EVOdrops
EVOdrops is a translational approach for microfluidics and biochemical methods towards the engineering of proteins and systems of industrial or therapeutic interest. Two fundamental aspects of protein engineering will be effectively combined:
- Generation of a large and controlled genetic diversity usable as a pool of active catalysts containing unknown variants of interest.
- Analysis and selection at an ultra-high throughput of libraries to identify improved variants fulfilling the user-defined constraints (rate of catalysis, specificity, stability).
EVOdrops Innovative Training Network will train a new generation of PhD students in a multidisciplinary network of researchers from different communities – biology, biotechnology, microfluidics and microtechnology engineering – to explore directed evolution processes for protein engineering in an integrative way that transcends the training provided in one single team or even institution. The students will be trained to develop and apply a global and multi-disciplinary approach based on key enabling technologies for high-throughput analysis in biological fields.
Our overarching goal is to optimize processes at all levels of the chain of operation to reach ultra-high throughput, improved sensitivity, and reliability of systems for the selection of variants of fundamental, medicinal, practical and industrial interest.
