullen, B., Gameroff, M. J., Ward, J., Bailey, M. E.S., Lyall, D. M., Lyall, L. M., MacSweeney, N., Murphy, E., Sangha, N., Shen, X., Strawbridge, R. J., van Dijk, M. T., Zhu, X., Smith, D. J., Talati, A., Whalley, H. C., Cavanagh, J., Weissman, M. M. (2023) Cognitive function in people with familial risk of depression. JAMA Psychiatry, 80, pp. 610-620. (doi: 10.1001/jamapsychiatry.2023.0716)

Sunzini, F., Schrepf, A., Clauw, D. J., Basu, N. (2023) The biology of pain: through the rheumatology lens. Arthritis and Rheumatology, 75, pp. 650-660. (doi: 10.1002/art.42429)

Winthrop, K. L., Isaacs, J. D., Mease, P. J., Boumpas, D. T., Baraliakos, X., Gottenberg, J.-E., Siebert, S., Mosca, M., Basu, N., Orange, D., Lories, R., Aletaha, D., McInnes, I. B., Huizinga, T. W.J., Voll, R. E., Gravallese, E. M., Breedveld, F. C., Smolen, J. S. (2023) Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2022. Annals of the Rheumatic Diseases, 82, pp. 594-598. (doi: 10.1136/ard-2022-223528)

Mumuni, A. N., Krishnadas, R., Cavanagh, J. (2023) Peripheral inflammation is associated with alterations in brain biochemistry and mood: evidence from in vivo proton magnetic resonance spectroscopy study. Pure and Applied Chemistry, 95, pp. 289-300. (doi: 10.1515/pac-2022-1119)

Steyer, A. M., Buscham, T. J., Lorenz, C., Hümmert, S., Eichel-Vogel, M. A., Schadt, L. C., Edgar, J. M., Köster, S., Möbius, W., Nave, K.-A., Werner, H. B. (2023) Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. Glia, 71, pp. 509-523. (doi: 10.1002/glia.24290)

de Almeida, M. M.A., Watson, A. E.S., Bibi, S., Dittmann, N. L., Goodkey, K., Sharafodinzadeh, P., Galleguillos, D., Nakhaei-Nejad, M., Kosaraju, J., Steinberg, N., Wang, B. S., Footz, T., Giuliani, F., Wang, J., Sipione, S., Edgar, J. M., Voronova, A. (2023) Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. Stem Cell Reports, 18, pp. 519-533. (doi: 10.1016/j.stemcr.2022.12.001)

Stefanov, K., Al-Wasity, S., Parkinson, J. T., Waiter, G. D., Cavanagh, J., Basu, N. (2023) Brain mapping inflammatory arthritis related fatigue in the pursuit of novel therapeutics. Lancet Rheumatology, 5, pp. e99-e109. (doi: 10.1016/S2665-9913(23)00007-3)

Needham, E. J. et al. (2022) Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses. Brain, 145, pp. 4097-4107. (doi: 10.1093/brain/awac321)

Kwon, J., Arsenis, C., Suessmilch, M., McColl, A., Cavanagh, J., Morris, B. J. (2022) Differential effects of toll-like receptor activation and differential mediation by MAP kinases of immune responses in microglial cells. Cellular and Molecular Neurobiology, 42, pp. 2655-2671. (doi: 10.1007/s10571-021-01127-x)

Leighton, S. P., Herron, J. W., Jackson, E., Sheridan, M., Deligianni, F., Cavanagh, J. (2022) Delirium and the risk of developing dementia: a cohort study of 12 949 patients. Journal of Neurology, Neurosurgery and Psychiatry, 93, pp. 822-827. (doi: 10.1136/jnnp-2022-328903)

Baldacchino, K., Peveler, W. J., Lemgruber, L., Sherrard Smith, R., Scharler, C., Hayden, L., Komarek, L., Lindsay, S. L., Barnett, S. C., Edgar, J. M., Linington, C., Thümmler, K. (2022) Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system. Experimental Neurology, 354, (doi: 10.1016/j.expneurol.2022.114113)

