Professor Mariola Kurowska-Stolarska

  • Professor of Immune Pathology and Homeostasis (Immunology & Infection)

telephone: 01413306085
email: Mariola.Kurowska-Stolarska@glasgow.ac.uk

RB423 Level B4, Iii - Gbrc, University Place, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-2124-7777

Research interests

TISSUE IMMUNOBIOLOGY LAB

The role of Myeloid cells in tissue homeostasis, inflammation, and disease resolution

The research in our lab aims to dissect the active roles of tissue-resident macrophages and dendritic cells in the joints, skin, and lungs. We focus on (a) their roles in maintaining healthy tissue homeostasis, (b) understanding their involvement in the pathology of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), and (c) reinstating tissue homeostasis during sustained disease remission. While investigating the basic biology of these cells, we seek mechanisms that can be therapeutically harnessed to restore tissue homeostasis or identify biomarkers that can help match patients to the most optimal current treatments targeting inflammatory pathways.

To maximise the impact of human tissue discovery, our lab is guided by the principle of translation—from bedside-to-bench and back in which human and mouse research strategies are interconnected for optimal understanding of novel tissue pathways and clinical innovation. We deconvolute the heterogeneity of myeloid cells in biopsies from patients at various stages of disease trajectories, spanning from the initiation of the disease to drug-free remission. This is achieved through the application of single-cell omics and spatial transcriptomics. The function of identified cell clusters is tested using unique biopsy-derived micro-cocultures and synovial tissue organoid systems. Subsequently, we conduct detailed mechanistic studies in purpose-generated transgenic mice. Collaborating with Prof Alivernini's clinical translational lab and Prof Jaume Bacardit's explainable artificial intelligence (AI) tools; we then assess the biomarker/therapeutic potential of our discoveries in experimental medicine trials (see Figure 1).

A graphic showing the understanding the role of tissue myeloid cells in reinstating and maintaining tissue homeostasis  

Our lab functions within FOREUM funded multicentre RA and PsA consortia:

Synovial Tissue Macrophages (STMs) (Figure 2): Our lab has discovered functionally distinct synovial tissue macrophage (STM) populations and highlighted the pivotal role of communication between tissue-resident myeloid cells and fibroblasts in shaping tissue niches that regulate activation of infiltrating inflammatory and autoimmune cells. In health and drug-free RA remission, specific clusters of synovial resident myeloid and stromal cells together maintain homeostasis. For instance, lining-layer MerTKposTREM2pos synovial macrophages (STM) with a regulatory phenotype and lubricin-producing (CLIC5posPRG4pos) fibroblast-like synoviocytes (FLS) form a barrier against inflammation and aid joint mobility while interstitial MerTKposLYVE1pos STMs are located around blood vessels and control the influx of inflammatory cells.

Experimental mouse studies and human studies with early undifferentiated arthritis (UPA) suggest that the disruption of the MerTKposTREM2pos STM layer or pathogenic changes in their phenotype to TREM2low, with decreased expression of the regulatory pathways (e.g., VSIG4 and retinoic acid pathways) and an increase in inflammatory SPP1, may facilitate the onset of arthritis. This phenotypic shift in TREM2pos STMs creates an inflammation-permissive environment, enabling the initiation of synovitis associated with the influx of neutrophils and monocyte precursors of tissue infiltrating, highly inflammatory macrophages (e.g., MerTKnegSPP1pos and MerTKnegS100A12pos). This leads to a change in the lining layer FLS phenotype into MMPs/RANKL-producing joint-destructive phenotype and a selective expansion of CD90pos sub-lining FLS clusters (e.g., CXCL12posMHCIIpos) that drive chronicity of tissue inflammation. The transition from active arthritis to sustained remission that does not flare is associated with the restoration of the regulatory phenotypes in MerTKposTREM2pos and MerTKposLYVE1pos STMs that mediate tissue repair responses in stromal cells.

We are currently studying the origin and niche signals that drive the development of various STM clusters in health, RA, PsA and drug-free remission as well as the role of STM specific pathways (e.g., MerTK and VSIG4) in maintaining and reinstating joint homeostasis in drug free remission with the prospect of pinpointing novel therapeutic targets and/or biomarkers of disease trajectories.

A graphic showing the understanding the role of tissue myeloid cells in reinstating and maintaining tissue homeostasis

Synovial Tissue Dendritic cells (DC). DC in tissue and draining lymph nodes play a vital role in driving adaptive immune responses against pathogens while balancing immune tolerance versus autoimmunity. Thus, a better understanding the biology of tissue dendritic cells can help to re-instate immune tolerance in autoimmune diseases. We recently established that the synovium contains predominantly myeloid DCs comprising 15 transcriptionally distinct clusters. Their relative proportions, spatial distribution, and functions differ between health, active RA and RA in disease remission (in press). We developed specific methods and tools to investigate how these distinct synovial tissue DC clusters develop and regulate antigen-specific autologous lymphocytes. These include synovial tissue organoid system that enables tracking the developmental trajectories of specific synovial DC clusters from their blood precursors. In addition, autologous blood T-cells (from healthy and RA) CRISPR-Cas9 engineered to express TCR specific for multiple RA citrullinated-autoantigens enables us to assess the T-cell stimulatory versus tolerogenic functions of different autologous synovial tissue DC clusters.

Current RA treatments, while reinstating some of the mechanisms controlling inflammation in drug-free remission, don't reinstate immune tolerance thus we are currently investigating how to harness synovial tissue tolerogenic DC clusters to progress drug-free remission towards reminiscence of cure.

 

Collaborators

  

Other projects in the lab

 

Lab Group

Find out more about my lab group.

 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 2003 | 2002 | 2000 | 1999
Number of items: 108.

2024

Alivernini, S., Cañete, J. D., Bacardit, J. and Kurowska-Stolarska, M. (2024) Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis. Nature Medicine, 30(4), pp. 925-926. (doi: 10.1038/s41591-024-02818-w) (PMID:38361121)

Ng, M. T.H. et al. (2024) A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution. Nature Communications, 15, 1394. (doi: 10.1038/s41467-024-45341-9) (PMID:38374174) (PMCID:PMC10876649)

Paoletti, A. et al. (2024) Liposomal antagomiR-155-5p restores anti-inflammatory macrophages and improves arthritis in preclinical models of rheumatoid arthritis. Arthritis and Rheumatology, 76(1), pp. 18-31. (doi: 10.1002/art.42665) (PMID:37527031)

2023

Johnson, P. A., Ackerman, J. E., Kurowska-Stolarska, M. , Coles, M., Buckley, C. D. and Dakin, S. G. (2023) Three-dimensional, in-vitro approaches for modelling soft-tissue joint diseases. Lancet Rheumatology, 5(9), e553-e563. (doi: 10.1016/S2665-9913(23)00190-X) (PMID:38251499)

2022

van Gijsel-Bonnello, M. et al. (2022) Salt Inducible Kinase 2 regulates fibrosis during bleomycin-induced lung injury. Journal of Biological Chemistry, 298(12), 102644. (doi: 10.1016/j.jbc.2022.102644) (PMID:36309093) (PMCID:PMC9706632)

