Dr Timothy Palmer

  • Honorary Senior Research Fellow (School of Cardiovascular & Metabolic Health)

telephone: 01482465511
email: Tim.Palmer@glasgow.ac.uk

R421 Level 4, Institute of C&MS, Davidson Building, Glasgow G12 8QQ

Import to contacts

Biography

Having graduated from the University of Manchester in 1987 with a First Class BSc (Hons) degree in Biochemistry, I studied for my PhD within the Molecular Pharmacology Group here at the University of Glasgow, graduating in 1991. I carried out my postdoctoral studies in the Cardiology Division at Duke University Medical Centre in Durham, North Carolina, USA developing new molecular biological tools and experimental approaches to examine the regulation of cardioprotective signalling pathways. In 1997 I accepted a position here at Glasgow and am currently a Reader at the Institute of Cardiovascular and Medical Sciences.

Research interests

My research programme examines the molecular architecture of novel signalling pathways in vascular endothelial cells with the aim of exploiting these observations to improve treatments for cardiovascular diseases.

Research:

  • The JAK-STAT Pathway and the Development of Cardiovascular Disease

 

Publications

List by: Type | Date

Jump to: 2021 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
Number of items: 48.

2021

Palmer, T. M. and Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

2019

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, 145(2), pp. 427-434. (doi: 10.1002/ijc.32126) (PMID:30650180)

2018

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S. , Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Speirs, C., Williams, J. J.L., Riches, K., Salt, I. P. and Palmer, T. M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001) (PMID:29037480)

Williams, J. J.L., Al-Otaiq, N., Mullen, W. , Burchmore, R. , Liu, L., Baillie, G. S. , Schaper, F., Pilch, P. F. and Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)

2017

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

2016

Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., Gould, G. W. and Salt, I. P. (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochemical Journal, 473(24), pp. 4681-4697. (doi: 10.1042/BCJ20160211) (PMID:27784766) (PMCID:PMC5147050)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)

2015

Palmer, T. P. and Yarwood, S. J. (2015) Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1. Journal of Cell Signaling, 1(1), 1000103. (doi: 10.4172/jcs.1000103)

Parnell, E., Palmer, T. M. and Yarwood, S. J. (2015) The future of EPAC-targeted therapeutics: agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), pp. 203-214. (doi: 10.1016/j.tips.2015.02.003) (PMID:25744542) (PMCID:PMC4392396)

2014

Williams, J., Munro, K. and Palmer, T. (2014) Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells, 3(2), pp. 546-562. (doi: 10.3390/cells3020546) (PMID:24886706) (PMCID:PMC4092859)

Williams, J. J.L. and Palmer, T. M. (2014) Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochemical Society Transactions, 42(2), pp. 284-288. (doi: 10.1042/BST20130270) (PMID:24646232)

2013

Rutherford, C. et al. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), e927. (doi: 10.1038/cddis.2013.455)

Cannavo, A. et al. (2013) β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation, 128(15), pp. 1612-1622. (doi: 10.1161/CIRCULATIONAHA.113.002659)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi: 10.1016/j.molcel.2013.03.016)

2012

Salt, I. P. and Palmer, T. M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)

Dondelinger, F., Rogers, S. , Filippone, M., Cretella, R., Palmer, T., Smith, R., Millar, A. and Husmeier, D. (2012) Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching. In: WCSB2012 - 9th International Workshop on Computational Systems Biology, Ulm, Germany, 4-6 Jun 2012,

Parnell, E., Smith, B. O. , Palmer, T. M., Terrin, A., Zaccolo, M. and Yarwood, S. J. (2012) Regulation of the inflammatory response of vascular endothelial cells by EPAC1. British Journal of Pharmacology, 166(2), pp. 434-446. (doi: 10.1111/j.1476-5381.2011.01808.x)

Milne, G. R., Palmer, T. M. and Yarwood, S. J. (2012) Novel control of cAMP-regulated transcription in vascular endothelial cells. Biochemical Society Transactions, 40(1), pp. 1-5. (doi: 10.1042/BST20110606)

Williams, J. J.L. and Palmer, T. M. (2012) Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. Biochemical Society Transactions, 40(1), pp. 215-218. (doi: 10.1042/BST20110629) (PMID:22260693)