Bachmair, E.-M., Martin, K., Aucott, L., Dhaun, N., Dures, E., Emsley, R., Gray, S. R., Kidd, E., Kumar, V., Lovell, K., MacLennan, G., McNamee, P., Norrie, J., Paul, L., Packham, J., Ralston, S. H., Siebert, S., Wearden, A., Macfarlane, G., Basu, N., on behalf of the LIFT study group, (2022) Remotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases (LIFT): a multicentre, randomised, controlled, open-label, parallel-group trial. Lancet Rheumatology, 4, pp. e534-e545. (doi: 10.1016/S2665-9913(22)00156-4)

Craig, M. T., Witton, J. (2022) A cellular switchboard in memory circuits. Science, 377, pp. 262-263. (doi: 10.1126/science.add2681)

Goñi, M., Basu, N., Murray, A. D., Waiter, G. D. (2022) Brain predictors of fatigue in Rheumatoid Arthritis: a machine learning study. PLoS ONE, 17, (doi: 10.1371/journal.pone.0269952)

Scott, J., Havyarimana, E., Navarro-Gallinad, A., White, A., Wyse, J., van Geffen, J., van Weele, M., Buettner, A., Wanigasekera, T., Walsh, C., Aslett, L., Kelleher, J. D., Power, J., Ng, J., O’Sullivan, D., Hederman, L., Basu, N., Little, M. A., Zgaga, L. (2022) The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset. Arthritis Research and Therapy, 24, (doi: 10.1186/s13075-022-02834-6)

Goebel, A. et al. (2022) Research recommendations following the discovery of pain sensitising IgG autoantibodies in fibromyalgia syndrome. Pain Medicine, 23, pp. 1084-1094. (doi: 10.1093/pm/pnab338)

Crawford, C. L., Antoniou, C., Komarek, L., Schultz, V., Donald, C. L., Montague, P., Barnett, S. C., Linington, C., Willison, H. J., Kohl, A., Coleman, M. P., Edgar, J. M. (2022) SARM1 depletion slows axon degeneration in a CNS model of neurotropic viral infection. Frontiers in Molecular Neuroscience, 15, (doi: 10.3389/fnmol.2022.860410)

Lee, R., Leighton, S. P., Thomas, L., Gkoutos, G. V., Wood, S. J., Fenton, S.-J. H., Deligianni, F., Cavanagh, J., Mallikarjun, P. K. (2022) Prediction models in first-episode psychosis: systematic review and critical appraisal. British Journal of Psychiatry, 220, pp. 179-191. (doi: 10.1192/bjp.2021.219)

Rutherford, M. A., Basu, N. (2022) Reply to Riza and Hamit comment on ‘Factors influencing severe COVID‐19 in systemic vasculitis patients’ Arthritis and Rheumatology, 74, pp. 725-726. (doi: 10.1002/art.42024)

Montoye, A. H.K., Vondrasek, J. D., Neph, S. E., Basu, N., Paul, L., Bachmair, E.-M., Stefanov, K., Gray, S. R. (2022) Comparison of the activPAL CREA and VANE algorithms for characterization of posture and activity in free-living adults. Journal for the Measurement of Physical Behaviour, 5, pp. 49-57. (doi: 10.1123/jmpb.2021-0053)

Tank, R., Ward, J., Flegal, K. E., Smith, D. J., Bailey, M. E.S., Cavanagh, J., Lyall, D. M. (2022) Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology, 47, pp. 564-569. (doi: 10.1038/s41386-021-01190-4)

Bennett, S. E., Almeida, C., Bachmair, E.-M., Gray, S. R., Lovell, K., Paul, L., Wearden, A., Macfarlane, G. J., Basu, N., Dures, E. (2022) Remotely delivered cognitive-behavioural and personalised exercise interventions to lessen the impact of fatigue: a qualitative evaluation. Rheumatology Advances in Practice, 6, (doi: 10.1093/rap/rkac051)

Bennett, S. E., Almeida, C., Bachmair, E.-M., Gray, S. R., Lovell, K., Paul, L., Wearden, A., Macfarlane, G. J., Basu, N., Dures, E. (2022) Therapists’ experiences of remotely delivering cognitive-behavioural or graded-exercise interventions for fatigue: a qualitative evaluation. Rheumatology Advances in Practice, 6, (doi: 10.1093/rap/rkac083)

