Breaking the Code of Inflammation: How Cells Sense and Respond to Physical Signals.
Supervisors:
Dr Miguel Pineda, School of Molecular Biosciences (University of Glasgow)
Dr Carsten Schulte, Biomedical Engineering (University of Strathclyde)
Prof Nikolaj Gadegaard, Biomedical Engineering (University of Glasgow)
Summary:
This PhD project focuses on exploring how cells sense and respond to physical changes in their environment, particularly in the context of inflammation. The student will investigate the cellular glycocalyx—a layer of sugars on the cell surface—and its role as a mechanosensitive structure. By understanding how the glycocalyx translates physical forces into inflammatory signals, the project aims to uncover new strategies to control inflammation in chronic diseases such as cardiovascular disease, cancer, arthritis and other autoimmune disorders.
The student will gain training across diverse disciplines, including bioengineering, biomaterial sciences, and immunology. They will work with advanced cell culture systems, engineered substrates, and cutting-edge microscopy techniques to investigate how topography and mechanical forces affect cellular behavior. The interdisciplinary nature of the project will provide hands-on experience in biomaterials fabrication and immune cell regulation.
Throughout the PhD, the student will develop key research and technical skills in 3 different labs across the University of Glasgow and Strathclyde University, such as experimental design, data analysis, and hypothesis testing, alongside critical soft skills like scientific communication, project management, and collaboration. By the end of the project, they will be well-equipped to pursue careers in academia, biotechnology, and the pharmaceutical or medical device industries.