Sands, W. A., Woolson, H. D., Yarwood, S. J. and Palmer, T. M. (2012) Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter. Methods in Molecular Biology, 809, pp. 201-214. (doi: 10.1007/978-1-61779-376-9_14)

Williams, J. J.L. and Palmer, T. M. (2012) Interleukin-6 (IL6) signalling and its role in the development of cardiovascular disease. In: Carrasco, J. and Mota, M. (eds.) Endothelium and Epithelium: Composition, Functions and Pathology. Series: Human anatomy and physiology; Cell biology research progress. Nova Science Publishers: Hauppauge, N.Y., pp. 157-173. ISBN 9781614708742

2011

Lawlor, D.A., Fraser, A., Macdonald-Wallis, C., Nelson, S.M. , Palmer, T.M., Davey Smith, G. and Tilling, K. (2011) Maternal and offspring adiposity-related genetic variants and gestational weight gain. American Journal of Clinical Nutrition, 94(1), pp. 149-155. (doi: 10.3945/ajcn.110.010751)

Milne, G. and Palmer, T. M. (2011) Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor. Scientific World Journal, 11, pp. 320-339. (doi: 10.1100/tsw.2011.22)

2010

Safhi, M. M. A., Rutherford, C., Ledent, C., Sands, W. A. and Palmer, T. M. (2010) Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A2a adenosine receptor. Molecular Pharmacology, 77(6), pp. 968-978. (doi: 10.1124/mol.109.062455)

Mundell, S.J., Matharu, A.-L., Palmer, T.M., Benovic, J.L. and Kelly, E. (2010) Deletion of the distal COOH-terminus of the A2B adenosine receptor switches agonist-induced internalisation to an arrestin- and clathrin-independent pathway and inhibits receptor recycling. British Journal of Pharmacology, 159(3), pp. 518-533. (doi: 10.1111/j.1476-5381.2009.00598.x)

Rutherford, C. and Palmer, T.M. (2010) Molecular basis of protective anti-inflammatory signalling by cyclic AMP in the vascular endothelium. In: Choi, S. (ed.) Systems Biology of Signaling Networks. Series: Systems biology (1). Springer, pp. 561-588. ISBN 9781441957962

2009

Woolson, H. D., Thomson, V. S., Rutherford, C., Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. Cellular Signalling, 21(11), pp. 1706-1715. (doi: 10.1016/j.cellsig.2009.07.009) (PMID:32549377) (PMCID:PMC7352853)

Borland, G., Bird, R. J., Palmer, T. M. and Yarwood, S. J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)

2008

Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)

Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)

Palmer, T.M. and Trevethick, M.A. (2008) Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction. British Journal of Pharmacology, 153, S27-S34. (doi: 10.1038/sj.bjp.0707524) (PMID:18026131)

Sands, W.A. and Palmer, T.M. (2008) Regulating gene transcription in response to cyclic AMP elevation. Cellular Signalling, 20(3), pp. 460-466. (doi: 10.1016/j.cellsig.2007.10.005)

2006

Sands, W.A., Woolson, H.D., Milne, G.R., Rutherford, C. and Palmer, T.M. (2006) Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Molecular and Cellular Biology, 26(17), pp. 6333-6346.

Funakoshi, H. et al. (2006) Regulated overexpression of the A(1)-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation, 114, pp. 2240-2250. (doi: 10.1161/CIRCULATIONAHA.106.620211)

2005

Rutherford, C., Ord-Shrimpton, F., Sands, W., Pediani, J., Benovic, J., McGrath, J. and Palmer, T. (2005) Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P(3). Cellular Signalling, 17, pp. 997-1009. (doi: 10.1016/j.cellsig.2004.11.018)

Sands, W. and Palmer, T. (2005) Adenosine receptors and the control of endothelial cell function in inflammatory disease. Immunology Letters, 101, pp. 1-11. (doi: 10.1016/j.imlet.2005.04.005)

Sands, W. and Palmer, T. (2005) Inhibition of pro-inflammatory cytokine receptor signalling by CAMP in vascular endothelial cells. Biochemical Society Transactions, 33, pp. 1126-1128.