Kurowska-Stolarska, M. and Alivernini, S. (2022) Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nature Reviews Rheumatology, 18, pp. 384-397. (doi: 10.1038/s41584-022-00790-8) (PMID:35672464)

Farina, L. et al. (2022) Pro nerve growth factor and its receptor p75NTR activate inflammatory responses in synovial fibroblasts: a novel targetable mechanism in arthritis. Frontiers in Immunology, 13, 818630. (doi: 10.3389/fimmu.2022.818630) (PMID:35309353) (PMCID:PMC8931659)

Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)

Micheroli, R. et al. (2022) Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis. RMD Open, 8(1), e001949. (doi: 10.1136/rmdopen-2021-001949) (PMID:34987094) (PMCID:PMC8734041)

2021

Clayton, S. A. et al. (2021) Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48. Science Advances, 7(50), eabl5182. (doi: 10.1126/sciadv.abl5182) (PMID:34878835)

Akbar, M., MacDonald, L. , Crowe, L. A.N., Carlberg, K., Kurowska-Stolarska, M. , Ståhl, P. L., Snelling, S. J.B., McInnes, I. B. and Millar, N. L. (2021) Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Annals of the Rheumatic Diseases, 80(11), pp. 1494-1497. (doi: 10.1136/annrheumdis-2021-220256) (PMID:34001518) (PMCID:PMC8522454)

MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)

Clayton, S. A., MacDonald, L. , Kurowska-Stolarska, M. and Clark, A. R. (2021) Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis. Frontiers in Immunology, 12, 1488. (doi: 10.3389/fimmu.2021.673916) (PMID:33995417) (PMCID:PMC8118696)

Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788) (PMCID:PMC8058094)

Rayner, F. et al. (2021) BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study. BMC Rheumatology, 5, 22. (doi: 10.1186/s41927-021-00194-3) (PMID:34275488) (PMCID:PMC8286860)

2020

Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)

Ramilowski, J. A. et al. (2020) Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Research, 30(7), pp. 1060-1072. (doi: 10.1101/gr.254219.119) (PMID:32718982) (PMCID:PMC7397864)

2019

Finlay, S. et al. (2019) Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts. 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA, 08-13 Nov 2019.

McShane, L. , Tabas, I., Lemke, G., Kurowska-Stolarska, M. and Maffia, P. (2019) TAM receptors in cardiovascular disease. Cardiovascular Research, 115(5), pp. 1286-1295. (doi: 10.1093/cvr/cvz100) (PMID:30980657) (PMCID:PMC6587925)

Elmesmari, A. et al. (2019) Do Functional Interactions Between Macrophages and Synovial Fibroblasts Drive Synovial Pathology or Resolution of Inflammation? European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Finlay, S. et al. (2019) Single-cell Transcriptomic and Functional Analyses Reveal Novel Heterogeneity in Pathogenic Pathways Mediated by Human Synovial Tissue Macrophages. European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Goncalves-Alves, E. et al. (2019) MicroRNA-155 controls T helper cell activation during viral infection. Frontiers in Immunology, 10, 1367. (doi: 10.3389/fimmu.2019.01367) (PMID:31275315) (PMCID:PMC6593301)

2018

Alivernini, S. et al. (2018) Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation. 2018 ACR/ARHP Annual Meeting, Chicago, IL, 19-24 Oct 2018. (Unpublished)

Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska-Stolarska, M. and McInnes, I.B. (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology, 193(1), pp. 13-23. (doi: 10.1111/cei.13098) (PMID:29315512) (PMCID:PMC6038003)

Elmesmari, A., Alivernini, S., Tolusso, B., Bui, L., Vaughan, D. , Federico, F., Gremese, E., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Stolarska Synovial Tissue CD1c+ Dendritic Cells in Rheumatoid Arthritis Express High Levels of the Epigenetic Regulator of Inflammation, Microrna-155 and Inflammatory Cytokines. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Finlay, S., Alivernini, S., Elmesmari, A., Tolusso, B., Ferraccioli, G., Gremese, E., Petricca, L., McInnes, I. B. , Kurowska-Stolarska, M. and Filer, A. (2018) Activation of Mertk+cd206+ Subpopulation of Human Synovial Tissue-Resident Macrophages Limits Inflammatory Response. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Cooles, F. A.H., Anderson, A. E., Skelton, A., Pratt, A. G., Kurowska-Stolarska, M. S. , McInnes, I. , Hilkens, C. M.U. and Isaacs, J. D. (2018) Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis. Frontiers in Immunology, 9, 755. (doi: 10.3389/fimmu.2018.00755) (PMID:29867920) (PMCID:PMC5968398)

Hecht, I. et al. (2018) ILDR2 is a novel B7-like protein that negatively regulates T cell responses. Journal of Immunology, 200(6), pp. 2025-2037. (doi: 10.4049/jimmunol.1700325) (PMID:29431694)

Shams, K., Kurowska-Stolarska, M. , Schütte, F., Burden, A. D., McKimmie, C. S. and Graham, G. J. (2018) MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Journal of Biological Chemistry, 293(8), pp. 3003-3012. (doi: 10.1074/jbc.M117.809780) (PMID:29279330) (PMCID:PMC5827444)

Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M. and Clark, A. R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi: 10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)

Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. Microphage Biology in the Single-Cell Era, Ghent, Belgium, 2018. (Unpublished)

2017

Kurowska-Stolarska, M. and Alivernini, S. (2017) Synovial tissue macrophages: friend or foe? RMD Open, 3(2), e000527. (doi: 10.1136/rmdopen-2017-000527) (PMID:29299338) (PMCID:PMC5729306)

Jaigrdar, S. A., Benson, R. A. , Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi: 10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)

Saferding, V. et al. (2017) MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. Journal of Autoimmunity, 82, pp. 74-84. (doi: 10.1016/j.jaut.2017.05.006) (PMID:28545737)

Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)

Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)

Elmesmari, A., Alivernini, S., Vaughan, D. , Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Characterisation of Synovium Tissues Macropahges. Rheumatology 2017, Birmingham, UK, 25-27 April 2017. (Unpublished)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)

Chen, L. et al. (2017) miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. Annals of the Rheumatic Diseases, 76(3), pp. 620-624. (doi: 10.1136/annrheumdis-2016-210175) (PMID:28039186)

2016

Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)

Huesa, C. et al. (2016) Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology. Annals of the Rheumatic Diseases, 75(11), pp. 1989-1997. (doi: 10.1136/annrheumdis-2015-208268) (PMID:26698846) (PMCID:PMC5099200)

Alivernini, S. et al. (2016) MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nature Communications, 7, 12970. (doi: 10.1038/ncomms12970) (PMID:27671860) (PMCID:PMC5052655)

Bolognini, D. et al. (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. Journal of Biological Chemistry, 291, pp. 18915-18931. (doi: 10.1074/jbc.M116.736157) (PMID:27385588) (PMCID:PMC5009265)