Kwon, J., Suessmilch, M., McColl, A., Cavanagh, J., Morris, B. J. (2021) Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk. Scientific Reports, 11, (doi: 10.1038/s41598-021-03216-9)

Kitzbichler, M. G., Aruldass, A. R., Barker, G. J., Wood, T. C., Dowell, N. G., Hurley, S. A., McLean, J., Correia, M., Clarke, C., Pointon, L., Cavanagh, J., Cowen, P., Pariante, C., Cercignani, M., Bullmore, E. T., Harrison, N. A. (2021) Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks. Molecular Psychiatry, 26, pp. 7346-7354. (doi: 10.1038/s41380-021-01272-1)

Edgar, J. M., McGowan, E., Chapple, K., Möbius, W., Lemgruber, L., Insall, R. H., Nave, K.-A., Boullerne, A. (2021) Rio-Hortega's drawings revisited with fluorescent proteins define a cytoplasm filled channel system of CNS myelin. Journal of Anatomy, 239, pp. 1241-1255. (doi: 10.1111/joa.13577)

Xiao, M.-F., Roh, S.-E., Zhou, J., Chien, C.-C., Lucey, B. P., Craig, M. T., Hayes, L. N., Coughlin, J. M., Leweke, F. M., Jia, M., Xu, D., Zhou, W., Talbot Jr, C. C., Arnold, D. B., Staley, M., Jiang, C., Reti, I. M., Sawa, A., Pelkey, K. A., McBain, C. J., Savonenko, A., Worley, P. F. (2021) A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function. Science Advances, 7, (doi: 10.1126/sciadv.abf6935)

Aruldass, A. R., Kitzbichler, M. G., Morgan, S. E., Lim, S., Lynall, M.-E., Turner, L., Vertes, P., Cavanagh, J., Cowen, P., Pariante, C. M., Harrison, N. A., Bullmore, E. T. (2021) Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression. Brain, Behavior, and Immunity, 98, pp. 299-309. (doi: 10.1016/j.bbi.2021.08.226)

Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Depp, C., Sasmita, A. O., Vasileva, M. H., Scholz, P., Zhao, Y., Krueger-Burg, D., Wichert, S., Brown, E. R., Michail, K., Nave, K.-A., Bonn, S., Odoardi, F., Rossner, M., Ischebeck, T., Edgar, J. M., Saher, G. (2021) Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Reports, 37, (doi: 10.1016/j.celrep.2021.109889)

Philobos, M., Perkins, A., Karabyas, M., Dospinescu, P., Fluck, N., Kidder, D., Chapman, F., Dhaun, N., Basu, N. (2021) A real-world assessment of mycophenolate mofetil for remission-induction in eosinophilic granulomatosis with polyangiitis. Rheumatology International, 41, pp. 1811-1814. (doi: 10.1007/s00296-021-04961-w)

Pugh, D., Grayson, P., Basu, N., Dhaun, N. (2021) Aortitis: recent advances, current concepts and future possibilities. Heart, 107, pp. 1620-1629. (doi: 10.1136/heartjnl-2020-318085)

Fragoulis, G. E., Brock, J., Basu, N., McInnes, I. B., Siebert, S. (2021) The role for JAK inhibitors in the treatment of immune-mediated rheumatic and related conditions. Journal of Allergy and Clinical Immunology, 148, pp. 941-952. (doi: 10.1016/j.jaci.2021.08.010)

Rutherford, M. A., Scott, J., Karabayas, M., Antonelou, M., Gopaluni, S., Gray, D., Barrett, J., Brix, S. R., Dhaun, N., McAdoo, S. P., Smith, R., Geddes, C., Jayne, D., Luqmani, R., Salama, A. D., Little, M., Basu, N. (2021) Risk factors for severe outcomes in patients with systemic vasculitis & COVID-19: a bi-national registry-based cohort study. Arthritis and Rheumatology, 73, pp. 1713-1719. (doi: 10.1002/art.41728)

Schultz, V., Barrie, J. A., Donald, C. L., Crawford, C. L., Mullin, M., Anderson, T. J., Solomon, T., Barnett, S. C., Linington, C., Kohl, A., Willison, H. J., Edgar, J. M. (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia, 69, pp. 2023-2036. (doi: 10.1002/glia.24010)

