Microbiology PhD/iPhD/MSc (Research)

Our interests lie in the interaction between bacterial pathogens and their hosts at the mucosal interface. We study key virulence determinants of bacterial pathogens and the host factors that influence outcome of disease, particularly within the immune system. Using both animal models and human systems, we aim to develop better drugs and vaccines for the treatment and prevention of infection.

PhD: 3-4 years full-time; 5 years part-time;
MSc (Research): 1 year full-time; 2 years part-time;
IPhD: 5 years full-time;

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Research projects

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Host-Pathogene Interactions in Pneumococcal Infection

Supervisor: Professor Tom J Evans

Project outline: Infection with Streptococcus pneumoniae (Pneumococcus) remains a significant medical problem. Invasive disease includes pneumonia, sepsis and CNS infections. Mortality remains high, especially in the developing world. We study the intercations between this pathogen and the host, in order to understand better the innate and acquired immune mechanisms that underlie protection against infection. This project will study the role that the cytokine IL-17 plays in host defence against infection. This cytokine co-ordinates a neutrophil response to the infection that can be protective or harmful dependent on the bacterial strain. We will investigate the mechanisms of this effect and analyse the adaptations that the pneumococcus makes to allow it to resist innate and acquired immune clearance. Results from these studies will help in the identification of bacterial targets that could be exploited for novel therapeutic interventions and/or as the basis of a vaccine.

Summary aim: To determine the key innate and acquired immune responses that allow IL-17 to exert its biological effects in pneumococcal infection

Techniques used: Multi-colour Flow cytometry, qPCR, animal models of infection, ELISA, Intracellular cytokine detection

References

Future Microbiol. 2012 Jan;7(1):33-46. doi: 10.2217/fmb.11.146. What is different about serotype 1 pneumococci? Ritchie ND, Mitchell TJ, Evans TJ.

Contact: Professor Tom Evans, Level 4, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK. Phone: +44 (0)141 330 8418, Fax: +44 (0)141 330 4297

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Overview

Growing resistance to antibiotics poses a grave threat to human health and developing novel strategies to combat bacterial infections is one of this century’s most important scientific challenges. Microbiology at the School of Infection and Immunity is focused on a molecular understanding bacterial pathogenesis and utilising this to develop novel therapeutics for the treatment of bacterial infections.

Individual research projects may cover a range of human pathogens that cause community and hospital acquired infections in addition to economically important animal pathogens. The bacterial species studied include S. aureus, E. coli, S. pneumoniae, P. aeruginosa, C. difficile, C. jejuni, S. enteric and P. multocida.

Basic science, preclinical and clinical areas are available for study, with individual research projects tailored around the expertise of principal investigators within the School. A range of technical approaches are covered including molecular biology, genetics, genomics, proteomics, immunology, structural biology, biophysics and in vitro and in vivo models of disease. Specific areas of interest include:

molecular basis of virulence in Staphylococcus aureus and C. difficile
bacterial manipulation of apoptosis
bacteriophage and pathogenicity island genetics
development of therapeutic anti-virulence strategies
pneumonia and cystic fibrosis
interactions of bacteria with the host immune system
genomic approaches to understanding pathogen evolution
novel therapeutic approaches for the treatment of C. difficile infection
mechanisms of Campylobacter jejuni pathogenesis
development of therapeutic species specific antibiotics

Study options

PhD

Duration: 3/4 years full-time; 5 years part-time

Individual research projects are tailored around the expertise of principal investigators.

Integrated PhD programmes (5 years)

Our Integrated PhD allows you to combine masters level teaching with your chosen research direction in a 1+3+1 format.

International students with MSc and PhD scholarships/funding do not have to apply for 2 visas or exit and re-enter the country between programmes. International and UK/EU students may apply.

Year 1

Taught masters level modules are taken alongside students on our masters programmes. Our research-led teaching supports you to fine tune your research ideas and discuss these with potential PhD supervisors. You will gain a valuable introduction to academic topics, research methods, laboratory skills and the critical evaluation of research data. Your grades must meet our requirements in order to gain entry on to your pre-selected PhD research project. If not, you will have the options to pay outstanding MSc fees and complete with masters degree only.

Years 2, 3 and 4

PhD programme with research/lab work, completing an examinable piece of independent research in year 4.

Year 5

Thesis write up.

MSc (Research)

Duration: 1 year full-time; 2 years part-time

Entry requirements

A 2.1 Honours degree or equivalent.

English language requirements

For applicants whose first language is not English, the University sets a minimum English Language proficiency level.

International English Language Testing System (IELTS) Academic module (not General Training)

6.5 with no subtests under 6.0
Tests must have been taken within 2 years 5 months of start date. Applicants must meet the overall and subtest requirements using a single test.

Common equivalent English language qualifications accepted for entry to this programme:

TOEFL (ibt, my best or athome)

79; with Reading 13; Listening 12; Speaking 18;Writing 21
Tests must have been taken within 2 years 5 months of start date. Applicants must meet the overall and subtest requirements , this includes TOEFL mybest.

Pearsons PTE Academic

59 with minimum 59 in all subtests
Tests must have been taken within 2 years 5 months of start date. Applicants must meet the overall and subtest requirements using a single test.

Cambridge Proficiency in English (CPE) and Cambridge Advanced English (CAE)

176 overall, no subtest less than 169
Tests must have been taken within 2 years 5 months of start date. Applicants must meet the overall and subtest requirements using a single test.

