Imaging into the brain using single-pixel techniques for multi-dimensional investigations
Supervisors:
Dr Akhil Kallepalli, Biomedical Engineering (University of Strathclyde)
Prof Anthony Chalmers, School of Cancer Sciences (University of Glasgow)
Dr Karin Williams, School of Cancer Sciences (University of Glasgow)
Prof John Greenman, Faculty of Health Sciences (University of Hull)
Summary:
Glioblastoma (GBM) is the most prevalent and aggressive primary brain tumour in adults. In this interdisciplinary project, the doctoral researcher will unravel new knowledge regarding the tumour and its environment using single-pixel imaging techniques. The research brings together expertise and support from researchers at the universities of Strathclyde, Glasgow and Hull, with extensive training opportunities across imaging, clinical research and tissue handling.
The wide spectrum of training opportunities across the three labs includes:
- Building novel systems and developing algorithms for high-resolution, multi-dimensional microscopic imaging in an optics team focussed on translating physics to the clinic (Kallepalli Lab, Strathclyde).
- Culture of, and handling human GBM tissues for treatment and protocol testing, and functional tracing of cellular responses, along with histopathological and transcriptome analysis of tissues (Chalmers Lab, Glasgow).
- Design and manufacture of microphysiological systems and devices, and their use in preparing tissue at various scales for imaging and other techniques (Greenman Lab, Hull).
Furthermore, there is ample opportunity to develop skills such as 3D printing, handling and preparing tissue for various analytical and diagnostic techniques, engineering and building optical systems, and disseminating the results in biomedical engineering, cancer studies and biophotonics meetings and conferences, to name a few.