Cole, J. J., McColl, A., Shaw, R., Lynall, M. E., Cowen, P. J., de Boer, P., Drevets, W. C., Harrison, N., Pariante, C., Pointon, L., Goodyear, C., Bullmore, E., Cavanagh, J. (2021) No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing. Translational Psychiatry, 11, (doi: 10.1038/s41398-021-01506-4)

Macfarlane, G. J., Beasley, M., Scott, N., Chong, H., McNamee, P., McBeth, J., Basu, N., Hannaford, P. C., Jones, G. T., Keeley, P., Prescott, G. J., Lovell, K. (2021) Maintaining musculoskeletal health using a behavioural therapy approach: a population-based randomised controlled trial (the MAmMOTH study) Annals of the Rheumatic Diseases, 80, pp. 903-911. (doi: 10.1136/annrheumdis-2020-219091)

Derakhshan, M. H., Morton, F., Fragoulis, G. E., Paterson, C., Dale, J., Basu, N., Mcinnes, I., Porter, D., Siebert, S. (2021) Opioids and analgesic use in early rheumatoid arthritis: a longitudinal analysis of linked real-world prescription data. (doi: 10.1136/annrheumdis-2021-eular.2672)

Sarica, S. H., Gallacher, P. J., Dhaun, N., Sznajd, J., Harvie, J., McLaren, J., McGeoch, L., Kumar, V., Amft, N., Erwig, L., Marks, A., Bruno, L., Zöllner, Y., Black, C., Basu, N. (2021) Multimorbidity in anti-neutrophil cytoplasmic antibody-associated vasculitis: results from a longitudinal, multi-centre data-linkage study. Arthritis and Rheumatology, 73, pp. 651-659. (doi: 10.1002/art.41557)

Kelly, C. A., Nisar, M., Arthanari, S., Carty, S., Woodhead, F. A., Price-Forbes, A., Middleton, D., Dempsey, O., Miller, D., Basu, N., Dawson, J., Sathi, N., Ahmad, Y., Palmer, E., Iqbal, K., Janakiraman, G., Koduri, G., Young, A. (2021) Rheumatoid arthritis related interstitial lung disease – improving outcomes over 25 years: a large multicentre UK study. Rheumatology, 60, pp. 1882-1890. (doi: 10.1093/rheumatology/keaa577)

Schultz, V., Cumberworth, S. L., Gu, Q., Johnson, N., Donald, C. L., McCanney, G. A., Barrie, J. A., Da Silva Filipe, A., Linington, C., Willison, H. J., Edgar, J. M., Barnett, S. C., Kohl, A. (2021) Zika virus infection leads to demyelination and axonal injury in mature CNS cultures. Viruses, 13, (doi: 10.3390/v13010091)

Berghoff, S. A. et al. (2021) Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience, 24, pp. 47-60. (doi: 10.1038/s41593-020-00757-6)

De Lorenzo, G., Tandavanitj, R., Doig, J., Setthapramote, C., Poggianella, M., Sanchez Velazquez, R., Scales, H., Edgar, J. M., Kohl, A., Brewer, J., Burrone, O. R., Patel, A. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95, (doi: 10.1128/JVI.01415-20)

Leighton, S. P., Krishnadas, R., Upthegrove, R., Marwaha, S., Steyerberg, E. W., Gkoutos, G. V., Broome, M. R., Liddle, P. F., Everard, L., Singh, S. P., Freemantle, N., Fowler, D., Jones, P. B., Sharma, V., Murray, R., Wykes, T., Drake, R. J., Buchan, I., Rogers, S., Cavanagh, J., Lewis, S. W., Birchwood, M., Mallikarjun, P. K. (2021) Development and validation of a non-remission risk prediction model in first episode psychosis: an analysis of two longitudinal studies. Schizophrenia Bulletin Open, 2, (doi: 10.1093/schizbullopen/sgab041)