Lavery, C. A., Kurowska-Stolarska, M. , Holmes, W. , Donnelly, I., Caslake, M., Collier, A., Baker, A. H. and Miller, A. M. (2016) miR-34a-/- mice are susceptible to diet-induced obesity. Obesity, 24(8), pp. 1741-1751. (doi: 10.1002/oby.21561) (PMID:27377585) (PMCID:PMC4979678)

Komai-Koma, M., Wang, E., Kurowska-Stolarska, M. , Li, D., McSharry, C. and Xu, D. (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi: 10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)

Elmesmari, A., Alivernini, S., McInnes, I. B. and Kurowska-Stolarska, M. (2016) Targeting miR-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production. Scottish Society of Rheumatology Meeting 2016, Dundee, 2016. (Unpublished)

2015

Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)

2014

Li, D. et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. Journal of Allergy and Clinical Immunology, 134(6), 1422-1432.e11. (doi: 10.1016/j.jaci.2014.05.011) (PMID:24985397) (PMCID:PMC4258609)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)

Elmesmari, A., Pushparaj, P. N., Reilly, J., Kerr, S., Kurowska-Stolarska, M. and McInnes, I. B. (2014) Role of SPHKs and S1PRs in Rheumatoid Arthritis. 3rd European Congress of Immunology (ECI 2012), Glasgow, UK, 5-8 Sept 2012. (Unpublished)

Holla, S., Kurowska-Stolarska, M. , Bayry, J. and Balaji, K. (2014) Selective inhibition of IFNG-induced autophagy by Mir155- and Mir31-responsive WNT5A and SHH signaling. Autophagy, 10(2), pp. 311-330. (doi: 10.4161/auto.27225)

2013

Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi: 10.1136/annrheumdis-2012-202872) (PMID:23434566)

Frleta, M., Rainey, A.-A., Gilchrist, D.S., Crawford, L., Baxter, D., Kurowska-Stolarska, M. and McInnes, I.B. (2013) Mir-27b as Biomarker and Regulator of IL-6R Pathway in Resistant Rheumatoid Arthritis Monocyte. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S1035.

Millar, N.L. , Gilchrist, D.S., Kurowska-Stolarska, M. , Murrell, G.A.C. and McInnes, I. B. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: EULAR 2013: Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June 2013, p. 140.

Millar, N. L. , Gilchrist, D. S., Kurowska-Stolarska, M. , Murrell, G. A.C. and McInnes, I. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S405.

Miller, A. M., Gilchrist, D. S., Nijjar, J., Araldi, E., Ramirez, C. M., Lavery, C. A., Fernández-Hernando, C., McInnes, I. B. and Kurowska-Stolarska, M. (2013) MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE, 8(8), e72324. (doi: 10.1371/journal.pone.0072324) (PMID:23991091) (PMCID:PMC3749101)

Rainey, A.-A., Gilchrist, D. S., Tange, C. E., Frleta, M., Crawford, L., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-125a: A novel regulator of IL-6 and TLR driven pathways in RA pathogenesis. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S404.

Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.

2012

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. , Rainey, A.-A., Pich, D., McInnes, I.B. , Hammerschmidt, W., O'Neill, L.A.J. and Masters, S.L. (2012) Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1 production. Journal of Immunology, 189(8), pp. 3795-3799. (doi: 10.4049/jimmunol.1200312) (PMID:22984081)

Statache, G., Rainey, A.-A., Masters, S., Balanescu, A., McInnes, I. B. and Kurowska-Stolarska, M. (2012) Regulation of microrna 223 expression in a gouty arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S811. (doi: 10.1002/art.37735)

Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)

Elmesmari, A., Pushparaj, P., Reilly, J., Kerr, S., Kurowska-Stolarska, M. and McInnes, I. (2012) The role of SPHKs and SIPRs in rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 260. (doi: 10.1111/imm.12002)

Statache, G., Rainey, A., Crawford, L., Masters, S., Balanescu, A., McInnes, I. and Kurowska-Stolarska, M. (2012) Regulation of microRNA 223 expression in a gouty arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 227. (doi: 10.1111/imm.12002)

Ghorpade, D. S., Leyland, R., Kurowska-Stolarska, M. , Patil, S. A. and Balaji, K. N. (2012) MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Molecular and Cellular Biology, 32(12), pp. 2239-2253. (doi: 10.1128/MCB.06597-11)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. , Rainey, A., Pitch, D., Hammerschmidt, W., O’Neill, L. and Masters, S. (2012) miR-223 targets IL-1β production and is decreased in synovial fluid monocytes from arthritis patients. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, 12-15 May 2012, pp. 9-10. (doi: 10.1111/j.1445-5994.2012.02761.x)

Baxter, D., McInnes, I.B. and Kurowska-Stolarska, M. (2012) Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunology and Cell Biology, 90(3), pp. 288-292. (doi: 10.1038/icb.2011.114) (PMID:22249200)

Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)

Kurowska-Stolarska, M. , Hasoo, M., Gilchrist, D. G., Ruzicska, E., Asquith, D., Welsh, D., Crawford, L., Hirani, N., McInnes, I. B. and McSharry, C. (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)

2011

Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)

Zaiss, M. M. et al. (2011) IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-α–mediated bone loss. Journal of Immunology, 186(11), pp. 6097-6105. (doi: 10.4049/jimmunol.1003487) (PMID:21515798)

Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.

2010

Stolarski, B., Kurowska-Stolarska, M. , Kewin, P., Xu, D. and Liew, F. Y. (2010) IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation. Journal of Immunology, 185(6), pp. 3472-3480. (doi: 10.4049/jimmunol.1000730)

Xu, D. et al. (2010) IL-33 exacerbates autoantibody-induced arthritis. Journal of Immunology, 184(5), pp. 2620-2626. (doi: 10.4049/jimmunol.0902685) (PMID:20139274)

Kurowska-Stolarska, M. , Hueber, A., Stolarski, B. and McInnes, I. B. (2010) Interleukin-33: a novel mediator with a role in distinct disease pathologies. Journal of Internal Medicine, 269(1), pp. 29-35. (doi: 10.1111/j.1365-2796.2010.02316.x) (PMID:21158975)

Kurowska-Stolarska, M. , Ballantine, L., Stolarski, B., Hunter, J., Hueber, A., Gracie, J.A., Liew, F. Y. and McInnes, I. B. (2010) miR-155 and miR-34a regulate proinflammatory cytokine production by human monocytes. In: European Workshop for Rheumatology Research, Bamberg, Germany, 4-7 Mar 2010, A30-A30. (doi: 10.1136/ard.2010.129619g)

2009

Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)

Kurowska-Stolarska, M. et al. (2009) Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast-dependent osteoclastogenesis. Arthritis and Rheumatism, 60(12), pp. 3663-3675. (doi: 10.1002/art.25001)

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

2008

Kurowska-Stolarska, M. et al. (2008) IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. Journal of Immunology, 181(7), pp. 4780-4790.