2004

Sands, W., Martin, A., Strong, E. and Palmer, T. (2004) Specific inhibition of nuclear factor-kappa B-dependent inflammatory responses by cell type-specific mechanisms upon A(2A) adenosine receptor gene transfer. Molecular Pharmacology, 66, pp. 1147-1159. (doi: 10.1124/mol.104.001107)

2003

Palmer, T., Ferguson, G. and Watterson, K. (2003) Dissecting the regulatory mechanisms controlling inhibitory adenosine receptor signaling. Drug Development Research, 58, pp. 302-314. (doi: 10.1002/ddr.10185)

Perry, C., Palmer, T., Cleland, S., Morton, I., Salt, I. , Petrie, J. , Gould, G. and Connell, J. (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi: 10.1042/CS20020320)

2002

Ferguson, G., Watterson, K.R. and Palmer, T.M. (2002) Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A(1) and rat A(3) adenosine receptors: Consequences for agonist-stimulated translocation of arrestin3. Biochemistry, 41, pp. 14748-14761. (doi: 10.1021/bi0262911)

Klinger, M., Kuhn, M., Just, H., Stefan, E., Palmer, T., Freissmuth, M. and Nanoff, C. (2002) Removal of the carboxy terminus of the A(2A)-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 366, pp. 287-298. (doi: 10.1007/s00210-002-0617-z)

Palmer, T. (2002) Molecular regulation of adenosine receptor signalling: implications for the design of novel cardioprotective and anti-inflammatory therapies. Recent Research Developments in Molecular Pharmacology, 1, pp. 53-75.

Watterson, K., Johnston, E., Chalmers, C., Pronin, A., Cook, S., Benovic, J. and Palmer, T. (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)

2001

Alderton, F., Rakhit, S., Kong, K.C., Palmer, T., Sambi, B., Pyne, S. and Pyne, N.J. (2001) Tethering of the platelet-derived growth factor ß receptor to G-protein-coupled receptors - A novel platform for integrative signaling by these receptor classes in mammalian cells. Journal of Biological Chemistry, 276, pp. 28578-28585. (doi: 10.1074/jbc.M102771200)

2000

Ferguson, G., Watterson, K. R. and Palmer, T. M. (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Molecular Pharmacology, 57(3), pp. 546-552. (doi: 10.1124/mol.57.3.546) (PMID:10692495)

This list was generated on Thu Nov 21 03:32:26 2024 GMT.
Jump to: Articles | Book Sections | Conference Proceedings
Number of items: 48.

Articles

Palmer, T. M. and Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, 145(2), pp. 427-434. (doi: 10.1002/ijc.32126) (PMID:30650180)

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S. , Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Speirs, C., Williams, J. J.L., Riches, K., Salt, I. P. and Palmer, T. M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001) (PMID:29037480)

Williams, J. J.L., Al-Otaiq, N., Mullen, W. , Burchmore, R. , Liu, L., Baillie, G. S. , Schaper, F., Pilch, P. F. and Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., Gould, G. W. and Salt, I. P. (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochemical Journal, 473(24), pp. 4681-4697. (doi: 10.1042/BCJ20160211) (PMID:27784766) (PMCID:PMC5147050)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)

Palmer, T. P. and Yarwood, S. J. (2015) Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1. Journal of Cell Signaling, 1(1), 1000103. (doi: 10.4172/jcs.1000103)

Parnell, E., Palmer, T. M. and Yarwood, S. J. (2015) The future of EPAC-targeted therapeutics: agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), pp. 203-214. (doi: 10.1016/j.tips.2015.02.003) (PMID:25744542) (PMCID:PMC4392396)

Williams, J., Munro, K. and Palmer, T. (2014) Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells, 3(2), pp. 546-562. (doi: 10.3390/cells3020546) (PMID:24886706) (PMCID:PMC4092859)

Williams, J. J.L. and Palmer, T. M. (2014) Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochemical Society Transactions, 42(2), pp. 284-288. (doi: 10.1042/BST20130270) (PMID:24646232)

Rutherford, C. et al. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), e927. (doi: 10.1038/cddis.2013.455)