Pugh, D., Karabayas, M., Basu, N., Cid, M. C., Goel, R., Goodyear, C. S., Grayson, P. C., McAdoo, S. P., Mason, J. C., Owen, C., Weyand, C. M., Youngstein, T., Dhaun, N. (2021) Large-vessel vasculitis. Nature Reviews Disease Primers, 7, (doi: 10.1038/s41572-021-00327-5)

King, C., Druce, K. L., Nightingale, P., Kay, E., Basu, N., Salama, A. D., Harper, L. (2021) Predicting relapse in ANCA-associated vasculitis: a systematic review and meta-analysis. Rheumatology Advances in Practice, 5, (doi: 10.1093/rap/rkab018)

Bourgognon, J.-M., McColl, A., Suessmilch, M., Krishnadas, R., Cavanagh, J. (2021) Stress, immune system and the brain. Cambridge University Press

Karabayas, M., Dospinescu, P., Fluck, N., Kidder, D., Fordyce, G., Hollick, R.J., De Bari, C., Basu, N. (2020) Evaluation of adjunctive mycophenolate for large vessel giant cell arteritis. Rheumatology Advances in Practice, 4, (doi: 10.1093/rap/rkaa069)

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Cheung, S. M., Keenan, K., Senn, N., Hutcheon, G., Chan, K., Erwig, L., Schrepf, A., Dospinescu, P., Gray, S., Waiter, G., He, J., Basu, N. (2019) Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study. Arthritis Care and Research, 71, pp. 1640-1646. (doi: 10.1002/acr.23833)

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Nevado-Holgado, A. J., Ribe, E., Thei, L., Furlong, L., Angel-Mayer, M., Quan, J., Richardson, J. C., Cavanagh, J., Lovestone, S. (2019) Genetic and real-world clinical data, combined with empirical validation, nominate JAK-STAT signaling as a target for Alzheimer’s Disease therapeutic development. Cells, 8, (doi: 10.3390/cells8050425)

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Bijland, S., Thomson, G., Euston, M., Michail, K., Thümmler, K., Mücklisch, S., Crawford, C. L., Barnett, S. C., McLaughlin, M., Anderson, T. J., Linington, C., Brown, E. R., Kalkman, E. R., Edgar, J. M. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, (doi: 10.12688/f1000research.16802.1)

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Beasley, M., Freidin, M. B., Basu, N., Williams, F. M.K., Macfarlane, G. J. (2019) What is the effect of alcohol consumption on the risk of chronic widespread pain? A Mendelian randomisation study using UK Biobank. Pain, 160, pp. 501-507. (doi: 10.1097/j.pain.0000000000001426)

Openshaw, R. L., Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J., Pratt, J. A., Morris, B. J. (2019) JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. Journal of Neuroinflammation, 16, (doi: 10.1186/s12974-019-1408-5)

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Schrepf, A., Williams, D. A., Gallop, R., Naliboff, B. D., Basu, N., Kaplan, C., Harper, D. E., Landis, J. R., Clemens, J. Q., Strachan, E., Griffith, J. W., Afari, N., Hassett, A., Pontari, M. A., Clauw, D. J., Harte, S. E. (2018) Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: a MAPP Research Network study. Pain, 159, pp. 2002-2011. (doi: 10.1097/j.pain.0000000000001299)

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Matraiah, E. H., Olisaka, N., Philipos, M., Walbaum, D., Dospinescu, P., Fluck, N., Basu, N., Kidder, D. (2018) Late-onset Pneumocystis jirovecii pneumonia (PJP) in patients with ANCA-associated vasculitis. Clinical Rheumatology, 37, pp. 1991-1996. (doi: 10.1007/s10067-018-4155-6)

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Goñi, M., Basu, N., Murray, A. D., Waiter, G. D. (2018) Neural indicators of fatigue in chronic diseases: a systematic review of MRI studies. Diagnostics, 8, (doi: 10.3390/diagnostics8030042)

Schrepf, A., Kaplan, C. M., Ichesco, E., Larkin, T., Harte, S. E., Harris, R. E., Murray, A. D., Waiter, G. D., Clauw, D. J., Basu, N. (2018) A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis. Nature Communications, 9, (doi: 10.1038/s41467-018-04648-0)