Oxford English Test

Oxford ELLT 7
R&L: OIDI level no less than 6 with Reading: 21-24 Listening: 15-17
W&S: OIDI level no less than 6

Trinity College Tests

Integrated Skills in English II & III & IV: ISEII Distinction with Distinction in all sub-tests.

University of Glasgow Pre-sessional courses

Tests are accepted for 2 years following date of successful completion.

Alternatives to English Language qualification

Degree from majority-English speaking country (as defined by the UKVI including Canada if taught in English)
- students must have studied for a minimum of 2 years at Undergraduate level, or 9 months at Master's level, and must have complete their degree in that majority-English speaking country and within the last 6 years
Undergraduate 2+2 degree from majority-English speaking country (as defined by the UKVI including Canada if taught in English)
- students must have completed their final two years study in that majority-English speaking country and within the last 6 years

For international students, the Home Office has confirmed that the University can choose to use these tests to make its own assessment of English language ability for visa applications to degree level programmes. The University is also able to accept UKVI approved Secure English Language Tests (SELT) but we do not require a specific UKVI SELT for degree level programmes. We therefore still accept any of the English tests listed for admission to this programme.

Pre-sessional courses

The University of Glasgow accepts evidence of the required language level from the English for Academic Study Unit Pre-sessional courses. We also consider other BALEAP accredited pre-sessional courses:

Fees and funding

Fees

2024/25

UK: £4,786
International & EU: £30,240

Prices are based on the annual fee for full-time study. Fees for part-time study are half the full-time fee.

Irish nationals who are living in the Common Travel Area of the UK, EU nationals with settled or pre-settled status, and Internationals with Indefinite Leave to remain status can also qualify for home fee status.

Fee status and policies

Alumni discount

We offer a 20% discount to our alumni on all Postgraduate Research and full Postgraduate Taught Masters programmes. This includes University of Glasgow graduates and those who have completed Junior Year Abroad, Exchange programme or International Summer School with us. The discount is applied at registration for students who are not in receipt of another discount or scholarship funded by the University. No additional application is required.

Possible additional fees

Re-submission by a research student £540
Submission for a higher degree by published work £1,355
Submission of thesis after deadline lapsed £350
Submission by staff in receipt of staff scholarship £790

Depending on the nature of the research project, some students will be expected to pay a bench fee (also known as research support costs) to cover additional costs. The exact amount will be provided in the offer letter.

Funding

The iPhD is not supported by University of Glasgow Scholarship/Funding

BBSRC Doctoral Training Partnerships
External funding information

Support

The College of Medical, Veterinary and Life Sciences Graduate School provides a vibrant, supportive and stimulating environment for all our postgraduate students. We aim to provide excellent support for our postgraduates through dedicated postgraduate convenors, highly trained supervisors and pastoral support for each student.

Our overarching aim is to provide a research training environment that includes:

provision of excellent facilities and cutting edge techniques
training in essential research and generic skills
excellence in supervision and mentoring
interactive discussion groups and seminars
an atmosphere that fosters critical cultural policy and research analysis
synergy between research groups and areas
extensive multidisciplinary and collaborative research
extensive external collaborations both within and beyond the UK
a robust generic skills programme including opportunities in social and commercial training

Research environment

If you study with us, you will join a community of 26 postgraduate taught and 150 postgraduate research students. Our School brings together world-leading basic, applied, clinical and translational researchers to study infection with a focus on the viral, parasitic and bacterial pathogens of both humans and animals, and immunology and inflammation with a focus on chronic inflammatory diseases.

Despite the continual development of new therapies, antibiotics and vaccines, chronic inflammatory and infectious diseases still pose persistent health threats, we aim to:

understand the basic science of the immune systems and how the immune system can inturn affect disease outcome understand the biology of parasites, viruse and bacteria and the interactions with their hosts, that in turn leads to high levels of infectious diseases worldwide
develop therapies (drugs and vaccines) targeted on these processes
explore new treatments and strategies in clinical and translational medicine

Research centres:

How to apply

Identify potential supervisors

All Postgraduate Research Students are allocated a supervisor who will act as the main source of academic support and research mentoring. You may want to identify a potential supervisor and contact them to discuss your research proposal before you apply. Please note, even if you have spoken to an academic staff member about your proposal you still need to submit an online application form.

You can find relevant academic staff members with our staff research interests search.

IPhD applicants do not need to contact a supervisor, as you will choose from a list of IPhD projects. Each project has named supervisors.

Gather your documents

Before applying please make sure you gather the following supporting documentation:

Final or current degree transcripts including grades (and an official translation, if needed) – scanned copy in colour of the original document.
Degree certificates (and an official translation, if needed): scanned copy in colour of the original document
Two references on headed paper and signed by the referee. One must be academic, the other can be academic or professional [except iPhD applicants, where only one academic or professional reference is required]. References may be uploaded as part of the application form or you may enter your referees contact details on the application form. We will then email your referee and notify you when we receive the reference. We can also accept confidential references direct to rio-researchadmissions@glasgow.ac.uk, from the referee’s university or business email account.
Research proposal, CV, samples of written work as per requirements for each subject area. iPhD applicants do not need to submit any of these as you will start your programme by choosing a masters.
Completed College of MVLS Postgraduate Research Cover Letter

Notes for iPhD applicants

add 'I wish to study the MSc in (select MSc from IPhD project choices) as the masters taught component of the IPhD' in the research proposal box
For supervisor name, please ensure you write the named supervisors from your chosen IPhD project.