Julia Isakova

email: j.isakova.1@research.gla.ac.uk

Research title: Developing RAMAN-based methodology to investigate cell glycosylation signatures

Research Summary

Can rheumatoid arthritis diagnosis be made smarter and faster?

Due to its highly variable nature, 5-20% of rhematoid arthritis (RA) patients are considered difficult to treat, often showing poor responses to medication. My research focuses on synovial fibroblasts, which are responsible for maintaining joint health but become activated in RA, leading to local inflammation. This activation is linked to epigenetic changes and reductions in surface sialic acid (SA) levels, affecting cell signaling and inflammation. By studying the glycome of these cells and using Raman spectroscopy to detect changes in SA, I aim to discover how fibroblast activity correlates with different RA phenotypes, providing new insights for personalized treatment approaches.

Supervisors

Conference

IRDG 232nd Sponsor Meeting – HORIBA 

Project presetation 

GLORI Symposium 2024

Conference poster

 

Teaching

Teaching Assistant

  • MBChB PBL Facilitator
  • MVLS Demonstrator