Druce, K. L., Aikman, L., Dilleen, M., Burden, A., Szczypa, P., Basu, N. (2018) Fatigue independently predicts different work disability dimensions in etanercept-treated rheumatoid arthritis and ankylosing spondylitis patients. Arthritis Research and Therapy, 20, (doi: 10.1186/s13075-018-1598-8)

Konda, P. C., Edgar, J., Barnett, S., Harvey, A. R. (2018) Minimally Invasive Microscopy Using GRIN Lens Microendoscopes. (doi: 10.1364/BRAIN.2018.BTh4C.4)

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Krishnadas, R., Cooper, S.-A., Nicol, A., Pimlott, S., Soni, S., Holland, A., McArthur, L., Cavanagh, J. (2018) Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader–Willi syndrome. British Journal of Psychiatry, 212, pp. 57-58. (doi: 10.1192/bjp.2017.7)

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Nerurkar, L., McColl, A., Graham, G., Cavanagh, J. (2017) The systemic response to topical Aldara treatment is mediated through direct TLR7 stimulation as Imiquimod enters the circulation. Scientific Reports, 7, (doi: 10.1038/s41598-017-16707-5)

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Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., McBain, C. J. (2017) Hippocampal GABAergic inhibitory interneurons. Physiological Reviews, 97, pp. 1619-1747. (doi: 10.1152/physrev.00007.2017)

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Harris, R. E., Ichesco, E., Cummiford, C., Hampson, J. P., Chenevert, T. L., Basu, N., Zick, S. M. (2017) Brain connectivity patterns dissociate action of specific acupressure treatments in fatigued breast cancer survivors. Frontiers in Neurology, 8, (doi: 10.3389/fneur.2017.00298)

Cumberworth, S. L., Barrie, J. A., Cunningham, M. E., Gomes de Figueiredo, D. P., Schultz, V., Wilder-Smith, A. J., Brennan, B., Pena, L. J., de Oliveira França, R. F., Linington, C., Barnett, S. C., Willison, H. J., Kohl, A., Edgar, J. M. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, (doi: 10.1186/s40478-017-0450-8)

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Mackay, G. A., Campbell, S., Jampana, R., Cavanagh, J. (2017) A 50 year old with a rapid neuropsychiatric deterioration and choreaform movements. Practical Neurology, (doi: 10.1136/practneurol-2016-001481)

Kalk, N.J., Guo, Q., Owen, D., Cherian, R., Erritzoe, D., Gilmour, A., Ribeiro, A.S., McGonigle, J., Waldman, A., Matthews, P., Cavanagh, J., McInnes, I., Dar, K., Gunn, R., Rabiner, E.A., Lingford-Hughes, A.R. (2017) Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. Translational Psychiatry, 7, (doi: 10.1038/tp.2016.264)

Jani, B. D., Boachie, C., McCowan, C., Barry, S. J.E., Cavanagh, J., Mair, F. S. (2017) Relationship of depression screening in cardiometabolic disease with vascular events and mortality: findings from a large primary care cohort with 4 years follow-up. European Heart Journal: Quality of Care and Clinical Outcomes, 3, pp. 61-73. (doi: 10.1093/ehjqcco/qcw045)

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Whibley, D., Dean, L. E., Basu, N. (2016) Management of widespread pain and fibromyalgia. Current Treatment Options in Rheumatology, 2, pp. 312-320. (doi: 10.1007/s40674-016-0056-5)

Dale, J., Paterson, C., Tierney, A., Ralston, S. H., Reid, D. M., Basu, N., Harvie, J., McKay, N. D., Saunders, S., Wilson, H., Munro, R., Richmond, R., Baxter, D., McMahon, M., McLaren, J., Kumar, V., Siebert, S., McInnes, I., Porter, D. (2016) The Scottish Early Rheumatoid Arthritis (SERA) Study: an inception cohort and biobank. BMC Musculoskeletal Disorders, 17, (doi: 10.1186/s12891-016-1318-y)

Druce, K. L., Bhattacharya, Y., Jones, G. T., Macfarlane, G. J., Basu, N. (2016) Most patients who reach disease remission following anti-TNF therapy continue to report fatigue: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Rheumatology, 55, pp. 1786-1790. (doi: 10.1093/rheumatology/kew241)

