Elka Kyurkchieva
Research title: Investigating Bifunctional Protein Degraders to Silence PDE4 Activity in Disease
Publications
2024
Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, (doi: 10.1111/febs.17359) (PMID:39673076) (Early Online Publication)
Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546)
2023
Kyurkchieva, E. and Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28(7), 133. (doi: 10.31083/j.fbl2807133) (PMID:37525918)
Paes, D. et al. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80(7), 178. (doi: 10.1007/s00018-023-04804-w) (PMID:37306762) (PMCID:PMC10261250)
2022
Baillie, G. et al. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2. 60th Annual ESPE (ESPE 2022), Rome, Italy, 15-17 Sept 2022.
Articles
Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, (doi: 10.1111/febs.17359) (PMID:39673076) (Early Online Publication)
Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546)
Kyurkchieva, E. and Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28(7), 133. (doi: 10.31083/j.fbl2807133) (PMID:37525918)
Paes, D. et al. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80(7), 178. (doi: 10.1007/s00018-023-04804-w) (PMID:37306762) (PMCID:PMC10261250)
Conference or Workshop Item
Baillie, G. et al. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2. 60th Annual ESPE (ESPE 2022), Rome, Italy, 15-17 Sept 2022.