Cannavo, A. et al. (2013) β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation, 128(15), pp. 1612-1622. (doi: 10.1161/CIRCULATIONAHA.113.002659)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi: 10.1016/j.molcel.2013.03.016)

Salt, I. P. and Palmer, T. M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)

Parnell, E., Smith, B. O. , Palmer, T. M., Terrin, A., Zaccolo, M. and Yarwood, S. J. (2012) Regulation of the inflammatory response of vascular endothelial cells by EPAC1. British Journal of Pharmacology, 166(2), pp. 434-446. (doi: 10.1111/j.1476-5381.2011.01808.x)

Milne, G. R., Palmer, T. M. and Yarwood, S. J. (2012) Novel control of cAMP-regulated transcription in vascular endothelial cells. Biochemical Society Transactions, 40(1), pp. 1-5. (doi: 10.1042/BST20110606)

Williams, J. J.L. and Palmer, T. M. (2012) Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. Biochemical Society Transactions, 40(1), pp. 215-218. (doi: 10.1042/BST20110629) (PMID:22260693)

Sands, W. A., Woolson, H. D., Yarwood, S. J. and Palmer, T. M. (2012) Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter. Methods in Molecular Biology, 809, pp. 201-214. (doi: 10.1007/978-1-61779-376-9_14)

Lawlor, D.A., Fraser, A., Macdonald-Wallis, C., Nelson, S.M. , Palmer, T.M., Davey Smith, G. and Tilling, K. (2011) Maternal and offspring adiposity-related genetic variants and gestational weight gain. American Journal of Clinical Nutrition, 94(1), pp. 149-155. (doi: 10.3945/ajcn.110.010751)

Milne, G. and Palmer, T. M. (2011) Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor. Scientific World Journal, 11, pp. 320-339. (doi: 10.1100/tsw.2011.22)

Safhi, M. M. A., Rutherford, C., Ledent, C., Sands, W. A. and Palmer, T. M. (2010) Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A2a adenosine receptor. Molecular Pharmacology, 77(6), pp. 968-978. (doi: 10.1124/mol.109.062455)

Mundell, S.J., Matharu, A.-L., Palmer, T.M., Benovic, J.L. and Kelly, E. (2010) Deletion of the distal COOH-terminus of the A2B adenosine receptor switches agonist-induced internalisation to an arrestin- and clathrin-independent pathway and inhibits receptor recycling. British Journal of Pharmacology, 159(3), pp. 518-533. (doi: 10.1111/j.1476-5381.2009.00598.x)

Woolson, H. D., Thomson, V. S., Rutherford, C., Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. Cellular Signalling, 21(11), pp. 1706-1715. (doi: 10.1016/j.cellsig.2009.07.009) (PMID:32549377) (PMCID:PMC7352853)

Borland, G., Bird, R. J., Palmer, T. M. and Yarwood, S. J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)

Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)

Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)

Palmer, T.M. and Trevethick, M.A. (2008) Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction. British Journal of Pharmacology, 153, S27-S34. (doi: 10.1038/sj.bjp.0707524) (PMID:18026131)

Sands, W.A. and Palmer, T.M. (2008) Regulating gene transcription in response to cyclic AMP elevation. Cellular Signalling, 20(3), pp. 460-466. (doi: 10.1016/j.cellsig.2007.10.005)

Sands, W.A., Woolson, H.D., Milne, G.R., Rutherford, C. and Palmer, T.M. (2006) Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Molecular and Cellular Biology, 26(17), pp. 6333-6346.

Funakoshi, H. et al. (2006) Regulated overexpression of the A(1)-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation, 114, pp. 2240-2250. (doi: 10.1161/CIRCULATIONAHA.106.620211)

Rutherford, C., Ord-Shrimpton, F., Sands, W., Pediani, J., Benovic, J., McGrath, J. and Palmer, T. (2005) Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P(3). Cellular Signalling, 17, pp. 997-1009. (doi: 10.1016/j.cellsig.2004.11.018)

Sands, W. and Palmer, T. (2005) Adenosine receptors and the control of endothelial cell function in inflammatory disease. Immunology Letters, 101, pp. 1-11. (doi: 10.1016/j.imlet.2005.04.005)

Sands, W. and Palmer, T. (2005) Inhibition of pro-inflammatory cytokine receptor signalling by CAMP in vascular endothelial cells. Biochemical Society Transactions, 33, pp. 1126-1128.