Jani, B. D., Cavanagh, J., Barry, S. J.E., Der, G., Sattar, N., Mair, F. S. (2016) Relationship between blood pressure values, depressive symptoms and cardiovascular outcomes in patients with cardiometabolic disease. Journal of Clinical Hypertension, 18, pp. 1027-1035. (doi: 10.1111/jch.12813)

McClean, A., Morgan, M. D., Basu, N., Bosch, J. A., Nightingale, P., Jones, D., Harper, L. (2016) Physical fatigue, fitness, and muscle function in patients with antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Care and Research, 68, pp. 1332-1339. (doi: 10.1002/acr.22827)

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Dahal, L. N., Basu, N., Youssef, H., Khanolkar, R. C., Barker, R. N., Erwig, L. P., Ward, F. J. (2016) Immunoregulatory soluble CTLA-4 modifies effector T-cell responses in systemic lupus erythematosus. Arthritis Research and Therapy, 18, (doi: 10.1186/s13075-016-1075-1)

Kronisch, C., McLernon, D. J., Dale, J., Paterson, C., Ralston, S. H., Reid, D. M., Tierney, A., Harvie, J., McKay, N., Wilson, H. E., Munro, R., Saunders, S., Richmond, R., Baxter, D., McMahon, M., Kumar, V., McLaren, J., Siebert, S., McInnes, I. B., Porter, D., Macfarlane, G. J., Basu, N. (2016) Brief report: predicting functional disability: one-year results from the Scottish Early Rheumatoid Arthritis inception cohort. Arthritis and Rheumatology, 68, pp. 1596-1602. (doi: 10.1002/art.39627)

Druce, K. L., Jones, G. T., Macfarlane, G. J., Basu, N. (2016) Examining changes in central and peripheral pain as mediates of fatigue improvement: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Arthritis Care and Research, 68, pp. 922-926. (doi: 10.1002/acr.22803)

Mccoll, A., Thomson, C. A., Nerurkar, L., Graham, G. J., Cavanagh, J. (2016) TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain. Journal of Neuroinflammation, 13, (doi: 10.1186/s12974-016-0562-2)

Macfarlane, G. J., Beasley, M., Prescott, G., McNamee, P., Keeley, P., Artus, M., McBeth, J., Hannaford, P., Jones, G. T., Basu, N., Norrie, J., Lovell, K. (2016) The Maintaining Musculoskeletal Health (MAmMOTH) Study: Protocol for a randomised trial of cognitive behavioural therapy versus usual care for the prevention of chronic widespread pain. BMC Musculoskeletal Disorders, 17, (doi: 10.1186/s12891-016-1037-4)

Krishnadas, R., Nicol, A., Sassarini, J., Puri, N., Burden, A. D., Leman, J., Combet, E., Pimlott, S., Hadley, D., McInnes, I. B., Cavanagh, J. (2016) Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans. Brain, Behavior, and Immunity, 51, pp. 29-38. (doi: 10.1016/j.bbi.2015.08.005)

Druce, K. L., Jones, G. T., Macfarlane, G. J., Verstappen, S. M.M., Basu, N. (2015) The longitudinal course of fatigue in rheumatoid arthritis: results from the Norfolk Arthritis Register. Journal of Rheumatology, 42, pp. 2059-2065. (doi: 10.3899/jrheum.141498)

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Arnone, D., Mumuni, A. N., Jauhar, S., Condon, B., Cavanagh, J. (2015) Indirect evidence of selective glial involvement in glutamate-based mechanisms of mood regulation in depression: Meta-analysis of absolute prefrontal neuro-metabolic concentrations. European Neuropsychopharmacology, 25, pp. 1109-1117. (doi: 10.1016/j.euroneuro.2015.04.016)

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Watts, R. A., Mahr, A., Mohammad, A. J., Gatenby, P., Basu, N., Flores-Suárez, L. F. (2015) Classification, epidemiology and clinical subgrouping of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Nephrology Dialysis Transplantation, 30, pp. i14-i22. (doi: 10.1093/ndt/gfv022)

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Basu, N., Hollick, R., Mahr, A. (2015) Classification of vasculitis. EULAR

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