The Grove Lab
Molecular Virology + Artificial Intelligence
Check out Viro3D - our database of viral predicted protein structures.
You can learn more about our work at the Grove Lab website.
See a complete list of our publications here.
Research Overview
In the Grove Lab, we harness cutting-edge artificial intelligence alongside classical experimental virology to investigate the structure, function and evolution of viral proteins. Our focus is viral entry glycoproteins, but our combined computational and experimental approach is broadly applicable across molecular virology.
AI-Enabled Discovery
Artificial intelligence is revolutionising molecular virology, enabling us to predict viral protein structures, infer evolutionary relationships, and identify novel targets for vaccines or therapies.
Good-old-fashioned Experimental Virology
Experimental virology research grounds our computational predictions in real-world biology. We apply a range of classical virological techniques to explore viral entry, host interactions, and evolution.
Lab Highlights
We used protein structure prediction to reveal the evolutionary history of the Flaviviridae.
We investigated functional changes in the spike protein of various SARS-CoV-2 variants, see here, here and here.
We discovered a shared and (probably) novel membrane fusion mechanism in the Hepaci- Pegi- and Pestiviruses.