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Kurowska-Stolarska, M. S. , Kewin, P., Stolarski, B., Fraser, A., Xu, D., McInnes, I. and Liew, F. Y. (2008) A role of IL-33 in bone turnover. In: 72nd Annual Scientific Meeting of the American College of Rheumatology and the 43rd Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Francisco CA, USA, 24-29 Oct 2008, S895.

Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2008) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased local Th2 cytokine and chemokine production. In: Scottish Thoracic Society Meeting, Stirling, UK, 26 Oct 2007, p. 50. (doi: 10.1258/rsmsmj.53.2.48)

2007

Ospelt, C., Kurowska-Stolarska, M. , Neidhart, M., Michel, B. A., Gay, R. E., Laufer, S. and Gay, S. (2007) The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. Annals of the Rheumatic Diseases, 67(4), pp. 524-529. (doi: 10.1136/ard.2007.071589)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2007) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased ST2 dependent local Th2 cytokine and chemokine production. In: Winter Meeting of the British-Thoracic-Society, London, UK, 05-07 Dec 2007, A1.

2005

Distler, J. H.W., Jüngel, A., Kurowska-Stolarska, M. , Michel, B. A., Gay, R. E., Gay, S. and Distler, O. (2005) Nucleofection: a new, highly efficient transfection method for primary human keratinocytes. Experimental Dermatology, 14(4), pp. 315-20. (doi: 10.1111/j.0906-6705.2005.00276.x)

Kurowska-Stolarska, M. et al. (2005) The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis. In: 25th European Workshop for Rheumatology Research, Glasgow, UK, 24-27 Feb 2005, P48. (doi: 10.1186/ar1569)

Kurowska-Stolarska, M. , Neidhart, M., Michel, B.A., Simmen, B.R. and Gay, R.E. (2005) Licofelone, a COX/5-LOX inhibitor blocks chemoattraction of Th1 cells by down regulation of CXCR3 ligands in synovial fibroblasts. In: 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, USA, 12-17 Nov 2005, S568.

2004

Ospelt, C. et al. (2004) Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways. In: Sixth International Symposium on Advances in Targeted Therapies, Venice, Italy, 28 Apr - 2 May 2004, ii90-ii91. (doi: 10.1136/ard.2004.028324)

Kurowska-Stolarska, M. , Distler, J., Pap, T., Jungel, A., Michel, B.A., Simmen, B.R., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of differentiation-2 (Id-2) induced by hypoxia promotes bone de radation in rheumatoid arthritis (RA). In: 68th Annual Scientific Meeting of the American College of Rheumatology/39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S655.

Jüngel, A. et al. (2004) Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis and Rheumatism, 50(5), pp. 1468-1476. (doi: 10.1002/art.20218)

Distler, J. H.W., Wenger, R. H., Gassmann, M., Kurowska-Stolarska, M. , Hirth, A., Gay, S. and Distler, O. (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis and Rheumatism, 50(1), pp. 10-23. (doi: 10.1002/art.11425)

Kurowska-Stolarska, M. , Distler, J., Pap, T., Hirth, A., Moritz, W., Michel, B.A., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of helix-loop-helix transcription factor ID-2 triggered by hypoxia and proinflammatory cytokines promotes the activated phenotype of synovial fibroblasts facilitating bone degradation. In: 5th Annual Congress of the European League Against Rheumatism (EULAR 2004), Berlin, Germany, 9-12 June 2004, p. 79.

Ospelt, C., Kurowska-Stolarska, M. , Neidhart, M., Michel, B.A., Simmen, B.R., Gay, R.E. and Gay, S. (2004) Licofelone, a cylooxygenase/5-lipoxygenase inhibitor reduces expression of IP-10 in rheumatoid arthritis synovial fibroblasts. In: 68th Annual Scientific Meeting of the American College of Rheumatology / 39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S570.

2003

Distler, J. H. W., Hirth, A., Kurowska-Stolarska, M. , Gay, R. E., Gay, S. and Distler, O. (2003) Angiogenic and angiostatic factors in the molecular control of angiogenesis. Quarterly Journal of Nuclear Medicine, 47(3), pp. 149-61.

Kurowska-Stolarska, M. , Distler, J., Moritz, W., Marti, H., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2003) The expression of inhibitor of differentiation-2 (Id-2) is induced by hypoxia in synovial fibroblasts independently of HIF-1a. In: 67th Annual Scientific Meeting of the American College of Rheumatology/38th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Orlando, FL, USA, 23-28 Oct 2003, S146.

Kurowska-Stolarska, M. , Distler, O., Rudnicka, W., Distler, J., Gay, R.E., Maslinski, W. and Gay, S. (2003) IL-15 and its role in rheumatoid arthritis. In: 3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit, Miyakazi, Japan, 14-17 Sept 2003, p. 139. (doi: 10.1186/ar940)

2002

Kurowska-Stolarska, M. , Rudnicka, W., Janicka, I., Chorazy, M., Kowalczewski, J., Ziolkowska, M., Ferrari-Lacraz, S., Ferrari-Lacraz, S., Strom, T.B. and Maslinski, W. (2002) Endogenous IL-15 in autocrine fashion enhances rheumatoid arthritis fibroblast-like synoviocytes proliferation and resistance to apoptosis. In: 66th Annual Scientific Meeting of the American College of Rheumatology/37th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, New Orleans, LA, USA, 24-29 Oct 2002, S554.

Kurowska-Stolarska, M. , Rudnicka, W., Kontny, E., Janicka, I., Chorazy, M., Kowalczewski, J., Ziółkowska, M., Ferrari-Lacraz, S., Strom, T. B. and Maśliński, W. (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. Journal of Immunology, 169(4), pp. 1760-7. (doi: 10.4049/​jimmunol.169.4.1760)

Ziolkowska, M. et al. (2002) High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis and Rheumatism, 46(7), pp. 1744-1753. (doi: 10.1002/art.10388)

Kurowska, M. , Rudnicka, W., Maślińska, D. and Maśliński, W. (2002) Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Annals of the New York Academy of Sciences, 966, pp. 441-445. (doi: 10.1111/j.1749-6632.2002.tb04245.x)

2000

Kontny, E., Szczepańska, K., Kowalczewski, J., Kurowska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (2000) The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 43(10), pp. 2169-2177.

Kontny, E., Kurowska, M. , Szczepańska, K. and Maśliński, W. (2000) Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. Journal of Leukocyte Biology, 67(2), pp. 249-258.

