Course Catalogue

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This course covers core concepts in modern pharmacology set within the context of drug discovery and development. Pharmacology is a quantitative discipline and a key element of this course will be to develop skills and understanding of the quantitative aspects of pharmacology. Another strong theme is the understanding of drug action based on knowledge of drug structure and drug-receptor interactions and the discovery of good drug targets. 

Normally, there is one 3-hour session on Mondays.

Normally, only available to final-year School of Life Sciences students in a Pharmacology programme. Visiting students may be allowed to enrol, at the discretion of the School of Life Sciences Chief Adviser and the Course Coordinator. 

None

The course will be assessed by a 2-hour examination (75%) and in-course assessment consisting of a data handling and interpretation written assignment (25%). 

Reassessments are normally available for all courses, except those which contribute to the Honours classification. For non-Honours courses, students are offered reassessment in all or any of the components of assessment if the satisfactory (threshold) grade for the overall course is not achieved at the first attempt. This is normally grade D3 for undergraduate students and grade C3 for postgraduate students. Exceptionally it may not be possible to offer reassessment of some coursework items, in which case the mark achieved at the first attempt will be counted towards the final course grade. Any such exceptions for this course are described below. 

This course aims to provide students with a thorough background in advanced concepts in modern pharmacology and drug discovery, coupled to a detailed theoretical background, and containing a strong numerical component.

By the end of this course, students will be able to: 

■ Plot graphs, handle data sets and calculate key pharmacological parameters; 

■ Discuss the fundamental role of chemistry in drug discovery; 

■ Evaluate the power and theoretical basis of modern drug screening approaches; 

■ Discuss how drug:protein interactions can be identified and quantified, both in vivo and in vitro; 

■ Illustrate the power of bioinformatics in drug discovery, with a clear appreciation of the technology, strengths and limitations of the approaches; 

■ Discuss the principles of key stages of the drug discovery process from target identification and compound screening to preclinical and clinical testing. 

Students must submit at least 75% by weight of the components (including examinations) of the course's summative assessment.