Sands, W., Martin, A., Strong, E. and Palmer, T. (2004) Specific inhibition of nuclear factor-kappa B-dependent inflammatory responses by cell type-specific mechanisms upon A(2A) adenosine receptor gene transfer. Molecular Pharmacology, 66, pp. 1147-1159. (doi: 10.1124/mol.104.001107)

Palmer, T., Ferguson, G. and Watterson, K. (2003) Dissecting the regulatory mechanisms controlling inhibitory adenosine receptor signaling. Drug Development Research, 58, pp. 302-314. (doi: 10.1002/ddr.10185)

Perry, C., Palmer, T., Cleland, S., Morton, I., Salt, I. , Petrie, J. , Gould, G. and Connell, J. (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi: 10.1042/CS20020320)

Ferguson, G., Watterson, K.R. and Palmer, T.M. (2002) Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A(1) and rat A(3) adenosine receptors: Consequences for agonist-stimulated translocation of arrestin3. Biochemistry, 41, pp. 14748-14761. (doi: 10.1021/bi0262911)

Klinger, M., Kuhn, M., Just, H., Stefan, E., Palmer, T., Freissmuth, M. and Nanoff, C. (2002) Removal of the carboxy terminus of the A(2A)-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 366, pp. 287-298. (doi: 10.1007/s00210-002-0617-z)

Palmer, T. (2002) Molecular regulation of adenosine receptor signalling: implications for the design of novel cardioprotective and anti-inflammatory therapies. Recent Research Developments in Molecular Pharmacology, 1, pp. 53-75.

Watterson, K., Johnston, E., Chalmers, C., Pronin, A., Cook, S., Benovic, J. and Palmer, T. (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)

Alderton, F., Rakhit, S., Kong, K.C., Palmer, T., Sambi, B., Pyne, S. and Pyne, N.J. (2001) Tethering of the platelet-derived growth factor ß receptor to G-protein-coupled receptors - A novel platform for integrative signaling by these receptor classes in mammalian cells. Journal of Biological Chemistry, 276, pp. 28578-28585. (doi: 10.1074/jbc.M102771200)

Ferguson, G., Watterson, K. R. and Palmer, T. M. (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Molecular Pharmacology, 57(3), pp. 546-552. (doi: 10.1124/mol.57.3.546) (PMID:10692495)

Book Sections

Williams, J. J.L. and Palmer, T. M. (2012) Interleukin-6 (IL6) signalling and its role in the development of cardiovascular disease. In: Carrasco, J. and Mota, M. (eds.) Endothelium and Epithelium: Composition, Functions and Pathology. Series: Human anatomy and physiology; Cell biology research progress. Nova Science Publishers: Hauppauge, N.Y., pp. 157-173. ISBN 9781614708742

Rutherford, C. and Palmer, T.M. (2010) Molecular basis of protective anti-inflammatory signalling by cyclic AMP in the vascular endothelium. In: Choi, S. (ed.) Systems Biology of Signaling Networks. Series: Systems biology (1). Springer, pp. 561-588. ISBN 9781441957962

Conference Proceedings

Dondelinger, F., Rogers, S. , Filippone, M., Cretella, R., Palmer, T., Smith, R., Millar, A. and Husmeier, D. (2012) Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching. In: WCSB2012 - 9th International Workshop on Computational Systems Biology, Ulm, Germany, 4-6 Jun 2012,

This list was generated on Thu Nov 21 03:32:26 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Regulation of Anti-inflammatory Gene Expression in Vascular Endothelial Cells by EPAC1
    British Heart Foundation
    2015 - 2018
     
  • SUPPRESSION OF IL-6 TRANS-SIGNALLING BY BMP4:A MISSING LINK" IN THE DEVELOPMENT OF PULMONARY ARTERIAL HYPERTENSION?"
    British Heart Foundation
    2014 - 2017
     