1999

Kontny, E., Grabowska, A., Kowalczewski, J., Kurowska-Stolarska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (1999) Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 42(12), pp. 2552-60. (doi: 10.1002/1529-0131(199912)42:12<2552::AID-ANR7>3.0.CO;2-V)

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Articles

Alivernini, S., Cañete, J. D., Bacardit, J. and Kurowska-Stolarska, M. (2024) Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis. Nature Medicine, 30(4), pp. 925-926. (doi: 10.1038/s41591-024-02818-w) (PMID:38361121)

Ng, M. T.H. et al. (2024) A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution. Nature Communications, 15, 1394. (doi: 10.1038/s41467-024-45341-9) (PMID:38374174) (PMCID:PMC10876649)

Paoletti, A. et al. (2024) Liposomal antagomiR-155-5p restores anti-inflammatory macrophages and improves arthritis in preclinical models of rheumatoid arthritis. Arthritis and Rheumatology, 76(1), pp. 18-31. (doi: 10.1002/art.42665) (PMID:37527031)

Johnson, P. A., Ackerman, J. E., Kurowska-Stolarska, M. , Coles, M., Buckley, C. D. and Dakin, S. G. (2023) Three-dimensional, in-vitro approaches for modelling soft-tissue joint diseases. Lancet Rheumatology, 5(9), e553-e563. (doi: 10.1016/S2665-9913(23)00190-X) (PMID:38251499)

van Gijsel-Bonnello, M. et al. (2022) Salt Inducible Kinase 2 regulates fibrosis during bleomycin-induced lung injury. Journal of Biological Chemistry, 298(12), 102644. (doi: 10.1016/j.jbc.2022.102644) (PMID:36309093) (PMCID:PMC9706632)

Kurowska-Stolarska, M. and Alivernini, S. (2022) Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nature Reviews Rheumatology, 18, pp. 384-397. (doi: 10.1038/s41584-022-00790-8) (PMID:35672464)

Farina, L. et al. (2022) Pro nerve growth factor and its receptor p75NTR activate inflammatory responses in synovial fibroblasts: a novel targetable mechanism in arthritis. Frontiers in Immunology, 13, 818630. (doi: 10.3389/fimmu.2022.818630) (PMID:35309353) (PMCID:PMC8931659)

Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)

Micheroli, R. et al. (2022) Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis. RMD Open, 8(1), e001949. (doi: 10.1136/rmdopen-2021-001949) (PMID:34987094) (PMCID:PMC8734041)

Clayton, S. A. et al. (2021) Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48. Science Advances, 7(50), eabl5182. (doi: 10.1126/sciadv.abl5182) (PMID:34878835)

Akbar, M., MacDonald, L. , Crowe, L. A.N., Carlberg, K., Kurowska-Stolarska, M. , Ståhl, P. L., Snelling, S. J.B., McInnes, I. B. and Millar, N. L. (2021) Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Annals of the Rheumatic Diseases, 80(11), pp. 1494-1497. (doi: 10.1136/annrheumdis-2021-220256) (PMID:34001518) (PMCID:PMC8522454)

MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)

Clayton, S. A., MacDonald, L. , Kurowska-Stolarska, M. and Clark, A. R. (2021) Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis. Frontiers in Immunology, 12, 1488. (doi: 10.3389/fimmu.2021.673916) (PMID:33995417) (PMCID:PMC8118696)

Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788) (PMCID:PMC8058094)

Rayner, F. et al. (2021) BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study. BMC Rheumatology, 5, 22. (doi: 10.1186/s41927-021-00194-3) (PMID:34275488) (PMCID:PMC8286860)

Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)

Ramilowski, J. A. et al. (2020) Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Research, 30(7), pp. 1060-1072. (doi: 10.1101/gr.254219.119) (PMID:32718982) (PMCID:PMC7397864)

McShane, L. , Tabas, I., Lemke, G., Kurowska-Stolarska, M. and Maffia, P. (2019) TAM receptors in cardiovascular disease. Cardiovascular Research, 115(5), pp. 1286-1295. (doi: 10.1093/cvr/cvz100) (PMID:30980657) (PMCID:PMC6587925)

Goncalves-Alves, E. et al. (2019) MicroRNA-155 controls T helper cell activation during viral infection. Frontiers in Immunology, 10, 1367. (doi: 10.3389/fimmu.2019.01367) (PMID:31275315) (PMCID:PMC6593301)

Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska-Stolarska, M. and McInnes, I.B. (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology, 193(1), pp. 13-23. (doi: 10.1111/cei.13098) (PMID:29315512) (PMCID:PMC6038003)

Cooles, F. A.H., Anderson, A. E., Skelton, A., Pratt, A. G., Kurowska-Stolarska, M. S. , McInnes, I. , Hilkens, C. M.U. and Isaacs, J. D. (2018) Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis. Frontiers in Immunology, 9, 755. (doi: 10.3389/fimmu.2018.00755) (PMID:29867920) (PMCID:PMC5968398)

Hecht, I. et al. (2018) ILDR2 is a novel B7-like protein that negatively regulates T cell responses. Journal of Immunology, 200(6), pp. 2025-2037. (doi: 10.4049/jimmunol.1700325) (PMID:29431694)

Shams, K., Kurowska-Stolarska, M. , Schütte, F., Burden, A. D., McKimmie, C. S. and Graham, G. J. (2018) MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Journal of Biological Chemistry, 293(8), pp. 3003-3012. (doi: 10.1074/jbc.M117.809780) (PMID:29279330) (PMCID:PMC5827444)

Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M. and Clark, A. R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi: 10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)

Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)

Kurowska-Stolarska, M. and Alivernini, S. (2017) Synovial tissue macrophages: friend or foe? RMD Open, 3(2), e000527. (doi: 10.1136/rmdopen-2017-000527) (PMID:29299338) (PMCID:PMC5729306)

Jaigrdar, S. A., Benson, R. A. , Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi: 10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)

Saferding, V. et al. (2017) MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. Journal of Autoimmunity, 82, pp. 74-84. (doi: 10.1016/j.jaut.2017.05.006) (PMID:28545737)

Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)

Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)

Chen, L. et al. (2017) miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. Annals of the Rheumatic Diseases, 76(3), pp. 620-624. (doi: 10.1136/annrheumdis-2016-210175) (PMID:28039186)

Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)

Huesa, C. et al. (2016) Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology. Annals of the Rheumatic Diseases, 75(11), pp. 1989-1997. (doi: 10.1136/annrheumdis-2015-208268) (PMID:26698846) (PMCID:PMC5099200)

Alivernini, S. et al. (2016) MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nature Communications, 7, 12970. (doi: 10.1038/ncomms12970) (PMID:27671860) (PMCID:PMC5052655)

Bolognini, D. et al. (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. Journal of Biological Chemistry, 291, pp. 18915-18931. (doi: 10.1074/jbc.M116.736157) (PMID:27385588) (PMCID:PMC5009265)

Lavery, C. A., Kurowska-Stolarska, M. , Holmes, W. , Donnelly, I., Caslake, M., Collier, A., Baker, A. H. and Miller, A. M. (2016) miR-34a-/- mice are susceptible to diet-induced obesity. Obesity, 24(8), pp. 1741-1751. (doi: 10.1002/oby.21561) (PMID:27377585) (PMCID:PMC4979678)

Komai-Koma, M., Wang, E., Kurowska-Stolarska, M. , Li, D., McSharry, C. and Xu, D. (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi: 10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)

Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)

Li, D. et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. Journal of Allergy and Clinical Immunology, 134(6), 1422-1432.e11. (doi: 10.1016/j.jaci.2014.05.011) (PMID:24985397) (PMCID:PMC4258609)

Holla, S., Kurowska-Stolarska, M. , Bayry, J. and Balaji, K. (2014) Selective inhibition of IFNG-induced autophagy by Mir155- and Mir31-responsive WNT5A and SHH signaling. Autophagy, 10(2), pp. 311-330. (doi: 10.4161/auto.27225)

Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi: 10.1136/annrheumdis-2012-202872) (PMID:23434566)

Miller, A. M., Gilchrist, D. S., Nijjar, J., Araldi, E., Ramirez, C. M., Lavery, C. A., Fernández-Hernando, C., McInnes, I. B. and Kurowska-Stolarska, M. (2013) MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE, 8(8), e72324. (doi: 10.1371/journal.pone.0072324) (PMID:23991091) (PMCID:PMC3749101)

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. , Rainey, A.-A., Pich, D., McInnes, I.B. , Hammerschmidt, W., O'Neill, L.A.J. and Masters, S.L. (2012) Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1 production. Journal of Immunology, 189(8), pp. 3795-3799. (doi: 10.4049/jimmunol.1200312) (PMID:22984081)

Ghorpade, D. S., Leyland, R., Kurowska-Stolarska, M. , Patil, S. A. and Balaji, K. N. (2012) MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Molecular and Cellular Biology, 32(12), pp. 2239-2253. (doi: 10.1128/MCB.06597-11)

Baxter, D., McInnes, I.B. and Kurowska-Stolarska, M. (2012) Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunology and Cell Biology, 90(3), pp. 288-292. (doi: 10.1038/icb.2011.114) (PMID:22249200)

Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)

Zaiss, M. M. et al. (2011) IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-α–mediated bone loss. Journal of Immunology, 186(11), pp. 6097-6105. (doi: 10.4049/jimmunol.1003487) (PMID:21515798)

Stolarski, B., Kurowska-Stolarska, M. , Kewin, P., Xu, D. and Liew, F. Y. (2010) IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation. Journal of Immunology, 185(6), pp. 3472-3480. (doi: 10.4049/jimmunol.1000730)

Xu, D. et al. (2010) IL-33 exacerbates autoantibody-induced arthritis. Journal of Immunology, 184(5), pp. 2620-2626. (doi: 10.4049/jimmunol.0902685) (PMID:20139274)

Kurowska-Stolarska, M. , Hueber, A., Stolarski, B. and McInnes, I. B. (2010) Interleukin-33: a novel mediator with a role in distinct disease pathologies. Journal of Internal Medicine, 269(1), pp. 29-35. (doi: 10.1111/j.1365-2796.2010.02316.x) (PMID:21158975)

Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)

Kurowska-Stolarska, M. et al. (2009) Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast-dependent osteoclastogenesis. Arthritis and Rheumatism, 60(12), pp. 3663-3675. (doi: 10.1002/art.25001)

Kurowska-Stolarska, M. et al. (2008) IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. Journal of Immunology, 181(7), pp. 4780-4790.

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)

Ospelt, C., Kurowska-Stolarska, M. , Neidhart, M., Michel, B. A., Gay, R. E., Laufer, S. and Gay, S. (2007) The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. Annals of the Rheumatic Diseases, 67(4), pp. 524-529. (doi: 10.1136/ard.2007.071589)

Distler, J. H.W., Jüngel, A., Kurowska-Stolarska, M. , Michel, B. A., Gay, R. E., Gay, S. and Distler, O. (2005) Nucleofection: a new, highly efficient transfection method for primary human keratinocytes. Experimental Dermatology, 14(4), pp. 315-20. (doi: 10.1111/j.0906-6705.2005.00276.x)

Jüngel, A. et al. (2004) Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis and Rheumatism, 50(5), pp. 1468-1476. (doi: 10.1002/art.20218)

Distler, J. H.W., Wenger, R. H., Gassmann, M., Kurowska-Stolarska, M. , Hirth, A., Gay, S. and Distler, O. (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis and Rheumatism, 50(1), pp. 10-23. (doi: 10.1002/art.11425)

Distler, J. H. W., Hirth, A., Kurowska-Stolarska, M. , Gay, R. E., Gay, S. and Distler, O. (2003) Angiogenic and angiostatic factors in the molecular control of angiogenesis. Quarterly Journal of Nuclear Medicine, 47(3), pp. 149-61.

Kurowska-Stolarska, M. , Rudnicka, W., Kontny, E., Janicka, I., Chorazy, M., Kowalczewski, J., Ziółkowska, M., Ferrari-Lacraz, S., Strom, T. B. and Maśliński, W. (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. Journal of Immunology, 169(4), pp. 1760-7. (doi: 10.4049/​jimmunol.169.4.1760)

Ziolkowska, M. et al. (2002) High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis and Rheumatism, 46(7), pp. 1744-1753. (doi: 10.1002/art.10388)

Kurowska, M. , Rudnicka, W., Maślińska, D. and Maśliński, W. (2002) Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Annals of the New York Academy of Sciences, 966, pp. 441-445. (doi: 10.1111/j.1749-6632.2002.tb04245.x)

Kontny, E., Szczepańska, K., Kowalczewski, J., Kurowska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (2000) The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 43(10), pp. 2169-2177.

Kontny, E., Kurowska, M. , Szczepańska, K. and Maśliński, W. (2000) Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. Journal of Leukocyte Biology, 67(2), pp. 249-258.

Kontny, E., Grabowska, A., Kowalczewski, J., Kurowska-Stolarska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (1999) Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 42(12), pp. 2552-60. (doi: 10.1002/1529-0131(199912)42:12<2552::AID-ANR7>3.0.CO;2-V)

Conference or Workshop Item

Finlay, S. et al. (2019) Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts. 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA, 08-13 Nov 2019.

Elmesmari, A. et al. (2019) Do Functional Interactions Between Macrophages and Synovial Fibroblasts Drive Synovial Pathology or Resolution of Inflammation? European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Finlay, S. et al. (2019) Single-cell Transcriptomic and Functional Analyses Reveal Novel Heterogeneity in Pathogenic Pathways Mediated by Human Synovial Tissue Macrophages. European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Alivernini, S. et al. (2018) Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation. 2018 ACR/ARHP Annual Meeting, Chicago, IL, 19-24 Oct 2018. (Unpublished)

Elmesmari, A., Alivernini, S., Tolusso, B., Bui, L., Vaughan, D. , Federico, F., Gremese, E., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Stolarska Synovial Tissue CD1c+ Dendritic Cells in Rheumatoid Arthritis Express High Levels of the Epigenetic Regulator of Inflammation, Microrna-155 and Inflammatory Cytokines. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Finlay, S., Alivernini, S., Elmesmari, A., Tolusso, B., Ferraccioli, G., Gremese, E., Petricca, L., McInnes, I. B. , Kurowska-Stolarska, M. and Filer, A. (2018) Activation of Mertk+cd206+ Subpopulation of Human Synovial Tissue-Resident Macrophages Limits Inflammatory Response. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. Microphage Biology in the Single-Cell Era, Ghent, Belgium, 2018. (Unpublished)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)