  • Inhibition of endothelial mitogen-activated protein kinases by amp-activated protein kinase
    British Heart Foundation
    2014 - 2017
     
  • Limiting SOCS3 degradation to inhibit Th17 cell expansion.
    NHS Greater Glasgow and Clyde
    2013 - 2014
     
  • An 'Omics Fingerprint of IL-6 Action in Vascular Endothelial Cells (ISSF STS)
    Wellcome Trust
    2013 - 2013
     
  • Extracellular signal-regulated kinase 5 (ERK5) and regulation of neuroendocrine differentiation in prostate cancer
    Chief Scientist Office
    2012 - 2014
     
  • Inhibition of vascular Stat Signalling by Amp-Activated Protein Kinase (AMPK).
    British Heart Foundation
    2012 - 2015
     
  • The sensitive assessment of the activity of cellular signalling pathways regulating insulin action and the cardiovascular complications of diabetes
    Diabetes UK
    2011 - 2014
     
  • Reversal of endothelial interleukin-6 signalling in by AMPK: a new mechanism underlying increased cardiovascular disease risk and identification of new drug targets.
    NHS Greater Glasgow and Clyde
    2011 - 2012
     
  • The Role of EPAC1-regulated Protein Kinase C Isoforms in Mediating C/EBPdelta -dependent, Anti-inflammatory Actions of Cyclic AMP in Vascular Endothelial Cells
    British Heart Foundation
    2010 - 2013
     
  • Reversal of pro-inflammatory interleukin-6 signalling by cyclic AMP-mediated induction of suppressor of cytokine signalling-3(SOCS-3)
    Chest Heart and Stroke Scotland
    2010 - 2011
     
  • EPAC1 and ERK-dependent activation of C/EBP transcription factors: a new cyclic AMP-activated anti-inflammatory gene expression module in vascular endothelial cells
    British Heart Foundation
    2009 - 2011
     
  • Priming phosphorylated STAT proteins for cytokine-triggered degradation in vascular endothelial cells: A new anti-inflammatory role for the A2A adenosine receptor.
    British Heart Foundation
    2007 - 2010
     
  • The EPAC-C/EBP pathway - a new route for the control of gene expression by cyclic AMP
    Biotechnology and Biological Sciences Research Council
    2006 - 2009
     
  • SOCS3 induction - a new physiological role for the cAMP sensor Epac in limiting endothelial dysfunction
    British Heart Foundation
    2005 - 2008
     
  • Identification of the molecular mechanisms controlling atherogenic signalling from the lysophosphatidic acid receptors LPA1 and LPA3
    British Heart Foundation
    2003 - 2006
     
  • Subcellular compartmentalisation analysis by confocal microscopy
    Biotechnology and Biological Sciences Research Council
    2003 - 2007
     

Additional information

Editorial Board

  • 2010 - present: ISRN Pharmacology

Grant Advisory Board

  • 2006 - present: FEBS - Working Group on Women in Science (WISE)
  • 2004 - present: European Commission Framework VI - CA/STREP Committee member for assessment of proposals received in the area of Functional Genomics

Invited International Presentations

  • 2007: Glasgow, Scotland - Co-organiser of LifeScience 2007 symposium on “Advances in the biology of adenosine receptors: focus on the adenosine A2A receptor”
  • 2007: University of Durham, Durham, England - Contemporary Issues in Cyclic Nucleotide Signalling.
  • 2003: Essex, England - Chair and Organiser of Biochemical Society symposium “Integration of mitogenic and migratory signals from G-protein-coupled receptors and tyrosine kinases” , University of Essex
  • 2002: Heraklion, Crete - Invited symposium speaker on sphingosine-1-phosphate receptor regulation. 7th World Congress on Advances in Oncology and 5th International Symposium on Molecular Medicine
  • 2002: Surfers Paradise, Gold Coast, Australia - Invited symposium speaker on inhibitory adenosine receptor regulation. Purines 2002 International Conference

Professional Learned Society

  • 2010 - present: British Society for Cardiovascular Research - Member
  • 2010 - present: International Society for Heart Research - Member
  • 1997 - present: Biochemical Society - Member. Serving onTheme Panel V (Signal Transduction) from 2003, Group (2002-2003)

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