Elmesmari, A., Alivernini, S., Vaughan, D. , Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Characterisation of Synovium Tissues Macropahges. Rheumatology 2017, Birmingham, UK, 25-27 April 2017. (Unpublished)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)

Elmesmari, A., Alivernini, S., McInnes, I. B. and Kurowska-Stolarska, M. (2016) Targeting miR-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production. Scottish Society of Rheumatology Meeting 2016, Dundee, 2016. (Unpublished)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)

Elmesmari, A., Pushparaj, P. N., Reilly, J., Kerr, S., Kurowska-Stolarska, M. and McInnes, I. B. (2014) Role of SPHKs and S1PRs in Rheumatoid Arthritis. 3rd European Congress of Immunology (ECI 2012), Glasgow, UK, 5-8 Sept 2012. (Unpublished)

Conference Proceedings

Frleta, M., Rainey, A.-A., Gilchrist, D.S., Crawford, L., Baxter, D., Kurowska-Stolarska, M. and McInnes, I.B. (2013) Mir-27b as Biomarker and Regulator of IL-6R Pathway in Resistant Rheumatoid Arthritis Monocyte. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S1035.

Millar, N.L. , Gilchrist, D.S., Kurowska-Stolarska, M. , Murrell, G.A.C. and McInnes, I. B. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: EULAR 2013: Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June 2013, p. 140.

Millar, N. L. , Gilchrist, D. S., Kurowska-Stolarska, M. , Murrell, G. A.C. and McInnes, I. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S405.

Rainey, A.-A., Gilchrist, D. S., Tange, C. E., Frleta, M., Crawford, L., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-125a: A novel regulator of IL-6 and TLR driven pathways in RA pathogenesis. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S404.

Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.

Statache, G., Rainey, A.-A., Masters, S., Balanescu, A., McInnes, I. B. and Kurowska-Stolarska, M. (2012) Regulation of microrna 223 expression in a gouty arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S811. (doi: 10.1002/art.37735)

Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)

Elmesmari, A., Pushparaj, P., Reilly, J., Kerr, S., Kurowska-Stolarska, M. and McInnes, I. (2012) The role of SPHKs and SIPRs in rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 260. (doi: 10.1111/imm.12002)

Statache, G., Rainey, A., Crawford, L., Masters, S., Balanescu, A., McInnes, I. and Kurowska-Stolarska, M. (2012) Regulation of microRNA 223 expression in a gouty arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 227. (doi: 10.1111/imm.12002)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. , Rainey, A., Pitch, D., Hammerschmidt, W., O’Neill, L. and Masters, S. (2012) miR-223 targets IL-1β production and is decreased in synovial fluid monocytes from arthritis patients. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, 12-15 May 2012, pp. 9-10. (doi: 10.1111/j.1445-5994.2012.02761.x)

Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)

Kurowska-Stolarska, M. , Hasoo, M., Gilchrist, D. G., Ruzicska, E., Asquith, D., Welsh, D., Crawford, L., Hirani, N., McInnes, I. B. and McSharry, C. (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)

Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.

Kurowska-Stolarska, M. , Ballantine, L., Stolarski, B., Hunter, J., Hueber, A., Gracie, J.A., Liew, F. Y. and McInnes, I. B. (2010) miR-155 and miR-34a regulate proinflammatory cytokine production by human monocytes. In: European Workshop for Rheumatology Research, Bamberg, Germany, 4-7 Mar 2010, A30-A30. (doi: 10.1136/ard.2010.129619g)

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

Kurowska-Stolarska, M. S. , Kewin, P., Stolarski, B., Fraser, A., Xu, D., McInnes, I. and Liew, F. Y. (2008) A role of IL-33 in bone turnover. In: 72nd Annual Scientific Meeting of the American College of Rheumatology and the 43rd Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Francisco CA, USA, 24-29 Oct 2008, S895.

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2008) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased local Th2 cytokine and chemokine production. In: Scottish Thoracic Society Meeting, Stirling, UK, 26 Oct 2007, p. 50. (doi: 10.1258/rsmsmj.53.2.48)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2007) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased ST2 dependent local Th2 cytokine and chemokine production. In: Winter Meeting of the British-Thoracic-Society, London, UK, 05-07 Dec 2007, A1.

Kurowska-Stolarska, M. et al. (2005) The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis. In: 25th European Workshop for Rheumatology Research, Glasgow, UK, 24-27 Feb 2005, P48. (doi: 10.1186/ar1569)

Kurowska-Stolarska, M. , Neidhart, M., Michel, B.A., Simmen, B.R. and Gay, R.E. (2005) Licofelone, a COX/5-LOX inhibitor blocks chemoattraction of Th1 cells by down regulation of CXCR3 ligands in synovial fibroblasts. In: 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, USA, 12-17 Nov 2005, S568.

Ospelt, C. et al. (2004) Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways. In: Sixth International Symposium on Advances in Targeted Therapies, Venice, Italy, 28 Apr - 2 May 2004, ii90-ii91. (doi: 10.1136/ard.2004.028324)

Kurowska-Stolarska, M. , Distler, J., Pap, T., Jungel, A., Michel, B.A., Simmen, B.R., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of differentiation-2 (Id-2) induced by hypoxia promotes bone de radation in rheumatoid arthritis (RA). In: 68th Annual Scientific Meeting of the American College of Rheumatology/39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S655.

Kurowska-Stolarska, M. , Distler, J., Pap, T., Hirth, A., Moritz, W., Michel, B.A., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of helix-loop-helix transcription factor ID-2 triggered by hypoxia and proinflammatory cytokines promotes the activated phenotype of synovial fibroblasts facilitating bone degradation. In: 5th Annual Congress of the European League Against Rheumatism (EULAR 2004), Berlin, Germany, 9-12 June 2004, p. 79.

Ospelt, C., Kurowska-Stolarska, M. , Neidhart, M., Michel, B.A., Simmen, B.R., Gay, R.E. and Gay, S. (2004) Licofelone, a cylooxygenase/5-lipoxygenase inhibitor reduces expression of IP-10 in rheumatoid arthritis synovial fibroblasts. In: 68th Annual Scientific Meeting of the American College of Rheumatology / 39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S570.

Kurowska-Stolarska, M. , Distler, J., Moritz, W., Marti, H., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2003) The expression of inhibitor of differentiation-2 (Id-2) is induced by hypoxia in synovial fibroblasts independently of HIF-1a. In: 67th Annual Scientific Meeting of the American College of Rheumatology/38th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Orlando, FL, USA, 23-28 Oct 2003, S146.

Kurowska-Stolarska, M. , Distler, O., Rudnicka, W., Distler, J., Gay, R.E., Maslinski, W. and Gay, S. (2003) IL-15 and its role in rheumatoid arthritis. In: 3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit, Miyakazi, Japan, 14-17 Sept 2003, p. 139. (doi: 10.1186/ar940)

Kurowska-Stolarska, M. , Rudnicka, W., Janicka, I., Chorazy, M., Kowalczewski, J., Ziolkowska, M., Ferrari-Lacraz, S., Ferrari-Lacraz, S., Strom, T.B. and Maslinski, W. (2002) Endogenous IL-15 in autocrine fashion enhances rheumatoid arthritis fibroblast-like synoviocytes proliferation and resistance to apoptosis. In: 66th Annual Scientific Meeting of the American College of Rheumatology/37th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, New Orleans, LA, USA, 24-29 Oct 2002, S554.

This list was generated on Thu Nov 21 02:33:46 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Identifying synovial and tenosynovial cellular and molecular mechanisms and biomarkers of transition from pre-clinical RA to RA
    Versus Arthritis
    2024 - 2028
     
  • Human 3D synovial tissue organoids as a versatile tool to facilitate anti-rheumatic drug development for rheumatoid arthritis (3D4RA)
    ZonMw
    2024 - 2024
     
  • Quality not quantity: evaluating the role of immune mRNA isoforms at single-cell level in inflammatory arthritis
    Tenovus Scotland
    2024 - 2024
     
  • Dissecting the cellular and molecular atlas of Rheumatoid Arthritis (RA) in sustained remission to identify pathways maintaining remission and triggering flares.
    Foundation for Research in Rheumatology
    2023 - 2025
     
  • Identifying therapeutic targets to treat and prevent disease flare in rheumatoid arthritis
    Medical Research Council
    2022 - 2024
     
  • Identifying the mechanisms and biomarkers of transition from Psoriasis (PsO) to Psoriatic Arthritis (PsA)
    Foundation for Research in Rheumatology
    2022 - 2024
     
  • Defining AXL Role in Atherosclerosis
    British Heart Foundation
    2021 - 2023
     
  • Dissecting innate immune determinants of severity and resolution in a longitudinal study of COVID-19
    UK Research and Innovation
    2020 - 2022
     
  • The mechanisms by which JAK inhibition fosters disease remission in Psoriatic Arthritis and Rheumatoid Arthritis treated with Tofacitinib.
    Pfizer
    2020 - 2023
     
  • Dissecting the role of distinct phenotypic clusters of synovial tissue macrophages in the regulation of joint homeostasis and the resolution of joint inflammation in Rheumatoid Arthritis
    Versus Arthritis
    2020 - 2024
     
  • The double life of platelets: Do platelets provide fuel or foam for inflammatory arthritis?
    Versus Arthritis
    2020 - 2022
     
  • The double life of platelets: Do platelets provide fuel or foam for inflammatory arthritis?
    Versus Arthritis
    2020 - 2024
     
  • ArthritisHeal
    European Commission
    2019 - 2023
     
  • Joint enterprise: the collaboration of synovial fibroblasts and macrophages to sustain inflammation
    Arthritis Research UK
    2018 - 2019
     
  • BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (BIO-FLARE study)
    Medical Research Council
    2017 - 2021
     
  • ISSF Catalyst@ The Glasgow ??? FANTOM6 consortium investigation of the role of LncRNAs in specifying tissue macrophage phenotypes
    Wellcome Trust
    2015 - 2016
     
  • MIR-34a AS POSSIBLE EPIGENETIC REGULATOR OF INFLAMMATION DRIVEN FIBROSIS IN SYSTEMIC SCLEROSIS
    British Society for Rheumatology
    2015 - 2015
     
  • Designer Receptor Exclusively Activated by Designer Drug' to define the role of short chain fatty acids in metabolic disease and inflammation (Fatty acid DREADD)
    Biotechnology and Biological Sciences Research Council
    2014 - 2014
     
  • Microparticles as carriers of genetic material - a new mechanism of intercellular communication that underlies the pathogenesis of rheumatoid arthritis
    Tenovus Scotland
    2014 - 2015
     
  • Identification of disease-associated pathways induced in Psoriatic Arthritis synovial fibroblasts by biomechanical stress (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • GPR120: a G protein-coupled receptor with the potential to regulate insulin secretion and inflammation
    Biotechnology and Biological Sciences Research Council
    2013 - 2017
     
  • Expression of SYK in skin and Synovial tissues and identity of cell type.
    Astrazeneca (SE)
    2012 - 2013
     
  • Does a micro-RNA network regulate BMP-7 in different phases of osteoarthritis of the knee?
    Tenovus Scotland
    2012 - 2013
     
  • MicroRNA in monocytes: its contribution to the pathogenesis of arthritis and cardiovascular co-morbidity
    Arthritis Research UK
    2009 - 2014
     

Supervision

Jack Frew: 2320454F@student.gla.ac.uk

Luxin Yang: 2285540Y@student.gla.ac.uk

Marcus Doohan: 2439044D@student.gla.ac.uk

Dr Dario Bruno: 2624949B@student.gla.ac.uk

Olympia Hardy:  2505621H@student.gla.ac.uk

Caglar Cil (PGR): 2492741C@student.gla.ac.uk

 

Professional activities & recognition

Prizes, awards & distinctions

  • 2018: Award for the best science abstract at European League Against Rheumatism Conference (European Society of Rheumatology) EULAR (Amsterdam, Netherlands)
  • 2017: Award for the best science abstract at European League Against Rheumatism Conference (European Society of Rheumatology) EULAR (Madrid, Spain)
  • 2009: Arthritis Research UK Career Development Fellowship (Glasgow, UK)
  • 2005: Young Investigator Award, European Workshop for Rheumatology Research (Glasgow, UK)
  • 2002: Polish Rheumatology Society Award for the best scientific paper (Warsaw, Poland)
  • 2002: Harmann-Muller Fellowship (Zurich, Switzerland)

Selected international presentations

  • 2024: The European Alliance of Associations for Rheumatology (EULAR), (Vienna, Austria)
  • 2024: The 9th Conference on Osteoimmunology (Loutraki, Greece,)
  • 2023: The 18th International Congress of Immunology – IUIS 2023 (Cape Town, SA)
  • 2023: The European Alliance of Associations for Rheumatology (EULAR) (Milan, Italy)
  • 2023: Advanced in Targeted Therapies (ATT) meeting (Niece, France)
  • 2022: 5th International Therapeutic Tolerance workshop (Newcastle, UK)
  • 2022: The European Alliance of Associations for Rheumatology (EULAR) (Copenhagen , Denmark)
  • 2022: The British Society of Immunology meeting (Liverpool, UK)
  • 2022: The British Society of Rheumatology Meeting (Glasgow, UK)
  • 2022: The Japanese College Rheumatology Meeting (JRM) (Japan)
  • 2021: Biomarkers in Rheumatic Diseases, 12th International Meeting (Rome, Italy)
  • 2021: European Congress of Immunology (ECI) (online)
  • 2020: European Workshop for Rheumatology Research (EWRR) (Gent, Brussels)
  • 2019: Forum on Rheumatoid Arthritis (Washington, USA)

A head and shoulders profile shot of Professor Mariola Kurowska-Stolarska